LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 28

Search options

  1. Article ; Online: An Intraocular Spectacle.

    Adeghate, Jennifer / Goldburg, Samantha R / Kaden, Talia R

    Ophthalmology. Retina

    2023  Volume 7, Issue 8, Page(s) 736

    MeSH term(s) Humans ; Eyeglasses ; Refraction, Ocular ; Visual Acuity
    Language English
    Publishing date 2023-05-17
    Publishing country United States
    Document type Journal Article
    ISSN 2468-6530
    ISSN (online) 2468-6530
    DOI 10.1016/j.oret.2023.04.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: An Update on the Molecular and Cellular Basis of Pharmacotherapy in Type 2 Diabetes Mellitus.

    Mahgoub, Mohamed Omer / Ali, Ifrah Ismail / Adeghate, Jennifer O / Tekes, Kornélia / Kalász, Huba / Adeghate, Ernest A

    International journal of molecular sciences

    2023  Volume 24, Issue 11

    Abstract: Diabetes mellitus (DM) is a chronic illness with an increasing global prevalence. More than 537 million cases of diabetes were reported worldwide in 2021, and the number is steadily increasing. The worldwide number of people suffering from DM is ... ...

    Abstract Diabetes mellitus (DM) is a chronic illness with an increasing global prevalence. More than 537 million cases of diabetes were reported worldwide in 2021, and the number is steadily increasing. The worldwide number of people suffering from DM is projected to reach 783 million in 2045. In 2021 alone, more than USD 966 billion was spent on the management of DM. Reduced physical activity due to urbanization is believed to be the major cause of the increase in the incidence of the disease, as it is associated with higher rates of obesity. Diabetes poses a risk for chronic complications such as nephropathy, angiopathy, neuropathy and retinopathy. Hence, the successful management of blood glucose is the cornerstone of DM therapy. The effective management of the hyperglycemia associated with type 2 diabetes includes physical exercise, diet and therapeutic interventions (insulin, biguanides, second generation sulfonylureas, glucagon-like peptide 1 agonists, dipeptidyl-peptidase 4 inhibitors, thiazolidinediones, amylin mimetics, meglitinides, α-glucosidase inhibitors, sodium-glucose cotransporter-2 inhibitors and bile acid sequestrants). The optimal and timely treatment of DM improves the quality of life and reduces the severe burden of the disease for patients. Genetic testing, examining the roles of different genes involved in the pathogenesis of DM, may also help to achieve optimal DM management in the future by reducing the incidence of DM and by enhancing the use of individualized treatment regimens.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/complications ; Hypoglycemic Agents/therapeutic use ; Hypoglycemic Agents/pharmacology ; Quality of Life ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Dipeptidyl-Peptidase IV Inhibitors/pharmacology ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use
    Chemical Substances Hypoglycemic Agents ; Sodium-Glucose Transporter 2 Inhibitors ; Dipeptidyl-Peptidase IV Inhibitors
    Language English
    Publishing date 2023-05-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24119328
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Boucher-Neuhauser Syndrome: Chorioretinal Changes in a Single Case Over Time.

    Adeghate, Jennifer O / Sherman, Jerome / Bass, Sherry / Liu, James / Hufnagel, Robert B / Yannuzzi, Lawrence A

    Retinal cases & brief reports

    2024  

    Abstract: Purpose: To describe chorioretinal changes in a single case of Boucher-Neuhauser Syndrome (BNHS) over 45 years of follow-up. Methods: Retrospective chart review was performed. Color fundus photography from 1977 to 2003 was obtained and digitized. ... ...

    Abstract Purpose: To describe chorioretinal changes in a single case of Boucher-Neuhauser Syndrome (BNHS) over 45 years of follow-up. Methods: Retrospective chart review was performed. Color fundus photography from 1977 to 2003 was obtained and digitized. Current fundus photography was obtained with widefield imaging. High-resolution spectral-domain optical coherence tomography (OCT) was performed. Genetic analysis was performed using an inherited retinal disorders panel. Results: Fundus examination demonstrated central chorioretinal atrophy with sclerotic choroidal vessels. Short posterior ciliary arteries became more prominent and tortuous over time. Mid-peripheral atrophy extends to the equator and demonstrates a scalloped pattern with islands of atrophy intervening with areas of normal retina. The far periphery remained minimally affected. High-resolution OCT demonstrated outer retinal atrophy and choriocapillaris loss. Genetic testing showed a homozygous variant for PNPLA6 and a heterozygous variant for TYRP1. Conclusion: Chorioretinal changes in BNHS vary in onset and severity. It is important to diagnose this condition in order to begin timely management of visual and systemic sequelae.
    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Journal Article
    ISSN 1937-1578
    ISSN (online) 1937-1578
    DOI 10.1097/ICB.0000000000001556
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Repair of a Tractional Retinal Detachment in the Setting of an Idiopathic Vasoproliferative Tumor.

