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  1. Article: An Evaluation of Medical Students' Perceptions, Knowledge, and Attitudes About People With Disability After Attending the Learning Session on Disability Competency: A Cross-Sectional Study.

    Saurabh, Manoj K / Ranjan, Amit / Patel, Tejas K

    Cureus

    2024  Volume 16, Issue 2, Page(s) e53878

    Abstract: Background and objective The Medical Council of India [now replaced by the National Medical Commission (NMC)] has implemented a new competency-based curriculum for medical education. Eight competencies in the curriculum are related to the principles of ... ...

    Abstract Background and objective The Medical Council of India [now replaced by the National Medical Commission (NMC)] has implemented a new competency-based curriculum for medical education. Eight competencies in the curriculum are related to the principles of disability-inclusive compassionate care. This study aimed to evaluate the knowledge, perceptions, and attitudes among undergraduate medical students about people with disability after attending learning sessions on disability competency. Materials and methods After they attended the learning session during the foundation course, participants were evaluated by using a questionnaire involving 26 questions, of which 17 were based on the Likert scale to assess general perceptions towards the person with a disability, while three questions aimed to assess attitudes, and six closed-ended questions tried to assess knowledge about disability. Results In the present study, 79.7% (n=157) of the students thought that people with disabilities faced problems getting involved in society, and 81.2% (n=160) felt that it was harder for them to make friends than others. The majority of the students disagreed with the idea that people with disabilities are a burden on society (n=149, 75.6%) or their families (n=119, 60.4%); 65% (n=128) of the students thought that people with disabilities are more determined than others to reach their goals and achieve more owing to their disability (n=104, 52.85%). A total of 161 (81.7%) students disagreed with the statement that people with disabilities should not be optimistic about their future. A comparison of the pre- and post-test data revealed that students' knowledge regarding disability increased and they gained a more positive attitude towards people with a disability after attending teaching and learning sessions (p<0.0001). Conclusion Our findings showed a significant improvement in the undergraduate medical students' understanding and empathy toward individuals with disabilities following sessions on disability competency. Teaching and learning sessions on disability competencies for newly admitted students in medical school can sensitize, orient, increase knowledge, and develop positive attitudes toward people with disabilities. Further studies on the topic are needed involving different phases of clinical teaching.
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.53878
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Alcohol consumption: An important epidemiological factor in COVID-19?

    Vasudeva, Abhimanyu / Patel, Tejas K

    Journal of global health

    2020  Volume 10, Issue 2, Page(s) 20335

    MeSH term(s) Alcohol Drinking/epidemiology ; Alcohol Drinking/physiopathology ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/physiopathology ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/physiopathology ; Pulmonary Alveoli/drug effects ; Pulmonary Alveoli/metabolism ; Risk Factors ; SARS-CoV-2 ; Severity of Illness Index
    Keywords covid19
    Language English
    Publishing date 2020-07-31
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 2741629-X
    ISSN 2047-2986 ; 2047-2978
    ISSN (online) 2047-2986
    ISSN 2047-2978
    DOI 10.7189/jogh.10.020335
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Role of Selective Serotonin Reuptake Inhibitors in the Treatment of Hypochondriasis: A Systematic Review.

    Prithviraj, Manoj / Mohanraj, Palani Selvam / Patel, Tejas K / Das, Arani

    Cureus

    2023  Volume 15, Issue 9, Page(s) e45286

    Abstract: Hypochondriasis is a condition characterized by an unrealistic fear of having a serious medical illness resulting in health anxiety. Currently, no evidence-based pharmacological treatment options are available for the treatment of hypochondriasis. Since ... ...

