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  1. Book ; Online: Sodium Intake and Related Diseases

    Strazzullo, Pasquale / Santini, Antonello / Lucarini, Massimo / Durazzo, Alessandra / Lombardi-Boccia, Ginevra / Sette, Stefania

    2022  

    Keywords Research & information: general ; Biology, life sciences ; Food & society ; tight junction ; Na+ cotransport ; leaky epithelia ; blood pressure ; inflammation ; mineralocorticoid receptor ; Rac1 ; renal injury ; salt-sensitive hypertension ; salt intake ; sodium ; hypertension ; cardiovascular risk ; mortality ; prognosis ; salt ; heart failure ; ambulatory heart failure ; epidemiological studies ; MST3 ; STK24 ; high potassium ; ENaC ; NKCC2 ; SPAK ; OSR1 ; WNK4 ; n/a
    Language 0|e
    Size 1 electronic resource (90 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021609067
    ISBN 9783036519302 ; 3036519300
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Dietary Salt Restriction and Adherence to the Mediterranean Diet: A Single Way to Reduce Cardiovascular Risk?

    D'Elia, Lanfranco / Strazzullo, Pasquale

    Journal of clinical medicine

    2024  Volume 13, Issue 2

    Abstract: The dietary restriction of salt intake and the adhesion to Mediterranean dietary patterns are among the most recommended lifestyle modifications for the prevention of cardiovascular diseases. A large amount of evidence supports these recommendations; ... ...

    Abstract The dietary restriction of salt intake and the adhesion to Mediterranean dietary patterns are among the most recommended lifestyle modifications for the prevention of cardiovascular diseases. A large amount of evidence supports these recommendations; indeed, several studies show that a higher adherence to Mediterranean dietary patterns is associated with a reduced risk of cardiovascular disease. Likewise, findings from observational and clinical studies suggest a causal role of excess salt intake in blood pressure increase, cardiovascular organ damage, and the incidence of cardiovascular diseases. In this context, it is also conceivable that the beneficial effects of these two dietary patterns overlap because Mediterranean dietary patterns are typically characterized by a large consumption of plant-based foods with low sodium content. However, there is little data on this issue, and heterogeneous results are available on the relationship between adherence to salt restriction and to Mediterranean dietary patterns. Thus, this short review focuses on the epidemiological and clinical evidence of the relationship between the adherence to Mediterranean dietary patterns and dietary salt restriction in the context of cardiovascular risk.
    Language English
    Publishing date 2024-01-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13020486
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Role of dietary sodium/potassium ratio in the blood pressure rise with age: novel evidence from the Coronary Artery Risk Development in Young Adults study.

    Strazzullo, Pasquale

    Journal of hypertension

    2021  Volume 39, Issue 8, Page(s) 1549–1551

    MeSH term(s) Blood Pressure ; Coronary Vessels ; Humans ; Potassium ; Potassium, Dietary ; Sodium, Dietary ; Young Adult
    Chemical Substances Potassium, Dietary ; Sodium, Dietary ; Potassium (RWP5GA015D)
    Language English
    Publishing date 2021-06-21
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/HJH.0000000000002851
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 614: Show issues

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  4. Article ; Online: Isolated systolic hypertension of the young and sodium intake.

    D'Elia, Lanfranco / Strazzullo, Pasquale

    Minerva medica

    2021  Volume 113, Issue 5, Page(s) 788–797

    Abstract: Isolated systolic hypertension is associated with higher risk of cardiovascular disease and all-cause mortality. Despite being the most common form of hypertension in the elderly, it is also detectable among young and middle-aged subjects. Dietary salt ( ... ...

    Abstract Isolated systolic hypertension is associated with higher risk of cardiovascular disease and all-cause mortality. Despite being the most common form of hypertension in the elderly, it is also detectable among young and middle-aged subjects. Dietary salt (sodium chloride) intake is an important determinant of blood pressure, and high salt intake is associated with greater risk of hypertension and cardiovascular events. In most countries, habitual salt intake at all age categories largely exceeds the international recommendations. Excess salt intake, often interacting with overweight and insulin resistance, may contribute to the development and maintenance of isolated systolic hypertension in young individuals by causing endothelial dysfunction and promoting arterial stiffness through a number of mechanisms, namely increase in the renin-angiotensin-aldosterone system activity, sympathetic tone and salt-sensitivity. This short review focused on the epidemiological and clinical evidence, the mechanistic pathways and the cluster of pathophysiological factors whereby excess salt intake may favor the development and maintenance of isolated systolic hypertension in young people.
    MeSH term(s) Humans ; Adolescent ; Middle Aged ; Aged ; Sodium Chloride, Dietary/adverse effects ; Isolated Systolic Hypertension
    Chemical Substances Sodium Chloride, Dietary
    Language English
    Publishing date 2021-09-29
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 123586-2
    ISSN 1827-1669 ; 0026-4806
    ISSN (online) 1827-1669
    ISSN 0026-4806
    DOI 10.23736/S0026-4806.21.07740-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: In memoriam Gianni Barba.

