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  1. Article ; Online: Metabolomics analysis based on a UPLC-Q-TOF-MS metabolomics approach to compare Lin-Xia-Shan-Shen and garden ginseng.

    Chen, Jing / Yuan, Ying / Ran, Xiaoku / Guo, Na / Dou, Deqiang

    RSC advances

    2018  Volume 8, Issue 53, Page(s) 30616–30623

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2018-08-30
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/c8ra04823a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: LIN-12/Notch regulates lag-1 and lin-12 expression during anchor cell/ventral uterine precursor cell fate specification.

    Park, Seong Kyun / Choi, Vit Na / Hwang, Byung Joon

    Molecules and cells

    2013  Volume 35, Issue 3, Page(s) 249–254

    Abstract: During Caenorhabditis elegans gonadal development, a stochastic interaction between the LIN-12 ... cell (AC)/pre-ventral uterine (VU) precursor cells. Both cells express lin-12 and lag-2 ... before specification, and a small difference in LIN-12 activity leads to the exclusive expression of lin-12 in VUs and ...

    Abstract During Caenorhabditis elegans gonadal development, a stochastic interaction between the LIN-12/Notch receptor and the LAG-2/Delta ligand initiates cell fate specification of two equivalent pre-anchor cell (AC)/pre-ventral uterine (VU) precursor cells. Both cells express lin-12 and lag-2 before specification, and a small difference in LIN-12 activity leads to the exclusive expression of lin-12 in VUs and lag-2 in the AC through an unknown feedback mechanism. In this Notch signaling process, the cleaved LIN-12/Notch intracellular domain (NICD) binds to the LAG-1/CSL transcriptional repressor, forming a transcriptional activator complex containing LAG-1 and NICD. Here we show that clustered LAG-1 binding sites in lin-12 and lag-1 are involved in regulating lin-12 and lag-1 expression during AC/VU cell fate specification. Both genes are expressed in VU cells, but not the AC, after specification. We also show that lin-12 is necessary for lag-1 expression in VU cells. Interestingly, lin-12 (null) animals express lag-1 in the AC, suggesting that LIN-12 signaling is necessary for the suppression of lag-1 expression in the AC. Ectopic expression of lag-1 cDNA in the AC causes a defect in the vulvaluterine (V-U) connection; therefore, LAG-1 should be eliminated in the AC to form a normal V-U connection at a later developmental stage in wild-type animals.
    MeSH term(s) Animals ; Base Sequence ; Binding Sites ; Body Patterning/genetics ; Caenorhabditis elegans/cytology ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/growth & development ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Caenorhabditis elegans Proteins/physiology ; Cell Differentiation ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Female ; Gene Expression Regulation ; Genes, Helminth ; Receptors, Notch/physiology ; Uterus/cytology ; Uterus/growth & development ; Vulva/cytology ; Vulva/growth & development
    Chemical Substances Caenorhabditis elegans Proteins ; DNA-Binding Proteins ; LAG-1 protein, C elegans ; Lin-12 protein, C elegans ; Receptors, Notch
    Language English
    Publishing date 2013-03-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1148964-9
    ISSN 0219-1032 ; 1016-8478
    ISSN (online) 0219-1032
    ISSN 1016-8478
    DOI 10.1007/s10059-013-2333-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4713: Show issues Location:
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  3. Article ; Online: The Murine Bladder Supports a Population of Stromal Sca-1+/CD34+/lin- Mesenchymal Stem Cells.

    Lilly, Meredith A / Kulkulka, Natalie A / Firmiss, Paula R / Ross, Michael J / Flum, Andrew S / Santos, Grace B Delos / Bowen, Diana K / Dettman, Robert W / Gong, Edward M

    PloS one

    2015  Volume 10, Issue 11, Page(s) e0141437

    Abstract: ... fluorescence activated cell sorting (FACS), we identified a Sca-1+/ CD34+/ lin- (PECAM-: CD45-: Ter119-) population in the adult ... by postnatal day 1. Cultured Sca-1+/ CD34+/ lin- bladder cells self-renewed, formed colonies and spontaneously ... Partial obstruction resulted in upregulation of fibrosis genes within the Sca-1+/CD34+/lin- population ...

