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  1. Article ; Online: A converged ubiquitin-proteasome pathway for the degradation of TOC and TOM tail-anchored receptors.

    Yang, Meijing / Chen, Shuai / Lim, Shey-Li / Yang, Lang / Zhong, Jia Yi / Chan, Koon Chuen / Zhao, Zhizhu / Wong, Kam-Bo / Wang, Junqi / Lim, Boon Leong

    Journal of integrative plant biology

    2024  

    Abstract: ... membrane) and the TOM (translocon on the outer mitochondrial membrane) complexes for import ... ubiquitin-proteasome pathway for the degradation of Arabidopsis thaliana TOC and TOM tail-anchored receptors ...

    Abstract In plants, thousands of nucleus-encoded proteins translated in the cytosol are sorted to chloroplasts and mitochondria by binding to specific receptors of the TOC (translocon on the outer chloroplast membrane) and the TOM (translocon on the outer mitochondrial membrane) complexes for import into those organelles. The degradation pathways for these receptors are unclear. Here, we discovered a converged ubiquitin-proteasome pathway for the degradation of Arabidopsis thaliana TOC and TOM tail-anchored receptors. The receptors are ubiquitinated by E3 ligase(s) and pulled from the outer membranes by the AAA
    Language English
    Publishing date 2024-03-19
    Publishing country China (Republic : 1949- )
    Document type Journal Article
    ZDB-ID 2130095-1
    ISSN 1744-7909 ; 1672-9072
    ISSN (online) 1744-7909
    ISSN 1672-9072
    DOI 10.1111/jipb.13645
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Response to Jaime A Teixeira da Silva's article, "Suggestions for fortifying the discoverability of papers published in European Science Editing"

    Tom Lang

    European Science Editing, Vol 46, Iss , Pp 1-

    2020  Volume 1

    Keywords Academies and learned societies ; AS1-945 ; Bibliography. Library science. Information resources ; Z
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Pensoft Publishers
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: The intentional search for meaning

    Tom Lang

    European Science Editing, Vol 46, Iss , Pp 1-

    developing technical editing skills

    2020  Volume 7

    Abstract: The purpose of technical editing is to prepare specific information, for a specific medium, to help a specific audience, accomplish a specific goal. What defines technical editing is its purpose—to help readers act—not the scientific discipline in which ... ...

    Abstract The purpose of technical editing is to prepare specific information, for a specific medium, to help a specific audience, accomplish a specific goal. What defines technical editing is its purpose—to help readers act—not the scientific discipline in which it is found. Still, traditions of technical editing differ greatly by subject matter (nuclear physics, field biology), document types (scientific articles, computer user manuals), audiences (regulatory agencies, consumers), and specific publication conventions (writing instruction manuals, documenting experiments). Because technical editing developed in the physical sciences and engineering, the term often refers only to editing in those fields. However, whereas technical editors in industry often enter the profession with degrees in technical communications, editors in other scientific fields typically receive little or no professional training in editing. Accordingly, I describe here four techniques proven to be effective in training technical editors in any branch of science. A basic technique involves applying 12 specific and evidence-based ‘edits’ that improve comprehension. In an intermediate technique, ‘structured editing,’ described here for the first time, editors follow a structured process of analysing and revising a text by completing four sequential tasks. An advanced technique—shortening a 250-word abstract to 100 words without losing content—will develop critical thinking and sharpen language skills. Finally, I describe a collaborative technique based on ‘deliberate practice,’ in which a small group of editors discusses a text in detail, in long sessions, over extended periods, to develop a high degree of skill.
    Keywords editing ; training technical editors ; technical wri ; Academies and learned societies ; AS1-945 ; Bibliography. Library science. Information resources ; Z
    Subject code 028
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Pensoft Publishers
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Editorial: BCIs: research and development in children.

    Kirton, Adam / Kinney-Lang, Eli / Norton, James / Chau, Tom

    Frontiers in human neuroscience

    2023  Volume 17, Page(s) 1201623

    Language English
    Publishing date 2023-05-16
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2425477-0
    ISSN 1662-5161
    ISSN 1662-5161
    DOI 10.3389/fnhum.2023.1201623
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Editorial: Organ cross talk and its impact on the clinical course in multiple trauma and critical illness.

