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  1. Book ; Online: Analyse der wirtschaftlichen Lage ökologisch wirtschaftender Betriebe im Wirtschaftsjahr 2021/22

    Kuhnert, Heike / Offermann, Frank

    2023  

    Keywords Text ; ddc:630
    Language German
    Publisher Thünen-Institut für Betriebswirtschaft
    Publishing country de
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Book ; Online: Analyse der wirtschaftlichen Lage ökologisch wirtschaftender Betriebe im Wirtschaftsjahr 2021/22

    Kuhnert, Heike / Offermann, Frank

    2023  

    Abstract: Im deutschen Testbetriebsnetz des Bundesministeriums für Ernährung und Landwirtschaft (BMEL) wird auch die wirtschaftliche Lage von ökologisch wirtschaftenden Betrieben in Deutschland erfasst. Das Thünen-Institut für Betriebswirtschaft wertet die Daten ... ...

    Abstract Im deutschen Testbetriebsnetz des Bundesministeriums für Ernährung und Landwirtschaft (BMEL) wird auch die wirtschaftliche Lage von ökologisch wirtschaftenden Betrieben in Deutschland erfasst. Das Thünen-Institut für Betriebswirtschaft wertet die Daten jährlich aus und erstellt einen Ergebnisbericht. Der aktuelle Bericht fasst die wichtigsten Ergebnisse des Wirtschaftsjahres 2021/22 zusammen.
    Keywords Farm economics
    Language German
    Publishing country dk
    Document type Book ; Online
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  3. Article ; Online: Toxoplasma gondii Infections and Associated Factors in Female Children and Adolescents, Germany.

    Giese, Laura / Seeber, Frank / Aebischer, Anton / Kuhnert, Ronny / Schlaud, Martin / Stark, Klaus / Wilking, Hendrik

    Emerging infectious diseases

    2024  Volume 30, Issue 5, Page(s) 995–999

    Abstract: In a representative sample of female children and adolescents in Germany, Toxoplasma gondii seroprevalence was 6.3% (95% CI 4.7%-8.0%). With each year of life, the chance of being seropositive increased by 1.2, indicating a strong force of infection. ... ...

    Abstract In a representative sample of female children and adolescents in Germany, Toxoplasma gondii seroprevalence was 6.3% (95% CI 4.7%-8.0%). With each year of life, the chance of being seropositive increased by 1.2, indicating a strong force of infection. Social status and municipality size were found to be associated with seropositivity.
    MeSH term(s) Humans ; Female ; Germany/epidemiology ; Toxoplasmosis/epidemiology ; Toxoplasmosis/parasitology ; Adolescent ; Child ; Toxoplasma/immunology ; Seroepidemiologic Studies ; Child, Preschool ; Risk Factors ; Infant ; Antibodies, Protozoan/blood
    Chemical Substances Antibodies, Protozoan
    Language English
    Publishing date 2024-04-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid3005.231045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The effect of early skin-to-skin contact after cesarean section on breastfeeding duration and development of atopic-allergic diseases.

    Stephan, Yvonne / Müller, Hans-Helge / Kühnert, Maritta / Meinhold-Heerlein, Ivo / Ibrahimi, Gentiana / Reitz, Maleen / Schemmann, Hannah / Oehmke, Frank / Köhler, Siegmund / Renz, Harald

    European journal of midwifery

    2024  Volume 8

    Abstract: Introduction: Breastfeeding to strengthen the immune system suggests allergy prevention as a possible option. The connection between breastfeeding and the development of atopic-allergic diseases is being discussed. The primary aim of this work was to ... ...

    Abstract Introduction: Breastfeeding to strengthen the immune system suggests allergy prevention as a possible option. The connection between breastfeeding and the development of atopic-allergic diseases is being discussed. The primary aim of this work was to investigate an association of the first early skin-to-skin contact following cesarean section with the development of atopic diseases within the 1st year of life.
    Methods: The present study was conducted as a bicentric prospective cohort study in central Germany with a 15-month recruitment period. Data collection was by telephone interviews with a follow-up of 12 months. The statistical evaluation procedure was based on a hierarchical test of the association of early skin-to-skin contact between mother and child with the two main outcome measures. The primary outcome is the duration of breastfeeding. The second outcome is the onset of atopic-allergic disease within the 1st year of life.
    Results: Mothers breastfed longer if they had skin-to-skin contact within the first 30 minutes postpartum [χ²(df=5) = 19.020, p=0.002], if they breastfed their newborns early immediately after birth (p<0.001), and if the first skin-to-skin contact lasted more than one hour [χ²(df=4) = 19.617, p<0.001]. Regarding atopic-allergic diseases, no significant effects of skin-to-skin contact were found in relation to disease development. Regarding breastfeeding, no significant effects of atopic-allergic diseases could be detected either.
    Conclusions: The results of this study reflect the benefits of skin-to-skin contact in the context of breastfeeding and atopic disease. The current scientific knowledge regarding skin contact and the development of atopic-allergic diseases should be extended and deepened.
    Language English
    Publishing date 2024-01-24
    Publishing country Greece
    Document type Journal Article
    ISSN 2585-2906
    ISSN (online) 2585-2906
    DOI 10.18332/ejm/176213
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Praxismanagement: Verträge mit der Familie