    Abstract Bladder fibrosis is an undesired end point of injury of obstruction and often renders the smooth muscle layer noncompliant. In many cases, the long-term effect of bladder fibrosis is renal failure. Despite our understanding of the progression of this disease, little is known about the cellular mechanisms that lead to a remodeled bladder wall. Resident stem (progenitor) cells have been identified in various organs such as the brain, heart and lung. These cells function normally during organ homeostasis, but become dysregulated after organ injury. Here, we aimed to characterize a mesenchymal progenitor cell population as a first step in understanding its role in bladder fibrosis. Using fluorescence activated cell sorting (FACS), we identified a Sca-1+/ CD34+/ lin- (PECAM-: CD45-: Ter119-) population in the adult murine bladder. These cells were localized to the stromal layer of the adult bladder and appeared by postnatal day 1. Cultured Sca-1+/ CD34+/ lin- bladder cells self-renewed, formed colonies and spontaneously differentiated into cells expressing smooth muscle genes. These cells differentiated into other mesenchymal lineages (chondrocytes, adipocytes and osteocytes) upon culture in induction medium. Both acute and partial obstruction of the bladder reduced expression of CD34 and changed localization of Sca-1 to the urothelium. Partial obstruction resulted in upregulation of fibrosis genes within the Sca-1+/CD34+/lin- population. Our data indicate a resident, mesenchymal stem cell population in the bladder that is altered by bladder obstruction. These findings provide new information about the cellular changes in the bladder that may be associated with bladder fibrosis.
    MeSH term(s) Animals ; Antigens, CD34/metabolism ; Antigens, Ly/metabolism ; Cell Lineage ; Cells, Cultured ; Fibrosis ; Flow Cytometry ; Fluorescent Antibody Technique ; Membrane Proteins/metabolism ; Mesenchymal Stromal Cells/physiology ; Mice ; Polymerase Chain Reaction ; Urinary Bladder/cytology ; Urinary Bladder/pathology ; Urinary Bladder Neck Obstruction/pathology
    Chemical Substances Antigens, CD34 ; Antigens, Ly ; Ly6a protein, mouse ; Membrane Proteins
    Language English
    Publishing date 2015
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0141437
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Clustered LAG-1 binding sites in lag-1/CSL are involved in regulating lag-1 expression during lin-12/Notch-dependent cell-fate specification.

    Choi, Vit Na / Park, Seong Kyun / Hwang, Byung Joon

    BMB reports

    2013  Volume 46, Issue 4, Page(s) 219–224

    Abstract: ... in Caenorhabditis elegans is initiated by a stochastic interaction between LIN-12/Notch receptor and LAG-2/Delta ligand ... in two neighboring Z1.ppp and Z4.aaa cells. Both cells express lin-12 and lag-2 before specification, and ... a small difference in LIN-12 activity leads to the exclusive expressions of lin-12 in VU and lag-2 ...

    Abstract The cell-fate specification of the anchor cell (AC) and a ventral uterine precursor cell (VU) in Caenorhabditis elegans is initiated by a stochastic interaction between LIN-12/Notch receptor and LAG-2/Delta ligand in two neighboring Z1.ppp and Z4.aaa cells. Both cells express lin-12 and lag-2 before specification, and a small difference in LIN-12 activity leads to the exclusive expressions of lin-12 in VU and lag-2 in the AC, through a feedback mechanism of unknown nature. Here we show that the expression pattern of lag-1/CSL, a transcriptional repressor itself that turns into an activator upon binding of the intracellular domain of Notch, overlaps with that of lin-12. Site-directed mutagenesis of LAG-1 binding sites in lag-1 maintains its expression in the AC, and eliminates it in the VU. Thus, AC/VU cell-fate specification appears to involve direct regulation of lag-1 expression by the LAG-1 protein, activating its transcription in VU cells, but repressing it in the AC.
    MeSH term(s) Amino Acid Motifs ; Animals ; Binding Sites ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Cell Differentiation ; Cell Line ; Mutagenesis, Site-Directed ; Protein Binding ; Receptors, Notch/metabolism ; Signal Transduction ; Transcription, Genetic
    Chemical Substances Caenorhabditis elegans Proteins ; Lin-12 protein, C elegans ; Receptors, Notch
    Language English
    Publishing date 2013-04-23
    Publishing country Korea (South)
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2410389-5
    ISSN 1976-670X ; 1976-6696
    ISSN (online) 1976-670X
    ISSN 1976-6696
    DOI 10.5483/bmbrep.2013.46.4.269
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4202: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Clustered LAG-1 binding sites in lag-1/CSL are involved in regulating lag-1 expression during lin-12/Notch-dependent cell-fate specification

    Vit Na Choi / Seong Kyun Park / Byung Joon Hwang

    BMB Reports, Vol 46, Iss 4, Pp 219-

    2013  Volume 224

    Abstract: ... in Caenorhabditis elegans isinitiated by a stochastic interaction between LIN-12/Notchreceptor and LAG-2/Delta ligand in two ... neighboring Z1.pppand Z4.aaa cells. Both cells express lin-12 and lag-2 beforespecification, and a small ... difference in LIN-12 activity leads tothe exclusive expressions of lin-12 in VU and lag-2 in the AC ...

