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Article ; Online: SMIT1 Expression in Arterial Tissue: A Potential New Trigger of Vascular Dysfunctions and ROS Production in Rats.

Grandperrin, Antoine / Strock, Eva / Petit, Léna / Risdon, Sydney / Boulghobra, Doria / Gayrard, Sandrine / Reboul, Cyril / Walther, Guillaume / Battault, Sylvain / Meyer, Grégory

Arteriosclerosis, thrombosis, and vascular biology

2024 Volume 44, Issue 5, Page(s) e168–e170

MeSH term(s)	Animals ; Reactive Oxygen Species/metabolism ; Rats ; Male ; Arteries/metabolism ; Arteries/physiopathology ; Arteries/pathology
Chemical Substances	Reactive Oxygen Species
Language	English
Publishing date	2024-03-14
Publishing country	United States
Document type	Research Support, Non-U.S. Gov't ; Letter
ZDB-ID	1221433-4
ISSN	1524-4636 ; 1079-5642
ISSN (online)	1524-4636
ISSN	1079-5642
DOI	10.1161/ATVBAHA.123.320547
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Article: Correction to: Docking and

Petit, Léna / Vernès, Léa / Cadoret, Jean-Paul

Journal of applied phycology

2021 Volume 33, Issue 3, Page(s) 1603–1604

Abstract: This corrects the article DOI: 10.1007/s10811-021-02372-9.]. ...

Abstract	[This corrects the article DOI: 10.1007/s10811-021-02372-9.].
Language	English
Publishing date	2021-05-10
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	1002324-0
ISSN	1573-5176 ; 0921-8971
ISSN (online)	1573-5176
ISSN	0921-8971
DOI	10.1007/s10811-021-02476-2
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Article: Docking and

Petit, Léna / Vernès, Léa / Cadoret, Jean-Paul

Journal of applied phycology

2021 Volume 33, Issue 3, Page(s) 1579–1602

Abstract: A race is currently being launched as a result of the international health situation. This race aims to find, by various means, weapons to counter the Covid-19 pandemic now widespread on all continents. The aquatic world and in particular that of ... ...

Abstract	A race is currently being launched as a result of the international health situation. This race aims to find, by various means, weapons to counter the Covid-19 pandemic now widespread on all continents. The aquatic world and in particular that of photosynthetic organisms is regularly highlighted but paradoxically little exploited in view of the tremendous possibilities it offers. Computational tools allow not only to clear the existence and activity of many molecules but also to model their relationships with receptors identified in potential hosts. On a routine basis, our laboratory carries out a research activity on functionalities of molecules derived from algae using Supplementary information: The online version contains supplementary material available at 10.1007/s10811-021-02372-9.
Language	English
Publishing date	2021-03-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1002324-0
ISSN	1573-5176 ; 0921-8971
ISSN (online)	1573-5176
ISSN	0921-8971
DOI	10.1007/s10811-021-02372-9
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Article: Docking and in silico toxicity assessment of Arthrospira compounds as potential antiviral agents against SARS-CoV-2

Petit, Léna / Vernès, Léa / Cadoret, Jean-Paul

Journal of applied phycology. 2021 June, v. 33, no. 3

2021

Abstract	A race is currently being launched as a result of the international health situation. This race aims to find, by various means, weapons to counter the Covid-19 pandemic now widespread on all continents. The aquatic world and in particular that of photosynthetic organisms is regularly highlighted but paradoxically little exploited in view of the tremendous possibilities it offers. Computational tools allow not only to clear the existence and activity of many molecules but also to model their relationships with receptors identified in potential hosts. On a routine basis, our laboratory carries out a research activity on functionalities of molecules derived from algae using in silico tools. We have implemented our skills in algae biology and in modeling, as tests in order to identify molecules expressed by the genus Arthrospira showing an antiviral potential and more particularly anti-SARS-CoV-2. Using consensus docking and redocking with Autodock Vina and SwissDock, we were able to identify several promising molecules from Arthrospira: phycocyanobilin, phycoerythrobilin, phycourobilin, and folic acid. These four compounds showed reliable binding energies comprised between − 6.95 and − 7.45 kcal.mol⁻¹ in Autodock Vina and between − 9.285 and − 10.35 kcal.mol⁻¹ with SwissDock. Toxicity prediction as well as current regulations provided promising arguments for the inclusion of these compounds in further studies to assess their ability to compete with the SARS-CoV-2/ACE2 complex both in vitro and in vivo.
Keywords	Arthrospira ; COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; algology ; computer simulation ; folic acid ; photosynthesis ; prediction ; toxicity
Language	English
Dates of publication	2021-06
Size	p. 1579-1602.
Publishing place	Springer Netherlands
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1002324-0
ISSN	1573-5176 ; 0921-8971
ISSN (online)	1573-5176
ISSN	0921-8971
DOI	10.1007/s10811-021-02372-9
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Article ; Online: Aging Is Associated With Lower Neuroactive Steroids and Worsened Outcomes Following Cerebral Ischemia in Male Mice.

