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  1. Article ; Online: Comparison of outcomes between intracytoplasmic sperm injection and in vitro fertilization inseminations with preimplantation genetic testing for aneuploidy, analysis of Society for Assisted Reproductive Technology Clinic Outcome Reporting System data.

    Tozour, Jessica N / Arnott, Alicia / Akerman, Meredith / Sung, Linda / Vintzileos, Anthony / Fritz, Rani

    Fertility and sterility

    2024  

    Abstract: Objective: To evaluate whether insemination via intracytoplasmic sperm injection (ICSI) provides any benefit over in vitro fertilization (IVF) insemination for nonmale factor infertility with respect to preimplantation genetic testing (PGT) results and ... ...

    Abstract Objective: To evaluate whether insemination via intracytoplasmic sperm injection (ICSI) provides any benefit over in vitro fertilization (IVF) insemination for nonmale factor infertility with respect to preimplantation genetic testing (PGT) results and pregnancy outcome.
    Design: Retrospective cohort study of the Society for Assisted Reproductive Technology database.
    Settings: US-based fertility clinics reporting to the Society for Assisted Reprodcutive Technology.
    Patients: Patients undergoing IVF or ICSI inseminations in nonmale factor PGT for aneuploidy cycles.
    Intervention: In vitro fertilization vs. ICSI inseminations.
    Main outcome measures: Primary outcomes were the percentage of embryos suitable for transfer and live birth rates (LBRs). Secondary outcomes included subgroup analysis for embryos suitable for transfer on cycles from patients ≥35-year-old vs. <35-year-old, ≤6 oocytes retrieved vs. >6 oocytes retrieved, and unexplained infertility. Additionally, gestational age at delivery and birth weight between IVF and ICSI inseminations were evaluated.
    Results: A total of 30,446 nonmale factor PGT diagnoses for aneuploidy cycles were evaluated, of which 4,867 were IVF inseminations and 25,579 were ICSI inseminations. Following exclusion criteria and adjustment for any necessary confounding variables, no significant differences existed in embryos suitable for transfer between IVF and ICSI treatment cycles, 41.6% (40.6%, 42.6%) vs. 42.5% (42.0%, 42.9%), respectively, or in LBRs, 50.1% (37.8, 62.4%) vs. 50.8% (38.5%, 62.9%), respectively.
    Conclusion: There were no significant differences in the rates of embryos suitable for transfer and LBRs between IVF and ICSI inseminations in nonmale factor cycles undergoing PGT for aneuploidy.
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80133-1
    ISSN 1556-5653 ; 0015-0282
    ISSN (online) 1556-5653
    ISSN 0015-0282
    DOI 10.1016/j.fertnstert.2023.12.041
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 73: Show issues Location:
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  2. Article ; Online: Genome entropy and network centrality contrast exploration and exploitation in evolution of foodborne pathogens.

    Chang, Sheryl L / Suster, Carl J E / Rockett, Rebecca J / Svahn, Adam J / Cliff, Oliver M / Arnott, Alicia / Wang, Qinning / Kim, Rady / Suliman, Basel / Gall, Mailie / Sorrell, Tania C / Sintchenko, Vitali / Prokopenko, Mikhail

    Physical biology

    2023  Volume 20, Issue 4

    Abstract: Modelling evolution of foodborne pathogens is crucial for mitigation and prevention of outbreaks. We apply network-theoretic and information-theoretic methods to trace evolutionary pathways ... ...

    Abstract Modelling evolution of foodborne pathogens is crucial for mitigation and prevention of outbreaks. We apply network-theoretic and information-theoretic methods to trace evolutionary pathways of
    MeSH term(s) Disease Outbreaks ; Epidemics
    Language English
    Publishing date 2023-06-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2133216-2
    ISSN 1478-3975 ; 1478-3967
    ISSN (online) 1478-3975
    ISSN 1478-3967
    DOI 10.1088/1478-3975/acd899
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  3. Article ; Online: Genomic Surveillance Enables Suitability Assessment of

    Rockett, Rebecca J / Arnott, Alicia / Wang, Qinning / Howard, Peter / Sintchenko, Vitali

    Journal of clinical microbiology

    2020  Volume 58, Issue 9

    Abstract: ... ...

    Abstract Salmonella
    MeSH term(s) Australia ; Genomics ; Humans ; Multilocus Sequence Typing ; Salmonella/genetics ; Salmonella Infections/diagnosis ; Salmonella enterica/genetics
    Language English
    Publishing date 2020-08-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.00038-20
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  4. Article: Added Value of Genomic Surveillance of Virulence Factors in Shiga Toxin-Producing

    Sim, Eby M / Kim, Ryan / Gall, Mailie / Arnott, Alicia / Howard, Peter / Valcanis, Mary / Howden, Benjamin P / Sintchenko, Vitali

    Frontiers in microbiology

    2021  Volume 12, Page(s) 713724

    Abstract: The disease caused by Shiga toxin- ... ...

