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  1. Article ; Online: A converged ubiquitin-proteasome pathway for the degradation of TOC and TOM tail-anchored receptors.

    Yang, Meijing / Chen, Shuai / Lim, Shey-Li / Yang, Lang / Zhong, Jia Yi / Chan, Koon Chuen / Zhao, Zhizhu / Wong, Kam-Bo / Wang, Junqi / Lim, Boon Leong

    Journal of integrative plant biology

    2024  

    Abstract: ... membrane) and the TOM (translocon on the outer mitochondrial membrane) complexes for import ... ubiquitin-proteasome pathway for the degradation of Arabidopsis thaliana TOC and TOM tail-anchored receptors ...

    Abstract In plants, thousands of nucleus-encoded proteins translated in the cytosol are sorted to chloroplasts and mitochondria by binding to specific receptors of the TOC (translocon on the outer chloroplast membrane) and the TOM (translocon on the outer mitochondrial membrane) complexes for import into those organelles. The degradation pathways for these receptors are unclear. Here, we discovered a converged ubiquitin-proteasome pathway for the degradation of Arabidopsis thaliana TOC and TOM tail-anchored receptors. The receptors are ubiquitinated by E3 ligase(s) and pulled from the outer membranes by the AAA
    Language English
    Publishing date 2024-03-19
    Publishing country China (Republic : 1949- )
    Document type Journal Article
    ZDB-ID 2130095-1
    ISSN 1744-7909 ; 1672-9072
    ISSN (online) 1744-7909
    ISSN 1672-9072
    DOI 10.1111/jipb.13645
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Response to Jaime A Teixeira da Silva's article, "Suggestions for fortifying the discoverability of papers published in European Science Editing"

    Tom Lang

    European Science Editing, Vol 46, Iss , Pp 1-

    2020  Volume 1

    Keywords Academies and learned societies ; AS1-945 ; Bibliography. Library science. Information resources ; Z
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Pensoft Publishers
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: The intentional search for meaning

    Tom Lang

    European Science Editing, Vol 46, Iss , Pp 1-

    developing technical editing skills

    2020  Volume 7

    Abstract: The purpose of technical editing is to prepare specific information, for a specific medium, to help a specific audience, accomplish a specific goal. What defines technical editing is its purpose—to help readers act—not the scientific discipline in which ... ...

    Abstract The purpose of technical editing is to prepare specific information, for a specific medium, to help a specific audience, accomplish a specific goal. What defines technical editing is its purpose—to help readers act—not the scientific discipline in which it is found. Still, traditions of technical editing differ greatly by subject matter (nuclear physics, field biology), document types (scientific articles, computer user manuals), audiences (regulatory agencies, consumers), and specific publication conventions (writing instruction manuals, documenting experiments). Because technical editing developed in the physical sciences and engineering, the term often refers only to editing in those fields. However, whereas technical editors in industry often enter the profession with degrees in technical communications, editors in other scientific fields typically receive little or no professional training in editing. Accordingly, I describe here four techniques proven to be effective in training technical editors in any branch of science. A basic technique involves applying 12 specific and evidence-based ‘edits’ that improve comprehension. In an intermediate technique, ‘structured editing,’ described here for the first time, editors follow a structured process of analysing and revising a text by completing four sequential tasks. An advanced technique—shortening a 250-word abstract to 100 words without losing content—will develop critical thinking and sharpen language skills. Finally, I describe a collaborative technique based on ‘deliberate practice,’ in which a small group of editors discusses a text in detail, in long sessions, over extended periods, to develop a high degree of skill.
    Keywords editing ; training technical editors ; technical wri ; Academies and learned societies ; AS1-945 ; Bibliography. Library science. Information resources ; Z
    Subject code 028
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Pensoft Publishers
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Editorial: BCIs: research and development in children.

    Kirton, Adam / Kinney-Lang, Eli / Norton, James / Chau, Tom

    Frontiers in human neuroscience

    2023  Volume 17, Page(s) 1201623

    Language English
    Publishing date 2023-05-16
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2425477-0
    ISSN 1662-5161
    ISSN 1662-5161
    DOI 10.3389/fnhum.2023.1201623
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Editorial: Organ cross talk and its impact on the clinical course in multiple trauma and critical illness.

