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Article ; Online: Microalbuminuria and mortality in individuals with coronary heart disease: A meta-analysis of a prospective study.

Govardi, Ericko / Yulianda, Dicky / Habib, Faisal / Pakpahan, Cennikon

2023 Volume 75, Issue 4, Page(s) 229–235

Abstract: Aim: Microalbuminuria has been elevated as an outcome predictor in cardiovascular medicine. However, due to the small number of studies investigating the association of microalbuminuria and mortality in the coronary heart disease (CHD) population, the ... ...

Abstract	Aim: Microalbuminuria has been elevated as an outcome predictor in cardiovascular medicine. However, due to the small number of studies investigating the association of microalbuminuria and mortality in the coronary heart disease (CHD) population, the prognosis value of microalbuminuria in CHD remains under debate. The objective of this meta-analysis was to investigate the relationship between microalbuminuria and mortality in individuals with CHD. Method: A comprehensive literature search was performed using Pubmed, EuroPMC, Science Direct, and Google Scholar from 2000 to September 2022. Only prospective studies investigating microalbuminuria and mortality in CHD patients were selected. The pooled effect estimate was reported as risk ratio (RR). Results: 5176 patients from eight prospective observational studies were included in this meta-analysis. Individuals with CHD have a greater overall risk of all-cause mortality (ACM) [rR = 2.07 (95% CI = 1.70-2.44); p = 0.0003; I Conclusion: This meta-analysis indicates that microalbuminuria is associated with a higher risk of mortality in individuals with CHD. Microalbuminuria can serve as a predictor of poor outcomes in CHD patients.
MeSH term(s)	Humans ; Prospective Studies ; Coronary Disease/complications ; Coronary Disease/epidemiology ; Prognosis ; Heart ; Risk Factors ; Observational Studies as Topic
Language	English
Publishing date	2023-05-18
Publishing country	India
Document type	Meta-Analysis ; Journal Article ; Review
ZDB-ID	604366-5
ISSN	2213-3763 ; 0019-4832
ISSN (online)	2213-3763
ISSN	0019-4832
DOI	10.1016/j.ihj.2023.05.006
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Article ; Online: A systematic review of retinoic acid in the journey of spermatogonium to spermatozoa: From basic to clinical application.

Margiana, Ria / Pakpahan, Cennikon / Pangestu, Mulyoto

F1000Research

2022 Volume 11, Page(s) 552

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Germ Cells ; Humans ; Infertility, Male ; Male ; Observational Studies as Topic ; Spermatogenesis/physiology ; Spermatozoa ; Tretinoin/metabolism ; Tretinoin/pharmacology
Chemical Substances	Tretinoin (5688UTC01R)
Language	English
Publishing date	2022-05-20
Publishing country	England
Document type	Systematic Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2699932-8
ISSN	2046-1402 ; 2046-1402
ISSN (online)	2046-1402
ISSN	2046-1402
DOI	10.12688/f1000research.110510.2
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Article ; Online: Framing and understanding the whole aspect of oral sex from social and health perspectives: a narrative review.

Pakpahan, Cennikon / Darmadi, Darmadi / Agustinus, Agustinus / Rezano, Andri

F1000Research

2022 Volume 11, Page(s) 177

Abstract: Historically, oral sex is part of human sexual behaviour even though some consider it taboo, and its expression is deemed inappropriate. Human rights also stand out as technology becomes more sophisticated, leading to its practice disclosure in the ... ...

Abstract	Historically, oral sex is part of human sexual behaviour even though some consider it taboo, and its expression is deemed inappropriate. Human rights also stand out as technology becomes more sophisticated, leading to its practice disclosure in the 21
MeSH term(s)	Female ; Humans ; Pregnancy ; Religion ; Sexual Behavior/psychology ; Sexually Transmitted Diseases
Language	English
Publishing date	2022-02-14
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2699932-8
ISSN	2046-1402 ; 2046-1402
ISSN (online)	2046-1402
ISSN	2046-1402
DOI	10.12688/f1000research.108675.3
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Article ; Online: Association between serum midkine levels and tumor size in Indonesian hepatocellular carcinoma patients: a cross-sectional study.

