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Book: Autoantibodies in organ specific autoimmune diseases

Conrad, Karsten / Schößler, Werner / Hiepe, Falk / Fritzler, Marvin J.

a diagnostic reference

(Autoantigens, autoantibodies, autoimmunity ; Volume 8)

2017

Author's details	Karsten Conrad, Werner Schößler, Falk Hiepe, Marvin J. Fritzler
Series title	Autoantigens, autoantibodies, autoimmunity ; Volume 8
Collection
Keywords	Autoaggressionskrankheit ; Serodiagnostik ; Autoantikörper
Subject	Serologische Diagnostik ; Serologische Untersuchung ; Serumdiagnostik ; Immundiagnostik ; Immunodiagnostik ; Autoantikörperkrankheit ; Autoimmunkrankheit ; Autoimmunopathie ; Autoimmunerkrankung
Language	English
Size	XVI, 348 Seiten, Illustrationen
Edition	second edition
Publisher	Pabst Science Publishers
Publishing place	Lengerich ; Berlin ; Bremen ; Miami ; Riga ; Viernheim ; Wien ; Zagreb
Publishing country	Germany
Document type	Book
HBZ-ID	HT019513374
ISBN	978-3-95853-348-6 ; 9783958533493 ; 3-95853-348-5 ; 3958533493
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
2018 A 466	available for loan (reading room)	Lesesaal EG

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Article ; Online: Update on autoantibodies and related biomarkers in autoimmune inflammatory myopathies.

Choi, May Y / Satoh, Minoru / Fritzler, Marvin J

Current opinion in rheumatology

2023 Volume 35, Issue 6, Page(s) 383–394

MeSH term(s)	Humans ; Autoantibodies ; Myositis/diagnosis ; Autoimmune Diseases ; Biomarkers
Chemical Substances	Autoantibodies ; Biomarkers
Language	English
Publishing date	2023-07-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	1045317-9
ISSN	1531-6963 ; 1040-8711
ISSN (online)	1531-6963
ISSN	1040-8711
DOI	10.1097/BOR.0000000000000957
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Article ; Online: Comment on: Concordance between myositis autoantibodies and anti-nuclear antibody patterns in a real-world, Australian cohort.

Mahler, Michael / Satoh, Minoru / Fritzler, Marvin J

Rheumatology (Oxford, England)

2022 Volume 61, Issue 9, Page(s) e290–e291

MeSH term(s)	Antibodies, Antinuclear ; Australia ; Autoantibodies ; Cohort Studies ; Humans ; Myositis
Chemical Substances	Antibodies, Antinuclear ; Autoantibodies
Language	English
Publishing date	2022-03-18
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/keac155
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Article ; Online: Autoantibodies in SLE: prediction and the

Choi, M Y / Fritzler, M J

Lupus

2019 Volume 28, Issue 11, Page(s) 1285–1293

Abstract: Autoantibodies (AA) and antinuclear antibodies (ANA) serve as key diagnostic and classification criteria for systemic lupus erythematosus (SLE). More than 200 different AA have been reported in SLE, although only a handful (<20) are considered " ... ...

Abstract	Autoantibodies (AA) and antinuclear antibodies (ANA) serve as key diagnostic and classification criteria for systemic lupus erythematosus (SLE). More than 200 different AA have been reported in SLE, although only a handful (<20) are considered "mainstream" because they are widely and routinely used in diagnostic, research and clinical medicine. Although the vast majority of AA have been relegated to the diminished status of "orphan" AA, some serve as predictors of SLE because they first appear in very early or subclinical SLE. Some AA are pathogenic, whereas others are thought to protect against or ameliorate disease progression and, hence, taken together can be used as predictive biomarkers of prognosis. Although studies have shown that specific AA are detected in the preclinical phase of SLE and are biomarkers of increased risk of developing the disease, AA are currently not widely used to predict very early SLE in individuals who have low pretest probability of disease. With the advent of multianalyte arrays with analytic algorithms, emerging evidence indicates that when certain combinations of biomarkers, such as the interferon signature and stem cell factor accompany AA and ANA, the predictive power for SLE is markedly increased.
MeSH term(s)	Antibodies, Antinuclear/immunology ; Autoantibodies/immunology ; Biomarkers/metabolism ; Disease Progression ; Humans ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/immunology ; Lupus Erythematosus, Systemic/physiopathology ; Prognosis
Chemical Substances	Antibodies, Antinuclear ; Autoantibodies ; Biomarkers
Language	English
Publishing date	2019-08-09
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1154407-7
ISSN	1477-0962 ; 0961-2033
ISSN (online)	1477-0962
ISSN	0961-2033
DOI	10.1177/0961203319868531
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Article ; Online: Anti-KIF20B autoantibodies in systemic autoimmune rheumatic diseases: Their high prevalence in systemic lupus erythematosus.

