LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 47

Search options

  1. Article ; Online: Donate for your Secrets: Relationship between Secrecy, Guilt and Donation Behavior.

    Chen, Jiaxin / Duan, Jinyun / Wang, Tingxi / Li, Sixian / Yu, Boming

    Psychological reports

    2023  , Page(s) 332941231156817

    Abstract: Previous research has well documented the negative sides of secrecy, ignoring its potential constructive aspects. Based on the concept of compensatory behavior, this study conducted two experiments with 532 adults to explore the mediating role of felt ... ...

    Abstract Previous research has well documented the negative sides of secrecy, ignoring its potential constructive aspects. Based on the concept of compensatory behavior, this study conducted two experiments with 532 adults to explore the mediating role of felt guilt between secrecy and donation, and the moderating role of moral identity. Study 1 (
    Language English
    Publishing date 2023-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 205658-6
    ISSN 1558-691X ; 0033-2941
    ISSN (online) 1558-691X
    ISSN 0033-2941
    DOI 10.1177/00332941231156817
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 668: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Leader Phubbing and Employee Job Performance: The Effect of Need for Social Approval.

    Xu, Tingting / Wang, Tingxi / Duan, Jinyun

    Psychology research and behavior management

    2022  Volume 15, Page(s) 2303–2314

    Abstract: Purpose: A workplace leader's phubbing (snubbing by using the phone) can create social distance between the leader and employee. We tested whether this social distance might reduce trust, with a negative impact on job performance. The negative impact ... ...

    Abstract Purpose: A workplace leader's phubbing (snubbing by using the phone) can create social distance between the leader and employee. We tested whether this social distance might reduce trust, with a negative impact on job performance. The negative impact might be especially strong for employees with a high need for social approval (NFSA).
    Methods: Full-time employees (N = 246; 51.63% male, M
    Results: Regression-based analyses were used to test a moderated serial mediation model. Leader phubbing was associated with employees' poorer job performance, and this association was mediated by social distance and in turn, low trust. The negative effects of leader phubbing were stronger for employees with a higher NFSA.
    Conclusion: This study adds new evidence to the literature on phubbing by showing that employees' perceptions of leader phubbing might hinder employee job performance. Furthermore, the boundary condition of employee NFSA was emphasized and further expanded the literature in this field. This research provides insights into how the negative impact of leader phubbing on employee job performance can be prevented or reduced.
    Language English
    Publishing date 2022-08-23
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2495093-2
    ISSN 1179-1578
    ISSN 1179-1578
    DOI 10.2147/PRBM.S370409
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Rapid Evaluation of the Resistance of Citrus Germplasms Against

    Duan, Shuo / Long, Yunfei / Cheng, Shuyuan / Li, Jinyun / Ouyang, Zhigang / Wang, Nian

    Phytopathology

    2022  Volume 112, Issue 4, Page(s) 765–774

    Abstract: Xanthomonas ... ...

    Abstract Xanthomonas citri
    MeSH term(s) Citrus/microbiology ; Plant Breeding ; Plant Diseases/microbiology ; Xanthomonas/genetics
    Language English
    Publishing date 2022-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208889-7
    ISSN 1943-7684 ; 0031-949X
    ISSN (online) 1943-7684
    ISSN 0031-949X
    DOI 10.1094/PHYTO-04-21-0175-R
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 698: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Intranasal delivery of small extracellular vesicles from specific subpopulation of mesenchymal stem cells mitigates traumatic spinal cord injury.

    Sun, Yi / Zhao, Jinyun / Liu, Quanbo / Xu, Yan / Qin, Yiming / He, Rundong / Zheng, Lifu / Xie, Yong / Li, Chengjun / Wu, Tianding / Cao, Yong / Duan, Chunyue / Lu, Hongbin / Hu, Jianzhong

    Journal of controlled release : official journal of the Controlled Release Society

    2024  Volume 369, Page(s) 335–350

    Abstract: Vascular injury following spinal cord injury (SCI) can significantly exacerbate secondary SCI and result in neurological dysfunction. Strategies targeting angiogenesis have demonstrated potential in enhancing functional recovery post-SCI. In the context ... ...

