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  1. Article: Accommodation with anticancer drug shortage: A Lebanese harmful solution.

    Kattan, Clarisse / Kattan, Joseph

    Frontiers in oncology

    2023  Volume 12, Page(s) 1055113

    Language English
    Publishing date 2023-01-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.1055113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: COVID-19 pandemic shakes the trust between oncologists and their patients.

    Kattan, Joseph / Assi, Tarek

    International journal of clinical practice

    2021  Volume 75, Issue 10, Page(s) e14556

    MeSH term(s) COVID-19 ; Humans ; Oncologists ; Pandemics ; SARS-CoV-2 ; Trust
    Language English
    Publishing date 2021-07-05
    Publishing country India
    Document type Journal Article
    ZDB-ID 1386246-7
    ISSN 1742-1241 ; 1368-5031
    ISSN (online) 1742-1241
    ISSN 1368-5031
    DOI 10.1111/ijcp.14556
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.301: Show issues Location:
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  3. Article ; Online: Advanced bladder cancer management: history in the making.

    Zouein, Joseph / Boueri, Myriam / Kourie, Hampig Raphael / Kattan, Joseph / Nemr, Elie

    Future oncology (London, England)

    2023  Volume 19, Issue 39, Page(s) 2565–2567

    MeSH term(s) Humans ; Urinary Bladder Neoplasms/diagnosis ; Urinary Bladder Neoplasms/epidemiology ; Urinary Bladder Neoplasms/therapy ; Carcinoma, Transitional Cell ; Immunotherapy
    Language English
    Publishing date 2023-12-12
    Publishing country England
    Document type Editorial
    ZDB-ID 2274956-1
    ISSN 1744-8301 ; 1479-6694
    ISSN (online) 1744-8301
    ISSN 1479-6694
    DOI 10.2217/fon-2023-0908
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6478: Show issues Location:
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  4. Article ; Online: Learning by Debate: Innovative Tool in the Hematology-Oncology Fellowship Program.

    Samaha, Ramy / Kattan, Clarisse / Rassy, Elie / Kattan, Joseph

    Journal of cancer education : the official journal of the American Association for Cancer Education

    2021  Volume 37, Issue 6, Page(s) 1641–1644

    Abstract: The knowledge base for medicine and medical education is continuously evolving, prominently medical oncology. These quick advances expose the oncologists to the pressing need to be up-to-date in their fields and complicate the oncology education of ... ...

    Abstract The knowledge base for medicine and medical education is continuously evolving, prominently medical oncology. These quick advances expose the oncologists to the pressing need to be up-to-date in their fields and complicate the oncology education of medical students and oncology fellows. As the international societies have developed new tools to help both practitioners and trainees stay abreast of the new advances, we have incorporated the debate teaching tool in our oncology fellowship program. A survey of the participants in the debate sessions over the last three years shows that fellows considered this teaching tool effective in consolidating and enriching their medical knowledge, enhancing their research and presentation skills, improving cognitive and communication skills as well as encouraging evidence-based learning.
    MeSH term(s) Humans ; Fellowships and Scholarships ; Education, Medical, Graduate ; Hematology/education ; Medical Oncology/education ; Curriculum
    Language English
    Publishing date 2021-03-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 632898-2
    ISSN 1543-0154 ; 0885-8195 ; 1543-1154
    ISSN (online) 1543-0154
    ISSN 0885-8195 ; 1543-1154
    DOI 10.1007/s13187-021-02002-5
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    Zs.A 2185: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Should immune checkpoint inhibitors be contraindicated in lung cancer patients with latent tuberculosis?

    Haddad, Fady Gh / Kattan, Clarisse / Kattan, Joseph

    Immunotherapy

    2020  Volume 12, Issue 11, Page(s) 759–762

    MeSH term(s) Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Contraindications, Drug ; Drug-Related Side Effects and Adverse Reactions ; Humans ; Immune Checkpoint Inhibitors/adverse effects ; Immune Checkpoint Inhibitors/therapeutic use ; Latent Infection/etiology ; Latent Tuberculosis/complications ; Latent Tuberculosis/diagnosis ; Latent Tuberculosis/drug therapy ; Lung Neoplasms/complications ; Lung Neoplasms/diagnosis ; Lung Neoplasms/drug therapy ; Mass Screening ; Mycobacterium tuberculosis/physiology
    Chemical Substances Antineoplastic Agents ; Immune Checkpoint Inhibitors
    Language English
    Publishing date 2020-06-09
    Publishing country England
    Document type Editorial
    ISSN 1750-7448
    ISSN (online) 1750-7448
    DOI 10.2217/imt-2020-0069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: PD-L1 protein expression by Combined Positive Score (CPS) in patients with muscle invasive or advanced urothelial carcinoma: a single institution experience.