    Horst, Klemens / Mollnes, Tom Eirik / Huber-Lang, Markus / Hildebrand, Frank

    Frontiers in immunology

    2023  Volume 14, Page(s) 1195371

    MeSH term(s) Humans ; Critical Illness ; Biomarkers ; Multiple Trauma ; Disease Progression
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-04-05
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1195371
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Material Transport Characteristics in Planetary Roller Melt Granulation.

    Lang, Tom / Bramböck, Andreas / Thommes, Markus / Bartsch, Jens

    Pharmaceutics

    2023  Volume 15, Issue 8

    Abstract: Melt granulation for improving material handling by modifying particle size distribution offers significant advantages compared to the standard methods of dry and wet granulation in dust reduction, obviating a subsequent drying step. Furthermore, current ...

    Abstract Melt granulation for improving material handling by modifying particle size distribution offers significant advantages compared to the standard methods of dry and wet granulation in dust reduction, obviating a subsequent drying step. Furthermore, current research in pharmaceutical technology aims for continuous methods, as these have an enhanced potential to reduce product quality fluctuations. Concerning both aspects, the use of a planetary roller granulator is consequential. The process control with these machines benefits from the enhanced ratio of heated surface to processed volume, compared to the usually-applied twin-screw systems. This is related to the unique concept of planetary spindles flowing around a central spindle in a roller cylinder. Herein, the movement pattern defines the transport characteristics, which determine the energy input and overall processing conditions. The aim of this study is to investigate the residence time distribution in planetary roller melt granulation (PRMG) as an indicator for the material transport. By altering feed rate and rotation speed, the fill level in the granulator is adjusted, which directly affects the average transport velocity and mixing volume. The two-compartment model was utilized to reflect these coherences, as the model parameters symbolize the sub-processes of axial material transport and mixing.
    Language English
    Publishing date 2023-07-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15082039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Laparoscopic Living donor liver transplantation in irresectable intrahepatic cholangiocarcinoma in primary sclerosing cholangitis associated liver cirrhosis.

    Bednarsch, Jan / Lang, Sven A / Heise, Daniel / Strnad, Pavel / Neumann, Ulf P / Ulmer, Tom F

    Zeitschrift fur Gastroenterologie

    2024  Volume 62, Issue 1, Page(s) 50–55

    Abstract: Intrahepatic cholangiocarcinoma (iCCA) is the second most common primary liver tumor and usually associated with a poor oncological prognosis. The current gold standard is the surgical resection of the tumor with subsequent adjuvant therapy. However, in ... ...

    Title translation Leberlebendspende beim technisch irresektablen intrahapatischen Cholangiokarzinom in Leberzirrhose bei primär sklerosierender Cholangitis.
    Abstract Intrahepatic cholangiocarcinoma (iCCA) is the second most common primary liver tumor and usually associated with a poor oncological prognosis. The current gold standard is the surgical resection of the tumor with subsequent adjuvant therapy. However, in case of irresectability e.g. in case of liver cirrhosis, a palliative treatment regime is conducted.This report demonstrates the case of an irresectable iCCA in liver cirrhosis due to primary sclerosing cholangitis (PSC) treated by living-donor liver transplantation (LDLT) facilitated by minimal invasive donor hepatectomy. No postoperative complications were observed in the donor and the donor was released on the 6
    MeSH term(s) Humans ; Bile Duct Neoplasms/complications ; Bile Duct Neoplasms/diagnosis ; Bile Duct Neoplasms/surgery ; Bile Ducts, Intrahepatic ; Cholangiocarcinoma/complications ; Cholangiocarcinoma/diagnosis ; Cholangiocarcinoma/surgery ; Cholangitis, Sclerosing/complications ; Cholangitis, Sclerosing/diagnosis ; Cholangitis, Sclerosing/surgery ; Laparoscopy ; Liver Cirrhosis/complications ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/surgery ; Liver Transplantation ; Living Donors ; Neoplasm Recurrence, Local
    Language English
    Publishing date 2024-01-09
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0172-8504 ; 0044-2771
    ISSN (online) 1439-7803
    ISSN 0172-8504 ; 0044-2771
    DOI 10.1055/a-2221-6126
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 111: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.A 111/X: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: The Coronavirus Pandemic: "The Show Must NOT Go On".

