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Article ; Online: Total Synthesis of Amphidinolide K, a Macrolide That Stabilizes F-Actin.

Sánchez, Dani / Andreou, Thanos / Costa, Anna M / Meyer, Kevin G / Williams, David R / Barasoain, Isabel / Díaz, J Fernando / Lucena-Agell, Daniel / Vilarrasa, Jaume

The Journal of organic chemistry

2015 Volume 80, Issue 17, Page(s) 8511–8519

Abstract: The total synthesis of (-)-amphidinolide K (1) based on asymmetric addition of allylsilane C1-C8 ...

Abstract	The total synthesis of (-)-amphidinolide K (1) based on asymmetric addition of allylsilane C1-C8 to enal C9-C22 is reported. The 1,9,18-tris-O-TBDPS ether was converted into the desired 9,18-dihydroxy acid. Its macrolactonization was accomplished by the Shiina method. Compound 1 together with some of its stereoisomers and analogues were subjected to evaluation of the possible disruption of the α,β-tubulin-microtubule and/or G-actin-F-actin equilibria. Compound 1 behaves as a stabilizer of actin filaments (F-actin) in vitro.
MeSH term(s)	Actins/chemistry ; Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Macrolides/chemical synthesis ; Macrolides/chemistry ; Molecular Structure ; Stereoisomerism ; Tubulin/chemistry
Chemical Substances	Actins ; Anti-Bacterial Agents ; Macrolides ; Tubulin ; amphidinolide K
Language	English
Publishing date	2015-09-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.5b00966
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Article ; Online: Oral anticoagulant therapy and bleeding events with vitamin K antagonists in patients with atrial fibrillation in a Hungarian county hospital.

Mark, Laszlo / Dani, Győző / Vendrey, Robert / Paragh, György / Katona, Andras

Medical science monitor : international medical journal of experimental and clinical research

2015 Volume 21, Page(s) 518–525

Abstract: Background: Vitamin K antagonists, despite their tight therapeutic spectrum and the fear ... of vitamin K antagonist therapy are necessary. As the possibilities for this are limited, we believe ...

Abstract	Background: Vitamin K antagonists, despite their tight therapeutic spectrum and the fear of bleeding complications, were long the most important drugs used in anticoagulant therapy. The aim of this study was to evaluate the quality of anticoagulant therapy and its relation with bleedings in everyday clinical practice. Material and methods: We analyzed the data of 272 patients with non-valvular atrial fibrillation treated in our county hospital using retrospective data collection of the last 1008±384 days. The INR (International Normalized Ratio) values and the time in therapeutic range (TTR) were analyzed. We asked patients about bleeding complications and searched the medical records. Results: The TTR proved to be 64% and there was no statistically significant difference between that of 252 (92.7%) patients taking acenocoumarol and 20 (7.3%) on warfarin. Analyzing various factors leading to TTR under 70%, we found that none of them have a significant impact. Significantly more bleeding events occurred in the first 3 months after the initiation of anticoagulant therapy and in patients with TTR under 70%, but the latter was not significant after adjustment for factors influencing bleeding (OR 1.607, CI 0.571-4.522, p=0.392). Conclusions: Although the present study's TTR values were similar to those found in the warfarin branch of various large-scale international trials and in real-life settings, further improvement of vitamin K antagonist therapy are necessary. As the possibilities for this are limited, we believe that the new type anticoagulant agents have a place in everyday clinical practice.
MeSH term(s)	Acenocoumarol ; Administration, Oral ; Aged ; Anticoagulants/administration & dosage ; Anticoagulants/adverse effects ; Atrial Fibrillation/drug therapy ; Female ; Hemorrhage/chemically induced ; Hemorrhage/pathology ; Humans ; Hungary ; Male ; Retrospective Studies ; Statistics, Nonparametric ; Time Factors ; Vitamin K/antagonists & inhibitors ; Warfarin
Chemical Substances	Anticoagulants ; Vitamin K (12001-79-5) ; Warfarin (5Q7ZVV76EI) ; Acenocoumarol (I6WP63U32H)
Language	English
Publishing date	2015-02-17
Publishing country	United States
Document type	Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1439041-3
ISSN	1643-3750 ; 1234-1010
ISSN (online)	1643-3750
ISSN	1234-1010
DOI	10.12659/MSM.892360
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Book ; Online: Tight bounds on the threshold for permuted k-colorability

Dani, Varsha / Moore, Cristopher / Olson, Anna

2011

Abstract: If each edge (u,v) of a graph G=(V,E) is decorated with a permutation pi_{u,v} of k objects, we say ... that it has a permuted k-coloring if there is a coloring sigma from V to {1,.,k} such that sigma(v) is ... we conjecture that the threshold d_k for permuted k-colorability in random graphs G(n,m=dn/2 ...