Koizumi, Haruka / Muro, Yoshinao / Yamashita, Yuta / Takeichi, Takuya / Fritzler, Marvin J / Akiyama, Masashi

The Journal of dermatology

2023 Volume 50, Issue 8, Page(s) 990–998

Abstract: The kinesin superfamily protein 20B (KIF20B), also known as M-phase phosphoprotein-1, is a plus-end ...

Abstract	The kinesin superfamily protein 20B (KIF20B), also known as M-phase phosphoprotein-1, is a plus-end-directed motor enzyme for cytokinesis. Anti-KIF20B antibodies have been reported in idiopathic ataxia, but no previous studies have examined anti-KIF20B antibodies in systemic autoimmune rheumatic diseases (SARDs). We aimed to establish methods for detecting anti-KIF20B antibodies and to investigate the clinical significance of these antibodies in SARDs. Serum samples from 597 patients with various SARDs and 46 healthy controls (HCs) were included. Fifty-nine samples that had been examined by immunoprecipitation using the recombinant KIF20B protein produced by in vitro transcription/translation were used for establishing the ELISA cutoff with the same recombinant protein for measuring the anti-KIF20B antibodies. The ELISA performed well, showing close agreement with the immunoprecipitation results (Cohen's κ >0.8). The ELISA results for 643 samples showed the prevalence of anti-KIF20B to be higher in the systemic lupus erythematosus (SLE) patients than in the HCs (18/89 vs. 3/46, P = 0.045). Since no SARD other than SLE had higher frequencies of anti-KIF20B antibodies than those of the HCs, we investigated the clinical characteristics of anti-KIF20B antibody-positive cases in SLE. The score on the SLE Disease Activity Index-2000 (SLEDAI-2K) was significantly higher for the anti-KIF20B-positive SLE patients than for the anti-KIF20B-negative SLE patients (P = 0.013). In a multivariate regression analysis of the anti-single-stranded deoxyribonucleic acid, anti-double-stranded deoxyribonucleic acid, and anti-KIF20B antibodies, the presence of anti-KIF20B antibody was significantly associated with high SLEDAI-2K scores (P = 0.003). Anti-KIF20B antibodies were found in ~20% of patients with SLE and were associated with high SLEDAI-2K scores. Much larger cohort and longitudinal studies are needed to confirm the association between anti-KIF20B antibodies and SLE.
MeSH term(s)	Humans ; Autoantibodies ; Prevalence ; Lupus Erythematosus, Systemic ; DNA ; Rheumatic Diseases ; Kinesins
Chemical Substances	Autoantibodies ; DNA (9007-49-2) ; KIF20B protein, human (EC 3.6.1.-) ; Kinesins (EC 3.6.4.4)
Language	English
Publishing date	2023-04-26
Publishing country	England
Document type	Journal Article
ZDB-ID	800103-0
ISSN	1346-8138 ; 0385-2407
ISSN (online)	1346-8138
ISSN	0385-2407
DOI	10.1111/1346-8138.16813
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Article: A Quality Assessment of Aquaporin-4 & Myelin Oligodendrocyte Glycoprotein Antibody Testing.

Krett, Jonathan D / Fritzler, Marvin J / Alikhani, Katayoun / Burton, Jodie M

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

2022 Volume 50, Issue 6, Page(s) 861–869

Abstract: Background: Accurate anti-aquaporin-4 (AQP4) and anti-myelin oligodendrocyte glycoprotein (MOG) autoantibody assays are needed to effectively diagnose neuromyelitis optica spectrum disorder and MOG antibody-associated disease. A proportion of patients ... ...