    Abstract Vascular injury following spinal cord injury (SCI) can significantly exacerbate secondary SCI and result in neurological dysfunction. Strategies targeting angiogenesis have demonstrated potential in enhancing functional recovery post-SCI. In the context of angiogenesis, the CD146
    Language English
    Publishing date 2024-04-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 632533-6
    ISSN 1873-4995 ; 0168-3659
    ISSN (online) 1873-4995
    ISSN 0168-3659
    DOI 10.1016/j.jconrel.2024.03.037
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2055: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: The influence of fear of isolation on contact experience disclosure: Evidence from safety management of the COVID-19 pandemic.

    Lu, Hongxu / Duan, Jinyun / Wu, Ting / Zhou, Bei / Xu, Changyuan

    Asian journal of social psychology

    2022  

    Abstract: As the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues to rage, disclosure of exposure to the virus is of great significance to safety management, especially considering the ... ...

    Abstract As the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues to rage, disclosure of exposure to the virus is of great significance to safety management, especially considering the long latency of the disease. We conducted a survey based on terror management theory of 2,542 people in 71 cities, representing all provinces in mainland China. The results revealed that fear of being isolated influenced disclosure of exposure to the virus and that this influence was mediated by defensive impression management motivation. An inclusive climate buffered both the direct and the indirect effects of fear of isolation on disclosure behaviour via defensive impression management motivation. The implications of these findings for research and safety management during the COVID-19 pandemic are discussed.
    Language English
    Publishing date 2022-02-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1482966-6
    ISSN 1467-839X ; 1367-2223
    ISSN (online) 1467-839X
    ISSN 1367-2223
    DOI 10.1111/ajsp.12527
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: An updated patent review of protein arginine N-methyltransferase inhibitors (2019-2022).

    Dong, Jinyun / Duan, Jilong / Hui, Zi / Garrido, Carmen / Deng, Zhangshuang / Xie, Tian / Ye, Xiang-Yang

    Expert opinion on therapeutic patents

    2023  Volume 32, Issue 12, Page(s) 1185–1205

    Abstract: Protein arginine methyltransferases (PRMTs), enzymes catalyzing the methylation of target proteins, play an essential role in maintaining functional homeostasis in normal physiology. Aberrant expressions and enhanced enzymatic activities of PRMTs have ... ...

    Abstract Protein arginine methyltransferases (PRMTs), enzymes catalyzing the methylation of target proteins, play an essential role in maintaining functional homeostasis in normal physiology. Aberrant expressions and enhanced enzymatic activities of PRMTs have been closely associated with pathological states such as cancer, inflammatory, immune, metabolic, and neurodegenerative diseases. Therefore, the development of inhibitors targeting PRMTs has attracted a great deal of attention in both pharmaceutical industries and academic community. This review focuses on the small-molecule inhibitors targeting PRMTs in cancer therapy in the patents published since 2019. The recent clinical development is also discussed here. In recent years, the discovery of small-molecule PRMT inhibitors, especially PRMT5 inhibitors has become a rapidly expanding research area for cancer therapy. Although a number of potent PRMT inhibitors with different chemical scaffolds have been developed and nine of them have entered into clinical trials, their scaffolds are relatively less diverse. Sub-type selectivity should be considered in drug discovery as nonselective inhibition of PRMTs may cause undesirable pharmacological effects. Hence, the development of new effective inhibitors with isoform-specific and tumor-biased distributions remains an important area for further studies.
    MeSH term(s) Humans ; Protein-Arginine N-Methyltransferases/metabolism ; Patents as Topic ; Enzyme Inhibitors/pharmacology ; Neoplasms/drug therapy ; Arginine/metabolism
    Chemical Substances Protein-Arginine N-Methyltransferases (EC 2.1.1.319) ; Enzyme Inhibitors ; Arginine (94ZLA3W45F) ; PRMT5 protein, human (EC 2.1.1.319)
    Language English
    Publishing date 2023-01-03
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1186201-4
    ISSN 1744-7674 ; 0962-2594 ; 1354-3776
    ISSN (online) 1744-7674
    ISSN 0962-2594 ; 1354-3776
    DOI 10.1080/13543776.2022.2163162
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3962: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Quantitative biochemical phenotypic heterogeneity of macrophages after myelin debris phagocytosis at a single cell level by synchrotron radiation fourier transform infrared microspectroscopy.

