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  1. Article ; Online: Effects of a School-Based Gardening, Cooking, and Nutrition Cluster Randomized Controlled Trial on Unprocessed and Ultra-Processed Food Consumption.

    Jeans, Matthew R / Landry, Matthew J / Vandyousefi, Sarvenaz / Hudson, Erin A / Burgermaster, Marissa / Bray, Molly S / Chandra, Joya / Davis, Jaimie N

    The Journal of nutrition

    2023  Volume 153, Issue 7, Page(s) 2073–2084

    Abstract: Background: School-based gardening and nutrition education interventions report improvements in dietary intake, notably through fruit and vegetables. However, gardening, cooking, and nutrition randomized controlled trials are limited in evaluating ... ...

    Abstract Background: School-based gardening and nutrition education interventions report improvements in dietary intake, notably through fruit and vegetables. However, gardening, cooking, and nutrition randomized controlled trials are limited in evaluating dietary quality, and none have examined processed food consumption to date.
    Objectives: The study examined the effects of Texas Sprouts (TX Sprouts), a gardening, cooking, and nutrition education intervention, compared with control on unprocessed and ultra-processed food (UPF) consumption in predominately low-income Hispanic children.
    Methods: TX Sprouts was a school-based cluster randomized controlled trial that consisted of 16 elementary schools randomly assigned to either the TX Sprouts intervention (n = 8 schools) or control (delayed intervention; n = 8 schools) over 3 y (2016-2019). TX Sprouts schools received an outdoor teaching garden and 18 1-h lessons taught by trained educators throughout the school year. Dietary intake data via 2 24-h dietary recalls were collected on a random subsample (n = 468) at baseline and postintervention. All foods and beverages were categorized using the NOVA food classification system (e.g., unprocessed, processed, ultra-processed). Generalized linear mixed effects modeling tested changes in percent calories and grams of NOVA groups between the intervention and control estimates with schools as random clusters.
    Results: Of the sample, 63% participated in the free and reduced-price lunch program, and 57% were Hispanic, followed by non-Hispanic White (21%) and non-Hispanic Black (12%). The intervention, compared to the control, resulted in an increase in consumption of unprocessed foods (2.3% compared with -1.8% g; P < 0.01) and a decrease in UPF (-2.4% compared with 1.4% g; P = 0.04). In addition, Hispanic children in the intervention group had an increase in unprocessed food consumption and a decrease in UPF consumption compared to non-Hispanic children (-3.4% compared with 1.5% g; P < 0.05).
    Conclusions: Study results suggest that school-based gardening, cooking, and nutrition education interventions can improve dietary intake, specifically increasing unprocessed food consumption and decreasing UPF consumption. This trial was registered at clinicaltrials.gov as NCT02668744.
    MeSH term(s) Child ; Humans ; Cooking/methods ; Diet ; Food, Processed ; Gardening/education ; Gardening/methods ; Health Promotion/methods ; Vegetables
    Language English
    Publishing date 2023-04-26
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
    ZDB-ID 218373-0
    ISSN 1541-6100 ; 0022-3166
    ISSN (online) 1541-6100
    ISSN 0022-3166
    DOI 10.1016/j.tjnut.2023.04.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Circadian rhythms and the gut microbiome synchronize the host's metabolic response to diet.

    Gutierrez Lopez, Diana E / Lashinger, Laura M / Weinstock, George M / Bray, Molly S

    Cell metabolism

    2021  Volume 33, Issue 5, Page(s) 873–887

    Abstract: The molecular circadian clock and symbiotic host-microbe relationships both evolved as mechanisms that enhance metabolic responses to environmental challenges. The gut microbiome benefits the host by breaking down diet-derived nutrients indigestible by ... ...