Darmadi, Darmadi / Ruslie, Riska Habriel / Pakpahan, Cennikon

Romanian journal of internal medicine = Revue roumaine de medecine interne

2022 Volume 60, Issue 4, Page(s) 229–234

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/pathology ; Midkine ; Cross-Sectional Studies ; Indonesia ; Venous Thrombosis/diagnostic imaging ; Venous Thrombosis/etiology
Chemical Substances	Midkine (137497-38-2)
Language	English
Publishing date	2022-11-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2015966-3
ISSN	2501-062X ; 0035-3973 ; 1582-3296
ISSN (online)	2501-062X
ISSN	0035-3973 ; 1582-3296
DOI	10.2478/rjim-2022-0014
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Article ; Online: Examination of ejaculate fructose levels on male infertility patients at various times and centrifugation using semiautomatic method.

Hermansyah, Hermansyah / Abdullah, Muhammad Fadhli / Pakpahan, Cennikon / I'tishom, Reny / Supardi, Supardi / Ilhamsyah, Ilhamsyah

Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica

2024 Volume 96, Issue 1, Page(s) 12186

Abstract: Objective: Various factors, such as obstructive azoospermia, cause infertility in men. Biochemical examination of ejaculate, especially measurement of fructose, can be an additional investigation that can be used for this diagnosis in reproductive ... ...

Abstract	Objective: Various factors, such as obstructive azoospermia, cause infertility in men. Biochemical examination of ejaculate, especially measurement of fructose, can be an additional investigation that can be used for this diagnosis in reproductive health. Examination of fructose is carried out after routine ejaculate analysis, resulting in prolonging the examination time so that it will affect the measurement of fructose level in the ejaculate and the accuracy of the diagnosis. This study aims to determine the best timing and procedure for measurement of fructose using a semiautomatic method. Methods: This research is an analytic observational study conducted at Dr. Soetomo General Hospital, Surabaya. A total of 13 ejaculate samples from infertile male patients who met the inclusion criteria were evaluated. Each ejaculate was divided into eight aliquots that were examined for fructose using a semiautomated method after different intervals of time and centrifugation modalities. Results: This study showed a significant difference in fructose levels when aliquots were centrifuged and examined immediately or after different interval of time (p=0.036). In addition, aliquots left standing for more than 60 minutes (p=0.012) and 120 minutes (p<0.001) before centrifugation, showed significantly lower levels compared to aliquots that were centrifuged and then immediately examined. Conclusions: We suggest that measuring fructose immediately after centrifugation is more reliable than measuring fructose left standing before or after centrifugation. Leaving the ejaculate standing will reduce the fructose level so that it does not resemble its real level.
MeSH term(s)	Humans ; Male ; Fructose ; Infertility, Male/diagnosis ; Infertility, Male/etiology ; Azoospermia ; Centrifugation ; Spermatozoa
Chemical Substances	Fructose (30237-26-4)
Language	English
Publishing date	2024-02-20
Publishing country	Italy
Document type	Observational Study ; Journal Article
ZDB-ID	1153526-x
ISSN	2282-4197 ; 1120-8538 ; 1124-3562
ISSN (online)	2282-4197
ISSN	1120-8538 ; 1124-3562
DOI	10.4081/aiua.2024.12186
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Article ; Online: Framing and understanding the whole aspect of oral sex from social and health perspectives

Agustinus Agustinus / Andri Rezano / Cennikon Pakpahan / Darmadi Darmadi

F1000Research, Vol

a narrative review [version 3; peer review: 2 approved, 1 not approved]

