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  1. Article: Clinical, Translational and Experimental Pharmacotherapeutics Advances.

    He, Zhiyao / Yu, Lei / Xu, Zhijie / Sun, Chenyu

    Journal of clinical medicine

    2023  Volume 12, Issue 3

    Abstract: Pharmacotherapeutics is the prevention and treatment of ailments, whether disorders or diseases, with medication [ ... ]. ...

    Abstract Pharmacotherapeutics is the prevention and treatment of ailments, whether disorders or diseases, with medication [...].
    Language English
    Publishing date 2023-02-01
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12031136
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Serological Exosome Metabolic Biopsy of Hepatocellular Carcinoma via Designed Core-Shell Nanoparticles.

    Yang, Chenyu / Chen, Haolin / Deng, Chunhui / Sun, Nianrong

    Analytical chemistry

    2024  

    Abstract: Exosome metabolite-based liquid biopsy is a promising strategy for large-scale application in practical clinics toward precise medicine. Given the current challenges in successive isolation and analysis of exosomes and their metabolites in this field, we ...

    Abstract Exosome metabolite-based liquid biopsy is a promising strategy for large-scale application in practical clinics toward precise medicine. Given the current challenges in successive isolation and analysis of exosomes and their metabolites in this field, we established a low-cost, high-throughput, and rapid platform for serological exosome metabolic biopsy of hepatocellular carcinoma (HCC) via designed core-shell nanoparticles. It starts with the efficient extraction of high-quality serum exosomes and exosome metabolic features, based on which significantly obvious sample clusters are observed by unsupervised cluster analysis. The following integration of feature selection and supervised machine learning enables the identification of six key metabolites and achieves high-performance prediction between HCC, liver cirrhosis, and healthy controls. Specifically, both sensitivity and accuracy achieve 100% among any pairwise intergroup discrimination in a blind test. The quality and reliability of six key metabolites are further evaluated and validated by using different machine learning algorithms and pathway exploration. Our platform contributes to the future growth of new liquid biopsy technologies for precision diagnosis and real-time monitoring of HCC, among other conditions.
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c02068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4033: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Ligand-mediated exciton dissociation and interparticle energy transfer on CsPbBr

    Zhong, Fengyi / Sheng, Jianping / Du, Chenyu / He, Ye / Sun, Yanjuan / Dong, Fan

    Science bulletin

    2024  Volume 69, Issue 7, Page(s) 901–912

    Abstract: Perovskite quantum dots (PQDs) hold immense potential as photocatalysts for ... ...

    Abstract Perovskite quantum dots (PQDs) hold immense potential as photocatalysts for CO
    Language English
    Publishing date 2024-01-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2816140-3
    ISSN 2095-9281 ; 2095-9273
    ISSN (online) 2095-9281
    ISSN 2095-9273
    DOI 10.1016/j.scib.2024.01.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Boosting exciton dissociation and charge transfer in CsPbBr

    Du, Chenyu / Sheng, Jianping / Zhong, Fengyi / He, Ye / Liu, Huiyu / Sun, Yanjuan / Dong, Fan

    Proceedings of the National Academy of Sciences of the United States of America

    2024  Volume 121, Issue 9, Page(s) e2315956121

    Abstract: Photo-catalytic ... ...

    Abstract Photo-catalytic CO
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2315956121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Clinical, Translational and Experimental Pharmacotherapeutics Advances

    Zhiyao He / Lei Yu / Zhijie Xu / Chenyu Sun

    Journal of Clinical Medicine, Vol 12, Iss 1136, p

    2023  Volume 1136

    Abstract: Pharmacotherapeutics is the prevention and treatment of ailments, whether disorders or diseases, with medication [.] ...

    Abstract Pharmacotherapeutics is the prevention and treatment of ailments, whether disorders or diseases, with medication [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Meclizine improves endometrial repair and reduces simulated menstrual bleeding in mice with induced adenomyosis.

    Mao, Chenyu / Liu, Xishi / Guo, Sun-Wei

    American journal of obstetrics and gynecology

    2024  

    Abstract: Background: Adenomyosis is one of the structural causes of abnormal uterine bleeding, which often presents as heavy menstrual bleeding. Mostly because of the poor understanding of its pathophysiology, medical management of adenomyosis-induced heavy ... ...

