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Article ; Online: Possible Scenarios on the Future of Polytechnic State University of Bicol (PSUB) – Research Culture by 2030 using Jim Dator’s Archetypes of Alternative Futures

Romeo Jr. Sotto / Seth Barandon / Juvy Bustamante / April Luzon / Marlon Pontillas / Harold Jan Terano

Journal of Education, Management and Development Studies, Vol 1, Iss 2, Pp 40-

2021 Volume 51

Abstract: ... Colleges (CSPC), to be known as Polytechnic State University of Bicol (PSUB). The paper utilized Jim Dator ...

Abstract	This paper explores possible scenarios for the Research Culture of Camarines Sur Polytechnic Colleges (CSPC), to be known as Polytechnic State University of Bicol (PSUB). The paper utilized Jim Dator’s four archetypes of alternative futures to construct PSUB’s Research Culture possible scenarios by 2030. This paper highlights the assumption that the research culture in PSUB is of world class quality and all of its faculty members are actively involved in research, its disciplined, collapsed, transformative, or business as usual scenarios. Four plausible scenarios have surfaced in this paper: Progressive Research Culture, Lax and Deficit Research Culture, Sophisticated Research Culture, and Transformative Research Culture. The article explored areas for a preferred future by 2030. It requires multiple drivers along faculty, students, administration and community for a better research culture. This study proved to be useful in crafting and anticipating the future scenarios of PSUB’s research culture. Preliminary as it may, this study highlighted important building blocks of the four future scenarios. Dator’s framework was proved to be very useful in developing the four scenarios, the use of other future study tools will further amplify plausible scenarios for the Polytechnic State University of Bicol.
Keywords	psub ; research culture ; future scenarios ; jim dator’s alternative futures ; Education ; L ; Social Sciences ; H
Subject code	650
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	Camarines Sur Polytechnic Colleges
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Do No Harm: Plastics are playing a major role in giving healthcare professionals the tools and capabilities they need to battle the COVID pandemic

Romeo, Jim

Keywords	covid19
Publisher	PMC
Document type	Article ; Online
DOI	10.1002/peng.20312
Database	COVID19

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Article: Connect the dots.

Romeo, Jim

Journal of AHIMA

2013 Volume 84, Issue 3, Page(s) 22–6; quiz 27

MeSH term(s)	Education, Continuing ; Electronic Health Records ; Information Services/organization & administration ; Medical Record Linkage ; Public-Private Sector Partnerships ; Systems Integration ; United States
Language	English
Publishing date	2013-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1093944-1
ISSN	1060-5487 ; 0273-9976
ISSN	1060-5487 ; 0273-9976
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Article ; Online: 2023 WSES guidelines for the prevention, detection, and management of iatrogenic urinary tract injuries (IUTIs) during emergency digestive surgery.

de'Angelis, Nicola / Schena, Carlo Alberto / Marchegiani, Francesco / Reitano, Elisa / De Simone, Belinda / Wong, Geoffrey Yuet Mun / Martínez-Pérez, Aleix / Abu-Zidan, Fikri M / Agnoletti, Vanni / Aisoni, Filippo / Ammendola, Michele / Ansaloni, Luca / Bala, Miklosh / Biffl, Walter / Ceccarelli, Graziano / Ceresoli, Marco / Chiara, Osvaldo / Chiarugi, Massimo / Cimbanassi, Stefania /

Coccolini, Federico / Coimbra, Raul / Di Saverio, Salomone / Diana, Michele / Dioguardi Burgio, Marco / Fraga, Gustavo / Gavriilidis, Paschalis / Gurrado, Angela / Inchingolo, Riccardo / Ingels, Alexandre / Ivatury, Rao / Kashuk, Jeffry L / Khan, Jim / Kirkpatrick, Andrew W / Kim, Fernando J / Kluger, Yoram / Lakkis, Zaher / Leppäniemi, Ari / Maier, Ronald V / Memeo, Riccardo / Moore, Ernest E / Ordoñez, Carlos A / Peitzman, Andrew B / Pellino, Gianluca / Picetti, Edoardo / Pikoulis, Manos / Pisano, Michele / Podda, Mauro / Romeo, Oreste / Rosa, Fausto / Tan, Edward / Ten Broek, Richard P / Testini, Mario / Tian Wei Cheng, Brian Anthony / Weber, Dieter / Sacco, Emilio / Sartelli, Massimo / Tonsi, Alfredo / Dal Moro, Fabrizio / Catena, Fausto

World journal of emergency surgery : WJES

2023 Volume 18, Issue 1, Page(s) 45

Abstract: Iatrogenic urinary tract injury (IUTI) is a severe complication of emergency digestive surgery. It can lead to increased postoperative morbidity and mortality and have a long-term impact on the quality of life. The reported incidence of IUTIs varies ... ...