    Abstract The molecular circadian clock and symbiotic host-microbe relationships both evolved as mechanisms that enhance metabolic responses to environmental challenges. The gut microbiome benefits the host by breaking down diet-derived nutrients indigestible by the host and generating microbiota-derived metabolites that support host metabolism. Similarly, cellular circadian clocks optimize organismal physiology to the environment by influencing the timing and coordination of metabolic processes. Host-microbe interactions are influenced by dietary quality and timing, as well as daily light/dark cycles that entrain circadian rhythms in the host. Together, the gut microbiome and the molecular circadian clock play a coordinated role in neural processing, metabolism, adipogenesis, inflammation, and disease initiation and progression. This review examines the bidirectional interactions between the circadian clock, gut microbiota, and host metabolic systems and their effects on obesity and energy homeostasis. Directions for future research and the development of therapies that leverage these systems to address metabolic disease are highlighted.
    MeSH term(s) Animals ; Circadian Rhythm/physiology ; Diet ; Energy Metabolism ; Feeding Behavior ; Gastrointestinal Microbiome ; Host Microbial Interactions ; Humans ; Obesity/metabolism ; Obesity/pathology ; Signal Transduction
    Language English
    Publishing date 2021-03-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2021.03.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Breakfast Consumption May Improve Fasting Insulin, HOMA-IR, and HbA1c Levels in Predominately Low-Income, Hispanic Children 7-12 Years of Age.

    Jeans, Matthew R / Vandyousefi, Sarvenaz / Landry, Matthew J / Leidy, Heather J / Gray, Megan J / Bray, Molly S / Widen, Elizabeth M / Davis, Jaimie N

    Nutrients

    2022  Volume 14, Issue 11

    Abstract: ... randomized control trials (RCT) have explored this association in low-income and racial/ethnic U.S. minority families ...

    Abstract Children from low-income households and minority families have high cardiometabolic risk. Although breakfast consumption is known to improve cardiometabolic health in children, limited randomized control trials (RCT) have explored this association in low-income and racial/ethnic U.S. minority families. This study conducted secondary analyses from TX Sprouts, a school-based gardening, cooking, and nutrition education RCT, to examine the intervention effect on breakfast consumption and how changes in breakfast consumption impact cardiometabolic risk in predominately low-income, multi-ethnic children. TX Sprouts consisted of 16 schools (8 intervention; 8 control) in greater Austin, TX. A total of 18 lessons were taught, including topics on breakfast consumption benefits and choosing healthy food options at school. Children completed clinical measures (e.g., anthropometrics, body composition via bioelectrical impedance), and the number of breakfast occasions (BO) per week (at home and school) was captured via validated survey at baseline and post-intervention. Post-study—Baseline changes in breakfast consumption were used to categorize students as: maintainers (BO −1 to 1 day/week), decreasers (BO ≤−2 day/week), and increasers (BO ≥2 day/week). Optional fasting blood draws were performed on a subsample. Generalized weighted linear mixed modeling tested differences between intervention and control, with schools as random clusters. Analysis of covariance and linear regression examined changes in breakfast consumption on cardiometabolic outcomes, controlling for age, sex, race/ethnicity, free and reduced-price school meal participation (FRL), school site, breakfast location, physical activity, baseline cardiometabolic measures, and BMI z-score. This study included 1417 children (mean age 9 years; 53% male; 58% Hispanic, 63% FRL; breakfast consumption patterns: 63% maintainers, 16% decreasers, and 21% increasers). There was no intervention effect on changes in breakfast consumption. Compared to decreasers, increasers had an increase in insulin (−0.3 µIU/mL vs. +4.1 µIU/mL; p = 0.01) and a larger increase in HOMA-IR (+0.4 vs. +1.5; p < 0.01). Every one-day increase in breakfast consumption decreased fasting insulin by 0.44 µIU/mL, HOMA-IR by 0.11, and hemoglobin A1c by 0.01% (p ≤ 0.03). Increased breakfast consumption was linked to improved glucose control, suggesting breakfast can mitigate risk in a high-risk population. To better understand underlying mechanisms linking breakfast consumption to improved metabolic health, RCTs focusing on breakfast quality and timing are warranted.
    MeSH term(s) Breakfast ; Cardiovascular Diseases ; Child ; Fasting ; Female ; Glycated Hemoglobin ; Hispanic or Latino ; Humans ; Insulin/metabolism ; Male
    Chemical Substances Glycated Hemoglobin A ; Insulin
    Language English
    Publishing date 2022-05-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14112320
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Understanding circadian gene function: animal models of tissue-specific circadian disruption.

