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Article: Evaluation of Amiodarone Use for New-Onset Atrial Fibrillation in Critically Ill Patients With Septic Shock.

Betthauser, Kevin D / Gibson, Gabrielle A / Piche, Shannon L / Pope, Hannah E

2019 Volume 56, Issue 2, Page(s) 116–123

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2019-08-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	1468893-1
ISSN	0018-5787
ISSN	0018-5787
DOI	10.1177/0018578719868405
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Article ; Online: Cannabinoid Signaling in Kidney Disease.

Arceri, Liana / Nguyen, Thanh Khoa / Gibson, Shannon / Baker, Sophia / Wingert, Rebecca A

Cells

2023 Volume 12, Issue 10

Abstract: Endocannabinoid signaling plays crucial roles in human physiology in the function of multiple systems. The two cannabinoid receptors, CB1 and CB2, are cell membrane proteins that interact with both exogenous and endogenous bioactive lipid ligands, or ... ...

Abstract	Endocannabinoid signaling plays crucial roles in human physiology in the function of multiple systems. The two cannabinoid receptors, CB1 and CB2, are cell membrane proteins that interact with both exogenous and endogenous bioactive lipid ligands, or endocannabinoids. Recent evidence has established that endocannabinoid signaling operates within the human kidney, as well as suggests the important role it plays in multiple renal pathologies. CB1, specifically, has been identified as the more prominent ECS receptor within the kidney, allowing us to place emphasis on this receptor. The activity of CB1 has been repeatedly shown to contribute to both diabetic and non-diabetic chronic kidney disease (CKD). Interestingly, recent reports of acute kidney injury (AKI) have been attributed to synthetic cannabinoid use. Therefore, the exploration of the ECS, its receptors, and its ligands can help provide better insight into new methods of treatment for a range of renal diseases. This review explores the endocannabinoid system, with a focus on its impacts within the healthy and diseased kidney.
MeSH term(s)	Humans ; Endocannabinoids/metabolism ; Ligands ; Kidney/pathology ; Renal Insufficiency, Chronic/pathology ; Cannabinoids/pharmacology ; Cannabinoids/metabolism
Chemical Substances	Endocannabinoids ; Ligands ; Cannabinoids
Language	English
Publishing date	2023-05-18
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12101419
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Article: The Antidiabetic Agent Acarbose Improves Anti-PD-1 and Rapamycin Efficacy in Preclinical Renal Cancer.

Orlandella, Rachael M / Turbitt, William J / Gibson, Justin T / Boi, Shannon K / Li, Peng / Smith, Daniel L / Norian, Lyse A

Cancers

2020 Volume 12, Issue 10

Abstract: Although immune checkpoint inhibitors and targeted therapeutics have changed the landscape of treatment for renal cell carcinoma (RCC), most patients do not experience significant clinical benefits. Emerging preclinical studies report that nutrition- ... ...

Abstract	Although immune checkpoint inhibitors and targeted therapeutics have changed the landscape of treatment for renal cell carcinoma (RCC), most patients do not experience significant clinical benefits. Emerging preclinical studies report that nutrition-based interventions and glucose-regulating agents can improve therapeutic efficacy. However, the impact of such agents on therapeutic efficacy in metastatic kidney cancer remains unclear. Here, we examined acarbose, an alpha-glucosidase inhibitor and antidiabetic agent, in a preclinical model of metastatic kidney cancer. We found that acarbose blunted postprandial blood glucose elevations in lean, nondiabetic mice and impeded the growth of orthotopic renal tumors, an outcome that was reversed by exogenous glucose administration. Delayed renal tumor outgrowth in mice on acarbose occurred in a CD8 T cell-dependent manner. Tumors from these mice exhibited increased frequencies of CD8 T cells that retained production of IFNγ, TNFα, perforin, and granzyme B. Combining acarbose with either anti-PD-1 or the mammalian target of rapamycin inhibitor, rapamycin, significantly reduced lung metastases relative to control mice on the same therapies. Our findings in mice suggest that combining acarbose with current RCC therapeutics may improve outcomes, warranting further study to determine whether acarbose can achieve similar responses in advanced RCC patients in a safe and likely cost-effective manner.
Language	English
Publishing date	2020-10-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers12102872
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Article ; Online: Accounting for population structure in genetic studies of cystic fibrosis.