Abstract	Iatrogenic urinary tract injury (IUTI) is a severe complication of emergency digestive surgery. It can lead to increased postoperative morbidity and mortality and have a long-term impact on the quality of life. The reported incidence of IUTIs varies greatly among the studies, ranging from 0.3 to 1.5%. Given the high volume of emergency digestive surgery performed worldwide, there is a need for well-defined and effective strategies to prevent and manage IUTIs. Currently, there is a lack of consensus regarding the prevention, detection, and management of IUTIs in the emergency setting. The present guidelines, promoted by the World Society of Emergency Surgery (WSES), were developed following a systematic review of the literature and an international expert panel discussion. The primary aim of these WSES guidelines is to provide evidence-based recommendations to support clinicians and surgeons in the prevention, detection, and management of IUTIs during emergency digestive surgery. The following key aspects were considered: (1) effectiveness of preventive interventions for IUTIs during emergency digestive surgery; (2) intra-operative detection of IUTIs and appropriate management strategies; (3) postoperative detection of IUTIs and appropriate management strategies and timing; and (4) effectiveness of antibiotic therapy (including type and duration) in case of IUTIs.
MeSH term(s)	Humans ; Digestive System Surgical Procedures ; Iatrogenic Disease/prevention & control ; Quality of Life ; Surgeons ; Urinary Tract
Language	English
Publishing date	2023-09-09
Publishing country	England
Document type	Journal Article ; Practice Guideline
ZDB-ID	2233734-9
ISSN	1749-7922 ; 1749-7922
ISSN (online)	1749-7922
ISSN	1749-7922
DOI	10.1186/s13017-023-00513-8
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Article: Hybrid core/shell microparticles and their use for understanding biological processes

Bachhuka, Akash / Agnieszka Mierczynska / Alex Cavallaro / Jim Manavis / John D. Hayball / Kerrilyn R. Diener / Krasimir Vasilev / Louise E. Smith / Romeo Marian / Susan N. Christo

Journal of colloid and interface science. 2015 Nov. 01, v. 457

2015

Abstract: Hybrid micro and nanoparticles have become a topic of intense research in recent years. This is due to the special properties of these materials that open new avenues in advanced applications. Herein, we report a novel method for the generation of hybrid ...

Abstract	Hybrid micro and nanoparticles have become a topic of intense research in recent years. This is due to the special properties of these materials that open new avenues in advanced applications. Herein, we report a novel method for the generation of hybrid particles utilising plasma polymerization. Poly (methyl methacrylate) (PMMA) beads were first coated with a thin allylamine based plasma polymer layer. Gold nanoparticles of engineered size and surface structure were then attached in a controlled manner to the plasma polymer coated beads. To generate uniform chemistry on the outermost surface and to preserve the nanotopography, we deposited a 5–10nm thin layer of Acpp. We demonstrated that these particles can be utilized in in vivo models to interrogate important biological phenomena. Specifically, we used them in mice to study the inflammatory and foreign body responses to surface nanotopography. The data strongly indicates that surface nanotopography and chemistry can modulate collagen production and the number of adhering immune cells. The method for generating hybrid particles reported here is solvent free and can open new opportunities in fields such as tissue engineering, drug delivery, biosensors, and regenerative medicine.
Keywords	biological properties and phenomena ; biosensors ; collagen ; drugs ; medicine ; methodology ; mice ; microparticles ; models ; nanogold ; nanoparticles ; polymerization ; polymethylmethacrylate ; solvents ; tissue engineering
Language	English
Dates of publication	2015-1101
Size	p. 9-17.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2015.06.040
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Postoperative pain management in non-traumatic emergency general surgery: WSES-GAIS-SIAARTI-AAST guidelines.

