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  1. Article ; Online: Molecular Detection of

    Mohammed, Rebin Rafaat / Enferadi, Ahmad / Sidiq, Karzan R / Sarani, Saeedeh / Khademi, Peyman / Jaydari, Amin / Ahmed, Avin Kawa

    Vector borne and zoonotic diseases (Larchmont, N.Y.)

    2023  Volume 23, Issue 10, Page(s) 514–519

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-08-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2047199-3
    ISSN 1557-7759 ; 1530-3667
    ISSN (online) 1557-7759
    ISSN 1530-3667
    DOI 10.1089/vbz.2023.0022
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  2. Article ; Online: Current Speculations on the Low Incidence Rate of the COVID-19 among Children

    Dana Khdr Sabir / Karzan R Sidiq / Shakhawan M Ali

    International Journal of School Health, Vol 7, Iss 2, Pp 61-

    2020  Volume 62

    Abstract: ...

    Abstract .
    Keywords covid-19 ; sars-cov-2 ; children ; immunity ; immunization ; vaccination ; Public aspects of medicine ; RA1-1270 ; covid19
    Language English
    Publishing date 2020-04-01T00:00:00Z
    Publisher Shiraz University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Does Early Childhood Vaccination Protect Against COVID-19?

    Sidiq, Karzan R / Sabir, Dana Khdr / Ali, Shakhawan M / Kodzius, Rimantas

    Frontiers in molecular biosciences

    2020  Volume 7, Page(s) 120

    Abstract: The coronavirus disease 2019 (COVID-19) is an on-going pandemic caused by the SARS-coronavirus-2 (SARS-CoV-2) which targets the respiratory system of humans. The published data show that children, unlike adults, are less susceptible to contracting the ... ...

    Abstract The coronavirus disease 2019 (COVID-19) is an on-going pandemic caused by the SARS-coronavirus-2 (SARS-CoV-2) which targets the respiratory system of humans. The published data show that children, unlike adults, are less susceptible to contracting the disease. This article aims at understanding why children constitute a minor group among hospitalized COVID-19 patients. Here, we hypothesize that the measles, mumps, and rubella (MMR) vaccine could provide a broad neutralizing antibody against numbers of diseases, including COVID-19. Our hypothesis is based on the 30 amino acid sequence homology between the SARS-CoV-2 Spike (S) glycoprotein (PDB: 6VSB) of both the measles virus fusion (F1) glycoprotein (PDB: 5YXW_B) and the rubella virus envelope (E1) glycoprotein (PDB: 4ADG_A). Computational analysis of the homologous region detected the sequence as antigenic epitopes in both measles and rubella. Therefore, we believe that humoral immunity, created through the MMR vaccination, provides children with advantageous protection against COVID-19 as well, however, an experimental analysis is required.
    Keywords covid19
    Language English
    Publishing date 2020-06-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2020.00120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Alanine metabolism in Bacillus subtilis.

    Sidiq, Karzan R / Chow, Man W / Zhao, Zhao / Daniel, Richard A

    Molecular microbiology

    2020  Volume 115, Issue 4, Page(s) 739–757

    Abstract: Both isomeric forms of alanine play a crucial role in bacterial growth and viability; the L-isomer of this amino acid is one of the building blocks for protein synthesis, and the D-isomer is incorporated into the bacterial cell wall. Despite a long ... ...

    Abstract Both isomeric forms of alanine play a crucial role in bacterial growth and viability; the L-isomer of this amino acid is one of the building blocks for protein synthesis, and the D-isomer is incorporated into the bacterial cell wall. Despite a long history of genetic manipulation of Bacillus subtilis using auxotrophic markers, the genes involved in alanine metabolism have not been characterized fully. In this work, we genetically characterized the major enzymes involved in B. subtilis alanine biosynthesis and identified an alanine permease, AlaP (YtnA), which we show has a major role in the assimilation of D-alanine from the environment. Our results provide explanations for the puzzling fact that growth of B. subtilis does not result in the significant accumulation of extracellular D-alanine. Interestingly, we find that in B. subtilis, unlike E. coli where multiple enzymes have a biochemical activity that can generate alanine, the primary synthetic enzyme for alanine is encoded by alaT, although a second gene, dat, can support slow growth of an L-alanine auxotroph. However, our results also show that Dat mediates the synthesis of D-alanine and its activity is influenced by the abundance of L-alanine. This work provides valuable insights into alanine metabolism that suggests that the relative abundance of D- and L-alanine might be linked with cytosolic pool of D and L-glutamate, thereby coupling protein and cell envelope synthesis with the metabolic status of the cell. The results also suggest that, although some of the purified enzymes involved in alanine biosynthesis have been shown to catalyze reversible reactions in vitro, most of them function unidirectionally in vivo.
    MeSH term(s) Alanine/metabolism ; Amino Acid Transport Systems/genetics ; Amino Acid Transport Systems/metabolism ; Bacillus subtilis/enzymology ; Bacillus subtilis/physiology ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Biosynthetic Pathways ; Membrane Transport Proteins/genetics ; Membrane Transport Proteins/metabolism ; Transaminases/metabolism
    Chemical Substances Amino Acid Transport Systems ; Bacterial Proteins ; Membrane Transport Proteins ; Transaminases (EC 2.6.1.-) ; Alanine (OF5P57N2ZX)
    Language English
    Publishing date 2020-11-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 619315-8
    ISSN 1365-2958 ; 0950-382X
    ISSN (online) 1365-2958
    ISSN 0950-382X
    DOI 10.1111/mmi.14640
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    Zs.A 2502: Show issues Location:
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  5. Article ; Online: Antimicrobial Activity of Combined Cinnamon Nanoemulsions-Antibiotics against Acinetobacter baumannii