    Abstract Hypochondriasis is a condition characterized by an unrealistic fear of having a serious medical illness resulting in health anxiety. Currently, no evidence-based pharmacological treatment options are available for the treatment of hypochondriasis. Since selective serotonin reuptake inhibitors (SSRIs) are the first-line treatment option for anxiety disorders, they may be useful for relieving hypochondriasis symptoms. Moreover, off-label use of SSRIs in these cases is highly prevalent in clinical practice. Thus, in this study, we aimed to review the available literature to assess the role of SSRIs in the treatment of hypochondriacal symptoms. A systematic search was conducted in PubMed, Scopus, ScienceDirect, Embase, and Cochrane Database of Systematic Reviews from the date of inception to December 2022. We included only randomized clinical trials (RCTs) investigating the effect of SSRIs in the treatment of hypochondriacal symptoms. Non-RCTs, observation studies, and animal studies were excluded. The Risk of Bias 2 tool was used to assess the quality of included studies. Out of 2264 articles, six RCTs met our inclusion criteria. Studies have been conducted using different SSRIs in the treatment of primary hypochondriasis and hypochondriacal symptoms associated with other psychiatric disorders. All the studies have found that the use of SSRIs has some beneficial role in improving hypochondriacal symptoms. This suggests that SSRIs may be one of the promising pharmacological interventions in the treatment of hypochondriasis.
    Language English
    Publishing date 2023-09-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.45286
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Mortality among patients due to adverse drug reactions that occur following hospitalisation: a meta-analysis.

    Patel, Parvati B / Patel, Tejas K

    European journal of clinical pharmacology

    2019  Volume 75, Issue 9, Page(s) 1293–1307

    Abstract: Purpose: To estimate the prevalence of mortality among patients that develop adverse drug reactions during hospitalisation (ADR: Methods: Two investigators searched PubMed, Google Scholar and related bibliography for studies reporting ADR: Results!# ...

    Abstract Purpose: To estimate the prevalence of mortality among patients that develop adverse drug reactions during hospitalisation (ADR
    Methods: Two investigators searched PubMed, Google Scholar and related bibliography for studies reporting ADR
    Results: Out of 349 full text assessed, 48 studies satisfying the selection criteria were included. The fatal ADR
    Conclusion: ADR
    MeSH term(s) Drug-Related Side Effects and Adverse Reactions/mortality ; Hospitalization/statistics & numerical data ; Humans ; Prevalence
    Language English
    Publishing date 2019-06-11
    Publishing country Germany
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 121960-1
    ISSN 1432-1041 ; 0031-6970
    ISSN (online) 1432-1041
    ISSN 0031-6970
    DOI 10.1007/s00228-019-02702-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Suspected cutaneous adverse drug reactions reported with traditional medicines: analysis of data for United Nations Asia region from WHO VigiBase.

    Barvaliya, Manish J / Chetan, A C / Chandan, N / Ray, Suman Kumar / Hegde, Harsha V / Unger, Banappa S / Patel, Tejas K / Roy, Subarna

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1088841

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-05-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1088841
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Comparison of effectiveness of interventions in reducing mortality in patients of toxic epidermal necrolysis: A network meta-analysis.

    Patel, Tejas K / Patel, Parvati B / Thakkar, Sejal

    Indian journal of dermatology, venereology and leprology

    2021  Volume 87, Issue 5, Page(s) 628–644

    Abstract: Background: Limited evidence is available about effectiveness and choice of immunomodulating treatment modalities for toxic epidermal necrolysis (TEN).: Aims: To compare the effectiveness of interventions to reduce mortality in patients of toxic ... ...