    Abstract The disease caused by Shiga toxin-producing
    Language English
    Publishing date 2021-12-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2021.713724
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  5. Article ; Online: Pangenome Analysis of a Salmonella Enteritidis Population Links a Major Outbreak to a Gifsy-1-Like Prophage Containing Anti-Inflammatory Gene

    Svahn, Adam J / Suster, Carl J E / Chang, Sheryl L / Rockett, Rebecca J / Sim, Eby M / Cliff, Oliver M / Wang, Qinning / Arnott, Alicia / Ramsperger, Marc / Sorrell, Tania C / Sintchenko, Vitali / Prokopenko, Mikhail

    Microbiology spectrum

    2023  , Page(s) e0279122

    Abstract: A major outbreak of the globally significant Salmonella Enteritidis foodborne pathogen was identified within a large clinical data set by a program of routine WGS of clinical presentations of salmonellosis in New South Wales, Australia. Pangenome ... ...

    Abstract A major outbreak of the globally significant Salmonella Enteritidis foodborne pathogen was identified within a large clinical data set by a program of routine WGS of clinical presentations of salmonellosis in New South Wales, Australia. Pangenome analysis helped to quantify and isolate prophage content within the accessory partition of the pangenome. A prophage similar to Gifsy-1 (henceforth GF-1L) was found to occur in all isolates of the outbreak core SNP cluster, and in three other isolates. Further analysis revealed that the GF-1L prophage carried the
    Language English
    Publishing date 2023-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.02791-22
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  6. Article ; Online: First documented gymnasium cluster of COVID-19 with whole genome sequencing in Australia.

    Ravindran, Bhavi / Gatens, Elizabeth / Pal, Naru / Sheppeard, Vicky / Calik, Anna / Alexander, Kate / Ashraf, Khizar / Arnott, Alicia / Sintchenko, Vitali / Dalton, Craig B

    Communicable diseases intelligence (2018)

    2023  Volume 47

    Abstract: Background: Transmission of coronavirus disease 2019 (COVID-19) has been demonstrated in fitness settings internationally. We report the first documented case of transmission of COVID-19 in a gymnasium in Australia in 2020.: Methods: Case finding and ...

    Abstract Background: Transmission of coronavirus disease 2019 (COVID-19) has been demonstrated in fitness settings internationally. We report the first documented case of transmission of COVID-19 in a gymnasium in Australia in 2020.
    Methods: Case finding and case interviews were conducted among attendees in a Western Sydney gymnasium, Australia. Whole genome sequencing using an amplicon-based approach was performed on all SARS CoV-2 polymerase chain reaction positive samples detected through surveillance.
    Results: We show that five cases of COVID-19 were linked to the gymnasium, with transmission occurring on 7 July 2020, when the index case transmitted the infection to four other gymnasium attendees through the sharing of an enclosed space.
    Conclusions: There is an ongoing risk of transmission of COVID-19 within gymnasium environments and they are justifiably classified as a 'high-risk' venue. There may be a need to expand ventilation and space requirements to prevent transmission of COVID-19 in such settings in the context of severe COVID-19 variants or to prevent respiratory disease transmission in general.
    MeSH term(s) Humans ; COVID-19/epidemiology ; SARS-CoV-2/genetics ; Fitness Centers ; Australia/epidemiology ; Whole Genome Sequencing
    Language English
    Publishing date 2023-09-21
    Publishing country Australia
    Document type Journal Article
    ISSN 2209-6051
    ISSN (online) 2209-6051
    DOI 10.33321/cdi.2023.47.55
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  7. Article ; Online: Emergent Omicron BR.2.1 sublineage of SARS-CoV-2 in New South Wales, Australia: a subvariant with high fitness but without increased disease severity.

    Howard-Jones, Annaleise R / Arnott, Alicia / Draper, Jenny / Gall, Mailie / Ellis, Sally / Marris, Kelsi / Selvey, Christine / Basile, Kerri / Dwyer, Dominic E / Sintchenko, Vitali / Kok, Jen

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2023  Volume 130, Page(s) 38–41

    Abstract: Objectives: To describe the epidemiology and impact of Omicron BR.2.1, an emergent SARS-CoV-2 Omicron BA.2.75 sublineage displaying high fitness compared to other cocirculating subvariants in New South Wales, Australia.: Methods: From September 01 to ...