Fernandez, Neïké / Petit, Anthony / Pianos, Antoine / Haddad, Léna / Schumacher, Michael / Liere, Philippe / Guennoun, Rachida

Endocrinology

2022 Volume 164, Issue 1

Abstract: Ischemic stroke is a leading cause of disability and death, and aging is the main nonmodifiable risk factor. Following ischemia, neuroactive steroids have been shown to play a key role in cerebroprotection. Thus, brain steroid concentrations at the time ... ...

Abstract	Ischemic stroke is a leading cause of disability and death, and aging is the main nonmodifiable risk factor. Following ischemia, neuroactive steroids have been shown to play a key role in cerebroprotection. Thus, brain steroid concentrations at the time of injury as well as their regulation after stroke are key factors to consider. Here, we investigated the effects of age and cerebral ischemia on steroid levels, behavioral outcomes, and neuronal degeneration in 3- and 18-month-old C57BL/6JRj male mice. Ischemia was induced by middle cerebral artery occlusion for 1 hour followed by reperfusion (MCAO/R) and analyses were performed at 6 hours after MCAO. Extended steroid profiles established by gas chromatography coupled with tandem mass spectrometry revealed that (1) brain and plasma concentrations of the main 5α-reduced metabolites of progesterone, 11-deoxycorticosterone, and corticosterone were lower in old than in young mice; (2) after MCAO/R, brain concentrations of progesterone, 5α-dihydroprogesterone, and corticosterone increased in young mice; and (3) after MCAO/R, brain concentrations of 5α-reduced metabolites of progesterone, 3α5α-tetrahydrodeoxycorticosterone, and 3β5α-tetrahydrodeoxycorticosterone were lower in old than in young mice. After ischemia, old mice showed increased sensori-motor deficits and more degenerating neurons in the striatum than young mice. Altogether, these findings strongly suggest that the decreased capacity of old mice to metabolize steroids toward the 5α-reduction pathway comparatively to young mice may contribute to the worsening of their stroke outcomes.
MeSH term(s)	Male ; Animals ; Mice ; Neurosteroids ; Progesterone ; Mice, Inbred C57BL ; Brain Ischemia ; Stroke ; Ischemia
Chemical Substances	Neurosteroids ; Progesterone (4G7DS2Q64Y)
Language	English
Publishing date	2022-10-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	427856-2
ISSN	1945-7170 ; 0013-7227
ISSN (online)	1945-7170
ISSN	0013-7227
DOI	10.1210/endocr/bqac183
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Article ; Online: The mitochondrial enzyme FAHD1 regulates complex II activity in breast cancer cells and is indispensable for basal BT-20 cells in vitro.

Holzknecht, Max / Guerrero-Navarro, Lena / Petit, Michele / Albertini, Eva / Damisch, Elisabeth / Simonini, Anna / Schmitt, Fernando / Parson, Walther / Fiegl, Heidelinde / Weiss, Alexander / Jansen-Duerr, Pidder

FEBS letters

2022 Volume 596, Issue 21, Page(s) 2781–2794

Abstract: The mitochondrial enzyme fumarylacetoacetate hydrolase domain-containing protein 1 (FAHD1) was identified to be upregulated in breast cancer tissues. Here, we show that FAHD1 is indispensable for the survival of BT-20 cells, representing the basal breast ...