    Horst, Klemens / Mollnes, Tom Eirik / Huber-Lang, Markus / Hildebrand, Frank

    Frontiers in immunology

    2023  Volume 14, Page(s) 1195371

    MeSH term(s) Humans ; Critical Illness ; Biomarkers ; Multiple Trauma ; Disease Progression
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-04-05
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1195371
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Material Transport Characteristics in Planetary Roller Melt Granulation.

    Lang, Tom / Bramböck, Andreas / Thommes, Markus / Bartsch, Jens

    Pharmaceutics

    2023  Volume 15, Issue 8

    Abstract: Melt granulation for improving material handling by modifying particle size distribution offers significant advantages compared to the standard methods of dry and wet granulation in dust reduction, obviating a subsequent drying step. Furthermore, current ...

    Abstract Melt granulation for improving material handling by modifying particle size distribution offers significant advantages compared to the standard methods of dry and wet granulation in dust reduction, obviating a subsequent drying step. Furthermore, current research in pharmaceutical technology aims for continuous methods, as these have an enhanced potential to reduce product quality fluctuations. Concerning both aspects, the use of a planetary roller granulator is consequential. The process control with these machines benefits from the enhanced ratio of heated surface to processed volume, compared to the usually-applied twin-screw systems. This is related to the unique concept of planetary spindles flowing around a central spindle in a roller cylinder. Herein, the movement pattern defines the transport characteristics, which determine the energy input and overall processing conditions. The aim of this study is to investigate the residence time distribution in planetary roller melt granulation (PRMG) as an indicator for the material transport. By altering feed rate and rotation speed, the fill level in the granulator is adjusted, which directly affects the average transport velocity and mixing volume. The two-compartment model was utilized to reflect these coherences, as the model parameters symbolize the sub-processes of axial material transport and mixing.
    Language English
    Publishing date 2023-07-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15082039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Laparoscopic Living donor liver transplantation in irresectable intrahepatic cholangiocarcinoma in primary sclerosing cholangitis associated liver cirrhosis.

    Bednarsch, Jan / Lang, Sven A / Heise, Daniel / Strnad, Pavel / Neumann, Ulf P / Ulmer, Tom F

    Zeitschrift fur Gastroenterologie

    2024  Volume 62, Issue 1, Page(s) 50–55

    Abstract: Intrahepatic cholangiocarcinoma (iCCA) is the second most common primary liver tumor and usually associated with a poor oncological prognosis. The current gold standard is the surgical resection of the tumor with subsequent adjuvant therapy. However, in ... ...

    Title translation Leberlebendspende beim technisch irresektablen intrahapatischen Cholangiokarzinom in Leberzirrhose bei primär sklerosierender Cholangitis.
    Abstract Intrahepatic cholangiocarcinoma (iCCA) is the second most common primary liver tumor and usually associated with a poor oncological prognosis. The current gold standard is the surgical resection of the tumor with subsequent adjuvant therapy. However, in case of irresectability e.g. in case of liver cirrhosis, a palliative treatment regime is conducted.This report demonstrates the case of an irresectable iCCA in liver cirrhosis due to primary sclerosing cholangitis (PSC) treated by living-donor liver transplantation (LDLT) facilitated by minimal invasive donor hepatectomy. No postoperative complications were observed in the donor and the donor was released on the 6
    MeSH term(s) Humans ; Bile Duct Neoplasms/complications ; Bile Duct Neoplasms/diagnosis ; Bile Duct Neoplasms/surgery ; Bile Ducts, Intrahepatic ; Cholangiocarcinoma/complications ; Cholangiocarcinoma/diagnosis ; Cholangiocarcinoma/surgery ; Cholangitis, Sclerosing/complications ; Cholangitis, Sclerosing/diagnosis ; Cholangitis, Sclerosing/surgery ; Laparoscopy ; Liver Cirrhosis/complications ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/surgery ; Liver Transplantation ; Living Donors ; Neoplasm Recurrence, Local
    Language English
    Publishing date 2024-01-09
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0172-8504 ; 0044-2771
    ISSN (online) 1439-7803
    ISSN 0172-8504 ; 0044-2771
    DOI 10.1055/a-2221-6126
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 111: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.A 111/X: Show issues Location:
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  8. Article ; Online: The Coronavirus Pandemic: "The Show Must NOT Go On".

