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  1. Article ; Online: Association of liver fibrosis biomarkers with overall and CVD mortality in the Korean population: The Dong-gu study.

    Choi, Seong-Woo / Kweon, Sun-Seog / Lee, Young-Hoon / Ryu, So-Yeon / Nam, Hae-Sung / Shin, Min-Ho

    PloS one

    2022  Volume 17, Issue 12, Page(s) e0277729

    Abstract: ... who participated in Dong-gu Study. The associations of liber fibrosis biomarkers with mortality were investigated ...

    Abstract This study evaluated the associations of liver fibrosis biomarkers [non-alcoholic fatty liver disease fibrosis score (NFS), fibrosis-4 (FIB-4), aspartate aminotransferase/platelet ratio index (APRI), and BARD score] with mortality in Korean adults aged ≥50 years. We analyzed 7,702 subjects who participated in Dong-gu Study. The associations of liber fibrosis biomarkers with mortality were investigated using Cox proportional hazards models. Overall mortality increased with increasing NFS level [adjusted hazard ratio (aHR) 4.3, 95% confidence interval (CI) 3.3-5.5 for high risk vs. low risk], increasing FIB-4 level (aHR 3.5, 95% CI 2.9-4.4 for high risk vs. low risk), and increasing APRI level (aHR 3.5, 95% CI 2.1-5.8 for high risk vs. low risk) but not with BARD score. The Harrell's concordance index for overall mortality for the NFS and FIB-4 was greater than that for the APRI and BARD score. In conclusion, NFS, FIB-4, and APRI showed a significant relationship with the overall mortality, and NFS and FIB-4 showed a significant relationship with the CVD mortality after adjustment for covariates. In addition, the NFS and FIB-4 were more predictive of overall mortality than the APRI and BARD score in Korean adults aged ≥50 years.
    MeSH term(s) Adult ; Humans ; Non-alcoholic Fatty Liver Disease/pathology ; Retrospective Studies ; Liver Cirrhosis/pathology ; Aspartate Aminotransferases ; Biomarkers ; Fibrosis ; Republic of Korea/epidemiology ; Cardiovascular Diseases/complications ; Biopsy ; Severity of Illness Index ; Liver/pathology
    Chemical Substances Aspartate Aminotransferases (EC 2.6.1.1) ; Biomarkers
    Language English
    Publishing date 2022-12-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0277729
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: RNA-Seq and 16S rRNA Reveals That Tian-Dong-Tang-Gan Powder Alleviates Environmental Stress-Induced Decline in Immune and Antioxidant Function and Gut Microbiota Dysbiosis in

    Xie, Xiao-Dong / Zhou, Ying / Sun, Yu-Bo / Yi, Shou-Li / Zhao, Yi / Chen, Qi / Xie, Ying-Hong / Cao, Mi-Xia / Yu, Mei-Ling / Wei, Ying-Yi / Zhang, Ling / Hu, Ting-Jun

    Antioxidants (Basel, Switzerland)

    2023  Volume 12, Issue 6

    Abstract: Ammonia stress and nitrite stress can induce immune depression and oxidative stress ... ...

    Abstract Ammonia stress and nitrite stress can induce immune depression and oxidative stress in
    Language English
    Publishing date 2023-06-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12061262
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Association between alcohol and bone mineral density in a Mendelian randomization study: the Dong-gu study.

    Choi, Chang Kyun / Kweon, Sun-Seog / Lee, Young-Hoon / Nam, Hae-Sung / Park, Kyeong-Soo / Ryu, So-Yeon / Choi, Seong-Woo / Shin, Min-Ho

    Journal of bone and mineral metabolism

    2021  Volume 40, Issue 1, Page(s) 167–173

    Abstract: ... and methods: This study enrolled 8892 participants from the Dong-gu study. Mendelian randomization ...