Abstract	The mitochondrial enzyme fumarylacetoacetate hydrolase domain-containing protein 1 (FAHD1) was identified to be upregulated in breast cancer tissues. Here, we show that FAHD1 is indispensable for the survival of BT-20 cells, representing the basal breast cancer cell type. A lentiviral knock-down of FAHD1 in the breast cancer cell lines MCF-7 and BT-20 results in lower succinate dehydrogenase (complex II) activity. In luminal MCF-7 cells, this leads to reduced proliferation when cultured in medium containing only glutamine as the carbon source. Of note, both cell lines show attenuated protein levels of the enzyme glutaminase (GLS) which activates programmed cell death in BT-20. These findings demonstrate that FAHD1 is crucial for the functionality of complex II in breast cancer cells and acts on glutaminolysis in the mitochondria.
MeSH term(s)	Mitochondria/metabolism ; Glutamine/metabolism ; Hydrolases/metabolism ; Apoptosis ; Cell Line ; Neoplasms
Chemical Substances	Glutamine (0RH81L854J) ; Hydrolases (EC 3.-)
Language	English
Publishing date	2022-08-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	212746-5
ISSN	1873-3468 ; 0014-5793
ISSN (online)	1873-3468
ISSN	0014-5793
DOI	10.1002/1873-3468.14462
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Article: Endothelial Cell Orientation and Polarity Are Controlled by Shear Stress and VEGF Through Distinct Signaling Pathways.

Vion, Anne-Clémence / Perovic, Tijana / Petit, Charlie / Hollfinger, Irene / Bartels-Klein, Eireen / Frampton, Emmanuelle / Gordon, Emma / Claesson-Welsh, Lena / Gerhardt, Holger

Frontiers in physiology

2021 Volume 11, Page(s) 623769

Abstract: Vascular networks form, remodel and mature under the influence of multiple signals of mechanical or chemical nature. How endothelial cells read and interpret these signals, and how they integrate information when they are exposed to both simultaneously ... ...

Abstract	Vascular networks form, remodel and mature under the influence of multiple signals of mechanical or chemical nature. How endothelial cells read and interpret these signals, and how they integrate information when they are exposed to both simultaneously is poorly understood. Here, we show using flow-induced shear stress and VEGF-A treatment on endothelial cells
Language	English
Publishing date	2021-03-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2020.623769
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Article ; Online: The mitochondrial enzyme FAHD1 regulates complex II activity in breast cancer cells and is indispensable for basal BT‐20 cells in vitro

Holzknecht, Max / Guerrero‐Navarro, Lena / Petit, Michèle / Albertini, Eva / Damisch, Elisabeth / Simonini, Anna / Schmitt, Fernando / Parson, Walther / Fiegl, Heidelinde / Weiss, Alexander / Jansen‐Duerr, Pidder

FEBS Letters. 2022 Nov., v. 596, no. 21 p.2781-2794

2022

Abstract: The mitochondrial enzyme fumarylacetoacetate hydrolase domain‐containing protein 1 (FAHD1) was identified to be upregulated in breast cancer tissues. Here, we show that FAHD1 is indispensable for the survival of BT‐20 cells, representing the basal breast ...

Abstract	The mitochondrial enzyme fumarylacetoacetate hydrolase domain‐containing protein 1 (FAHD1) was identified to be upregulated in breast cancer tissues. Here, we show that FAHD1 is indispensable for the survival of BT‐20 cells, representing the basal breast cancer cell type. A lentiviral knock‐down of FAHD1 in the breast cancer cell lines MCF‐7 and BT‐20 results in lower succinate dehydrogenase (complex II) activity. In luminal MCF‐7 cells, this leads to reduced proliferation when cultured in medium containing only glutamine as the carbon source. Of note, both cell lines show attenuated protein levels of the enzyme glutaminase (GLS) which activates programmed cell death in BT‐20. These findings demonstrate that FAHD1 is crucial for the functionality of complex II in breast cancer cells and acts on glutaminolysis in the mitochondria.
Keywords	breast neoplasms ; carbon ; glutaminase ; glutamine ; mitochondria ; neoplasm cells ; programmed cell death ; succinate dehydrogenase (quinone)
Language	English
Dates of publication	2022-11
Size	p. 2781-2794.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	212746-5
ISSN	1873-3468 ; 0014-5793
ISSN (online)	1873-3468
ISSN	0014-5793
DOI	10.1002/1873-3468.14462
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Article ; Online: Intermediate repeat expansions of TBP and STUB1: Genetic modifier or pure digenic inheritance in spinocerebellar ataxias?