    Dana Khdr Sabir / Karzan R. Sidiq

    Passer Journal, Vol 1, Iss 2, Pp 8-

    2019  Volume 11

    Abstract: Threats of Acinetobacter baumannii, a Gram-negative and multi-drug resistant bacterium,to the public health have recently received great attention worldwide. This is because the high incidence rate of the bacterial infections and the ability of the A. ... ...

    Abstract Threats of Acinetobacter baumannii, a Gram-negative and multi-drug resistant bacterium,to the public health have recently received great attention worldwide. This is because the high incidence rate of the bacterial infections and the ability of the A. baumannii to resist a wide range of antibiotics. This study is designed to investigate the antimicrobial activity of the cinnamon oil in water as Nano emulsions (NEs) alone and in combination with different antibiotics against clinical isolate of A. baumannii. At the beginning, the minimum inhibitory concentration (MIC) of different antibiotics and also cinnamon Nano emulsions (CNEs) are determined. Later, the synergistic effect of the CNEs with each of the studied antibiotics is also examined. Results showed that the bacterium has the highest resistant towards ampicillin (MIC = 700 µg/ml), followed by kanamycin, and gentamycin with MIC of each of the antibiotics was 200µg/ml and 150 µg/ml, respectively. Cinnamon Nano emulsions (CNEs) were also showed a profound inhibitory effect on A. baummanii. Interestingly, combinations of cinnamon Nano emulsions (CNEs) with either kanamycin or gentamycin, but not ampicillin, show a significant increase in the antimicrobial activity of each of the antibiotics compared to when they were used alone. The results of this study strongly suggest the potential application of CNEs in combination with antibiotics to overcome A. baummanii infections.
    Keywords cinnamon nanoemulsions ; multidrug resistance bacteria ; acinetobacter baumannii ; minimum inhibitory concentration ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 540
    Language English
    Publishing date 2019-09-01T00:00:00Z
    Publisher University of Garmian
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Does Early Childhood Vaccination Protect Against COVID-19?

    Sidiq, Karzan R. / Sabir, Dana Khdr / Ali, Shakhawan M. / Kodzius, Rimantas

    Frontiers in Molecular Biosciences

    2020  Volume 7

    Keywords covid19
    Publisher Frontiers Media SA
    Publishing country ch
    Document type Article ; Online
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2020.00120
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Factors Contributing to the Containment of the COVID-19 in Kurdistan Region of Iraq

    Sabir, Dana Khdr / Sidiq, Karzan R. / Abdullah, Hadi M. / Ali, Shakhawan M. / Khwarahm, Nabaz R.

    Advanced Journal of Emergency Medicine

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #679450
    Database COVID19

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  8. Article ; Online: Does Early Childhood Vaccination Protect Against COVID-19?

    Karzan R. Sidiq / Dana Khdr Sabir / Shakhawan M. Ali / Rimantas Kodzius

    Frontiers in Molecular Biosciences, Vol

    2020  Volume 7

    Abstract: The coronavirus disease 2019 (COVID-19) is an on-going pandemic caused by the SARS-coronavirus-2 (SARS-CoV-2) which targets the respiratory system of humans. The published data show that children, unlike adults, are less susceptible to contracting the ... ...