Coccolini, Federico / Corradi, Francesco / Sartelli, Massimo / Coimbra, Raul / Kryvoruchko, Igor A / Leppaniemi, Ari / Doklestic, Krstina / Bignami, Elena / Biancofiore, Giandomenico / Bala, Miklosh / Marco, Ceresoli / Damaskos, Dimitris / Biffl, Walt L / Fugazzola, Paola / Santonastaso, Domenico / Agnoletti, Vanni / Sbarbaro, Catia / Nacoti, Mirco / Hardcastle, Timothy C /

Mariani, Diego / De Simone, Belinda / Tolonen, Matti / Ball, Chad / Podda, Mauro / Di Carlo, Isidoro / Di Saverio, Salomone / Navsaria, Pradeep / Bonavina, Luigi / Abu-Zidan, Fikri / Soreide, Kjetil / Fraga, Gustavo P / Carvalho, Vanessa Henriques / Batista, Sergio Faria / Hecker, Andreas / Cucchetti, Alessandro / Ercolani, Giorgio / Tartaglia, Dario / Galante, Joseph M / Wani, Imtiaz / Kurihara, Hayato / Tan, Edward / Litvin, Andrey / Melotti, Rita Maria / Sganga, Gabriele / Zoro, Tamara / Isirdi, Alessandro / De'Angelis, Nicola / Weber, Dieter G / Hodonou, Adrien M / tenBroek, Richard / Parini, Dario / Khan, Jim / Sbrana, Giovanni / Coniglio, Carlo / Giarratano, Antonino / Gratarola, Angelo / Zaghi, Claudia / Romeo, Oreste / Kelly, Michael / Forfori, Francesco / Chiarugi, Massimo / Moore, Ernest E / Catena, Fausto / Malbrain, Manu L N G

World journal of emergency surgery : WJES

2022 Volume 17, Issue 1, Page(s) 50

Abstract: Background: Non-traumatic emergency general surgery involves a heterogeneous population that may present with several underlying diseases. Timeous emergency surgical treatment should be supplemented with high-quality perioperative care, ideally ... ...

Abstract	Background: Non-traumatic emergency general surgery involves a heterogeneous population that may present with several underlying diseases. Timeous emergency surgical treatment should be supplemented with high-quality perioperative care, ideally performed by multidisciplinary teams trained to identify and handle complex postoperative courses. Uncontrolled or poorly controlled acute postoperative pain may result in significant complications. While pain management after elective surgery has been standardized in perioperative pathways, the traditional perioperative treatment of patients undergoing emergency surgery is often a haphazard practice. The present recommended pain management guidelines are for pain management after non-traumatic emergency surgical intervention. It is meant to provide clinicians a list of indications to prescribe the optimal analgesics even in the absence of a multidisciplinary pain team. Material and methods: An international expert panel discussed the different issues in subsequent rounds. Four international recognized scientific societies: World Society of Emergency Surgery (WSES), Global Alliance for Infection in Surgery (GAIS), Italian Society of Anesthesia, Analgesia Intensive Care (SIAARTI), and American Association for the Surgery of Trauma (AAST), endorsed the project and approved the final manuscript. Conclusion: Dealing with acute postoperative pain in the emergency abdominal surgery setting is complex, requires special attention, and should be multidisciplinary. Several tools are available, and their combination is mandatory whenever is possible. Analgesic approach to the various situations and conditions should be patient based and tailored according to procedure, pathology, age, response, and available expertise. A better understanding of the patho-mechanisms of postoperative pain for short- and long-term outcomes is necessary to improve prophylactic and treatment strategies.
MeSH term(s)	Abdomen ; Analgesics ; Anesthesia ; Humans ; Pain, Postoperative/drug therapy ; Perioperative Care ; United States
Chemical Substances	Analgesics
Language	English
Publishing date	2022-09-21
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2233734-9
ISSN	1749-7922 ; 1749-7922
ISSN (online)	1749-7922
ISSN	1749-7922
DOI	10.1186/s13017-022-00455-7
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Article ; Online: Hybrid core/shell microparticles and their use for understanding biological processes.