    Sheng, Xiaolong / Xu, Jiaqi / Sun, Yi / Zhao, Jinyun / Cao, Yong / Jiang, Liyuan / Wu, Tianding / Lu, Hongbin / Duan, Chunyue / Hu, Jianzhong

    Analytica chimica acta

    2023  Volume 1271, Page(s) 341434

    Abstract: During the immuno-inflammatory pathophysiological process of spinal cord injury, traumatic brain injury, and ischemic stroke, macrophages play an important role in phagocytizing and clearing degenerated myelin debris. After phagocytizing myelin debris, ... ...

    Abstract During the immuno-inflammatory pathophysiological process of spinal cord injury, traumatic brain injury, and ischemic stroke, macrophages play an important role in phagocytizing and clearing degenerated myelin debris. After phagocytizing myelin debris, the biochemical phenotypes related to the biological function of macrophages show vast heterogeneity; however, it is not fully understood. Detecting biochemical changes after myelin debris phagocytosis by macrophages at a single-cell level is helpful to characterize phenotypic and functional heterogeneity. In this study, based on the cell model of myelin debris phagocytosis by macrophages in vitro, the biochemical changes in macrophages were investigated using Synchrotron radiation-based Fourier transform infrared (SR-FTIR) microspectroscopy. Infrared spectrum fluctuations, principal component analysis, and cell-to-cell Euclidean distance statistical analysis of specific spectrum regions revealed dynamic and significant changes in proteins and lipids within macrophages after myelin debris phagocytosis. Thus, SR-FTIR microspectroscopy is a powerful identification toolkit for exploring biochemical phenotype heterogeneity transformation that may be of great importance to providing an evaluation strategy for studying cell functions related to cellular substance distribution and metabolism.
    MeSH term(s) Myelin Sheath ; Synchrotrons ; Fourier Analysis ; Macrophages ; Phagocytosis/physiology ; Phenotype ; Spectroscopy, Fourier Transform Infrared/methods
    Language English
    Publishing date 2023-06-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1483436-4
    ISSN 1873-4324 ; 0003-2670
    ISSN (online) 1873-4324
    ISSN 0003-2670
    DOI 10.1016/j.aca.2023.341434
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Local delivery of EGFR

    Qin, Tian / Li, Chengjun / Xu, Yan / Qin, Yiming / Jin, Yuxin / He, Rundong / Luo, Zixiang / Zhao, Jinyun / Duan, Chunyue / Lu, Hongbin / Cao, Yong / Hu, Jianzhong

    Bioactive materials

    2023  Volume 33, Page(s) 424–443

    Abstract: Spinal cord injury (SCI) causes severe axon damage, usually leading to permanent paraparesis, which still lacks effective regenerative therapy. Recent studies have suggested that exosomes derived from neural stem cells (NSCs) may hold promise as ... ...

    Abstract Spinal cord injury (SCI) causes severe axon damage, usually leading to permanent paraparesis, which still lacks effective regenerative therapy. Recent studies have suggested that exosomes derived from neural stem cells (NSCs) may hold promise as attractive candidates for SCI treatment. Epidermal Growth Factor Receptor positive NSC (EGFR
    Language English
    Publishing date 2023-11-28
    Publishing country China
    Document type Journal Article
    ISSN 2452-199X
    ISSN (online) 2452-199X
    DOI 10.1016/j.bioactmat.2023.11.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article: Kdm6a-CNN1 axis orchestrates epigenetic control of trauma-induced spinal cord microvascular endothelial cell senescence to balance neuroinflammation for improved neurological repair.

    Li, Chengjun / Qin, Tian / Zhao, Jinyun / Jin, Yuxin / Qin, Yiming / He, Rundong / Wu, Tianding / Duan, Chunyue / Jiang, Liyuan / Yuan, Feifei / Lu, Hongbin / Cao, Yong / Hu, Jianzhong

    Bone research

    2024  Volume 12, Issue 1, Page(s) 19

    Abstract: Cellular senescence assumes pivotal roles in various diseases through the secretion of proinflammatory factors. Despite extensive investigations into vascular senescence associated with aging and degenerative diseases, the molecular mechanisms governing ... ...