    Birky, Tana L / Bray, Molly S

    IUBMB life

    2014  Volume 66, Issue 1, Page(s) 34–41

    Abstract: Circadian rhythms are the daily patterns that occur within an organism, from gene expression to behavior. These rhythms are governed not only externally by environmental cues but also internally, with cell-autonomous molecular clock mechanisms present ... ...

    Abstract Circadian rhythms are the daily patterns that occur within an organism, from gene expression to behavior. These rhythms are governed not only externally by environmental cues but also internally, with cell-autonomous molecular clock mechanisms present nearly ubiquitously throughout the cells of organisms. In more complex organisms, it has been suggested that the clock mechanisms serve varied functions depending on the tissue in which they are found. By disrupting core circadian gene function in specific tissues of animal models, the various roles of the circadian clock in differing tissues can begin to be defined. This review provides an overview of the model organisms used to elucidate tissue-specific functions of the molecular circadian clock.
    MeSH term(s) Animals ; Circadian Rhythm/physiology ; Circadian Rhythm Signaling Peptides and Proteins/genetics ; Circadian Rhythm Signaling Peptides and Proteins/metabolism ; Gene Expression ; Humans ; Models, Animal ; Organ Specificity
    Chemical Substances Circadian Rhythm Signaling Peptides and Proteins
    Language English
    Publishing date 2014-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1492141-8
    ISSN 1521-6551 ; 1521-6543
    ISSN (online) 1521-6551
    ISSN 1521-6543
    DOI 10.1002/iub.1241
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Comparison of School vs Home Breakfast Consumption with Cardiometabolic and Dietary Parameters in Low-Income, Multiracial/Ethnic Elementary School-Aged Children.

    Jeans, Matthew R / Landry, Matthew J / Asigbee, Fiona M / Vandyousefi, Sarvenaz / Ghaddar, Reem / Bray, Molly S / Leidy, Heather J / Davis, Jaimie N

    Journal of the Academy of Nutrition and Dietetics

    2021  Volume 122, Issue 4, Page(s) 833–847

    Abstract: Background: Breakfast consumption is often associated with improving cardiometabolic parameters and diet quality. However, literature evaluating breakfast consumption with these outcomes between the school and home environments is limited.: Objective!# ...

    Abstract Background: Breakfast consumption is often associated with improving cardiometabolic parameters and diet quality. However, literature evaluating breakfast consumption with these outcomes between the school and home environments is limited.
    Objective: This study examined relationships between breakfast consumption locations (school vs home) and cardiometabolic parameters, breakfast dietary intake, and daily dietary intake.
    Design: This cross-sectional study used baseline data from TX Sprouts, a 1-year school-based gardening, nutrition, and cooking cluster-randomized trial, implemented in 16 elementary schools in Austin, TX, during 2016 to 2019.
    Participants/setting: Analyses included 383 low-income, multiracial/ethnic elementary school-aged children (mean age = 9.2 years; 60.6% Hispanic; 70.5% free/reduced lunch; 58.5% home breakfast consumers).
    Main outcome measures: Cardiometabolic parameters were obtained via fasting blood draws, and dietary intake was assessed using one 24-hour dietary recall conducted on a random, unannounced weekday. Cardiometabolic and dietary parameters (ie, energy intake, macronutrients, and food group servings) for breakfast and for the day were evaluated.
    Statistical analyses performed: Multivariate analysis of covariance was performed to examine cardiometabolic parameters and dietary intake between school and home breakfasts.
    Results: School breakfast consumers (SBC) had lower fasting triglyceride levels than home breakfast consumers (HBC) (89.0 mg/dL vs 95.7 mg/dL; P = 0.03) (to convert to mmol/L, multiply by 0.0113). SBC had lower total fat for the day (P = 0.02) and lower total and saturated fat, sodium, and refined grains at breakfast (P ≤ 0.01) than HBC. However, SBC had lower protein at breakfast (P = 0.01) and higher carbohydrates, total sugar, and added sugar for the day and at breakfast (P ≤ 0.03) than HBC.
    Conclusions: SBC compared with HBC had lower fat intake, which may have contributed to the lower triglyceride level observed in SBC, but also had lower protein intake at breakfast and higher added sugar intake for the day and at breakfast. These results suggest dietary intake differed between HBC and SBC; that is, the home and school environments, but more research is needed to evaluate if such differences are due to School Breakfast Program guidelines.
    MeSH term(s) Breakfast ; Cardiovascular Diseases ; Child ; Cross-Sectional Studies ; Diet ; Energy Intake ; Humans ; Sugars ; Triglycerides
    Chemical Substances Sugars ; Triglycerides
    Language English
    Publishing date 2021-10-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2646718-5
    ISSN 2212-2672
    ISSN 2212-2672
    DOI 10.1016/j.jand.2021.10.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Implications of gene-behavior interactions: prevention and intervention for obesity.