Bachhuka, Akash / Christo, Susan N / Cavallaro, Alex / Diener, Kerrilyn R / Mierczynska, Agnieszka / Smith, Louise E / Marian, Romeo / Manavis, Jim / Hayball, John D / Vasilev, Krasimir

Journal of colloid and interface science

2015 Volume 457, Page(s) 9–17

Abstract	Hybrid micro and nanoparticles have become a topic of intense research in recent years. This is due to the special properties of these materials that open new avenues in advanced applications. Herein, we report a novel method for the generation of hybrid particles utilising plasma polymerization. Poly (methyl methacrylate) (PMMA) beads were first coated with a thin allylamine based plasma polymer layer. Gold nanoparticles of engineered size and surface structure were then attached in a controlled manner to the plasma polymer coated beads. To generate uniform chemistry on the outermost surface and to preserve the nanotopography, we deposited a 5-10 nm thin layer of Acpp. We demonstrated that these particles can be utilized in in vivo models to interrogate important biological phenomena. Specifically, we used them in mice to study the inflammatory and foreign body responses to surface nanotopography. The data strongly indicates that surface nanotopography and chemistry can modulate collagen production and the number of adhering immune cells. The method for generating hybrid particles reported here is solvent free and can open new opportunities in fields such as tissue engineering, drug delivery, biosensors, and regenerative medicine.
MeSH term(s)	Allylamine/chemistry ; Animals ; Foreign-Body Reaction ; Gold/chemistry ; Inflammation/metabolism ; Metal Nanoparticles/chemistry ; Mice ; Mice, Inbred C57BL ; Microchemistry ; Particle Size ; Polymethyl Methacrylate/chemistry ; Surface Properties
Chemical Substances	Allylamine (48G762T011) ; Gold (7440-57-5) ; Polymethyl Methacrylate (9011-14-7)
Language	English
Publishing date	2015-11-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2015.06.040
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: ALPAS (ALleviating PAndemic Severity) Through Foresight

Romeo B Sotto / April Z Luzon / Seth B Barandon / Jocelyn O Jintalan / Maria Joy I Idian / Estelito R Clemente / Marlon S Pontillas / Harold Jan R Terano / Juvy M Bustamante / Filmor J Murillo

Journal of Education, Management and Development Studies, Vol 3, Iss

Capping the Digital Divide

2023 Volume 1

Abstract: ... in the region and the possible scenarios using Jim Dator’s Future Scenario Archetypes, Causal Layered Analysis ...

Abstract	Everyone has lost their footing due to the pandemic. The academic community was unprepared, leaving both professors and students bewildered and without a sense of direction. The goal at the time was to overcome the calamity of educational discontinuity. Sustainable Development Goal (SDG) 4 – Education goal aims “to ensure inclusive and equitable quality education and promote lifelong learning opportunities for all” relative to this SDG and the surge of the pandemic, digital divide become prominent, altering the course of educational landscape in all levels across public and private institutions. In the Bicol region, education was delivered in many various forms and variability, predicting the future through strategic foresight could propel the region to a transformed future. This paper discusses in detail the status of education in the region and the possible scenarios using Jim Dator’s Future Scenario Archetypes, Causal Layered Analysis and through Scenario Planning Plus. Four plausible scenarios have surfaced in this paper: STUG-nation of Education, Unstable and Disarray of Educational elements, Flowing-restrained Education, and ORAGON Education. It requires multiple drivers as examined through the PESTEL that includes political, economic, social, technological, environmental, legal aspects. This study proved useful in crafting and anticipating the future scenarios of Bicol Region’s education. Preliminary as it may, this study highlighted important building blocks of future scenarios through foresight methods. Dator’s framework was proved to be very useful in developing the four scenarios, the use of other future study tools will further amplify plausible scenarios for the education of Bicol region and beyond.
Keywords	Digital divide ; Foresight ; Education ; Sustainable Development Goals (SDGs) ; L ; Social Sciences ; H
Subject code	910 ; 650
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Camarines Sur Polytechnic Colleges
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A globally optimal k-anonymity method for the de-identification of health data.