    Abstract Cellular senescence assumes pivotal roles in various diseases through the secretion of proinflammatory factors. Despite extensive investigations into vascular senescence associated with aging and degenerative diseases, the molecular mechanisms governing microvascular endothelial cell senescence induced by traumatic stress, particularly its involvement in senescence-induced inflammation, remain insufficiently elucidated. In this study, we present a comprehensive demonstration and characterization of microvascular endothelial cell senescence induced by spinal cord injury (SCI). Lysine demethylase 6A (Kdm6a), commonly known as UTX, emerges as a crucial regulator of cell senescence in injured spinal cord microvascular endothelial cells (SCMECs). Upregulation of UTX induces senescence in SCMECs, leading to an amplified release of proinflammatory factors, specifically the senescence-associated secretory phenotype (SASP) components, thereby modulating the inflammatory microenvironment. Conversely, the deletion of UTX in endothelial cells shields SCMECs against senescence, mitigates the release of proinflammatory SASP factors, and promotes neurological functional recovery after SCI. UTX forms an epigenetic regulatory axis by binding to calponin 1 (CNN1), orchestrating trauma-induced SCMECs senescence and SASP secretion, thereby influencing neuroinflammation and neurological functional repair. Furthermore, local delivery of a senolytic drug reduces senescent SCMECs and suppresses proinflammatory SASP secretion, reinstating a local regenerative microenvironment and enhancing functional repair after SCI. In conclusion, targeting the UTX-CNN1 epigenetic axis to prevent trauma-induced SCMECs senescence holds the potential to inhibit SASP secretion, alleviate neuroinflammation, and provide a novel treatment strategy for SCI repair.
    MeSH term(s) Cellular Senescence/genetics ; Endothelial Cells ; Epigenesis, Genetic ; Neuroinflammatory Diseases/metabolism ; Spinal Cord Injuries/genetics ; Animals ; Mice ; Histone Demethylases/metabolism ; Calponins/metabolism
    Chemical Substances Utx protein, mouse (EC 1.14.11.-) ; CNN1 protein, human ; Histone Demethylases (EC 1.14.11.-) ; Calponins
    Language English
    Publishing date 2024-03-25
    Publishing country China
    Document type Journal Article
    ZDB-ID 2803313-9
    ISSN 2095-6231 ; 2095-4700
    ISSN (online) 2095-6231
    ISSN 2095-4700
    DOI 10.1038/s41413-024-00323-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Targeted Delivery of RGD-CD146

    Xie, Yong / Sun, Yi / Liu, Yudong / Zhao, Jinyun / Liu, Quanbo / Xu, Jiaqi / Qin, Yiming / He, Rundong / Yuan, Feifei / Wu, Tianding / Duan, Chunyue / Jiang, Liyuan / Lu, Hongbin / Hu, Jianzhong

    ACS nano

    2023  Volume 17, Issue 18, Page(s) 18008–18024

    Abstract: Spinal cord injury (SCI) disrupts the blood-spinal cord barrier (BSCB), potentially exacerbating nerve damage and emphasizing the criticality of preserving the BSCB integrity during SCI treatment. This study explores an alternative therapeutic approach ... ...

    Abstract Spinal cord injury (SCI) disrupts the blood-spinal cord barrier (BSCB), potentially exacerbating nerve damage and emphasizing the criticality of preserving the BSCB integrity during SCI treatment. This study explores an alternative therapeutic approach for SCI by identifying a subpopulation of exosomes with stable BSCB function and achieving a specific targeted delivery. Specific subpopulations of CD146
    MeSH term(s) Mice ; Humans ; Animals ; CD146 Antigen ; Endothelial Cells ; Exosomes ; Adapalene ; Spinal Cord Injuries/therapy ; Immunologic Factors ; Mesenchymal Stem Cells ; Oligopeptides/pharmacology
    Chemical Substances CD146 Antigen ; Adapalene (1L4806J2QF) ; Immunologic Factors ; Oligopeptides
    Language English
    Publishing date 2023-09-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.3c04423
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top