    Bray, Molly S

    Obesity (Silver Spring, Md.)

    2008  Volume 16 Suppl 3, Page(s) S72–8

    Abstract: A vast body of research exists to demonstrate that obesity is a complex disorder with a strong genetic basis and a multifactorial etiology. Yet despite the overwhelming evidence that genes play an important role in the development of obesity, many people ...

    Abstract A vast body of research exists to demonstrate that obesity is a complex disorder with a strong genetic basis and a multifactorial etiology. Yet despite the overwhelming evidence that genes play an important role in the development of obesity, many people argue that the increasing prevalence of obesity is simply due to an abundance of palatable food and a dearth of opportunities for physical exercise. While activity and eating behaviors contribute substantially to the development of obesity, considering these to be the only etiologic factors is directly contradictory to what is now known about how eating and energy balance are regulated. Our understanding of the molecular processes controlling eating behavior, in particular, has accelerated exponentially in the last 10 years, and this is one area in which obesity genetics has made great progress. Our challenge is to understand more fully how genetic variation may interact with behavioral factors to influence the regulation of body weight and adiposity. Although exercise and diet strategies are used routinely for obesity treatment, there is a huge variability in how individuals respond to these interventions. There is also a substantial amount of evidence that such responses may also be regulated by genes. Understanding gene-response relationships is the key to developing more efficacious intervention and prevention programs for obesity.
    MeSH term(s) Body Weight ; Energy Intake/physiology ; Energy Metabolism/physiology ; Environment ; Feeding Behavior ; Genetic Variation ; Humans ; Nutrigenomics ; Obesity/etiology ; Obesity/genetics ; Obesity/therapy
    Language English
    Publishing date 2008-11-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2230457-5
    ISSN 1930-739X ; 1930-7381 ; 1071-7323
    ISSN (online) 1930-739X
    ISSN 1930-7381 ; 1071-7323
    DOI 10.1038/oby.2008.522
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  7. Article ; Online: Chronobiological Effects on Obesity.

    Bray, Molly S / Young, Martin E

    Current obesity reports

    2013  Volume 1, Issue 1, Page(s) 9–15

    Abstract: The development of obesity is the consequence of a multitude of complex interactions between both genetic and environmental factors. It has been suggested that the dramatic increase in the prevalence of obesity over the past 30 years has been the result ... ...

    Abstract The development of obesity is the consequence of a multitude of complex interactions between both genetic and environmental factors. It has been suggested that the dramatic increase in the prevalence of obesity over the past 30 years has been the result of environmental changes that have enabled the full realization of genetic susceptibility present in the population. Among the many environmental alterations that have occurred in our recent history is the ever-increasing dyssynchrony between natural cycles of light/dark and altered patterns of sleep/wake and eating behavior associated with our "24-hour" lifestyle. An extensive research literature has established clear links between increased risk for obesity and both sleep deprivation and shift work, and our understanding of the consequences of such dyssynchrony at the molecular level is beginning to emerge. Studies linking alterations in cellular circadian clocks to metabolic dysfunction point to the increasing importance of chronobiology in obesity etiology.
    Language English
    Publishing date 2013-04-17
    Publishing country United States
    Document type Journal Article
    ISSN 2162-4968
    ISSN (online) 2162-4968
    DOI 10.1007/s13679-011-0005-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Dogs re-engage human partners when joint social play is interrupted: a behavioural signature of shared intentionality?

    Horschler, Daniel J. / Bray, Emily E. / Gnanadesikan, Gitanjali E. / Byrne, Molly / Levy, Kerinne M. / Kennedy, Brenda S. / MacLean, Evan L.