Genetics in medicine : official journal of the American College of Medical Genetics

2022 Volume 25, Issue 2, Page(s) 100327

Abstract: Purpose: CAG/CAA repeat expansions in TBP: Methods: We systematically sequenced TBP repeats in 34 probands of dominant ataxia families with STUB1 variants. In addition, we searched for pathogenic STUB1 variants in probands with expanded alleles of ... ...

Abstract	Purpose: CAG/CAA repeat expansions in TBP Methods: We systematically sequenced TBP repeats in 34 probands of dominant ataxia families with STUB1 variants. In addition, we searched for pathogenic STUB1 variants in probands with expanded alleles of TBP Results: STUB1 variants were found in half of the TBP Conclusion: We show that intermediate TBP
MeSH term(s)	Humans ; Spinocerebellar Ataxias/genetics ; Spinocerebellar Ataxias/pathology ; Cerebellar Ataxia/genetics ; Phenotype ; Alleles ; Trinucleotide Repeat Expansion/genetics ; Ubiquitin-Protein Ligases/genetics
Chemical Substances	STUB1 protein, human (EC 2.3.2.27) ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
Language	English
Publishing date	2022-11-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1455352-1
ISSN	1530-0366 ; 1098-3600
ISSN (online)	1530-0366
ISSN	1098-3600
DOI	10.1016/j.gim.2022.10.009
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Article ; Online: The utility of the ‘Arable Weeds and Management in Europe’ database: Challenges and opportunities of combining weed survey data at a European scale

Metcalfe, Helen / Bürger, Jana / Redwitz, Christoph von / Cirujeda, Alicia / Fogliatto, Silvia / Dostatny, Denise F. / Gerowitt, Bärbel / Glemnitz, Michael / González‐Andújar, José L. / Hernández Plaza, Eva / Izquierdo, Jordi / Kolářová, Michaela / Ņečajeva, Jevgenija / Petit, Sandrine / Pinke, Gyula / Schumacher, Matthias / Ulber, Lena / Vidotto, Francesco / Fried, Guillaume

Weed Research. 2023 Feb., v. 63, no. 1 p.1-11

2023

Abstract: Over the last 30 years, many studies have surveyed weed vegetation on arable land. The ‘Arable Weeds and Management in Europe’ (AWME) database is a collection of 36 of these surveys and the associated management data. Here, we review the challenges ... ...

Abstract	Over the last 30 years, many studies have surveyed weed vegetation on arable land. The ‘Arable Weeds and Management in Europe’ (AWME) database is a collection of 36 of these surveys and the associated management data. Here, we review the challenges associated with combining disparate datasets and explore some of the opportunities for future research that present themselves thanks to the AWME database. We present three case studies repeating previously published national scale analyses with data from a larger spatial extent. The case studies, originally done in France, Germany and the UK, explore various aspects of weed ecology (community composition, management and environmental effects and within‐field distributions) and use a range of statistical techniques (canonical correspondence analysis, redundancy analysis and generalised linear mixed models) to demonstrate the utility and versatility of the AWME database. We demonstrate that (i) the standardisation of abundance data to a common measure, before the analysis of the combined dataset, has little impact on the outcome of the analyses, (ii) the increased extent of environmental or management gradients allows for greater confidence in conclusions and (iii) the main conclusions of analyses done at different spatial scales remain consistent. These case studies demonstrate the utility of a Europe‐wide weed survey database, for clarifying or extending results obtained from studies at smaller scales. This Europe‐wide data collection offers many more opportunities for analysis that could not be addressed in smaller datasets; including questions about the effects of climate change, macro‐ecological and biogeographical issues related to weed diversity as well as the dominance or rarity of specific weeds in Europe.
Keywords	arable soils ; climate change ; community structure ; correspondence analysis ; data collection ; databases ; geographical distribution ; research ; surveys ; vegetation ; weeds ; France ; Germany
Language	English
Dates of publication	2023-02
Size	p. 1-11.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	281281-2
ISSN	1365-3180 ; 0043-1737
ISSN (online)	1365-3180
ISSN	0043-1737
DOI	10.1111/wre.12562
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