    Strazzullo, Pasquale

    Nutrition, metabolism, and cardiovascular diseases : NMCD

    2014  Volume 24, Issue 8, Page(s) 807

    MeSH term(s) History, 21st Century ; Humans ; Italy ; Pediatric Obesity/history ; Societies, Scientific/history
    Language English
    Publishing date 2014-08-29
    Publishing country Netherlands
    Document type Biography ; Historical Article ; Journal Article ; Portrait
    ZDB-ID 1067704-5
    ISSN 1590-3729 ; 0939-4753
    ISSN (online) 1590-3729
    ISSN 0939-4753
    DOI 10.1016/j.numecd.2014.07.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3149: Show issues Location:
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  6. Article ; Online: Relationship between leptin and white blood cells: a potential role in infection susceptibility and severity-the Olivetti Heart Study.

    D'Elia, Lanfranco / Masulli, Maria / Iacone, Roberto / Russo, Ornella / Strazzullo, Pasquale / Galletti, Ferruccio

    Internal and emergency medicine

    2023  Volume 18, Issue 5, Page(s) 1429–1436

    Abstract: A number of evidence showed an emerging role of leptin on immune system, involving inflammation, and innate and adaptive immunity. Few observational studies have evaluated the relationship between leptin and immunity, albeit with low statistical power ... ...

    Abstract A number of evidence showed an emerging role of leptin on immune system, involving inflammation, and innate and adaptive immunity. Few observational studies have evaluated the relationship between leptin and immunity, albeit with low statistical power and methodological differences. Therefore, the aim of this study was to evaluate the potential role of leptin on the immunity, expressed as white blood cells (WBC)-and its subpopulations, by comprehensive multivariate models in a sample of adult men. A cross-sectional evaluation of a general population comprised 939 subjects participating in the Olivetti Heart Study, with available leptin levels and WBC-and its subpopulations. WBC were significantly and positively associated with leptin, C-reactive protein and HOMA index (p < 0.05), but not with age and anthropometric indices (p > 0.05). The multivariate analysis confirmed the association between leptin and WBC, after accounting for main confounders (p < 0.05). Additional analysis on WBC subpopulations showed a positive and significant correlation between leptin and lymphocytes, monocytes and eosinophils (p < 0.05), but not with neutrophils and basophils (p > 0.05). After stratification by body weight, the positive and significant association between leptin and WBC-and its subpopulations-was found in excess body weight participants. The results of this study indicate a direct relationship between leptin levels and WBC-and its subpopulations-in excess body weight participants. These results support the hypothesis that leptin has modulatory functions on immunity and role in the pathophysiology of immune-related diseases, in particular in those associated with excess body weight.
    MeSH term(s) Adult ; Male ; Humans ; Leptin ; Cross-Sectional Studies ; Leukocytes ; Neutrophils ; Body Weight
    Chemical Substances Leptin
    Language English
    Publishing date 2023-05-22
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-023-03313-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6673: Show issues Location:
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  7. Article ; Online: Time to define food salt targets in Italy starting with cereal-based products: A safe and practical way to reduce the heavy burden of cardiovascular disease.

    Strazzullo, Pasquale / Cairella, Giulia / D'Elia, Lanfranco / Scognamiglio, Umberto / Simonetti, Paolo

    Nutrition, metabolism, and cardiovascular diseases : NMCD

    2023  Volume 34, Issue 2, Page(s) 294–298

    Abstract: Background and aims: Excess salt intake is the leading dietary risk factor for cardiovascular disease in most countries, including Italy. While the cost-effectiveness of interventions aimed to reduce salt intake has been proved, the WHO recommendation ... ...