    The Association for the Study of Animal Behaviour Animal behaviour. 2022 Jan., v. 183

    2022  

    Abstract: Hypotheses regarding the evolution of uniquely human social cognition often emphasize not only mental state representation, but also mental state sharing. Mental state sharing is evident in instances of joint intentionality – mutual understanding between ...

    Abstract Hypotheses regarding the evolution of uniquely human social cognition often emphasize not only mental state representation, but also mental state sharing. Mental state sharing is evident in instances of joint intentionality – mutual understanding between individuals of each other's simultaneous and interdependent commitment to a shared activity or goal. Comparative studies supporting the human uniqueness of joint intentionality show that, as compared to human children, chimpanzees, Pan troglodytes, who engage with humans as cooperative partners do not altruistically help others achieve their goals across the same range of contexts, do not attempt to re-engage cooperative partners in problem-solving or social games at the same rate and do not show spontaneous role reversal. Although recent work supports the possibility that bonobos, Pan paniscus, may re-engage conspecific partners after interrupted social grooming, the extent to which other animals show similar behaviour across more diverse contexts remains largely unexplored. Domestic dogs', Canis familiaris, propensity to interact with humans in cooperative contexts makes them a potentially promising comparative model of prosocial mental state sharing. Here, we investigated a behavioural signature of joint intentionality during social play between humans and dogs (N=82). Our results present the first experimental evidence of re-engagement behaviour in dogs, as dogs preferentially attempted to reinitiate an interrupted social game with their previous partner relative to a passive bystander. These findings suggest that dogs exhibit a key marker of joint intentionality and open the door for future research on the cognitive mechanisms supporting this behaviour.
    Keywords Pan paniscus ; cognition ; conspecificity ; dogs ; evolution ; humans ; models ; problem solving
    Language English
    Dates of publication 2022-01
    Size p. 159-168.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 281-1
    ISSN 0003-3472
    ISSN 0003-3472
    DOI 10.1016/j.anbehav.2021.11.007
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: The influence of 15-week exercise training on dietary patterns among young adults.

    Joo, Jaehyun / Williamson, Sinead A / Vazquez, Ana I / Fernandez, Jose R / Bray, Molly S

    International journal of obesity (2005)

    2019  Volume 43, Issue 9, Page(s) 1681–1690

    Abstract: Background/objectives: Little is currently known about how exercise may influence dietary patterns and/or food preferences. The present study aimed to examine the effect of a 15-week exercise training program on overall dietary patterns among young ... ...

    Abstract Background/objectives: Little is currently known about how exercise may influence dietary patterns and/or food preferences. The present study aimed to examine the effect of a 15-week exercise training program on overall dietary patterns among young adults.
    Subjects/methods: This study consisted of 2680 young adults drawn from the Training Intervention and Genetics of Exercise Response (TIGER) study. Subjects underwent 15 weeks of aerobic exercise training, and exercise duration, intensity, and dose were recorded for each session using computerized heart rate monitors. In total, 4355 dietary observations with 102 food items were collected using a self-administered food frequency questionnaire before and after exercise training (n = 2476 at baseline; n = 1859 at 15 weeks). Dietary patterns were identified using a Bayesian sparse latent factor model. Changes in dietary pattern preferences were evaluated based on the pre/post-training differences in dietary pattern scores, accounting for the effects of gender, race/ethnicity, and BMI.
    Results: Within each of the seven dietary patterns identified, most dietary pattern scores were decreased following exercise training, consistent with increased voluntary regulation of food intake. A longer duration of exercise was associated with decreased preferences for the western (β: -0.0793; 95% credible interval: -0.1568, -0.0017) and snacking (β: -0.1280; 95% credible interval: -0.1877, -0.0637) patterns, while a higher intensity of exercise was linked to an increased preference for the prudent pattern (β: 0.0623; 95% credible interval: 0.0159, 0.1111). Consequently, a higher dose of exercise was related to a decreased preference for the snacking pattern (β: -0.0023; 95% credible interval: -0.0042, -0.0004) and an increased preference for the prudent pattern (β: 0.0029; 95% credible interval: 0.0009, 0.0048).
    Conclusions: The 15-week exercise training appeared to motivate young adults to pursue healthier dietary preferences and to regulate their food intake.
    MeSH term(s) Adult ; Body Mass Index ; Diet/statistics & numerical data ; Diet Records ; Exercise ; Female ; Food Preferences ; Health Promotion/methods ; Humans ; Male ; Prospective Studies ; Surveys and Questionnaires ; Young Adult
    Language English
    Publishing date 2019-01-18
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 752409-2
    ISSN 1476-5497 ; 0307-0565
    ISSN (online) 1476-5497
    ISSN 0307-0565
    DOI 10.1038/s41366-018-0299-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Distinct racial and ethnic metabolic syndrome characteristics: A comparative assessment in low-income children 7-10 years of age.