    Habibzadeh, Farrokh / Lang, Tom

    The international journal of occupational and environmental medicine

    2020  Volume 11, Issue 2, Page(s) 63–64

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-29
    Publishing country Iran
    Document type Editorial ; Comment
    ZDB-ID 2573169-5
    ISSN 2008-6814 ; 2008-6814
    ISSN (online) 2008-6814
    ISSN 2008-6814
    DOI 10.34172/ijoem.2020.1979
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The Coronavirus Pandemic

    Farrokh Habibzadeh / Tom Lang

    The International Journal of Occupational and Environmental Medicine, Vol 11, Iss 2 April, Pp 63-

    “The Show Must NOT Go On”

    2020  Volume 4

    Abstract: No abstract available] ...

    Abstract [No abstract available]
    Keywords coronavirus ; covid-19 ; sars-cov-2 ; pandemic ; social distancing ; Industrial medicine. Industrial hygiene ; RC963-969 ; covid19
    Language English
    Publishing date 2020-03-01T00:00:00Z
    Publisher National Iranian Oil Company (NIOC) Health Organization
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Effect of ‘loss of function’ mutation in <i> SER1 </i> in wine yeast: fermentation outcomes in co-inoculation with non-<i>Saccharomyces </i>

    Tom A. Lang / Michelle E. Walker / Paul K. Boss / Vladimir Jiranek

    OENO One. 2022, v. 56, no. 2

    2022  

    Abstract: In wine fermentation, improved wine complexity and sensorial properties can arise from the use of non-Saccharomyces yeast. Generally less alcohol tolerant, such strains often do not finish fermentation, therefore requiring a second inoculation with the ... ...

    Abstract In wine fermentation, improved wine complexity and sensorial properties can arise from the use of non-Saccharomyces yeast. Generally less alcohol tolerant, such strains often do not finish fermentation, therefore requiring a second inoculation with the more robust Saccharomyces cerevisiae, usually added on Day 3. This sequential approach affords non-Saccharomyces time to make an impact before being overtaken by S. cerevisiae. However, two inoculations are inconvenient; therefore the identification of a slow growing S. cerevisiae strain that can be used in a single co-inoculation with the non-Saccharomyces yeast is highly attractive. In this study we investigated the use of the naturally occurring ‘loss of function’ SER1 variant, identified in a Sake yeast, for the purposes of carrying out co-inoculated wine fermentations. The SER1-232(G > C; G78R) change was introduced into the commonly used wine strain, EC1118, via CRISPR/Cas9 editing. In a chemically defined grape juice medium, the SER1(G78R) mutant grew and fermented more slowly and increased acetic acid, succinic acid and glycerol concentrations. Simultaneous inoculation with the slower-growing mutant with a Metschnikowia pulcherrima or Lachancea thermotolerans strain in sterile Sauvignon blanc juice resulted in differences in sensorial compounds, most likely derived from the presence of non-Saccharomyces yeasts. The EC1118 SER1 (G78R) mutant completed fermentation with M. pulcherrima, MP2, and in fact improved the viability of MP2 compared to when it was used as a monoculture. The SER1 (G78R) mutant also promoted both the growth of the SO2-sensitive L. thermotolerans strain, Viniflora® Concerto™, in a juice high in SO2 and its subsequent dominance during fermentation. In co-fermentations with wild-type EC1118, the Concerto™ population was substantially reduced with no significant changes in wine properties. This research adds to our understanding of the use of a novel slow-growing S. cerevisiae yeast in wine fermentations co-inoculated with non-Saccharomyces strains.
    Keywords CRISPR-Cas systems ; Lachancea thermotolerans ; Metschnikowia pulcherrima ; Saccharomyces cerevisiae ; acetic acid ; alcohol tolerance ; fermentation ; glycerol ; grape juice ; mutants ; mutation ; sake ; succinic acid ; viability ; wine yeasts
    Language English
    Publishing place International Viticulture and Enology Society
    Document type Article
    ISSN 2494-1271
    DOI 10.20870/oeno-one.2022.56.2.4908
    Database NAL-Catalogue (AGRICOLA)

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