El Emam, Khaled / Dankar, Fida Kamal / Issa, Romeo / Jonker, Elizabeth / Amyot, Daniel / Cogo, Elise / Corriveau, Jean-Pierre / Walker, Mark / Chowdhury, Sadrul / Vaillancourt, Regis / Roffey, Tyson / Bottomley, Jim

Journal of the American Medical Informatics Association : JAMIA

2009 Volume 16, Issue 5, Page(s) 670–682

Abstract: Background: Explicit patient consent requirements in privacy laws can have a negative impact on health research, leading to selection bias and reduced recruitment. Often legislative requirements to obtain consent are waived if the information collected ... ...

Abstract	Background: Explicit patient consent requirements in privacy laws can have a negative impact on health research, leading to selection bias and reduced recruitment. Often legislative requirements to obtain consent are waived if the information collected or disclosed is de-identified. Objective: The authors developed and empirically evaluated a new globally optimal de-identification algorithm that satisfies the k-anonymity criterion and that is suitable for health datasets. Design: Authors compared OLA (Optimal Lattice Anonymization) empirically to three existing k-anonymity algorithms, Datafly, Samarati, and Incognito, on six public, hospital, and registry datasets for different values of k and suppression limits. Measurement Three information loss metrics were used for the comparison: precision, discernability metric, and non-uniform entropy. Each algorithm's performance speed was also evaluated. Results: The Datafly and Samarati algorithms had higher information loss than OLA and Incognito; OLA was consistently faster than Incognito in finding the globally optimal de-identification solution. Conclusions: For the de-identification of health datasets, OLA is an improvement on existing k-anonymity algorithms in terms of information loss and performance.
MeSH term(s)	Adolescent ; Adult ; Algorithms ; Confidentiality ; Female ; Humans ; Information Storage and Retrieval ; Male ; Medical Records Systems, Computerized
Language	English
Publishing date	2009-06-30
Publishing country	England
Document type	Comparative Study ; Evaluation Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1205156-1
ISSN	1527-974X ; 1067-5027
ISSN (online)	1527-974X
ISSN	1067-5027
DOI	10.1197/jamia.M3144
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Article ; Online: Identifying gene-environment interactions in schizophrenia: contemporary challenges for integrated, large-scale investigations.

van Os, Jim / Rutten, Bart P / Myin-Germeys, Inez / Delespaul, Philippe / Viechtbauer, Wolfgang / van Zelst, Catherine / Bruggeman, Richard / Reininghaus, Ulrich / Morgan, Craig / Murray, Robin M / Di Forti, Marta / McGuire, Philip / Valmaggia, Lucia R / Kempton, Matthew J / Gayer-Anderson, Charlotte / Hubbard, Kathryn / Beards, Stephanie / Stilo, Simona A / Onyejiaka, Adanna /