    Jeans, Matthew R / Ghaddar, Reem / Vandyousefi, Sarvenaz / Landry, Matthew J / Gray, Megan J / Leidy, Heather J / Whittaker, Tiffany A / Bray, Molly S / Davis, Jaimie N

    Pediatric obesity

    2022  Volume 17, Issue 10, Page(s) e12925

    Abstract: Background: Pediatric MetS prevalence varies due to lack of consensus on evaluative criteria and associated thresholds, with most not recommending a diagnosis <10 years. However, MetS risk components are becoming evident earlier in life and affect races ...

    Abstract Background: Pediatric MetS prevalence varies due to lack of consensus on evaluative criteria and associated thresholds, with most not recommending a diagnosis <10 years. However, MetS risk components are becoming evident earlier in life and affect races and ethnicities disproportionately.
    Objectives: To compare the prevalence of MetS based on existing definitions and elucidate racial- and ethnic-specific characteristics associated with MetS prevalence.
    Methods: The baseline and follow-up samples included 900 and 557 children 7-10 years, respectively. Waist circumference, BMI percentile, blood pressure, fasting plasma glucose (FPG), insulin, triglycerides, and high-density lipoprotein cholesterol (HDL-C) were measured. Agreement between MetS definitions was quantified via kappa statistics. MetS and risk factor prevalence and the predictability of metabolic parameters on MetS eight months later was evaluated via logistic regression. McFadden pseudo-R2 was reported as a measure of predictive ability, and the Akaike information criterion evaluated fit of each model.
    Results: The baseline sample was 55.0% male and 71.6% Hispanic, followed by non-Hispanic White (NHW) (17.3%) and non-Hispanic Black (NHB) (11.1%), with an average age of 9.2 years. MetS prevalence ranged from 7.6% to 21.4%, highest in Hispanic (9.0%-24.0%) and lowest in NHB children (4.0%-14.0%). Highest agreement was between Ford et al. and Cook et al. definitions (K = 0.88) and lowest agreements were consistently with the International Diabetes Federation criteria (K ≤ 0.57). Compared to NHW children, Hispanic children had higher odds for MetS (OR: 1.7; p = 0.03) and waist circumference, HDL-C, and FPG risk factors (p < 0.05), while NHB children had higher odds for the FPG risk factor (p ≤ 0.007) and lower odds for the plasma triglycerides risk factor (p = 0.002), across multiple MetS definitions. In longitudinal analyses, HDL-C was the strongest independent predictor of MetS in Hispanic and NHW children (p < 0.001 and p < 0.01, respectively), while plasma triglycerides was the strongest independent predictor of MetS in NHB children (p < 0.05).
    Conclusions: MetS prevalence was high in children ≤10 years, and proposed criteria are susceptible to racial and ethnic bias, diagnosing some populations more than other populations with high cardiovascular risk. Earlier preventative measures should be imposed in clinical settings, accounting for racial and ethnic differences, to mitigate disease onset.
    MeSH term(s) Blacks ; Child ; Cholesterol, HDL ; Female ; Hispanic or Latino ; Humans ; Male ; Metabolic Syndrome/diagnosis ; Metabolic Syndrome/ethnology ; Poverty ; Prevalence ; Risk Factors ; Triglycerides ; Waist Circumference ; Whites
    Chemical Substances Cholesterol, HDL ; Triglycerides
    Language English
    Publishing date 2022-05-12
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2655527-X
    ISSN 2047-6310 ; 2047-6302
    ISSN (online) 2047-6310
    ISSN 2047-6302
    DOI 10.1111/ijpo.12925
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