Article ; Online: Do reduced numbers of plasmacytoid dendritic cells contribute to the aggressive clinical course of COVID-19 in chronic lymphocytic leukaemia?
Scandinavian journal of immunology
2022 Volume 95, Issue 4, Page(s) e13153
Abstract: Infections with SARS-CoV-2 have been unduly severe in patients with haematological malignancies, in particular in those with chronic lymphocytic leukaemia (CLL). Based on a series of observations, we propose that an underlying mechanism for the ... ...
Abstract | Infections with SARS-CoV-2 have been unduly severe in patients with haematological malignancies, in particular in those with chronic lymphocytic leukaemia (CLL). Based on a series of observations, we propose that an underlying mechanism for the aggressive clinical course of COVID-19 in CLL is a paucity of plasmacytoid dendritic cells (pDCs) in these patients. Indeed, pDCs express Toll-like receptor 7 (TLR7), which together with interferon-regulatory factor 7 (IRF7), enables pDCs to produce large amounts of type I interferons, essential for combating COVID-19. Treatment of CLL with Bruton's tyrosine kinase (BTK) inhibitors increased the number of pDCs, likely secondarily to the reduction in the tumour burden. |
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MeSH term(s) | COVID-19/complications ; Dendritic Cells ; Humans ; Interferon Regulatory Factor-7 ; Leukemia, Lymphocytic, Chronic, B-Cell/complications ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; SARS-CoV-2 ; Toll-Like Receptor 7 |
Chemical Substances | IRF7 protein, human ; Interferon Regulatory Factor-7 ; Toll-Like Receptor 7 |
Language | English |
Publishing date | 2022-03-16 |
Publishing country | England |
Document type | Journal Article ; Review |
ZDB-ID | 120476-2 |
ISSN | 1365-3083 ; 0300-9475 |
ISSN (online) | 1365-3083 |
ISSN | 0300-9475 |
DOI | 10.1111/sji.13153 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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