Kingston, Hanley / Stilp, Adrienne M / Gordon, William / Broome, Jai / Gogarten, Stephanie M / Ling, Hua / Barnard, John / Dugan-Perez, Shannon / Ellinor, Patrick T / Gabriel, Stacey / Germer, Soren / Gibbs, Richard A / Gupta, Namrata / Rice, Kenneth / Smith, Albert V / Zody, Michael C / Blackman, Scott M / Cutting, Garry / Knowles, Michael R /

Zhou, Yi-Hui / Rosenfeld, Margaret / Gibson, Ronald L / Bamshad, Michael / Fohner, Alison / Blue, Elizabeth E

HGG advances

2022 Volume 3, Issue 3, Page(s) 100117

Abstract: ... ...

Abstract	CFTR
Language	English
Publishing date	2022-05-12
Publishing country	United States
Document type	Journal Article
ISSN	2666-2477
ISSN (online)	2666-2477
DOI	10.1016/j.xhgg.2022.100117
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Article ; Online: Testing the effects of combining azithromycin with inhaled tobramycin for

Nichols, David P / Singh, Pradeep K / Baines, Arthur / Caverly, Lindsay J / Chmiel, James F / GIbson, Ronald L / Lascano, Jorge / Morgan, Sarah J / Retsch-Bogart, George / Saiman, Lisa / Sadeghi, Hossein / Billings, Joanne L / Heltshe, Sonya L / Kirby, Shannon / Kong, Ada / Nick, Jerry A / Mayer-Hamblett, Nicole

Thorax

2021 Volume 77, Issue 6, Page(s) 581–588

Abstract: Rationale: Inhaled tobramycin and oral azithromycin are common chronic therapies in people with cystic fibrosis and : Methods: A 6-week prospective, randomised, placebo-controlled, double-blind trial testing oral azithromycin versus placebo combined ... ...

Abstract	Rationale: Inhaled tobramycin and oral azithromycin are common chronic therapies in people with cystic fibrosis and Methods: A 6-week prospective, randomised, placebo-controlled, double-blind trial testing oral azithromycin versus placebo combined with clinically prescribed inhaled tobramycin in individuals with cystic fibrosis and Results: Over a 6-week period, including 4 weeks of inhaled tobramycin, the relative change in FEV Conclusions: Despite having greater reduction in
MeSH term(s)	Administration, Inhalation ; Anti-Bacterial Agents/therapeutic use ; Azithromycin ; Cystic Fibrosis/complications ; Cystic Fibrosis/drug therapy ; Forced Expiratory Volume ; Humans ; Prospective Studies ; Pseudomonas Infections/drug therapy ; Pseudomonas aeruginosa ; Tobramycin
Chemical Substances	Anti-Bacterial Agents ; Azithromycin (83905-01-5) ; Tobramycin (VZ8RRZ51VK)
Language	English
Publishing date	2021-10-27
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	204353-1
ISSN	1468-3296 ; 0040-6376
ISSN (online)	1468-3296
ISSN	0040-6376
DOI	10.1136/thoraxjnl-2021-217782
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Article ; Online: Using dried blood spots for variant analysis for patients with haemophilia.

Amos, Lauren E / Yoo, Byunggil / Miller, Neil / Farrow, Emily G / Walter, Adam / Gibson, Margaret / Durham, Sara / Herd, Suzanne / Soden, Sarah / Carpenter, Shannon L

Haemophilia : the official journal of the World Federation of Hemophilia

2019 Volume 25, Issue 5, Page(s) e339–e341

MeSH term(s)	Blood/metabolism ; Female ; Hemophilia A/diagnosis ; Humans ; Male
Language	English
Publishing date	2019-07-30
Publishing country	England
Document type	Letter
ZDB-ID	1229713-6
ISSN	1365-2516 ; 1351-8216 ; 1355-0691
ISSN (online)	1365-2516
ISSN	1351-8216 ; 1355-0691
DOI	10.1111/hae.13824
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Zs.A 4249: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Feeling scared or worried self-report in children receiving cancer treatments using the Symptom Screening in Pediatrics Tool (SSPedi).