    Nasr, Sarah / Haddad, Fadi G / Khazen, Joseph / Kattan, Joseph / Trak-Smayra, Viviane

    BMC cancer

    2023  Volume 23, Issue 1, Page(s) 817

    Abstract: Introduction: Immune checkpoint inhibitors have revolutionized the treatment of patients with advanced urothelial carcinoma (UC) in the frontline and relapsed settings. Lebanon has one of the highest incidence of UC worldwide, yet no data exists ... ...

    Abstract Introduction: Immune checkpoint inhibitors have revolutionized the treatment of patients with advanced urothelial carcinoma (UC) in the frontline and relapsed settings. Lebanon has one of the highest incidence of UC worldwide, yet no data exists regarding the expression of PD-L1 by Combined Positive Score (CPS) in advanced disease.
    Methods: We reviewed all patients treated at our institution for high grade UC, stage pT2 and above, between January 2017 and March 2021. We assessed the expression of PD-L1 by immunohistochemistry using 22C3 clone, and analyzed the association between PD-L1 expression and clinicopathological characteristics. PD-L1 positivity was defined as CPS score ≥ 10.
    Results: A total of 101 patients with advanced UC were included, with a median age of 71 years (range, 38 to 96 years); 78% were ever-smokers. Ninety-three of 101 patients (92%) had conventional UC and 43 patients (43%) had positive PD-L1 expression, with 12 patients having CPS of 100. The analysis by molecular subtype showed that patients with maximal CPS of 100 were enriched in "basal" molecular subtype. However, no association was found between PD-L1 expression (positive versus negative) and clinicopathological characteristics.
    Conclusion: The positivity of PD-L1 expression as assessed by CPS using the 22C3 clone in our population was almost comparable to the results reported in the occidental literature. Therefore, PD-L1 expression, as a potential predictor of response to immunotherapy, concerns the same percentage of the Lebanese UC patients.
    MeSH term(s) Humans ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; B7-H1 Antigen/genetics ; Carcinoma, Transitional Cell ; Urinary Bladder Neoplasms ; Muscles ; Health Facilities
    Chemical Substances B7-H1 Antigen
    Language English
    Publishing date 2023-09-01
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2041352-X
    ISSN 1471-2407 ; 1471-2407
    ISSN (online) 1471-2407
    ISSN 1471-2407
    DOI 10.1186/s12885-023-11299-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Do checkpoint inhibitors compromise the cancer patients' immunity and increase the vulnerability to COVID-19 infection?

    Kattan, Joseph / Kattan, Clarisse / Assi, Tarek

    Immunotherapy

    2020  Volume 12, Issue 6, Page(s) 351–354

    Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) has been declared a pandemic by the WHO that claimed the lives of thousands of people within a few months. Cancer patients represent a vulnerable population due to the acquired ... ...

    Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) has been declared a pandemic by the WHO that claimed the lives of thousands of people within a few months. Cancer patients represent a vulnerable population due to the acquired immunodeficiency associated with anti-cancer therapy. Immune checkpoint inhibitors have largely impacted the prognosis of a multitude of malignancies with significant improvement in survival outcomes and a different, tolerable toxicity profile. In this paper, we assess the safety of ICI administration in cancer patients during the coronavirus pandemic in order to guide the usage of these highly efficacious agents.
    MeSH term(s) Antineoplastic Agents, Immunological/adverse effects ; COVID-19 ; Cell Cycle Checkpoints/drug effects ; Coronavirus Infections/complications ; Coronavirus Infections/physiopathology ; Disease Progression ; Humans ; Neoplasms/drug therapy ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/physiopathology
    Chemical Substances Antineoplastic Agents, Immunological
    Keywords covid19
    Language English
    Publishing date 2020-04-14
    Publishing country England
    Document type Editorial
    ZDB-ID 2495964-9
    ISSN 1750-7448 ; 1750-743X
    ISSN (online) 1750-7448
    ISSN 1750-743X
    DOI 10.2217/imt-2020-0077
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  8. Article ; Online: Cetuximab severe cutaneous toxicity… a gateway for bacteremia: case report.