Abstract	If each edge (u,v) of a graph G=(V,E) is decorated with a permutation pi_{u,v} of k objects, we say that it has a permuted k-coloring if there is a coloring sigma from V to {1,.,k} such that sigma(v) is different from pi_{u,v}(sigma(u)) for all (u,v) in E. Based on arguments from statistical physics, we conjecture that the threshold d_k for permuted k-colorability in random graphs G(n,m=dn/2), where the permutations on the edges are uniformly random, is equal to the threshold for standard graph k-colorability. The additional symmetry provided by random permutations makes it easier to prove bounds on d_k. By applying the second moment method with these additional symmetries, and applying the first moment method to a random variable that depends on the number of available colors at each vertex, we bound the threshold within an additive constant. Specifically, we show that for any constant epsilon > 0, for sufficiently large k we have 2 k ln k - ln k - 2 - epsilon < d_k < 2 k ln k - ln k - 1 + epsilon. In contrast, the best known bounds on d_k for standard k-colorability leave an additive gap of about ln k between the upper and lower bounds. Comment: 12 pages
Keywords	Mathematics - Combinatorics ; Condensed Matter - Statistical Mechanics ; Computer Science - Computational Complexity ; Mathematics - Probability
Subject code	511
Publishing date	2011-11-12
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Total Synthesis of Amphidinolide K, a Macrolide That Stabilizes F-Actin

SaÌnchez, Dani / Andreou Thanos / Costa Anna M / Meyer Kevin G / Williams David R / Barasoain Isabel / DiÌaz J. Fernando / Lucena-Agell Daniel / Vilarrasa Jaume

Journal of organic chemistry. 2015 Sept. 04, v. 80, no. 17

2015

Abstract: The total synthesis of (â)-amphidinolide K (1) based on asymmetric addition of allylsilane C1â ...

Abstract	The total synthesis of (â)-amphidinolide K (1) based on asymmetric addition of allylsilane C1âC8 to enal C9âC22 is reported. The 1,9,18-tris-O-TBDPS ether was converted into the desired 9,18-dihydroxy acid. Its macrolactonization was accomplished by the Shiina method. Compound 1 together with some of its stereoisomers and analogues were subjected to evaluation of the possible disruption of the Î±,Î²-tubulinâmicrotubule and/or G-actinâF-actin equilibria. Compound 1 behaves as a stabilizer of actin filaments (F-actin) in vitro.
Keywords	actin ; chemical reactions ; macrolides ; microfilaments ; organic chemistry ; stabilizers ; stereoisomers
Language	English
Dates of publication	2015-0904
Size	p. 8511-8519.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021%2Facs.joc.5b00966
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The effect of continuous long-term illumination with visible light in different spectral ranges on mammalian cells.

Dani, Sophie / Schütz, Kathleen / Dikici, Ezgi / Bernhardt, Anne / Lode, Anja

Scientific reports

2024 Volume 14, Issue 1, Page(s) 9444

Abstract: One of the biggest challenges in tissue engineering and regenerative medicine is to ensure oxygen supply of cells in the (temporary) absence of vasculature. With the vision to exploit photosynthetic oxygen production by microalgae, co-cultivated in close ...