    Habibzadeh, Farrokh / Lang, Tom

    The international journal of occupational and environmental medicine

    2020  Volume 11, Issue 2, Page(s) 63–64

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-29
    Publishing country Iran
    Document type Editorial ; Comment
    ZDB-ID 2573169-5
    ISSN 2008-6814 ; 2008-6814
    ISSN (online) 2008-6814
    ISSN 2008-6814
    DOI 10.34172/ijoem.2020.1979
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  9. Article ; Online: The Coronavirus Pandemic

    Farrokh Habibzadeh / Tom Lang

    The International Journal of Occupational and Environmental Medicine, Vol 11, Iss 2 April, Pp 63-

    “The Show Must NOT Go On”

    2020  Volume 4

    Abstract: No abstract available] ...

    Abstract [No abstract available]
    Keywords coronavirus ; covid-19 ; sars-cov-2 ; pandemic ; social distancing ; Industrial medicine. Industrial hygiene ; RC963-969 ; covid19
    Language English
    Publishing date 2020-03-01T00:00:00Z
    Publisher National Iranian Oil Company (NIOC) Health Organization
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Body composition is associated with postoperative complications in perihilar cholangiocarcinoma.

    Wang, Guanwu / Mantas, Anna / Heij, Lara R / Al-Masri, Tarick M / Liu, Dong / Heise, Daniel / Schmitz, Sophia M / Olde Damink, Steven W M / Luedde, Tom / Lang, Sven A / Ulmer, Tom F / Neumann, Ulf P / Bednarsch, Jan

    Cancer medicine

    2024  

    Abstract: Background: Perihilar cholangiocarcinoma (pCCA) is a malignant tumor of the hepatobiliary system which is still associated with a challenging prognosis. Postoperative complications play a crucial role in determining the overall prognosis of patients ... ...

    Abstract Background: Perihilar cholangiocarcinoma (pCCA) is a malignant tumor of the hepatobiliary system which is still associated with a challenging prognosis. Postoperative complications play a crucial role in determining the overall prognosis of patients with pCCA. Changes in body composition (BC) have been shown to impact the prognosis of various types of tumors. Therefore, our study aimed to investigate the correlation between BC, postoperative complications and oncological outcome in patients with pCCA.
    Methods: All patients with pCCA who underwent curative-intent surgery for pCCA between 2010 and 2022 were included in this analysis. BC was assessed using preoperative computed tomography and analyzed with the assistance of a 3D Slicer software. Univariate and multivariate binary logistic regression analyses were conducted to examine the relationship between BC and clinical characteristics including various measurements of postoperative complications and Cox regressions and Kaplan-Meier analysis to evaluate oncological risk factors in the study cohort.
    Results: BC was frequently altered in patients undergoing curative-intent liver resection for pCCA (n = 204) with 52.5% of the patients showing obesity, 55.9% sarcopenia, 21.6% sarcopenic obesity, 48.5% myosteatosis, and 69.1% visceral obesity. In multivariate analysis, severe postoperative complications (Clavien-Dindo ≥3b) were associated with body mass index (BMI) (Odds ratio (OR) = 2.001, p = 0.024), sarcopenia (OR = 2.145, p = 0.034), and myosteatosis (OR = 2.097, p = 0.017) as independent predictors. Furthermore, sarcopenia was associated with reduced overall survival (OS) in pCCA patients (sarcopenia vs. no-sarcopenia, 21 months vs. 32 months, p = 0.048 log rank).
    Conclusions: BC is highly associated with severe postoperative complications in patients with pCCA and shows tendency to be associated impaired overall survival. Preoperative assessment of BC and interventions to improve BC might therefore be key to improve outcome in pCCA patients undergoing surgical therapy.
    Language English
    Publishing date 2024-01-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2659751-2
    ISSN 2045-7634 ; 2045-7634
    ISSN (online) 2045-7634
    ISSN 2045-7634
    DOI 10.1002/cam4.6878
    Database MEDical Literature Analysis and Retrieval System OnLINE

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