    Abstract Background and aims: Excess salt intake is the leading dietary risk factor for cardiovascular disease in most countries, including Italy. While the cost-effectiveness of interventions aimed to reduce salt intake has been proved, the WHO recommendation to reduce salt intake by 30 % at the global level by 2025 is far from being reached.
    Methods and results: In Italy, two surveys of the general adult population have established that the average salt intake is still almost twice the WHO recommendation although it was reduced by 1.2 g/day between 2008-12 and 2018-19. Previous investigations had shown that non-discretionary salt added by the industry or by local craft producers represents at least 50 % of the total intake and indicated cereal-based products as the main source of non-discretionary salt. Two recent studies conducted by the Italian Society of Human Nutrition "Young Working Group" have provided updated information on the salt content of almost three thousand cereal-based products currently available on the Italian food market and shown that most of the items evaluated had a sodium content much higher than the sodium benchmarks recently proposed by WHO.
    Conclusions: Italy has built the foundations of an effective population strategy for salt intake reduction: it is time however to proceed with full commitment to food reformulation if any substantial further progress has to be made. Salt benchmarks for Italy need to be defined for the food categories most relevant to population salt intake and their implementation should ideally be mandatory after consultation with food producers.
    MeSH term(s) Adult ; Humans ; Sodium Chloride, Dietary/adverse effects ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/prevention & control ; Edible Grain/adverse effects ; Italy ; Sodium
    Chemical Substances Sodium Chloride, Dietary ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2023-12-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1067704-5
    ISSN 1590-3729 ; 0939-4753
    ISSN (online) 1590-3729
    ISSN 0939-4753
    DOI 10.1016/j.numecd.2023.12.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3149: Show issues Location:
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  8. Article ; Online: Reducing sodium and increasing potassium intake.

    Strazzullo, Pasquale

    BMJ (Clinical research ed.)

    2013  Volume 346, Page(s) f2195

    MeSH term(s) Adolescent ; Adult ; Child ; Humans ; Hypertension/diet therapy ; Potassium, Dietary/administration & dosage ; Sodium, Dietary
    Chemical Substances Potassium, Dietary ; Sodium, Dietary
    Language English
    Publishing date 2013-04-09
    Publishing country England
    Document type Editorial
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.f2195
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Sodium in drugs and hypertension.

    Strazzullo, Pasquale

    BMJ (Clinical research ed.)

    2013  Volume 347, Page(s) f7321

    MeSH term(s) Cardiovascular Diseases/chemically induced ; Female ; Humans ; Male ; Nonprescription Drugs/chemistry ; Sodium/adverse effects
    Chemical Substances Nonprescription Drugs ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2013-12-10
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.f7321
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Validation of salt intake measurements: comparisons of a food record checklist and spot-urine collection to 24-h urine collection.

    Beer-Borst, Sigrid / Hayoz, Stefanie / Gréa Krause, Corinna / Strazzullo, Pasquale

    Public health nutrition

    2022  Volume 25, Issue 11, Page(s) 2983–2994

    Abstract: Objective: Monitoring population salt intake is operationally and economically challenging. We explored whether a questionnaire assessment and a prediction of Na intake from spot-urine could replace or complement the recommended measurement of Na in 24- ... ...

    Abstract Objective: Monitoring population salt intake is operationally and economically challenging. We explored whether a questionnaire assessment and a prediction of Na intake from spot-urine could replace or complement the recommended measurement of Na in 24-h urine (24-h U).
    Design: Compare the agreement of a Na-specific food record checklist (FRCL) and a late-afternoon spot-urine measurement (PM-spot) with 24-h U measurement in estimating Na intake at group level. Each participant's use of these methods extended over 3 d. Agreement was assessed using mean (95 % CI) differences, linear regression models and Bland-Altman plots.
    Setting: The validation study was part of a 1-year workplace intervention trial to lower salt intake in Switzerland.
    Participants: Seventy women and 71 men, aged 21-61 years, completed three FRCL, and acceptable PM-spot and 24-h U samples at baseline (April-October 2015).
    Results: Mean Na intake estimates varied slightly across methods (3·5-3·9 g/d). Mean Na intake differences from 24-h U were 0·2 (95 % CI (0, 0·5)) g/d for FRCL and 0·4 (95 % CI (0·2, 0·6)) g/d for PM-spot. Linear regression models and Bland-Altmann plots more clearly depicted differences by sex and discretionary salt use.
    Conclusions: Although 24-h U remains the best reference method for monitoring Na intake at the population level, PM-spot and FRCL might be more practical instruments for frequent, periodic Na intake assessments. Population-specific prediction models to estimate 24-h U could be developed and evaluated.
    MeSH term(s) Female ; Humans ; Male ; Checklist ; Sodium ; Sodium Chloride, Dietary ; Sodium, Dietary ; Urine Specimen Collection/methods ; Clinical Trials as Topic
    Chemical Substances Sodium (9NEZ333N27) ; Sodium Chloride, Dietary ; Sodium, Dietary
    Language English
    Publishing date 2022-07-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Validation Study
    ZDB-ID 1436024-x
    ISSN 1475-2727 ; 1368-9800
    ISSN (online) 1475-2727
    ISSN 1368-9800
    DOI 10.1017/S1368980022001537
    Database MEDical Literature Analysis and Retrieval System OnLINE

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