2022 Volume 11

Abstract	Historically, oral sex is part of human sexual behaviour even though some consider it taboo, and its expression is deemed inappropriate. Human rights also stand out as technology becomes more sophisticated, leading to its practice disclosure in the 21st century. The large-scale oral sex discussion in media encourages people to express it, and there is feedback on whether it is right or not. It all depends on each person’s values. We found this sexual behaviour occurs everywhere regardless of religion, culture and race. Pop culture influences this behaviour considerably. It can be seen in music, movies and television programmes that allude to oral sex. Numerous motivations underlying this behaviour include sexual pleasure for the sake of psychological well-being. It is undeniable that this behaviour is still controversial. There is a risk of it causing disease, but it reportedly provides many benefits. Oral sex is not a new behaviour crossing boundaries, according to our theory. It is an old behaviour that has been highlighted because of the factors that support it. This behaviour, still considered taboo, has its disadvantages, such as sexually transmitted disease and oral cancer, but also has benefits, such as preventing preeclampsia.
Keywords	oral sex ; sexual behaviour ; psychological well-being ; pop culture ; sexually transmitted disease ; oral cancer ; eng ; Medicine ; R ; Science ; Q
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	F1000 Research Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A systematic review of retinoic acid in the journey of spermatogonium to spermatozoa

Mulyoto Pangestu / Ria Margiana / Cennikon Pakpahan

F1000Research, Vol

From basic to clinical application [version 2; peer review: 2 approved]

2022 Volume 11

Abstract: Background: Retinoic acid plays an essential role in testicular development and functions, especially spermatogenesis. We have reviewed the role of retinoic acid from basic (molecular) to clinical application. Methods: A search was conducted in the ... ...

Abstract	Background: Retinoic acid plays an essential role in testicular development and functions, especially spermatogenesis. We have reviewed the role of retinoic acid from basic (molecular) to clinical application. Methods: A search was conducted in the online database including PubMed, Google Scholar, and Scopus for English studies published in the last eight years about this issue. We used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines in assessing the studies we are going to investigate. Results: Studies indicated that retinoic acid plays an essential role during pluripotent stem cell migration and lineage commitment, cell differentiation, apoptosis, stem cell number regulation, and maturation arrest in spermatogenic cells. Retinoic acid can also affect related protein expression and signaling pathways at different stages of spermatogenesis. Four studies have applied retinoic acid to humans, all of them in the single-arm observational study. The results look promising but need further research with more controlled study methods, randomization, and large samples. Conclusions: This current systematic review emphasizes a novel retinoic acid mechanism that has not been well described in the literature previously on its functions during the first seven days of spermatogenesis, leading to new directions or explanations of male infertility cause and treatments as a part of reproductive health care.
Keywords	retinoic acid ; spermatozoa ; male infertility ; reproductive health care ; clinical application ; stem cell ; eng ; Medicine ; R ; Science ; Q
Subject code	571
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	F1000 Research Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Lay understanding and experience of sexual intercourse among couples with infertility undergoing an assisted reproduction technology program: A qualitative study.

Pakpahan, Cennikon / Agustinus, Agustinus / Sa'adi, Ashon / Nguyen, Thi Tu An / Liamputtong, Pranee / Effendy, Christantie / Hinting, Aucky

Heliyon

2024 Volume 10, Issue 5, Page(s) e26879

Abstract: Aim: To explore the perception and lay understanding of sexual intercourse and sexual life experiences among infertile couples before, during, and after undergoing an assisted reproduction technology (ART) program.: Method: The participants of this ... ...

Abstract	Aim: To explore the perception and lay understanding of sexual intercourse and sexual life experiences among infertile couples before, during, and after undergoing an assisted reproduction technology (ART) program. Method: The participants of this descriptive qualitative study were Indonesian couples with infertility who underwent an ART program. Semi-structured interviews were conducted between September and December 2022, and the participants' responses were recorded. Data were analyzed using a step-by-step analysis based on Braun's qualitative analysis. The study was reported based on the Consolidated Criteria for Reporting a Qualitative Research (COREQ) Checklist. Results: Fifty participants were included, and five themes were developed before and two themes during or after the ART program. The couples' knowledge varied as they experienced sexual intercourse at different periods, such as before, during, and after the ART program. Many participants reported that ART affected their emotions and mood, leading to decreased desire to engage in sexual intercourse. However, some used sexual intercourse as a basis for creating optimism and confidence in having offspring. Furthermore, couples perceived that the purpose of sexual intercourse is not only to have offspring but also to improve communication, promote intimacy, and express affection. In contrast, some perceived the ART program as time consuming, preventing them from engaging in sexual activities. However, not all couples considered sexual activity solely as a means of procreation. They concluded that sexual behavior is not only determined by genetics. Conclusion: Couples who underwent the ART program regardless of its effectiveness were aware that sexual interaction is not only for having children but also for preserving harmony and familial connection.
Language	English
Publishing date	2024-02-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e26879
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Article ; Online: "Am I Masculine?" A metasynthesis of qualitative studies on traditional masculinity on infertility.

