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  1. Article ; Online: Efficient replication of human nuclear DNA.

    Kunkel, Thomas A

    Cell research

    2022  Volume 32, Issue 9, Page(s) 797–798

    MeSH term(s) Cell Nucleus ; DNA ; DNA Replication ; Humans ; Virus Replication
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2022-07-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1319303-x
    ISSN 1748-7838 ; 1001-0602
    ISSN (online) 1748-7838
    ISSN 1001-0602
    DOI 10.1038/s41422-022-00690-2
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  2. Article: Chemokines in lung injury: Thomas A. Neff Lecture.

    Strieter, R M / Kunkel, S L / Keane, M P / Standiford, T J

    Chest

    1999  Volume 116, Issue 1 Suppl, Page(s) 103S–110S

    MeSH term(s) Animals ; Cell Adhesion Molecules/physiology ; Chemokines/physiology ; Chemokines, CC/physiology ; Chemokines, CXC/physiology ; Humans ; Neutrophils ; Respiratory Distress Syndrome, Adult
    Chemical Substances Cell Adhesion Molecules ; Chemokines ; Chemokines, CC ; Chemokines, CXC
    Language English
    Publishing date 1999-07
    Publishing country United States
    Document type Journal Article ; Lecture ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1378/chest.116.suppl_1.103s
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  3. Book ; Thesis: Einfluss eines nicht-detektierten Geruchsdefizites auf die psychische, physische und kognitive Verfassung

    Kunkel, Friederike / Hummel, Thomas / Welge-Lüssen, Antje

    2020  

    Institution Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde
    Author's details von Friederike Kunkel aus Berlin ; Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde [Dresden]
    Language German
    Size 70 Seiten, Illustrationen, Diagramme
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Technische Universität Dresden, Medizinische Fakultät, 2020
    HBZ-ID HT020859393
    Database Catalogue ZB MED Medicine, Health

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  4. Article ; Online: Ribonucleotide Incorporation by Eukaryotic B-Family Replicases and Its Implications for Genome Stability.

    Williams, Jessica S / Kunkel, Thomas A

    Annual review of biochemistry

    2022  Volume 91, Page(s) 133–155

    Abstract: Our current view of how DNA-based genomes are efficiently and accurately replicated continues to evolve as new details emerge on the presence of ribonucleotides in DNA. Ribonucleotides are incorporated during eukaryotic DNA replication at rates that make ...

    Abstract Our current view of how DNA-based genomes are efficiently and accurately replicated continues to evolve as new details emerge on the presence of ribonucleotides in DNA. Ribonucleotides are incorporated during eukaryotic DNA replication at rates that make them the most common noncanonical nucleotide placed into the nuclear genome, they are efficiently repaired, and their removal impacts genome integrity. This review focuses on three aspects of this subject: the incorporation of ribonucleotides into the eukaryotic nuclear genome during replication by B-family DNA replicases, how these ribonucleotides are removed, and the consequences of their presence or removal for genome stability and disease.
    MeSH term(s) DNA/genetics ; DNA/metabolism ; DNA Repair ; DNA Replication ; Eukaryota/genetics ; Eukaryota/metabolism ; Genomic Instability ; Nucleotidyltransferases/genetics ; Ribonucleotides/genetics ; Ribonucleotides/metabolism
    Chemical Substances Ribonucleotides ; DNA (9007-49-2) ; Nucleotidyltransferases (EC 2.7.7.-)
    Language English
    Publishing date 2022-03-14
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Intramural
    ZDB-ID 207924-0
    ISSN 1545-4509 ; 0066-4154
    ISSN (online) 1545-4509
    ISSN 0066-4154
    DOI 10.1146/annurev-biochem-032620-110354
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  5. Article ; Online: Fusing faculty development and student learning to address rapid curricular change.

    Horvath, Zsuzsa / Kunkel, Thomas C / Potluri, Anitha

    Journal of dental education

    2023  

    Language English
    Publishing date 2023-12-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410579-5
    ISSN 1930-7837 ; 0022-0337
    ISSN (online) 1930-7837
    ISSN 0022-0337
    DOI 10.1002/jdd.13446
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  6. Article ; Online: Extrinsic proofreading.