    Abstract Objectives: To describe the epidemiology and impact of Omicron BR.2.1, an emergent SARS-CoV-2 Omicron BA.2.75 sublineage displaying high fitness compared to other cocirculating subvariants in New South Wales, Australia.
    Methods: From September 01 to November 26, 2022, 4971 SARS-CoV-2 consensus genomes from unique patients were generated, and correlated with international travel and reinfection history, and admission to the intensive care unit.
    Results: BR.2.1 became the predominant variant by late November, and was responsible for a significantly higher proportion of community-acquired cases during the study period (55.1% vs 38.4%, P < 0.001). Reinfections (defined as occurring between 6 and 24 weeks after a prior diagnosis of COVID-19) were significantly higher among BR.2.1 compared to non-BR.2.1 infected persons (17.0% vs 6.0%, P < 0.001). BR.2.1 cases were also significantly younger compared to non-BR.2.1 (median age 48 years (interquartile range [IQR] 32) vs 53 years (IQR 32), P = 0.004). The proportion of patients admitted to the intensive care unit with BR.2.1 was not significantly higher than other subvariants (2.3% vs 2.0%, P = 0.717).
    Conclusion: Having emerged locally within New South Wales, BR.2.1 caused a significant number of SARS-CoV-2 reinfections, but with disease severity comparable with other currently circulating lineages. Given its rapid rise in prevalence, BR.2.1 has the potential to become established internationally.
    MeSH term(s) Humans ; Adult ; New South Wales/epidemiology ; SARS-CoV-2 ; Reinfection ; COVID-19/diagnosis ; COVID-19/epidemiology ; Australia ; Patient Acuity
    Chemical Substances carboxymethyl-dextran-A2-gadolinium-DOTA
    Language English
    Publishing date 2023-02-25
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2023.02.019
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    Zs.A 4516: Show issues Location:
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  8. Article ; Online: Epidemiologic Evidence for Airborne Transmission of SARS-CoV-2 during Church Singing, Australia, 2020.

    Katelaris, Anthea L / Wells, Jessica / Clark, Penelope / Norton, Sophie / Rockett, Rebecca / Arnott, Alicia / Sintchenko, Vitali / Corbett, Stephen / Bag, Shopna K

    Emerging infectious diseases

    2021  Volume 27, Issue 6, Page(s) 1677–1680

    Abstract: An outbreak of severe acute respiratory syndrome coronavirus 2 infection occurred among church attendees after an infectious chorister sang at multiple services. We detected 12 secondary case-patients. Video recordings of the services showed that case- ... ...

    Abstract An outbreak of severe acute respiratory syndrome coronavirus 2 infection occurred among church attendees after an infectious chorister sang at multiple services. We detected 12 secondary case-patients. Video recordings of the services showed that case-patients were seated in the same section, up to 15 m from the primary case-patient, without close physical contact, suggesting airborne transmission.
    MeSH term(s) Australia/epidemiology ; COVID-19 ; Humans ; SARS-CoV-2 ; Singing
    Language English
    Publishing date 2021-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2706.210465
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  9. Article ; Online: Consecutive Influenza Infections in Both Adults and Children.

    Arnott, Alicia / Carville, Kylie / Franklin, Lucinda / Sullivan, Sheena G

    The Journal of infectious diseases

    2017  Volume 215, Issue 4, Page(s) 658–659

    MeSH term(s) Adult ; Child ; Epidemics ; Herpesvirus 1, Cercopithecine ; Humans ; Influenza, Human/epidemiology ; Seasons
    Language English
    Publishing date 2017-03-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jix016
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    Zs.MO 445: Show issues

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  10. Article: Strategies for designing and monitoring malaria vaccines targeting diverse antigens.

    Barry, Alyssa E / Arnott, Alicia

    Frontiers in immunology

    2014  Volume 5, Page(s) 359

    Abstract: After more than 50 years of intensive research and development, only one malaria vaccine candidate, "RTS,S," has progressed to Phase 3 clinical trials. Despite only partial efficacy, this candidate is now forecast to become the first licensed malaria ... ...

    Abstract After more than 50 years of intensive research and development, only one malaria vaccine candidate, "RTS,S," has progressed to Phase 3 clinical trials. Despite only partial efficacy, this candidate is now forecast to become the first licensed malaria vaccine. Hence, more efficacious second-generation malaria vaccines that can significantly reduce transmission are urgently needed. This review will focus on a major obstacle hindering development of effective malaria vaccines: parasite antigenic diversity. Despite extensive genetic diversity in leading candidate antigens, vaccines have been and continue to be formulated using recombinant antigens representing only one or two strains. These vaccine strains represent only a small fraction of the diversity circulating in natural parasite populations, leading to escape of non-vaccine strains and challenging investigators' abilities to measure strain-specific efficacy in vaccine trials. Novel strategies are needed to overcome antigenic diversity in order for vaccine development to succeed. Many studies have now cataloged the global diversity of leading Plasmodium falciparum and Plasmodium vivax vaccine antigens. In this review, we describe how population genetic approaches can be applied to this rich data source to predict the alleles that best represent antigenic diversity, polymorphisms that contribute to it, and to identify key polymorphisms associated with antigenic escape. We also suggest an approach to summarize the known global diversity of a given antigen to predict antigenic diversity, how to select variants that best represent the strains circulating in natural parasite populations and how to investigate the strain-specific efficacy of vaccine trials. Use of these strategies in the design and monitoring of vaccine trials will not only shed light on the contribution of genetic diversity to the antigenic diversity of malaria, but will also maximize the potential of future malaria vaccine candidates.
    Language English
    Publishing date 2014-07-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2014.00359
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