    Soueidy, Charbel / Skaff, Stephanie / Stephan, Farid / Kattan, Joseph

    Anti-cancer drugs

    2022  Volume 34, Issue 1, Page(s) 187–189

    Abstract: EGFR inhibitors used in the treatment of metastatic wild-RAS colorectal cancer in combination with chemotherapy are associated with dermatologic side events that are low grade in most cases. We report a case of severe cutaneous toxicity secondary to ... ...

    Abstract EGFR inhibitors used in the treatment of metastatic wild-RAS colorectal cancer in combination with chemotherapy are associated with dermatologic side events that are low grade in most cases. We report a case of severe cutaneous toxicity secondary to cetuximab associated with bacterial cellulitis. A 57-year-old woman with metastatic adenocarcinoma of the colon, receiving FOLFIRI and Cetuximab as a first-line treatment, presented with a severe erythematous rash and xerosis resistant to local treatment with moisturizing emollients. Few days later, the patient becomes febrile, and the rash becomes more diffuse with a sandpaper appearance on the face, neck, chest, and flexor creases with exfoliation of large areas of skin. A bacterial cellulitis secondary to a dermatologic severe toxicity of Cetuximab was suspected. The patient started on antibiotics and local treatment with good response. This is a life-threatening cutaneous toxicity of cetuximab with secondary bacterial infection. Early recognition of cutaneous side effects of EGFR inhibitors is important to prevent such type of toxicities.
    MeSH term(s) Female ; Humans ; Middle Aged ; Cetuximab/adverse effects ; Antibodies, Monoclonal ; Cellulitis/chemically induced ; Cellulitis/drug therapy ; Drug Eruptions/drug therapy ; Drug Eruptions/etiology ; Drug Eruptions/prevention & control ; Colorectal Neoplasms/pathology ; Skin Diseases/chemically induced ; Exanthema/chemically induced ; Exanthema/drug therapy ; ErbB Receptors ; Bacteremia/chemically induced ; Bacteremia/drug therapy ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Fluorouracil/therapeutic use ; Leucovorin/therapeutic use
    Chemical Substances Cetuximab (PQX0D8J21J) ; Antibodies, Monoclonal ; ErbB Receptors (EC 2.7.10.1) ; Fluorouracil (U3P01618RT) ; Leucovorin (Q573I9DVLP)
    Language English
    Publishing date 2022-12-02
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1065301-6
    ISSN 1473-5741 ; 0959-4973
    ISSN (online) 1473-5741
    ISSN 0959-4973
    DOI 10.1097/CAD.0000000000001312
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3125: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Article ; Online: Hematopoietic stem cell transplantation dilemma during the COVID-19 era.

    Samaha, Ramy / Kattan, Joseph

    Future oncology (London, England)

    2020  Volume 16, Issue 22, Page(s) 1569–1573

    MeSH term(s) Betacoronavirus/immunology ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/immunology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/virology ; Donor Selection/standards ; Graft Rejection/immunology ; Graft Rejection/prevention & control ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/standards ; Humans ; Immunocompromised Host ; Infection Control/standards ; Neoplasms/immunology ; Neoplasms/therapy ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/immunology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/virology ; Practice Guidelines as Topic ; SARS-CoV-2 ; Transplantation Conditioning/adverse effects
    Keywords covid19
    Language English
    Publishing date 2020-05-27
    Publishing country England
    Document type Editorial
    ZDB-ID 2274956-1
    ISSN 1744-8301 ; 1479-6694
    ISSN (online) 1744-8301
    ISSN 1479-6694
    DOI 10.2217/fon-2020-0414
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6478: Show issues Location:
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  10. Article: Safety, efficacy and acceptability of SARS-CoV-2 vaccines in patients with cancer.

    Chebel, Roy / Labaki, Chris / Farhat, Maria / Kattan, Joseph

    Future virology

    2021  

    Language English
    Publishing date 2021-06-30
    Publishing country England
    Document type Editorial
    ISSN 1746-0794
    ISSN 1746-0794
    DOI 10.2217/fvl-2021-0072
    Database MEDical Literature Analysis and Retrieval System OnLINE

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