    Abstract Background: Limited evidence is available about effectiveness and choice of immunomodulating treatment modalities for toxic epidermal necrolysis (TEN).
    Aims: To compare the effectiveness of interventions to reduce mortality in patients of toxic epidermal necrolysis through network meta-analysis.
    Methods: Studies were retrieved using PubMed, Google Scholar and Cochrane Database of Systematic Reviews from inception to September 18, 2018. Only English language articles were considered. Observational and randomized controlled studies having ≥ 5 TEN patients in each intervention arm were included. Two investigators independently extracted study characteristics, intervention details and mortality data. Bayesian network meta-analysis was performed using the Markov chain Monte Carlo (MCMC) approach through the random effect model. The ranking analysis was done to provide a hierarchy of interventions. The consistency between direct and indirect evidence was assessed through node spit analysis. The primary outcome was to compare the mortality [Odds ratio OR (95% credibility interval CrI)] among all treatment modalities of TEN.
    Results: Twenty-four studies satisfying the selection criteria were included. The network analysis showed improved survival with cyclosporine as compared to supportive care [OR- 0.19 (95% CrI: 0.05, 0.59)] and intravenous immunoglobulin [OR- 0.21 (95% CrI: 0.05, 0.76)]. The hierarchy of treatments based on "surface under the cumulative ranking curves" (SUCRA) value were cyclosporine (0.93), steroid+intravenous immunoglobulin (0.76), etanercept (0.59), steroids (0.46), intravenous immunoglobulin (0.40), supportive care (0.34) and thalidomide (0.02). No inconsistencies between direct and indirect estimates were observed for any of the treatment pairs.
    Limitations: Evidence is mainly based on retrospective studies.
    Conclusion: The use of cyclosporine can reduce mortality in TEN patients. Other promising immunomodulators could be steroid+intravenous immunoglobulin combination and etanercept.
    MeSH term(s) Cyclosporine/therapeutic use ; Dermatologic Agents/therapeutic use ; Etanercept/therapeutic use ; Glucocorticoids/therapeutic use ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Immunologic Factors/therapeutic use ; Immunosuppressive Agents/therapeutic use ; Stevens-Johnson Syndrome/mortality ; Stevens-Johnson Syndrome/therapy
    Chemical Substances Dermatologic Agents ; Glucocorticoids ; Immunoglobulins, Intravenous ; Immunologic Factors ; Immunosuppressive Agents ; Cyclosporine (83HN0GTJ6D) ; Etanercept (OP401G7OJC)
    Language English
    Publishing date 2021-05-06
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 416068-x
    ISSN 0973-3922 ; 0019-5162 ; 0378-6323
    ISSN (online) 0973-3922
    ISSN 0019-5162 ; 0378-6323
    DOI 10.25259/IJDVL_605_19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Mortality among patients due to adverse drug reactions that lead to hospitalization: a meta-analysis.

    Patel, Tejas K / Patel, Parvati B

    European journal of clinical pharmacology

    2018  Volume 74, Issue 6, Page(s) 819–832

    Abstract: Purpose: The aim of this study was to estimate the prevalence of mortality among patients due to adverse drug reactions that lead to hospitalisation (fatal ADR: Methods: We identified prospective ADR: Results: Among 312 full-text articles assessed, ...

    Abstract Purpose: The aim of this study was to estimate the prevalence of mortality among patients due to adverse drug reactions that lead to hospitalisation (fatal ADR
    Methods: We identified prospective ADR
    Results: Among 312 full-text articles assessed, 49 studies satisfied the selection criteria and were included in the analysis. The mean prevalence of fatal ADR
    Conclusions: ADR
    MeSH term(s) Bias ; Drug-Related Side Effects and Adverse Reactions/mortality ; Hospitalization/statistics & numerical data ; Humans ; Prevalence
    Language English
    Publishing date 2018-03-19
    Publishing country Germany
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 121960-1
    ISSN 1432-1041 ; 0031-6970
    ISSN (online) 1432-1041
    ISSN 0031-6970
    DOI 10.1007/s00228-018-2441-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Renin-angiotensin-aldosterone system blockers and region-specific variations in COVID-19 outcomes: findings from a systematic review and meta-analysis.

    Kaur, Upinder / Chakrabarti, Sankha Shubhra / Patel, Tejas K

    Therapeutic advances in drug safety

    2021  Volume 12, Page(s) 20420986211011345

    Abstract: Background and aims: Coronavirus disease 2019 (COVID-19) has been observed to cause a high mortality in people with cardiometabolic diseases. Renin-angiotensin-aldosterone system (RAAS) blockers enhance the expression of ACE2, the binding receptor of ... ...