    Abstract Background: Adenomyosis is one of the structural causes of abnormal uterine bleeding, which often presents as heavy menstrual bleeding. Mostly because of the poor understanding of its pathophysiology, medical management of adenomyosis-induced heavy menstrual bleeding is still a challenge. We have previously reported that glycolysis is crucial to endometrial repair following menstruation and that suppressed glycolysis can cause heavy menstrual bleeding.
    Objective: This study aimed to test the hypothesis that meclizine, a drug with an excellent safety profile, alleviates heavy menstrual bleeding in mice with induced adenomyosis using a simulated menstruation model.
    Study design: Adenomyosis was induced in 36 female C57BL/6 mice using endometrial-myometrial interface disruption. Three months after induction, the mice were randomly divided into the following 3 groups: low-dose meclizine, high-dose meclizine, and controls. Treatment with meclizine or vehicle started shortly before the simulated menstruation procedure and ended before progesterone withdrawal. The amount of blood loss was quantified and uterine tissue was harvested for histologic evaluation of the grade of endometrial repair. We performed immunohistochemistry analysis of 4 proteins critically involved in glycolysis: Glut1 (glucose transporter 1), Hk2 (hexokinase 2), Pfkfb3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3), and Pkm2 (pyruvate kinase M2). The extent of tissue fibrosis in both ectopic and eutopic endometria was evaluated using Masson trichrome staining.
    Results: In mice with induced adenomyosis, meclizine accelerated endometrial repair in a dose-dependent manner and reduced the amount of menstrual bleeding. Meclizine administration raised endometrial immunoexpression of Hk2 and Pfkfb3 but not of Glut1 or Pkm2. The extent of endometrial fibrosis was reduced following the meclizine administration. Remarkably, these favorable changes were accompanied by the suppression of lesional progression, as evidenced by the dose-dependent reduction in the extent of fibrosis (a surrogate for lesional progression).
    Conclusion: These encouraging results, taken together, suggest that glycolysis may be a promising therapeutic target and that meclizine may hold therapeutic potential as a nonhormonal treatment for adenomyosis-induced heavy menstrual bleeding without exacerbating the disease.
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80016-8
    ISSN 1097-6868 ; 0002-9378
    ISSN (online) 1097-6868
    ISSN 0002-9378
    DOI 10.1016/j.ajog.2024.02.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Um I Zs.152: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Elbow instead of hand: is it more helpful or harmful?

    Liu, Haixia / Gao, Liang / Sun, Chenyu

    Journal of public health (Oxford, England)

    2022  Volume 43, Issue 4, Page(s) e656

    MeSH term(s) Elbow ; Elbow Joint ; Hand ; Humans
    Keywords covid19
    Language English
    Publishing date 2022-02-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2142082-8
    ISSN 1741-3850 ; 1741-3842
    ISSN (online) 1741-3850
    ISSN 1741-3842
    DOI 10.1093/pubmed/fdaa072
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2186: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Shifts from

    Yu, Runxian / Sun, Chenyu / Liu, Ying / Zhou, Renchao

    PeerJ

    2021  Volume 9, Page(s) e12260

    Abstract: ... Shifts ... ...

    Abstract Shifts from
    Language English
    Publishing date 2021-10-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703241-3
    ISSN 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.12260
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Chromosomal-level genome assembly of

    Zhong, Yan / Wu, Wei / Sun, Chenyu / Zou, Peishan / Liu, Ying / Dai, Seping / Zhou, Renchao

    Frontiers in plant science

    2023  Volume 14, Page(s) 1126319

    Abstract: ... ...

    Abstract Melastoma
    Language English
    Publishing date 2023-01-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2023.1126319
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Experimental study on the effect of Coumarone resin on the performance of SBS-modified asphalt.

    Feng, Chenyu / Hu, Chunhua / Sun, Zhaobin / Zhang, Hao / Xu, Zhaozhao

    PloS one

    2024  Volume 19, Issue 4, Page(s) e0301528

    Abstract: An inexpensive and high-performing solid Coumarone resin was added to Styrene-butadiene-styrene (SBS) copolymer-modified asphalt to enhance its storage stability and road performance. To assess the effect of Coumarone resin dosage on the SBS-modified ... ...

    Abstract An inexpensive and high-performing solid Coumarone resin was added to Styrene-butadiene-styrene (SBS) copolymer-modified asphalt to enhance its storage stability and road performance. To assess the effect of Coumarone resin dosage on the SBS-modified asphalt, a series of laboratory tests were conducted. The composite modified asphalt's segregation test was used to evaluate its storage stability, Dynamic Shear Rheometer (DSR) and Multiple Stress Creep Recovery (MSCR) tests were employed to investigate its high-temperature performance and permanent deformation resistance, and the Bending Beam Rheology (BBR) test was utilized to measure its low-temperature performance. Fluorescence microscopy was used to observe the composite modified asphalt's microstructure, and Fourier Transform Infrared Spectroscopy (FTIR) was conducted to study the changes in chemical structure during the modification process. The results showed that Coumarone resin can improve the compatibility of SBS and asphalt, improve the high-temperature performance and deformation resistance of SBS-modified asphalt, and adding an appropriate amount of Coumarone resin can help enhance the low-temperature cracking resistance of modified asphalt. The optimal dosage of Coumarone resin recommended for SBS-modified asphalt performance enhancement is 2% under the test conditions, as determined by comparing the test results of samples with various dosages.
    MeSH term(s) Hydrocarbons ; Benzofurans ; Styrene ; Cold Temperature ; Resins, Plant
    Chemical Substances asphalt (8052-42-4) ; Hydrocarbons ; Benzofurans ; Styrene (44LJ2U959V) ; Resins, Plant
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0301528
    Database MEDical Literature Analysis and Retrieval System OnLINE

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