    Kuhnert, Frank

    Dental-Magazin

    2014  Volume 32, Issue 1, Page(s) 68

    Language German
    Document type Article
    ZDB-ID 380595-5
    ISSN 0176-7291
    Database Current Contents Medicine

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    Zs.B 2732: Show issues Location:
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  6. Article: Finanzen: Steuern Sparen mit dem Praxis-PKW

    Kuhnert, Frank

    Dental-Magazin

    2013  Volume 31, Issue 7, Page(s) 74

    Language German
    Document type Article
    ZDB-ID 380595-5
    ISSN 0176-7291
    Database Current Contents Medicine

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  7. Article: Rickicaryophyllane A, a Caryophyllane from the Ascomyceteous Fungus Hypoxylon rickii and a 10-Norbotryane Congener.

    Wiebach, Vincent / Surup, Frank / Kuhnert, Eric / Stadler, Marc

    Natural product communications

    2018  Volume 11, Issue 7, Page(s) 909–912

    Abstract: Herein we report the isolation from Hypoxylon rickii of a new sesquiterpenoid (1) with a caryophyllane skeleton. The planar structure of 1 was elucidat ed by NMR and HRMS data as the 1,12-dihydro-l-hydroxyl derivative of caryophyllenol-I, for which we ... ...

    Abstract Herein we report the isolation from Hypoxylon rickii of a new sesquiterpenoid (1) with a caryophyllane skeleton. The planar structure of 1 was elucidat ed by NMR and HRMS data as the 1,12-dihydro-l-hydroxyl derivative of caryophyllenol-I, for which we propose the name rickicaryophyllane A. Its relative stereochemistry was assigned with a series of ID NOESY experiments, while the IR,2S,5R,9R absolute configuration was demonstrated by Mosher's analysis. Besides, we isolated 3-(hydroxymethyl)-1,1,3,5-tetramethyl-1,2,3,5,6,7-hexahydro-4H-inden-4-one (2) as a new 10-norbotryane derivative and the known metabolite orcacetophenone (3).
    MeSH term(s) Ascomycota/chemistry ; Molecular Structure ; Sesquiterpenes/chemistry ; Sesquiterpenes/metabolism
    Chemical Substances Sesquiterpenes ; rickicaryophyllane A
    Language English
    Publishing date 2018-11-19
    Publishing country United States
    Document type Journal Article
    ISSN 1934-578X
    ISSN 1934-578X
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  8. Article: Fetal Assessment in Pregnancy (Indication and Methodology for Fetal Monitoring in a Low-risk Population). Guideline of the DGGG, DEGUM, OEGGG and SGGG (S3-Level, AWMF Registry No. 015/089, February 2023).

    Schiermeier, Sven / von Kaisenberg, Constantin Sylvius / Kehl, Sven / Reister, Frank / Mosimann, Beatrice / Reif, Philipp / Harlfinger, Werner / König, Klaus / Schwarz, Christiane / Matern, Elke / Kühnert, Maritta / Schmitz, Ralf / Hoopmann, Markus / Ramsell, Andrea / Kalberer, Barbara Stocker / Heule, Petra Graf / Heinzl, Silke / Kayer, Beate / Gruber, Patricia /
    Steiner, Horst / Schaeffer, Leonard

    Geburtshilfe und Frauenheilkunde

    2023  Volume 83, Issue 8, Page(s) 996–1016

    Abstract: ... ...

    Abstract Purpose
    Language English
    Publishing date 2023-08-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80111-2
    ISSN 1438-8804 ; 0016-5751 ; 1615-3359
    ISSN (online) 1438-8804
    ISSN 0016-5751 ; 1615-3359
    DOI 10.1055/a-2096-1182
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  9. Article ; Online: Microenvironment-dependent growth of Sezary cells in humanized IL-15 mice.