Abstract	One of the biggest challenges in tissue engineering and regenerative medicine is to ensure oxygen supply of cells in the (temporary) absence of vasculature. With the vision to exploit photosynthetic oxygen production by microalgae, co-cultivated in close vicinity to oxygen-consuming mammalian cells, we are searching for culture conditions that are compatible for both sides. Herein, we investigated the impact of long-term illumination on mammalian cells which is essential to enable photosynthesis by microalgae: four different cell types-primary human fibroblasts, dental pulp stem cells, and osteoblasts as well as the murine beta-cell line INS-1-were continuously exposed to warm white light, red or blue light over seven days. We observed that illumination with red light has no adverse effects on viability, metabolic activity and growth of the cells whereas exposure to white light has deleterious effects that can be attributed to its blue light portion. Quantification of intracellular glutathione did not reveal a clear correlation of this effect with an enhanced production of reactive oxygen species. Finally, our data indicate that the cytotoxic effect of short-wavelength light is predominantly a direct effect of cell illumination; photo-induced changes in the cell culture media play only a minor role.
MeSH term(s)	Humans ; Light ; Animals ; Fibroblasts/metabolism ; Fibroblasts/radiation effects ; Fibroblasts/cytology ; Mice ; Reactive Oxygen Species/metabolism ; Cell Survival/radiation effects ; Dental Pulp/cytology ; Dental Pulp/radiation effects ; Osteoblasts/metabolism ; Osteoblasts/radiation effects ; Osteoblasts/cytology ; Cells, Cultured ; Cell Line ; Stem Cells/metabolism ; Stem Cells/radiation effects ; Stem Cells/cytology ; Glutathione/metabolism
Chemical Substances	Reactive Oxygen Species ; Glutathione (GAN16C9B8O)
Language	English
Publishing date	2024-04-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-60014-9
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Article: Adsorption of boric acid on pure and humic acid coated am-Al(OH)3: A boron K-edge XANES study.

Xu, Dani / Peak, Derek

Environmental science & technology

2006 Volume 41, Issue 3, Page(s) 903–908

Abstract: ... Boron (B) K-edge X-ray absorption near-edge structure (XANES) spectroscopy was used to investigate ...

Abstract	The fate and mobility of boric acid in the environment is largely controlled by adsorption reactions with soil organic matter and soil minerals to form surface complexes (Soil Sci Soc. Am. J. 1991, 55, 1582; Geochim. Cosmochim. Acta 2002, 67, 2551; Soil Sci. Soc. Am. J. 1995, 59, 405; Environ. Sci. Technol. 1995, 29, 302). In this study, boric acid adsorption on pure am-Al(OH)3 and 5% (w/w) humic acid (HA) coated am-Al(OH)3 were investigated both as a function of pH (4.5-11) and initial boric acid concentration (0-4.5 mmol L(-1)). Batch adsorption isotherm experiments were also conducted with samples exposed to atmospheric CO2 and anaerobic (N2) conditions to examine the effects of dissolved CO2 on boric acid adsorption. Boron (B) K-edge X-ray absorption near-edge structure (XANES) spectroscopy was used to investigate the coordination of boric acid adsorbed at mineral/water interfaces. The XANES spectra of boric acid adsorption samples showed that both trigonally and tetrahedrally coordinated B complexes were present on the mineral surface. Both macroscopic and spectroscopic experiments revealed that the combination of HA coating on am-Al(OH)3 and dissolved CO2 decreased boric acid adsorption compared to adsorption on pure am-Al(OH)3.
MeSH term(s)	Adsorption ; Aluminum Hydroxide/chemistry ; Atmosphere/chemistry ; Boric Acids/chemistry ; Carbon Dioxide/chemistry ; Humic Substances ; Hydrogen-Ion Concentration ; Nitrogen/chemistry ; Soil Pollutants/chemistry ; Spectrometry, X-Ray Emission ; Thermodynamics
Chemical Substances	Boric Acids ; Humic Substances ; Soil Pollutants ; Carbon Dioxide (142M471B3J) ; Aluminum Hydroxide (5QB0T2IUN0) ; Nitrogen (N762921K75) ; boric acid (R57ZHV85D4)
Language	English
Publishing date	2006-01-30
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	0013-936X
ISSN	0013-936X
DOI	10.1021/es0620383
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Cushingoid clinical features in a pediatric patient taking a natural supplement: Buyer beware.

Dani, Advika / Ede, Kaleo / Price, Harper / Gildenstern, Vanessa

JAAD case reports

2023 Volume 41, Page(s) 68–70

Language	English
Publishing date	2023-09-07
Publishing country	United States
Document type	Case Reports
ZDB-ID	2834220-3
ISSN	2352-5126
ISSN	2352-5126
DOI	10.1016/j.jdcr.2023.08.035
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Article ; Online: Risk factors for the development of acne in healthcare workers during the COVID-19 pandemic.

Dani, Advika / Eseonu, Amarachi / Bibee, Kristin

Archives of dermatological research

2022 Volume 315, Issue 4, Page(s) 1067–1070

Abstract: The COVID-19 pandemic has led to many healthcare workers having prolonged contact with tight-fitting masks, leading to maskne. "Maskne" is defined as acne secondary to mask use. There are limited studies on maskne during the COVID-19 pandemic. The ... ...