Hyslop, Shannon / Tomlinson, Deborah / Baggott, Christina / Dix, David / Gibson, Paul / Johnston, Donna L / Orsey, Andrea D / Portwine, Carol / Price, Vicky / Vanan, Magimairajan / Kuczynski, Susan / Spiegler, Brenda / Tomlinson, George A / Dupuis, L Lee / Sung, Lillian

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

2020 Volume 29, Issue 6, Page(s) 3137–3144

Abstract: Introduction: The objectives of this study were to describe reports of bother for feeling scared or worried among children with cancer and pediatric hematopoietic stem cell transplant (HSCT) recipients, and to identify factors associated with it.: ... ...

Abstract	Introduction: The objectives of this study were to describe reports of bother for feeling scared or worried among children with cancer and pediatric hematopoietic stem cell transplant (HSCT) recipients, and to identify factors associated with it. Methods: We included children receiving cancer treatments who were 8-18 years of age. Three patient types were enrolled: inpatients receiving active cancer treatment, outpatients receiving maintenance acute lymphoblastic leukemia chemotherapy, and outpatients in survivorship. Amount of bother due to feeling scared or worried yesterday or today was self-reported using the Symptom Screening in Pediatrics Tool (SSPedi) on a 0-4 scale. Risk factors were evaluated using logistic regression. Results: Among the 502 children included, 225 (45.0%) reported any degree of bother (score ≥ 1) and 29 (5.8%) reported severe bother (score ≥ 3) for feeling scared or worried. In multiple regression evaluating any bother, boys were less likely to be bothered (odds ratio (OR) 0.60, 95% confidence interval (CI) 0.41-0.87) and inpatients receiving active cancer treatment were more likely to be bothered compared to outpatients in survivorship (OR 3.58, 95% CI 2.00-6.52). The only factor associated with being severely bothered by feeling scared or worried was clinic visit or admission due to fever (OR 4.57, 95% CI 1.24-13.60). Discussion: We found 45% of children receiving cancer treatments reported being bothered by feeling scared or worried. Girls and inpatients receiving active treatment experienced more bother of any degree, while visiting the hospital due to fever was associated with being severely bothered. Future work should identify interventions to prevent or alleviate this symptom.
MeSH term(s)	Adolescent ; Child ; Early Detection of Cancer/methods ; Female ; Humans ; Male ; Mass Screening ; Neoplasms/psychology ; Neoplasms/therapy ; Pediatrics ; Self Report ; Symptom Assessment/methods
Language	English
Publishing date	2020-10-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1134446-5
ISSN	1433-7339 ; 0941-4355
ISSN (online)	1433-7339
ISSN	0941-4355
DOI	10.1007/s00520-020-05818-x
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Article ; Online: Researching COVID to enhance recovery (RECOVER) pregnancy study: Rationale, objectives and design.

Metz, Torri D / Clifton, Rebecca G / Gallagher, Richard / Gross, Rachel S / Horwitz, Leora I / Jacoby, Vanessa L / Martin-Herz, Susanne P / Peralta-Carcelen, Myriam / Reeder, Harrison T / Beamon, Carmen J / Chan, James / Chang, A Ann / Costantine, Maged M / Fitzgerald, Megan L / Foulkes, Andrea S / Gibson, Kelly S / Güthe, Nick / Habli, Mounira / Hackney, David N /

Hoffman, Matthew K / Hoffman, M Camille / Hughes, Brenna L / Katz, Stuart D / Laleau, Victoria / Mallett, Gail / Mendez-Figueroa, Hector / Monzon, Vanessa / Palatnik, Anna / Palomares, Kristy T S / Parry, Samuel / Pettker, Christian M / Plunkett, Beth A / Poppas, Athena / Reddy, Uma M / Rouse, Dwight J / Saade, George R / Sandoval, Grecio J / Schlater, Shannon M / Sciurba, Frank C / Simhan, Hyagriv N / Skupski, Daniel W / Sowles, Amber / Thaweethai, Tanayott / Thomas, Gelise L / Thorp, John M / Tita, Alan T / Weiner, Steven J / Weigand, Samantha / Yee, Lynn M / Flaherman, Valerie J

PloS one

2023 Volume 18, Issue 12, Page(s) e0285351

Abstract: Importance: Pregnancy induces unique physiologic changes to the immune response and hormonal changes leading to plausible differences in the risk of developing post-acute sequelae of SARS-CoV-2 (PASC), or Long COVID. Exposure to SARS-CoV-2 during ... ...