    Abstract The coronavirus disease 2019 (COVID-19) is an on-going pandemic caused by the SARS-coronavirus-2 (SARS-CoV-2) which targets the respiratory system of humans. The published data show that children, unlike adults, are less susceptible to contracting the disease. This article aims at understanding why children constitute a minor group among hospitalized COVID-19 patients. Here, we hypothesize that the measles, mumps, and rubella (MMR) vaccine could provide a broad neutralizing antibody against numbers of diseases, including COVID-19. Our hypothesis is based on the 30 amino acid sequence homology between the SARS-CoV-2 Spike (S) glycoprotein (PDB: 6VSB) of both the measles virus fusion (F1) glycoprotein (PDB: 5YXW_B) and the rubella virus envelope (E1) glycoprotein (PDB: 4ADG_A). Computational analysis of the homologous region detected the sequence as antigenic epitopes in both measles and rubella. Therefore, we believe that humoral immunity, created through the MMR vaccination, provides children with advantageous protection against COVID-19 as well, however, an experimental analysis is required.
    Keywords children ; virus ; COVID-19 ; measles ; rubella ; immunity ; Biology (General) ; QH301-705.5 ; covid19
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Does Early Childhood Vaccination Protect Against COVID-19?

    Sidiq, Karzan R. / Sabir, Dana Khdr / Ali, Shakhawan M. / Kodzius, Rimantas

    Front. Mol. Biosci.

    Abstract: The coronavirus disease 2019 (COVID-19) is an on-going pandemic caused by the SARS-coronavirus-2 (SARS-CoV-2) which targets the respiratory system of humans. The published data show that children, unlike adults, are less susceptible to contracting the ... ...

    Abstract The coronavirus disease 2019 (COVID-19) is an on-going pandemic caused by the SARS-coronavirus-2 (SARS-CoV-2) which targets the respiratory system of humans. The published data show that children, unlike adults, are less susceptible to contracting the disease. This article aims at understanding why children constitute a minor group among hospitalized COVID-19 patients. Here, we hypothesize that the measles, mumps, and rubella (MMR) vaccine could provide a broad neutralizing antibody against numbers of diseases, including COVID-19. Our hypothesis is based on the 30 amino acid sequence homology between the SARS-CoV-2 Spike (S) glycoprotein (PDB: 6VSB) of both the measles virus fusion (F1) glycoprotein (PDB: 5YXW_B) and the rubella virus envelope (E1) glycoprotein (PDB: 4ADG_A). Computational analysis of the homologous region detected the sequence as antigenic epitopes in both measles and rubella. Therefore, we believe that humoral immunity, created through the MMR vaccination, provides children with advantageous protection against COVID-19 as well, however, an experimental analysis is required.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #615537
    Database COVID19

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  10. Article ; Online: The emerging roles of NGS in clinical oncology and personalized medicine.

    Hussen, Bashdar Mahmud / Abdullah, Sara Tharwat / Salihi, Abbas / Sabir, Dana Khdr / Sidiq, Karzan R / Rasul, Mohammed Fatih / Hidayat, Hazha Jamal / Ghafouri-Fard, Soudeh / Taheri, Mohammad / Jamali, Elena

    Pathology, research and practice

    2022  Volume 230, Page(s) 153760

    Abstract: Next-generation sequencing (NGS) has been increasingly popular in genomics studies over the last decade, as new sequencing technology has been created and improved. Recently, NGS started to be used in clinical oncology to improve cancer therapy through ... ...

    Abstract Next-generation sequencing (NGS) has been increasingly popular in genomics studies over the last decade, as new sequencing technology has been created and improved. Recently, NGS started to be used in clinical oncology to improve cancer therapy through diverse modalities ranging from finding novel and rare cancer mutations, discovering cancer mutation carriers to reaching specific therapeutic approaches known as personalized medicine (PM). PM has the potential to minimize medical expenses by shifting the current traditional medical approach of treating cancer and other diseases to an individualized preventive and predictive approach. Currently, NGS can speed up in the early diagnosis of diseases and discover pharmacogenetic markers that help in personalizing therapies. Despite the tremendous growth in our understanding of genetics, NGS holds the added advantage of providing more comprehensive picture of cancer landscape and uncovering cancer development pathways. In this review, we provided a complete overview of potential NGS applications in scientific and clinical oncology, with a particular emphasis on pharmacogenomics in the direction of precision medicine treatment options.
    MeSH term(s) Animals ; Biomarkers, Tumor/genetics ; Clinical Decision-Making ; Epigenome ; Epigenomics ; Gene Expression Profiling ; Genetic Predisposition to Disease ; High-Throughput Nucleotide Sequencing ; Humans ; Neoplasms/genetics ; Neoplasms/pathology ; Neoplasms/therapy ; Pharmacogenetics ; Phenotype ; Precision Medicine ; Predictive Value of Tests ; Prognosis ; Transcriptome
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2022-01-10
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 391889-0
    ISSN 1618-0631 ; 0344-0338
    ISSN (online) 1618-0631
    ISSN 0344-0338
    DOI 10.1016/j.prp.2022.153760
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