Abstract	The COVID-19 pandemic has led to many healthcare workers having prolonged contact with tight-fitting masks, leading to maskne. "Maskne" is defined as acne secondary to mask use. There are limited studies on maskne during the COVID-19 pandemic. The objective of this study is to identify risk factors for the development of maskne amongst healthcare workers. A cross-sectional survey was completed by 227 medical students, resident physicians, and nursing students at Johns Hopkins Medicine, with 68.7% of participants reporting development of maskne. Surgical masks and respirators were the most prevalent mask types worn at work. The most common prevention methods were the use of mild cleansers and moisturizers. Chi-squared analysis was used for data analysis. The results of this study indicate that gender (p = 0.003) and duration of mask use (p = 0.048) are significant risk factors for maskne development. These factors are non-modifiable, but may be used for more targeted education for prevention.
MeSH term(s)	Humans ; COVID-19/epidemiology ; Cross-Sectional Studies ; Pandemics ; Acne Vulgaris/epidemiology ; Health Personnel ; Risk Factors
Language	English
Publishing date	2022-11-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	130131-7
ISSN	1432-069X ; 0340-3696
ISSN (online)	1432-069X
ISSN	0340-3696
DOI	10.1007/s00403-022-02434-z
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Article: A choroid plexus apocrine secretion mechanism shapes CSF proteome and embryonic brain development.

Courtney, Ya'el / Head, Joshua P / Yimer, Elizabeth D / Dani, Neil / Shipley, Frederick B / Libermann, Towia A / Lehtinen, Maria K

bioRxiv : the preprint server for biology

2024

Abstract: We discovered that apocrine secretion by embryonic choroid plexus (ChP) epithelial cells contributes to the cerebrospinal fluid (CSF) proteome and influences brain development in mice. The apocrine response relies on sustained intracellular calcium ... ...

Abstract	We discovered that apocrine secretion by embryonic choroid plexus (ChP) epithelial cells contributes to the cerebrospinal fluid (CSF) proteome and influences brain development in mice. The apocrine response relies on sustained intracellular calcium signaling and calpain-mediated cytoskeletal remodeling. It rapidly alters the embryonic CSF proteome, activating neural progenitors lining the brain's ventricles. Supraphysiological apocrine secretion induced during mouse development by maternal administration of a serotonergic 5HT2C receptor agonist dysregulates offspring cerebral cortical development, alters the fate of CSF-contacting neural progenitors, and ultimately changes adult social behaviors. Critically, exposure to maternal illness or to the psychedelic drug LSD during pregnancy also overactivates the ChP, inducing excessive secretion. Collectively, our findings demonstrate a new mechanism by which maternal exposure to diverse stressors disrupts
Language	English
Publishing date	2024-01-16
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.01.08.574486
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Article: Activation of a Locus Coeruleus to Dorsal Hippocampus Noradrenergic Circuit Facilitates Associative Learning.

Tsetsenis, Theodoros / Badyna, Julia K / Li, Rebecca / Dani, John A

Frontiers in cellular neuroscience

2022 Volume 16, Page(s) 887679

Abstract: Processing of contextual information during a new episodic event is crucial for learning and memory. Neuromodulation in the hippocampus and prefrontal cortex plays an important role in the formation of associations between environmental cues and an ... ...

Abstract	Processing of contextual information during a new episodic event is crucial for learning and memory. Neuromodulation in the hippocampus and prefrontal cortex plays an important role in the formation of associations between environmental cues and an aversive experience. Noradrenergic neurons in the locus coeruleus send dense projections to both regions, but their contribution to contextual associative learning has not been established. Here, we utilize selective optogenetic and pharmacological manipulations to control noradrenergic transmission in the hippocampus during the encoding of a contextual fear memory. We find that boosting noradrenergic terminal release in the dorsal CA1 enhances the acquisition of contextual associative learning and that this effect requires local activation of β-adrenenergic receptors. Moreover, we show that increasing norepinephrine release can ameliorate contextual fear learning impairments caused by dopaminergic dysregulation in the hippocampus. Our data suggest that increasing of hippocampal noradrenergic activity can have important implications in the treatment of cognitive disorders that involve problems in contextual processing.
Language	English
Publishing date	2022-04-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452963-1
ISSN	1662-5102
ISSN	1662-5102
DOI	10.3389/fncel.2022.887679
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