Bourque, Francois / Modinos, Gemma / Tognin, Stefania / Calem, Maria / O'Donovan, Michael C / Owen, Michael J / Holmans, Peter / Williams, Nigel / Craddock, Nicholas / Richards, Alexander / Humphreys, Isla / Meyer-Lindenberg, Andreas / Leweke, F Markus / Tost, Heike / Akdeniz, Ceren / Rohleder, Cathrin / Bumb, J Malte / Schwarz, Emanuel / Alptekin, Köksal / Üçok, Alp / Saka, Meram Can / Atbaşoğlu, E Cem / Gülöksüz, Sinan / Gumus-Akay, Guvem / Cihan, Burçin / Karadağ, Hasan / Soygür, Haldan / Cankurtaran, Eylem Şahin / Ulusoy, Semra / Akdede, Berna / Binbay, Tolga / Ayer, Ahmet / Noyan, Handan / Karadayı, Gülşah / Akturan, Elçin / Ulaş, Halis / Arango, Celso / Parellada, Mara / Bernardo, Miguel / Sanjuán, Julio / Bobes, Julio / Arrojo, Manuel / Santos, Jose Luis / Cuadrado, Pedro / Rodríguez Solano, José Juan / Carracedo, Angel / García Bernardo, Enrique / Roldán, Laura / López, Gonzalo / Cabrera, Bibiana / Cruz, Sabrina / Díaz Mesa, Eva Ma / Pouso, María / Jiménez, Estela / Sánchez, Teresa / Rapado, Marta / González, Emiliano / Martínez, Covadonga / Sánchez, Emilio / Olmeda, Ma Soledad / de Haan, Lieuwe / Velthorst, Eva / van der Gaag, Mark / Selten, Jean-Paul / van Dam, Daniella / van der Ven, Elsje / van der Meer, Floor / Messchaert, Elles / Kraan, Tamar / Burger, Nadine / Leboyer, Marion / Szoke, Andrei / Schürhoff, Franck / Llorca, Pierre-Michel / Jamain, Stéphane / Tortelli, Andrea / Frijda, Flora / Vilain, Jeanne / Galliot, Anne-Marie / Baudin, Grégoire / Ferchiou, Aziz / Richard, Jean-Romain / Bulzacka, Ewa / Charpeaud, Thomas / Tronche, Anne-Marie / De Hert, Marc / van Winkel, Ruud / Decoster, Jeroen / Derom, Catherine / Thiery, Evert / Stefanis, Nikos C / Sachs, Gabriele / Aschauer, Harald / Lasser, Iris / Winklbaur, Bernadette / Schlögelhofer, Monika / Riecher-Rössler, Anita / Borgwardt, Stefan / Walter, Anna / Harrisberger, Fabienne / Smieskova, Renata / Rapp, Charlotte / Ittig, Sarah / Soguel-dit-Piquard, Fabienne / Studerus, Erich / Klosterkötter, Joachim / Ruhrmann, Stephan / Paruch, Julia / Julkowski, Dominika / Hilboll, Desiree / Sham, Pak C / Cherny, Stacey S / Chen, Eric Y H / Campbell, Desmond D / Li, Miaoxin / Romeo-Casabona, Carlos María / Emaldi Cirión, Aitziber / Urruela Mora, Asier / Jones, Peter / Kirkbride, James / Cannon, Mary / Rujescu, Dan / Tarricone, Ilaria / Berardi, Domenico / Bonora, Elena / Seri, Marco / Marcacci, Thomas / Chiri, Luigi / Chierzi, Federico / Storbini, Viviana / Braca, Mauro / Minenna, Maria Gabriella / Donegani, Ivonne / Fioritti, Angelo / La Barbera, Daniele / La Cascia, Caterina Erika / Mulè, Alice / Sideli, Lucia / Sartorio, Rachele / Ferraro, Laura / Tripoli, Giada / Seminerio, Fabio / Marinaro, Anna Maria / McGorry, Patrick / Nelson, Barnaby / Amminger, G Paul / Pantelis, Christos / Menezes, Paulo R / Del-Ben, Cristina M / Gallo Tenan, Silvia H / Shuhama, Rosana / Ruggeri, Mirella / Tosato, Sarah / Lasalvia, Antonio / Bonetto, Chiara / Ira, Elisa / Nordentoft, Merete / Krebs, Marie-Odile / Barrantes-Vidal, Neus / Cristóbal, Paula / Kwapil, Thomas R / Brietzke, Elisa / Bressan, Rodrigo A / Gadelha, Ary / Maric, Nadja P / Andric, Sanja / Mihaljevic, Marina / Mirjanic, Tijana

Schizophrenia bulletin

2014 Volume 40, Issue 4, Page(s) 729–736

Abstract: Recent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the ... ...

Abstract	Recent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the population risk conferred by individual molecular genetic variants is small. There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G × E), however, so far, thorough replication of findings is rare and G × E research still faces several conceptual and methodological challenges. In this article, we aim to review these recent developments and illustrate how integrated, large-scale investigations may overcome contemporary challenges in G × E research, drawing on the example of a large, international, multi-center study into the identification and translational application of G × E in schizophrenia. While such investigations are now well underway, new challenges emerge for G × E research from late-breaking evidence that genetic variation and environmental exposures are, to a significant degree, shared across a range of psychiatric disorders, with potential overlap in phenotype.
MeSH term(s)	Gene-Environment Interaction ; Genetic Predisposition to Disease ; Humans ; Schizophrenia/epidemiology ; Schizophrenia/genetics ; Schizophrenic Psychology ; Social Environment
Language	English
Publishing date	2014-05-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	439173-1
ISSN	1745-1701 ; 0586-7614
ISSN (online)	1745-1701
ISSN	0586-7614
DOI	10.1093/schbul/sbu069
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