Abstract	Background: Accurate anti-aquaporin-4 (AQP4) and anti-myelin oligodendrocyte glycoprotein (MOG) autoantibody assays are needed to effectively diagnose neuromyelitis optica spectrum disorder and MOG antibody-associated disease. A proportion of patients at our centre have been tested for anti-AQP4 and anti-MOG autoantibodies locally, followed by an outsourced test as part of real-world practice. Outsourced testing is costly and of unproven utility. We conducted a quality improvement project to determine the value of outsourced testing for anti-AQP4 and anti-MOG autoantibodies. Methods: All patients seen by Calgary neurological services who underwent cell-based testing for anti-AQP4 and/or anti-MOG autoantibodies at both MitogenDx (Calgary, AB) and Mayo Clinic Laboratories (Rochester, MN, USA) between 2016 and 2020 were identified from a provincial database. The interlaboratory concordance was calculated by pairing within-subject results collected no more than 365 days apart. Retrospective chart review was done for subjects with discordant results to determine features associated with discordance and use of outsourced testing. Results: Fifty-seven anti-AQP4 and 46 anti-MOG test pairs from January 2016 to July 2020 were analyzed. Concordant tests pairs comprised 54/57 (94.7%, 95%CI 88.9-100.0%) anti-AQP4 and 41/46 (89.1%, 95%CI 80.1-98.1%) anti-MOG results. Discordant anti-AQP4 pairs included two local weak positives (negative when outsourced) and one local negative (positive when outsourced). Discordant anti-MOG pairs were all due to local weak positives (negative when outsourced). Conclusion: Interlaboratory discordant results for cell-based testing of anti-AQP4 autoantibodies were rare. Local anti-MOG weak positive results were associated with discordance, highlighting the need for cautious interpretation based on the clinical context. Our findings may reduce redundant outsourced testing.
Language	English
Publishing date	2022-11-18
Publishing country	England
Document type	Journal Article
ZDB-ID	197622-9
ISSN	0317-1671
ISSN	0317-1671
DOI	10.1017/cjn.2022.324
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Article ; Online: Outcomes associated with antiphospholipid antibodies in COVID-19: A prospective cohort study.

Mendel, Arielle / Fritzler, Marvin J / St-Pierre, Yvan / Rauch, Joyce / Bernatsky, Sasha / Vinet, Évelyne

Research and practice in thrombosis and haemostasis

2023 Volume 7, Issue 1, Page(s) 100041

Abstract: ... when available) for aPL (anticardiolipin immunoglobulin [Ig]M/IgG, anti-β2-glycoprotein I IgM/IgG ...

Abstract	Background: The significance of antiphospholipid antibodies (aPL) in COVID-19 remains uncertain. Objectives: We determined whether aPL are associated with COVID-19 and/or thrombosis or adverse outcomes during hospitalization for COVID-19. Methods: Symptomatic adults tested for SARS-CoV-2 for clinical reasons (March-July 2020) with either ≥1 positive polymerase chain reaction (COVID-19+) or all negative (non-COVID-19) results were recruited to a biobank collecting plasma, clinical data, and outcomes. We tested baseline plasma samples (days 0-7) of all subjects (and day-30 samples in the COVID-19+ subjects, when available) for aPL (anticardiolipin immunoglobulin [Ig]M/IgG, anti-β2-glycoprotein I IgM/IgG, antiphosphatidylserine/prothrombin IgM/IgG, and lupus anticoagulant). We compared the baseline prevalence of aPL between the COVID-19+ and non-COVID-19 subjects. Among hospitalized COVID-19+ subjects, multivariable logistic regression was used to evaluate the association of aPL (and their subtypes) with arterial or venous thromboembolic events, acute kidney injury, intensive care unit admission, mechanical ventilation, and death after adjusting for potential confounders. Results: At baseline, 123 of 289 (43%) COVID+ subjects had ≥1 aPL versus 116 of 261 (32%) non-COVID-19 subjects (difference, 10%; 95% CI, 3%-18%). Among 89 COVID+ subjects with repeated samples, aPL persisted on day 30 in 15 of 34 (44%) subjects with baseline aPL positivity, and half of those without aPL at baseline developed one or more new aPL. In hospitalized COVID-19 subjects ( Conclusion: In patients with COVID-19, aPL may help identify an increased risk of thrombosis and other adverse outcomes.
Language	English
Publishing date	2023-01-07
Publishing country	United States
Document type	Journal Article
ISSN	2475-0379
ISSN (online)	2475-0379
DOI	10.1016/j.rpth.2023.100041
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Article ; Online: High intelligence may exacerbate paediatric inflammatory response to SARS-CoV-2 infection.