    Gao, Jie / Ren, Shumei / Choonoo, Gabrielle / Chen, Guoying / Frleta, Davor / Zhong, Jun / Gupta, Namita / Sharma, Prachi / Oyejide, Adelekan / Atwal, Gurinder S / Macdonald, Lynn / Murphy, Andrew / Kuhnert, Frank

    Disease models & mechanisms

    2023  Volume 16, Issue 10

    Abstract: Sezary syndrome (SS) is a rare, aggressive leukemic variant of cutaneous T-cell lymphoma (CTCL) that lacks adequate therapeutic options and representative small-animal models. Here, we demonstrate that IL-15 is a critical CTCL growth factor. Importantly, ...

    Abstract Sezary syndrome (SS) is a rare, aggressive leukemic variant of cutaneous T-cell lymphoma (CTCL) that lacks adequate therapeutic options and representative small-animal models. Here, we demonstrate that IL-15 is a critical CTCL growth factor. Importantly, an immunodeficient knock-in mouse model genetically engineered to express human IL-15 uniquely supported the growth of SS patient samples relative to conventional immunodeficient mouse strains. SS patient-derived xenograft (PDX) models recapacitated key pathological features of the human disease, including skin infiltration and spread of leukemic cells to the periphery, and maintained the dependence on human IL-15 upon serial in vivo passaging. Detailed molecular characterization of the engrafted cells by single-cell transcriptomic analysis revealed congruent neoplastic gene expression signatures but distinct clonal engraftment patterns. Overall, we document an important dependence of Sezary cell survival and proliferation on IL-15 signaling and the utility of immunodeficient humanized IL-15 mice as hosts for SS - and potentially other T and NK cell-derived hematologic malignancies - PDX model generation. Furthermore, these studies advocate the thorough molecular understanding of the resultant PDX models to maximize their translational impact.
    MeSH term(s) Humans ; Animals ; Mice ; Skin Neoplasms/metabolism ; Interleukin-15 ; Lymphoma, T-Cell, Cutaneous/pathology ; Sezary Syndrome/metabolism ; Sezary Syndrome/pathology ; Lymphocytes/metabolism ; Tumor Microenvironment
    Chemical Substances Interleukin-15
    Language English
    Publishing date 2023-10-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2451104-3
    ISSN 1754-8411 ; 1754-8403
    ISSN (online) 1754-8411
    ISSN 1754-8403
    DOI 10.1242/dmm.050190
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Hybridorubrins A-D: Azaphilone Heterodimers from Stromata of Hypoxylon fragiforme and Insights into the Biosynthetic Machinery for Azaphilone Diversification.

    Becker, Kevin / Pfütze, Sebastian / Kuhnert, Eric / Cox, Russell J / Stadler, Marc / Surup, Frank

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2020  Volume 27, Issue 4, Page(s) 1438–1450

    Abstract: The diversity of azaphilones in stromatal extracts of the fungus Hypoxylon fragiforme was investigated and linked to their biosynthetic machineries by using bioinformatics. Nineteen azaphilone-type compounds were isolated and characterized by NMR ... ...

    Abstract The diversity of azaphilones in stromatal extracts of the fungus Hypoxylon fragiforme was investigated and linked to their biosynthetic machineries by using bioinformatics. Nineteen azaphilone-type compounds were isolated and characterized by NMR spectroscopy and mass spectrometry, and their absolute stereoconfigurations were assigned by using Mosher ester analysis and electronic circular dichroism spectroscopy. Four unprecedented bis-azaphilones, named hybridorubrins A-D, were elucidated, in addition to new fragirubrins F and G and various known mitorubrin derivatives. Only the hybridorubrins, which are composed of mitorubrin and fragirubrin moieties, exhibited strong inhibition of Staphylococcus aureus biofilm formation. Analysis of the genome of H. fragiforme revealed the presence of two separate biosynthetic gene clusters (BGCs) hfaza1 and hfaza2 responsible for azaphilone formation. While the hfaza1 BGC likely encodes the assembly of the backbone and addition of fatty acid moieties to yield the (R)-configured series of fragirubrins, the hfaza2 BGC contains the necessary genes to synthesise the widely distributed (S)-mitorubrins. This study is the first example of two distant cross-acting fungal BGCs collaborating to produce two families of azaphilones and bis-azaphilones derived therefrom.
    MeSH term(s) Ascomycota/chemistry ; Benzopyrans/chemistry ; Fungi/chemistry ; Pigments, Biological/chemistry
    Chemical Substances Benzopyrans ; Pigments, Biological ; azaphilone
    Language English
    Publishing date 2020-12-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202003215
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