Pakpahan, Cennikon / Ibrahim, Raditya / William, William / Kandar, Patricia S / Darmadi, Darmadi / Khaerana, A St Aldilah / Supardi, Supardi

F1000Research

2023 Volume 12, Page(s) 252

Abstract: ... ...

Abstract	Background
MeSH term(s)	Humans ; Male ; Masculinity ; Infertility ; Men's Health ; Qualitative Research
Language	English
Publishing date	2023-03-09
Publishing country	England
Document type	Systematic Review
ZDB-ID	2699932-8
ISSN	2046-1402 ; 2046-1402
ISSN (online)	2046-1402
ISSN	2046-1402
DOI	10.12688/f1000research.131599.1
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Article ; Online: Role of klotho and fibroblast growth factor 23 in arterial calcification, thickness, and stiffness: a meta-analysis of observational studies.

Wungu, Citrawati Dyah Kencono / Susilo, Hendri / Alsagaff, Mochamad Yusuf / Witarto, Bendix Samarta / Witarto, Andro Pramana / Pakpahan, Cennikon / Gusnanto, Arief

Scientific reports

2024 Volume 14, Issue 1, Page(s) 5712

Abstract: This meta-analysis was conducted to clarify the role of klotho and fibroblast growth factor 23 (FGF-23) in human arterial remodeling across recent studies, in terms of arterial calcification, thickness, and stiffness. A systematic literature search was ... ...

Abstract	This meta-analysis was conducted to clarify the role of klotho and fibroblast growth factor 23 (FGF-23) in human arterial remodeling across recent studies, in terms of arterial calcification, thickness, and stiffness. A systematic literature search was conducted on five databases for articles up to December 2023. Arterial calcification, thickness, and stiffness were determined using the calcification score and artery affected, carotid intima-media thickness (CIMT), and pulse wave velocity (PWV), respectively. Sixty-two studies with a total of 27,459 individuals were included in this meta-analysis. Most studies involved chronic kidney disease patients. Study designs were mostly cross-sectional with only one case-control and nine cohorts. FGF-23 was positively correlated with arterial calcification (r = 0.446 [0.254-0.611], p < 0.0001 and aOR = 1.36 [1.09-1.69], p = 0.006), CIMT (r = 0.188 [0.02-0.354], p = 0.03), and PWV (r = 0.235 [0.159-0.310], p < 0.00001). By contrast, Klotho was inversely correlated with arterial calcification (r = - 0.388 [- 0.578 to - 0.159], p = 0.001) and CIMT (r = - 0.38 [- 0.53 to - 0.207], p < 0.00001). In conclusion, FGF-23 and Klotho were associated with arterial calcification, thickness, and stiffness, clarifying their role in arterial remodeling processes.
MeSH term(s)	Humans ; Carotid Intima-Media Thickness ; Cross-Sectional Studies ; Fibroblast Growth Factor-23 ; Pulse Wave Analysis ; Vascular Stiffness ; Observational Studies as Topic
Chemical Substances	Fibroblast Growth Factor-23 (7Q7P4S7RRE) ; FGF23 protein, human ; KL protein, human (EC 3.2.1.31)
Language	English
Publishing date	2024-03-08
Publishing country	England
Document type	Meta-Analysis ; Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-56377-8
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