    Zhou, Zhi-Xiong / Kunkel, Thomas A

    DNA repair

    2022  Volume 117, Page(s) 103369

    Abstract: The high fidelity of replication of the nuclear DNA genome in eukaryotes involves three processes. Correct rather than incorrect dNTPs are almost always incorporated by the three major replicases, DNA polymerases α, δ and ε. When an incorrect base is ... ...

    Abstract The high fidelity of replication of the nuclear DNA genome in eukaryotes involves three processes. Correct rather than incorrect dNTPs are almost always incorporated by the three major replicases, DNA polymerases α, δ and ε. When an incorrect base is occasionally inserted, the latter Pols δ and ε also have a 3 ´ to 5 ´ exonuclease activity that can remove the mismatch to allow correct DNA synthesis to proceed. Lastly, rare mismatches that escape proofreading activity and are present in newly replicated DNA can be removed by DNA mismatch repair. In this review, we consider evidence supporting the hypothesis that the second mechanism, proofreading, can operate in two different ways. Primer terminal mismatches made by either Pol δ or Pol ε can be 'intrinsically' proofread. This mechanism occurs by direct transfer of a misinserted base made at the polymerase active site to the exonuclease active site that is located a short distance away. Intrinsic proofreading allows mismatch excision without intervening enzyme dissociation. Alternatively, considerable evidence suggests that mismatches made by any of the three replicases can also be proofread by 'extrinsic' proofreading by Pol δ. Extrinsic proofreading occurs when a mismatch made by any of the three replicases is initially abandoned, thereby allowing the exonuclease active site of Pol δ to bind directly to and remove the mismatch before replication continues. Here we review the evidence that extrinsic proofreading significantly enhances the fidelity of nuclear DNA replication, and we then briefly consider the implications of this process for evolution and disease.
    MeSH term(s) DNA ; DNA Polymerase II/metabolism ; DNA Polymerase III/metabolism ; DNA Replication ; Exonucleases/metabolism
    Chemical Substances DNA (9007-49-2) ; DNA Polymerase II (EC 2.7.7.7) ; DNA Polymerase III (EC 2.7.7.7) ; Exonucleases (EC 3.1.-)
    Language English
    Publishing date 2022-07-04
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, N.I.H., Intramural
    ZDB-ID 2071608-4
    ISSN 1568-7856 ; 1568-7864
    ISSN (online) 1568-7856
    ISSN 1568-7864
    DOI 10.1016/j.dnarep.2022.103369
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  7. Article: Demonstration of the stabilization of solar salt at 620 C with a semi-closed configuration in a 100 kg-scale.

    Kunkel, Sebastian / Seeliger, Felix / Hanke, Andrea / Bauer, Thomas / Bonk, Alexander

    Heliyon

    2023  Volume 9, Issue 12, Page(s) e22363

    Abstract: Among the variety of energy storage techniques thermal energy storage (TES), based on molten salts, is already in use for the storage of heat in a gigawatt hour scale. At the time of writing virtually all TES in CSP utilize Solar Salt (60 wt-% ... ...

    Abstract Among the variety of energy storage techniques thermal energy storage (TES), based on molten salts, is already in use for the storage of heat in a gigawatt hour scale. At the time of writing virtually all TES in CSP utilize Solar Salt (60 wt-% NaNO
    Language English
    Publishing date 2023-11-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e22363
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  8. Article ; Online: Stability across the Whole Nuclear Genome in the Presence and Absence of DNA Mismatch Repair.

    Lujan, Scott Alexander / Kunkel, Thomas A

    Cells

    2021  Volume 10, Issue 5

    Abstract: We describe the contribution of DNA mismatch repair (MMR) to the stability of the eukaryotic nuclear genome as determined by whole-genome sequencing. To date, wild-type nuclear genome mutation rates are known for over 40 eukaryotic species, while ... ...