Abstract	Importance: Pregnancy induces unique physiologic changes to the immune response and hormonal changes leading to plausible differences in the risk of developing post-acute sequelae of SARS-CoV-2 (PASC), or Long COVID. Exposure to SARS-CoV-2 during pregnancy may also have long-term ramifications for exposed offspring, and it is critical to evaluate the health outcomes of exposed children. The National Institutes of Health (NIH) Researching COVID to Enhance Recovery (RECOVER) Multi-site Observational Study of PASC aims to evaluate the long-term sequelae of SARS-CoV-2 infection in various populations. RECOVER-Pregnancy was designed specifically to address long-term outcomes in maternal-child dyads. Methods: RECOVER-Pregnancy cohort is a combined prospective and retrospective cohort that proposes to enroll 2,300 individuals with a pregnancy during the COVID-19 pandemic and their offspring exposed and unexposed in utero, including single and multiple gestations. Enrollment will occur both in person at 27 sites through the Eunice Kennedy Shriver National Institutes of Health Maternal-Fetal Medicine Units Network and remotely through national recruitment by the study team at the University of California San Francisco (UCSF). Adults with and without SARS-CoV-2 infection during pregnancy are eligible for enrollment in the pregnancy cohort and will follow the protocol for RECOVER-Adult including validated screening tools, laboratory analyses and symptom questionnaires followed by more in-depth phenotyping of PASC on a subset of the overall cohort. Offspring exposed and unexposed in utero to SARS-CoV-2 maternal infection will undergo screening tests for neurodevelopment and other health outcomes at 12, 18, 24, 36 and 48 months of age. Blood specimens will be collected at 24 months of age for SARS-CoV-2 antibody testing, storage and anticipated later analyses proposed by RECOVER and other investigators. Discussion: RECOVER-Pregnancy will address whether having SARS-CoV-2 during pregnancy modifies the risk factors, prevalence, and phenotype of PASC. The pregnancy cohort will also establish whether there are increased risks of adverse long-term outcomes among children exposed in utero. Clinical trials.gov identifier: Clinical Trial Registration: http://www.clinicaltrials.gov. Unique identifier: NCT05172011.
MeSH term(s)	Adult ; Female ; Humans ; Pregnancy ; COVID-19/epidemiology ; Pandemics/prevention & control ; Post-Acute COVID-19 Syndrome ; Prospective Studies ; Retrospective Studies ; SARS-CoV-2
Language	English
Publishing date	2023-12-21
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Observational Study
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0285351
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Article: Longitudinal assessment of diagnostic test performance over the course of acute SARS-CoV-2 infection.

Smith, Rebecca L / Gibson, Laura L / Martinez, Pamela P / Ke, Ruian / Mirza, Agha / Conte, Madison / Gallagher, Nicholas / Conte, Abigail / Wang, Leyi / Fredrickson, Rick / Edmonson, Darci C / Baughman, Melinda E / Chiu, Karen K / Choi, Hannah / Jensen, Tor W / Scardina, Kevin R / Bradley, Shannon / Gloss, Stacy L / Reinhart, Crystal /

Yedetore, Jagadeesh / Owens, Alyssa N / Broach, John / Barton, Bruce / Lazar, Peter / Henness, Darcy / Young, Todd / Dunnett, Alastair / Robinson, Matthew L / Mostafa, Heba H / Pekosz, Andrew / Manabe, Yukari C / Heetderks, William J / McManus, David D / Brooke, Christopher B

medRxiv : the preprint server for health sciences

2021

Abstract: What is already known about this topic?: Diagnostic tests and sample types for SARS-CoV-2 vary in sensitivity across the infection period.: What is added by this report?: We show that both RTqPCR (from nasal swab and saliva) and the Quidel SARS Sofia ...