    Abstract Introduction: Many previous studies have reported a positive relationship between alcohol and bone mineral density (BMD). However, the causality between alcohol and BMD has not been fully evaluated.
    Materials and methods: This study enrolled 8892 participants from the Dong-gu study. Mendelian randomization (MR) using two-stage least-squared regression was used to evaluate the association between the genetically predicted amount of alcohol consumption per day and BMD. The aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism was used as instrumental variables for alcohol consumption. Age, smoking history, and BMI were adjusted in the multivariate model.
    Results: Self-reported alcohol consumption was positively related to total hip and lumbar spine BMD in both sexes. In multivariate Mendelian randomization analysis, the genetically predicted amount of alcohol consumption was positively associated with both total hip and lumbar spine BMD in men. Total hip BMD and lumbar spine BMD increased by 0.004 g/cm
    Conclusion: In our MR study, genetically predicted alcohol consumption was positively associated with BMD in men. This result suggests that the association between alcohol consumption and BMD is causal.
    MeSH term(s) Aldehyde Dehydrogenase, Mitochondrial/genetics ; Bone Density/genetics ; Causality ; Female ; Humans ; Lumbar Vertebrae ; Male ; Mendelian Randomization Analysis ; Polymorphism, Single Nucleotide/genetics
    Chemical Substances ALDH2 protein, human (EC 1.2.1.3) ; Aldehyde Dehydrogenase, Mitochondrial (EC 1.2.1.3)
    Language English
    Publishing date 2021-10-09
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1295123-7
    ISSN 1435-5604 ; 0914-8779
    ISSN (online) 1435-5604
    ISSN 0914-8779
    DOI 10.1007/s00774-021-01275-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4894: Show issues Location:
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  4. Article ; Online: 25-Hydroxyvitamin D Is Associated with Kidney Function: The Dong-gu Study.

    Choi, Seong-Woo / Kweon, Sun-Seog / Lee, Young-Hoon / Ryu, So-Yeon / Nam, Hae-Sung / Park, Kyeong-Soo / Kim, Sun A / Shin, Min-Ho

    Journal of nutritional science and vitaminology

    2018  Volume 64, Issue 6, Page(s) 385–390

    Abstract: ... who participated in a basic survey of the Dong-gu Study. Following an overnight fast, the blood and urine sample ...

    Abstract Although the kidneys play a leading part in the biosynthesis of vitamin D, there is no consensus regarding the relationship of the vitamin D concentration with kidney function. Thus, we aimed to estimate the correlation among 25-hydroxyvitamin D (25(OH)D), estimated glomerular filtration rate (eGFR), and albumin/creatinine ratio (ACR) in participants aged ≥50 y in Korea. This study consisted of 9,166 people who participated in a basic survey of the Dong-gu Study. Following an overnight fast, the blood and urine sample were assessed. The serum 25(OH)D, eGFR, ACR of each subject were measured. When adjusting for covariates and log-transformed ACR (Model III), the lower eGFR value was significantly associated with increasing 25(OH)D levels (<10.0: 71.5[70.5-72.4]; 10.0-14.9: 70.0 [69.5-70.4]; 15.0-19.9: 68.7 [68.3-69.2]; ≥20.0: 67.4 [66.8-67.9] mL/min/1.73 m
    MeSH term(s) Aged ; Albuminuria/blood ; Albuminuria/complications ; Creatinine/blood ; Female ; Glomerular Filtration Rate ; Humans ; Kidney/physiopathology ; Male ; Middle Aged ; Renal Insufficiency, Chronic/blood ; Renal Insufficiency, Chronic/complications ; Republic of Korea ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/complications
    Chemical Substances Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H) ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2018-12-26
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 191366-9
    ISSN 1881-7742 ; 0301-4800
    ISSN (online) 1881-7742
    ISSN 0301-4800
    DOI 10.3177/jnsv.64.385
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 596: Show issues Location:
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  5. Article: Association of Falls and Fear of Falling with Mortality in Korean Adults: The Dong-gu Study.