    Abstract We describe the contribution of DNA mismatch repair (MMR) to the stability of the eukaryotic nuclear genome as determined by whole-genome sequencing. To date, wild-type nuclear genome mutation rates are known for over 40 eukaryotic species, while measurements in mismatch repair-defective organisms are fewer in number and are concentrated on
    MeSH term(s) Cell Nucleus/genetics ; DNA Damage ; DNA Mismatch Repair ; DNA Mutational Analysis ; Genomic Instability ; Humans ; Mutation Rate ; Whole Genome Sequencing
    Language English
    Publishing date 2021-05-17
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10051224
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  9. Article ; Online: A simple but profound mutation in mouse DNA polymerase ε drives tumorigenesis.

    Kunkel, Thomas A

    The Journal of clinical investigation

    2018  Volume 128, Issue 9, Page(s) 3754–3756

    Abstract: Over 40 years ago, Loeb and colleagues proposed that errors in DNA replication produce a mutator phenotype that is involved in generating the multiple mutations required for tumor development. In this issue of the JCI, Li, Castrillon, and colleagues ... ...

    Abstract Over 40 years ago, Loeb and colleagues proposed that errors in DNA replication produce a mutator phenotype that is involved in generating the multiple mutations required for tumor development. In this issue of the JCI, Li, Castrillon, and colleagues describe a mouse model containing a single base change in the gene encoding replicative DNA polymerase ε (POLE) that mimics the "ultramutator" phenotype recently reported in many human tumors. Their seminal accomplishment validates Loeb's hypothesis and the use of mutational signatures to understand the origins and potentially the treatment of human tumors, and it offers an exciting opportunity to further explore the mechanisms responsible for normal DNA replication fidelity and their perturbations.
    MeSH term(s) Animals ; Carcinogenesis ; Cell Transformation, Neoplastic ; DNA Polymerase II/genetics ; DNA Replication ; Humans ; Mice ; Mutation ; Neoplasms
    Chemical Substances DNA Polymerase II (EC 2.7.7.7)
    Language English
    Publishing date 2018-08-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Comment
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI123021
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  10. Article ; Online: DNA polymerase λ Loop1 variant yields unexpected gain-of-function capabilities in nonhomologous end-joining.

    Kaminski, Andrea M / Chiruvella, Kishore K / Ramsden, Dale A / Bebenek, Katarzyna / Kunkel, Thomas A / Pedersen, Lars C

    DNA repair

    2024  Volume 136, Page(s) 103645

    Abstract: DNA polymerases lambda (Polλ) and mu (Polμ) are X-Family polymerases that participate in DNA double-strand break (DSB) repair by the nonhomologous end-joining pathway (NHEJ). Both polymerases direct synthesis from one DSB end, using template derived from ...

    Abstract DNA polymerases lambda (Polλ) and mu (Polμ) are X-Family polymerases that participate in DNA double-strand break (DSB) repair by the nonhomologous end-joining pathway (NHEJ). Both polymerases direct synthesis from one DSB end, using template derived from a second DSB end. In this way, they promote the NHEJ ligation step and minimize the sequence loss normally associated with this pathway. The two polymerases differ in cognate substrate, as Polλ is preferred when synthesis must be primed from a base-paired DSB end, while Polμ is required when synthesis must be primed from an unpaired DSB end. We generated a Polλ variant (Polλ
    MeSH term(s) DNA-Directed DNA Polymerase/metabolism ; Gain of Function Mutation ; DNA Polymerase beta/metabolism ; DNA Repair ; DNA/metabolism ; DNA End-Joining Repair
    Chemical Substances DNA polymerase beta2 (EC 2.7.7.-) ; DNA-Directed DNA Polymerase (EC 2.7.7.7) ; DNA Polymerase beta (EC 2.7.7.7) ; DNA (9007-49-2)
    Language English
    Publishing date 2024-02-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2071608-4
    ISSN 1568-7856 ; 1568-7864
    ISSN (online) 1568-7856
    ISSN 1568-7864
    DOI 10.1016/j.dnarep.2024.103645
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