Abstract	What is already known about this topic?: Diagnostic tests and sample types for SARS-CoV-2 vary in sensitivity across the infection period. What is added by this report?: We show that both RTqPCR (from nasal swab and saliva) and the Quidel SARS Sofia FIA rapid antigen tests peak in sensitivity during the period in which live virus can be detected in nasal swabs, but that the sensitivity of RTqPCR tests rises more rapidly in the pre-infectious period. We also use empirical data to estimate the sensitivities of RTqPCR and antigen tests as a function of testing frequency. What are the implications for public health practice?: RTqPCR tests will be more effective than rapid antigen tests at identifying infected individuals prior to or early during the infectious period and thus for minimizing forward transmission (provided results reporting is timely). All modalities, including rapid antigen tests, showed >94% sensitivity to detect infection if used at least twice per week. Regular surveillance/screening using rapid antigen tests 2-3 times per week can be an effective strategy to achieve high sensitivity (>95%) for identifying infected individuals.
Language	English
Publishing date	2021-03-22
Publishing country	United States
Document type	Preprint
DOI	10.1101/2021.03.19.21253964
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Article ; Online: Severely bothersome fatigue in children and adolescents with cancer and hematopoietic stem cell transplant recipients.

Tomlinson, Deborah / Baggott, Christina / Dix, David / Gibson, Paul / Hyslop, Shannon / Johnston, Donna L / Orsey, Andrea / Portwine, Carol / Price, Victoria / Vanan, Magimairajan / Kuczynski, Susan / Spiegler, Brenda / Tomlinson, George A / Dupuis, L Lee / Sung, Lillian

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

2018 Volume 27, Issue 7, Page(s) 2665–2671

Abstract: Background: Objectives were to describe bothersome fatigue in children with cancer and hematopoietic stem cell (HSCT) recipients and to identify factors associated with severely bothersome fatigue.: Methods: We included children ages 8-18 years ... ...

Abstract	Background: Objectives were to describe bothersome fatigue in children with cancer and hematopoietic stem cell (HSCT) recipients and to identify factors associated with severely bothersome fatigue. Methods: We included children ages 8-18 years treated for cancer or HSCT recipients from three groups: [1] receiving active cancer treatment and admitted to hospital for at least 3 days, [2] attending outpatient clinic for acute lymphoblastic leukemia maintenance therapy, and [3] attending outpatient clinic following treatment completion. Fatigue was measured using the Symptom Screening in Pediatrics Tool (SSPedi); severely bothersome fatigue was defined as a lot or extremely bothersome fatigue (score of 3-4 on 0-4 scale). Factors associated with severely bothersome fatigue were examined using univariate and multiple logistic regression. Results: Of 502 children included, 414 (82.5%) reported some degree of bothersome fatigue (scores 1-4), and 123 (24.5%) reported severely bothersome fatigue (score 3 or 4). In multiple regression analysis, factors significantly associated with severely bothersome fatigue were child age 11-14 and 15-18 years vs 8-10 years (odds ratio (OR) 2.11, 95% confidence interval (CI) 1.21-3.77 and OR 2.96, 95% CI 1.66-5.44), and inpatients receiving cancer treatment vs outpatients who had completed therapy (OR 3.85, 95% CI 2.17-7.27). Conclusions: We found that 82.5% of children with cancer or HSCT recipients reported bothersome fatigue and 24.5% of children reported severely bothersome fatigue. Risk factors for severely bothersome fatigue were older age and inpatients receiving active cancer treatment. Future work should evaluate systematic symptom screening in clinical practice and apply interventions to reduce fatigue.
MeSH term(s)	Adolescent ; Child ; Fatigue/etiology ; Female ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Logistic Models ; Male ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/physiopathology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Risk Factors ; Young Adult
Language	English
Publishing date	2018-11-26
Publishing country	Germany
Document type	Journal Article ; Multicenter Study
ZDB-ID	1134446-5
ISSN	1433-7339 ; 0941-4355
ISSN (online)	1433-7339
ISSN	0941-4355
DOI	10.1007/s00520-018-4555-9
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