    Oh, Jinkyu / Choi, Chang Kyun / Kim, Sun A / Kweon, Sun-Seog / Lee, Young-Hoon / Nam, Hae-Sung / Park, Kyeong-Soo / Ryu, So-Yeon / Choi, Seong-Woo / Shin, Min-Ho

    Chonnam medical journal

    2019  Volume 55, Issue 2, Page(s) 104–108

    Abstract: ... who participated in the Dong-gu Study. Falls in the past year were categorized as yes or no. Injurious falls were ...

    Abstract This study evaluated the association between falls and the fear of falling (FOF) with the risk of all-cause mortality in Korean adults. The study enrolled 4,386 subjects aged 50 years and over who participated in the Dong-gu Study. Falls in the past year were categorized as yes or no. Injurious falls were defined as falls that resulted in fractures, head injuries, sprains or strains, bruising or bleeding, or other unspecified injuries. FOF was classified as low or high. The associations of falls and fall-related characteristics with mortality were assessed using Cox proportional hazards models. The average follow-up was 7.8 years. During this period, 255 men and 146 women died. In a fully adjusted model, falls in the past year were not associated with an increased risk of all-cause mortality (hazard ratio [HR] 1.16, 95% confidence interval [CI] 0.85-1.58), but a history of injurious falls was associated with an increased risk of mortality (HR 1.36, 95% CI 1.04-1.79). Compared with subjects without a FOF, subjects who were moderately or very afraid of falling had a higher mortality rate (HR 1.26, 95% CI 0.97-1.63). In conclusion, injurious falls and a high FOF increased the risk of all-cause mortality in Koreans. This study suggests that injurious falls and FOF can predict mortality in the general population.
    Language English
    Publishing date 2019-05-23
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2536217-3
    ISSN 2233-7393 ; 2233-7385 ; 0377-9564
    ISSN (online) 2233-7393
    ISSN 2233-7385 ; 0377-9564
    DOI 10.4068/cmj.2019.55.2.104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: RNA-Seq and 16S rRNA Reveals That Tian–Dong–Tang–Gan Powder Alleviates Environmental Stress-Induced Decline in Immune and Antioxidant Function and Gut Microbiota Dysbiosis in Litopenaeus vannami

    Xie, Xiao-Dong / Zhou, Ying / Sun, Yu-Bo / Yi, Shou-Li / Zhao, Yi / Chen, Qi / Xie, Ying-Hong / Cao, Mi-Xia / Yu, Mei-Ling / Wei, Ying-Yi / Zhang, Ling / Hu, Ting-Jun

    Antioxidants. 2023 June 12, v. 12, no. 6

    2023  

    Abstract: ... resistance to nitrite stress improved after Tian–Dong–Tang–Gan Powder (TDTGP) treatment, but the mechanism is ...

    Abstract Ammonia stress and nitrite stress can induce immune depression and oxidative stress in Litopenaeus vannami (L. vannamei). Earlier reports showed that L. vannamei immunity, resistance to ammonia stress, and resistance to nitrite stress improved after Tian–Dong–Tang–Gan Powder (TDTGP) treatment, but the mechanism is not clear. In this study, three thousand L. vannamei were fed different doses of TDTGP for 35 days and then subjected to ammonia and nitrite stress treatments for 72 h. Transcriptome and 16-Seq ribosomal RNA gene sequencing (16S rRNA-seq) were used to analyze hepatopancreas gene expression and changes in gut microbiota abundance in each group. The results showed that after TDTGP treatment, hepatopancreas mRNA expression levels of immunity- and antioxidant-related genes were increased, the abundance of Vibrionaceae in the gut microbiota was decreased, and the abundance of Rhodobacteraceae and Flavobacteriaceae was increased. In addition, after TDTGP treatment, the effects of ammonia and nitrite stress on the mRNA expression of Pu, cat-4, PPAF2, HO, Hsp90b1, etc. were reduced and the disruption of the gut microbiota was alleviated. In short, TDTGP can regulate the immunity and antioxidant of L. vannamei by increasing the expression levels of immunity- and antioxidant-related genes and regulating the abundance of Rhodobacteraceae and Flavobacteriaceae in the gut microbiota.
    Keywords Flavobacteriaceae ; Litopenaeus ; Rhodobacteraceae ; Vibrionaceae ; ammonia ; antioxidant activity ; antioxidants ; decline ; dysbiosis ; gene expression ; genes ; hepatopancreas ; immunity ; intestinal microorganisms ; nitrites ; oxidative stress ; ribosomal RNA ; sequence analysis ; transcriptome
    Language English
    Dates of publication 2023-0612
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12061262
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: Forensic Features and Population Genetic Structure of Dong, Yi, Han, and Chuanqing Human Populations in Southwest China Inferred From Insertion/Deletion Markers.