McDonagh Hull, Pauline / Lashewicz, Bonnie M / Fritzler, Marvin J

Medical hypotheses

2021 Volume 155, Page(s) 110677

Abstract: The body's innate and acquiredimmunesystems are critical in responses to a wide spectrum of assaults, including SARS-CoV-2 infection. We identify studies of autoimmunity to support our hypothesis that a high intelligence quotient (IQ) may put children at ...

Abstract	The body's innate and acquiredimmunesystems are critical in responses to a wide spectrum of assaults, including SARS-CoV-2 infection. We identify studies of autoimmunity to support our hypothesis that a high intelligence quotient (IQ) may put children at increased risk for severe COVID-19 sequelae; especially those whose viral load is high and/or who develop multisystem inflammatory syndrome in children (MIS-C). MIS-C is associated with a higher risk of COVID-19 morbidity and death, even in otherwise healthy children. As information and evidence about SARS-CoV-2 infection continue to expand, our hypothesis suggests adding a potentially intriguing piece to the pandemic puzzle for further investigation. Drawing on a select review of published research and case reports, we discuss immune dysregulation in paediatric patients with a high IQ, including post-infection cytokine expression in the myocardium. Further, we provide a review of 27 paediatric (≤19 years; median age 16) cases of severe COVID-19 outcomes, drawn from media sources published between March and September 2020, in which we identify possible evidence of a 'hyper brain, hyper body' response to infection. We aver these cases are noteworthy given that paediatric death with COVID-19 disease is remarkably rare, and the estimated prevalence of a high IQ (or giftedness) is only 2% in the general population. These observations warrant prospective and retrospective studies of autoinflammatory markers and mechanisms to elucidate any special psychoneuroimmunological vulnerability in children with a high IQ, as such studies may raise implications for how and when prophylactic medical care is provided to children.
MeSH term(s)	Adolescent ; COVID-19 ; Child ; Humans ; Intelligence ; Prospective Studies ; Retrospective Studies ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome
Language	English
Publishing date	2021-09-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	193145-3
ISSN	1532-2777 ; 0306-9877
ISSN (online)	1532-2777
ISSN	0306-9877
DOI	10.1016/j.mehy.2021.110677
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Article: Diagnostic Utility of Anticarbamylated Protein Antibodies as Measured Using Carbamylated Fetal Calf Serum.

Mahler, Michael / Fritzler, Marvin J

The Journal of rheumatology

2018 Volume 45, Issue 3, Page(s) 438–439

MeSH term(s)	Arthritis, Rheumatoid ; Autoantibodies ; Connective Tissue Diseases ; Humans
Chemical Substances	Autoantibodies
Language	English
Publishing date	2018-03-02
Publishing country	Canada
Document type	Letter ; Comment
ZDB-ID	194928-7
ISSN	1499-2752 ; 0315-162X
ISSN (online)	1499-2752
ISSN	0315-162X
DOI	10.3899/jrheum.170677
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Article ; Online: Detection of myositis-specific antibodies: additional notes.

Mahler, Michael / Fritzler, Marvin J

Annals of the rheumatic diseases

2018 Volume 78, Issue 5, Page(s) e45

MeSH term(s)	Adolescent ; Adult ; Dermatomyositis ; Humans ; Myositis ; Rheumatic Diseases ; Rheumatology
Language	English
Publishing date	2018-02-14
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	7090-7
ISSN	1468-2060 ; 0003-4967
ISSN (online)	1468-2060
ISSN	0003-4967
DOI	10.1136/annrheumdis-2018-213153
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