    Abstract The cell-fate specification of the anchor cell (AC) and a ventraluterine precursor cell (VU) in Caenorhabditis elegans isinitiated by a stochastic interaction between LIN-12/Notchreceptor and LAG-2/Delta ligand in two neighboring Z1.pppand Z4.aaa cells. Both cells express lin-12 and lag-2 beforespecification, and a small difference in LIN-12 activity leads tothe exclusive expressions of lin-12 in VU and lag-2 in the AC,through a feedback mechanism of unknown nature. Here weshow that the expression pattern of lag-1/CSL, a transcriptionalrepressor itself that turns into an activator upon binding of theintracellular domain of Notch, overlaps with that of lin-12.Site-directed mutagenesis of LAG-1 binding sites in lag-1maintains its expression in the AC, and eliminates it in the VU.Thus, AC/VU cell-fate specification appears to involve directregulation of lag-1 expression by the LAG-1 protein, activatingits transcription in VU cells, but repressing it in the AC. [BMBReports 2013; 46(4): 219-224]
    Keywords Anchor cell/ventral uterine precursor cell ; Cell-fate specification ; CSL ; Feedback loop ; Notch signaling ; Biology (General) ; QH301-705.5 ; Biochemistry ; QD415-436
    Subject code 570
    Language English
    Publishing date 2013-04-01T00:00:00Z
    Publisher Korean Society for Biochemistry and Molecular Biology
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Book: Zhong yi lin chuang ge jue

    An, Na

    1991  

    Title translation Clinical Chinese traditional medicine in rhyme.
    Author's details An Na, Ji Xiaoren bian zhu
    MeSH term(s) Medicine, Chinese Traditional
    Language Chinese
    Size 9, 146 p.
    Edition Di 1 ban.
    Publisher Ke xue ji shu wen xian chu ban she
    Publishing place Beijing
    Document type Book
    ISBN 9787502313463 ; 750231346X
    Database Catalogue of the US National Library of Medicine (NLM)

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  7. Book: Le lin

    Lazarkévitch, N. A

    sa culture et son industrie dans l'Europe occidentale

    1925  

    Author's details N. A. Lazarkévitch
    Language French
    Size IX, 407 S., V Bl, Ill., Kt
    Publisher Gauthier-Villars
    Publishing place Paris
    Document type Book
    Database Former special subject collection: coastal and deep sea fishing

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  8. Book: Le lin

    Lazarkévich, N. A

    sa culture et son industrie dans l'Europe occidentale

    1925  

    Keywords Flax. ; Linen.
    Language French
    Size ix, 407, [1] p., plates, v folded plates :, ill. (4 plans) ;, 24 cm.
    Publisher Gauthier-Villars et cie
    Publishing place Paris
    Document type Book
    Note "Cette étude fut d'abord publiée en 1921, en langue russe, par l'Association centrale des liniculteurs, puis en 1922, en langue ue tchèque à Prague."--Avertissement de l'auteur.
    Database NAL-Catalogue (AGRICOLA)

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  9. Book ; Online: Molecular Biology of Bamboo mosaic Virus - A Type Member of the Potexvirus Genus

    Lin, Na-Sheng / Tsai, Ching-Hsiu / Hsu, Yau-Heiu

    2018  

    Abstract: The flexible filamentous plant viruses are responsible for more than half of all agricultural loss worldwide. Potexvirus is one of the two most important flexible filamentous plant viruses. Bamboo mosaic virus (BaMV), a single-stranded positive-sense RNA ...

    Abstract The flexible filamentous plant viruses are responsible for more than half of all agricultural loss worldwide. Potexvirus is one of the two most important flexible filamentous plant viruses. Bamboo mosaic virus (BaMV), a single-stranded positive-sense RNA virus, is a member of the Potexvirus genus of Alphaflexiviridae. It can infect at least 12 species of bamboo, causing a huge economic impact on the bamboo industry in Taiwan. The study of BaMV did not start extensively until the completion of the full-length sequencing of genomic RNA of BaMV and generation of the BaMV infectious cDNA clone in the early 1990s. Since then, BaMV has been extensively studied at the molecular, cellular and ecological level, covering both basic and applied researches, by a group of researchers in Taiwan. In this eBook, the content comprises 6 reviews and 4 articles. Seven of them are involved in the infection of BaMV covering viral RNA replication, viral RNA trafficking, and the host factors. Two of them are related to the vector transmission and the ecology of BaMV. The last one is the application of using BaMV as a viral vector to produce vaccines in plants
    Keywords Science (General) ; Microbiology ; Botany
    Size 1 electronic resource (109 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020099631
    ISBN 9782889454396 ; 2889454398
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  10. Article ; Online: Impact of duodenum-preserving pancreatic head resection and pancreatoduodenectomy on postoperative diarrhea: insights from trial sequential analysis.

    Xie, Dan-Na / Qian, Bao-Lin

    International journal of surgery (London, England)

    2024  

    Language English
    Publishing date 2024-05-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1097/JS9.0000000000001525
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6502: Show issues Location:
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