    Liu, Yubo / Zhang, Han / He, Guanglin / Ren, Zheng / Zhang, Hongling / Wang, Qiyan / Ji, Jingyan / Yang, Meiqing / Guo, Jianxin / Yang, Xiaomin / Sun, Jin / Ba, Jinxing / Peng, Dan / Hu, Rong / Wei, Lan-Hai / Wang, Chuan-Chao / Huang, Jiang

    Frontiers in genetics

    2020  Volume 11, Page(s) 360

    Abstract: ... individuals collected from four populations, Dong, Yi, Han, and Chuanqing residing in Guizhou. We calculated ... Chuanqing people show an additional genetic affinity with Han Chinese, highlighting the role of possible ...

    Abstract Guizhou province in southwest China has abundant genetic and cultural diversities, but the forensic features and genetic structure of Guizhou populations remain poorly understood due to the sparse sampling of present-day populations. Here, we present 30 insertion/deletion polymorphisms (InDels) data of 591 human individuals collected from four populations, Dong, Yi, Han, and Chuanqing residing in Guizhou. We calculated the forensic parameters of 30 InDel loci and found that this panel meets the efficiency of forensic personal identification based on the high combined power of discrimination, but it could only be used as a complementary tool in the parentage testing because of the lower combined probability of exclusion values. The studied populations are genetically closer related to geographically adjacent or linguistically related populations in southern China, such as the Tai-Kadai and Hmong-Mien speaking groups. The unrecognized ethnic Chuanqing people show an additional genetic affinity with Han Chinese, highlighting the role of possible military immigrations in their origin.
    Language English
    Publishing date 2020-04-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2020.00360
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Effect Modification of Acetaldehyde Dehydrogenase 2 rs671 Polymorphism on the Association between Alcohol Intake and Blood Pressure: the Dong-gu Study.

    Kim, Hye Yeon / Choi, Chang Kyun / Kweon, Sun Seog / Lee, Young Hoon / Nam, Hae Sung / Park, Kyeong Soo / Ryu, So Yeon / Choi, Seong Woo / Shin, Min Ho

    Journal of Korean medical science

    2020  Volume 35, Issue 9, Page(s) e14

    Abstract: ... Methods: This study consists of 8,526 participants in the Dong-gu Study. Multivariate logistic regression ...

    Abstract Background: Elevated blood pressure is a major preventable cause of cardiovascular diseases. Alcohol consumption is a well-known risk factor of elevated blood pressure. The aldehyde dehydrogenase 2 (
    Methods: This study consists of 8,526 participants in the Dong-gu Study. Multivariate logistic regression was used to calculate the odds ratio (OR) according to alcohol consumption after stratifying by gender and
    Results: In men, alcohol consumption was positively associated with both SBP and DBP in active
    Conclusion: ALDH2
    MeSH term(s) Alcohol Drinking ; Aldehyde Dehydrogenase, Mitochondrial/genetics ; Alleles ; Asian Continental Ancestry Group/genetics ; Blood Pressure/physiology ; Female ; Gene Frequency ; Genotype ; Humans ; Hypertension/diagnosis ; Hypertension/epidemiology ; Hypertension/genetics ; Life Style ; Male ; Middle Aged ; Odds Ratio ; Polymorphism, Genetic ; Republic of Korea/epidemiology ; Risk Factors
    Chemical Substances ALDH2 protein, human (EC 1.2.1.3) ; Aldehyde Dehydrogenase, Mitochondrial (EC 1.2.1.3)
    Language English
    Publishing date 2020-03-09
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 639262-3
    ISSN 1598-6357 ; 1011-8934
    ISSN (online) 1598-6357
    ISSN 1011-8934
    DOI 10.3346/jkms.2020.35.e14
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3163: Show issues Location:
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  9. Article ; Online: Cystatin C-based estimated GFR and albuminuria are independently associated with all-cause and CVD mortality in Korean population: The Dong-gu Study.