    Abstract Background and aims: Coronavirus disease 2019 (COVID-19) has been observed to cause a high mortality in people with cardiometabolic diseases. Renin-angiotensin-aldosterone system (RAAS) blockers enhance the expression of ACE2, the binding receptor of SARS-CoV-2, and can enhance viral infectivity. We aim to provide a pooled estimate of the effect of RAAS blockers on COVID-19 outcomes.
    Methods: A literature search was performed using MEDLINE/PubMed, Google Scholar and preprint servers. All clinical studies analyzing the effect of RAAS blockers on clinical outcomes in COVID-19 patients were included in this study. Newcastle-Ottawa scale was used for quality assessment of studies. MOOSE checklist was followed. Mortality and severity outcomes were recorded as pooled odds ratio (OR) with 95% Confidence Intervals (CIs) and level of heterogeneity (
    Results: In total 47 published studies were included in the final analysis, with a total of 26,432 patients from 31 studies in mortality analysis and 20,127 patients from 23 studies in severity analysis. No increased risk of mortality [Pooled OR 0.91 (0.65-1.26),
    Conclusion: RAAS blockers are not associated with increased mortality in COVID-19 patients and should be continued in hypertensives. US and European patients are at higher risk of severe outcomes. Pharmacogenetic differences may explain the ethnicity-related variations.
    Plain language summary: Effect of RAAS-blocking medicines on COVID-19
    Language English
    Publishing date 2021-05-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2583589-0
    ISSN 2042-0994 ; 2042-0986
    ISSN (online) 2042-0994
    ISSN 2042-0986
    DOI 10.1177/20420986211011345
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Impact of suspected adverse drug reactions on mortality and length of hospital stay in the hospitalised patients: a meta-analysis.

    Patel, Tejas K / Patel, Parvati B / Bhalla, Hira Lal / Dwivedi, Priyanka / Bajpai, Vijeta / Kishore, Surekha

    European journal of clinical pharmacology

    2022  

    Abstract: Purpose: To estimate the risk of mortality and length of stay in hospitalised patients who have experienced suspected adverse drug reactions (ADRs) as compared to patients who did not experience suspected ADRs.: Methods: A systematic literature ... ...

    Abstract Purpose: To estimate the risk of mortality and length of stay in hospitalised patients who have experienced suspected adverse drug reactions (ADRs) as compared to patients who did not experience suspected ADRs.
    Methods: A systematic literature search was conducted on databases for observational and randomised controlled studies conducted in any inpatient setting that reported deaths and/or length of hospital stay in patients who had suspected ADRs and did not have suspected ADRs during hospitalisation. PRISMA guidelines were strictly followed during the review. The methodological quality of included studies was assessed using a tool designed by Smyth et al. for the studies of adverse drug reactions. The meta-analytic summary of all-cause mortality was estimated using odds ratio-OR (95% CI) and length of stay using mean difference-MD (95% CI). Both outcomes were pooled using a random effect model (DerSimonian and Laird method). Subgroup and meta-regression were performed based on study variables: study design, age group, study ward, study region, types of suspected ADRs (ADR
    Results: After screening 475 relevant articles, 55 studies were included in this meta-analysis. Patients having suspected ADRs had reported significantly higher odds of all-cause mortality [OR: 1.50 (95% CI: 1.21-1.86; I
    Conclusion: Suspected ADRs significantly increase the risk of mortality and length of stay in hospitalised patients.
    Systematic review registration: CRD42020176320.
    Language English
    Publishing date 2022-11-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 121960-1
    ISSN 1432-1041 ; 0031-6970
    ISSN (online) 1432-1041
    ISSN 0031-6970
    DOI 10.1007/s00228-022-03419-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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