    Kim, Hye-Yeon / Kweon, Sun-Seog / Lee, Young-Hoon / Ryu, So-Yeon / Nam, Hae-Sung / Shin, Min-Ho / Park, Kyeong-Soo / Choi, Seong-Woo

    Maturitas

    2020  Volume 143, Page(s) 178–183

    Abstract: Objective: To assess the associations among the estimated glomerular filtration rate (eGFR), albumin to creatinine ratio (ACR), and all-cause and CVD mortality rate and to compare the performances of eGFR: Methods: Of the 9,260 subjects who ... ...

    Abstract Objective: To assess the associations among the estimated glomerular filtration rate (eGFR), albumin to creatinine ratio (ACR), and all-cause and CVD mortality rate and to compare the performances of eGFR
    Methods: Of the 9,260 subjects who participated in the baseline survey of a prospective longitudinal study conducted in Korea, 9,009 (men: 3,574 (39.7%); women: 5,435 (60.3%)) were included in this analysis after the exclusion of 217 subjects with missing eGFR and 34 subjects with missing ACR data.
    Main outcome measure: The associations of eGFR and ACR with all-cause and CVD mortality were investigated using Cox proportional hazards models that included sex, age, waist circumference, smoking, alcohol intake, degree of physical activity, hypertension, diabetes, systolic blood pressure, log-HbA
    Results: After adjustment for covariates, independent associations were found between all-cause mortality and the eGFR
    Conclusion: The eGFR
    MeSH term(s) Aged ; Aged, 80 and over ; Albuminuria/mortality ; Albuminuria/physiopathology ; Cardiovascular Diseases/mortality ; Cardiovascular Diseases/physiopathology ; Cystatin C ; Female ; Glomerular Filtration Rate ; Humans ; Male ; Middle Aged ; Republic of Korea
    Chemical Substances CST3 protein, human ; Cystatin C
    Language English
    Publishing date 2020-11-02
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 80460-5
    ISSN 1873-4111 ; 0378-5122
    ISSN (online) 1873-4111
    ISSN 0378-5122
    DOI 10.1016/j.maturitas.2020.10.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1432: Show issues Location:
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    Zs.MO 575: Show issues

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  10. Article: [Chemical constituents of Aconitum brachypodum from Dong-Chuan area].

    Wang, Hong-Yun / Zuo, Ai-Xue / Sun, Yun / Rao, Gao-Xiong

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2013  Volume 38, Issue 24, Page(s) 4324–4328

    Abstract: ... 80% ethanol extract of A. brachypodum collected from Dong-Chuan area was investigated, which led ...

    Abstract Aconitum brachypodum is traditionally known to be toxic chinese medicie, but its chemical constituents is not enough studied to date. To further elucidate the chemical constituents of A. brachypodum, 80% ethanol extract of A. brachypodum collected from Dong-Chuan area was investigated, which led to isolation of seventeen compounds. By spectroscopic methods, their structures were determined as hypaconitine (1), mesaconitine (2), talatisamine (3), neoline (4), fuziline (5), aconine (6), bullatine A (7), lepeine (8), songrine (9), isocorydine (10), beta-sitosterol (11), daucosterol (12), stearic acid (13), triacontanol (14), palmitic acid (15), benzoic acid (16), and inosine (17), respectively. All compounds except for compounds 1 and 7 were isolated from A. brachypodum for the first time.
    MeSH term(s) Aconitum/chemistry ; China ; Drugs, Chinese Herbal/chemistry ; Magnetic Resonance Spectroscopy
    Chemical Substances Drugs, Chinese Herbal
    Language Chinese
    Publishing date 2013-12
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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