    Adeghate, Jennifer O / Goldburg, Samantha R / Marr, Brian / Sheyman, Alan / Winokur, Jules / Kaden, Talia R

    Ophthalmic surgery, lasers & imaging retina

    2023  Volume 54, Issue 8, Page(s) 485–488

    Abstract: Vasoproliferative tumors (VPT) are benign retinal lesions that may cause epiretinal membrane proliferation and tractional retinal detachments (TRD). We describe a case of a 71-year-old woman who presented with a macula involving TRD in the setting of a ... ...

    Abstract Vasoproliferative tumors (VPT) are benign retinal lesions that may cause epiretinal membrane proliferation and tractional retinal detachments (TRD). We describe a case of a 71-year-old woman who presented with a macula involving TRD in the setting of a VPT. Given the limited number of publications on the management of these cases, we aim to articulate some principles we believe may be helpful in planning a surgical approach that maximizes postoperative anatomic and functional outcomes. We hope that our video provides useful guidance in preparing the vitreoretinal surgeon for managing this uncommon entity.
    MeSH term(s) Female ; Humans ; Aged ; Retinal Detachment/diagnosis ; Retinal Detachment/etiology ; Retinal Detachment/surgery ; Vitrectomy/methods ; Retinal Diseases/surgery ; Neoplasms/complications ; Neoplasms/surgery ; Epiretinal Membrane/complications ; Epiretinal Membrane/diagnosis ; Epiretinal Membrane/surgery ; Retrospective Studies
    Language English
    Publishing date 2023-08-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2701167-7
    ISSN 2325-8179 ; 2325-8160
    ISSN (online) 2325-8179
    ISSN 2325-8160
    DOI 10.3928/23258160-20230726-02
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 756: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Gut dysbiosis, insulin resistance and Alzheimer's disease: review of a novel approach to neurodegeneration.

    Lazar, Evelyn / Sherzai, Ayesha / Adeghate, Jennifer / Sherzai, Dean

    Frontiers in bioscience (Scholar edition)

    2021  Volume 13, Issue 1, Page(s) 17–29

    Abstract: Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) share many common features including inflammation, oxidative stress and neuronal degeneration. Insulin resistance (IR) appears to be a common path in these pathological processes. IR is an ... ...

    Abstract Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) share many common features including inflammation, oxidative stress and neuronal degeneration. Insulin resistance (IR) appears to be a common path in these pathological processes. IR is an early pathogenic event in AD, which leads to augmentation of hyperphosphorylated tau and Amyloid beta (Aβ). The reviewed studies related to AD have revealed a positive association between T2DM and AD. This association was maintained in peripheral hyperinsulinemia cases without the presence of T2DM, which might be due to decreased insulin transport to the brain or the inadequate cerebral insulin production. Gut dysbiosis induces inflammation and consequently provokes both peripheral and cerebral IR and can amplify processes promoting AD. Additionally, the risk of increased progression of AD was revealed due to pre-diabetes, T2DM and gut dysbiosis. The pro-inflammatory changes might affect progression of AD pathology by inhibition of the autophago-lysosomal pathway and cerebral insulin signaling pathway. This review elaborates the role that cerebral IR might play in the underlying pathological events in AD.
    MeSH term(s) Alzheimer Disease/metabolism ; Alzheimer Disease/microbiology ; Amyloid beta-Peptides/metabolism ; Brain/metabolism ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/microbiology ; Dysbiosis ; Humans ; Insulin Resistance
    Chemical Substances Amyloid beta-Peptides
    Language English
    Publishing date 2021-07-10
    Publishing country Singapore
    Document type Journal Article ; Review
    ZDB-ID 2565100-6
    ISSN 1945-0524 ; 1945-0516
    ISSN (online) 1945-0524
    ISSN 1945-0516
    DOI 10.52586/S550
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 7071: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Early (5-Day) Onset of Diabetes Mellitus Causes Degeneration of Photoreceptor Cells, Overexpression of Incretins, and Increased Cellular Bioenergetics in Rat Retina.

    Adeghate, Jennifer O / D'Souza, Crystal / Kántor, Orsolya / Tariq, Saeed / Souid, Abdul-Kader / Adeghate, Ernest

    Cells

    2021  Volume 10, Issue 8

    Abstract: The effects of early (5-day) onset of diabetes mellitus (DM) on retina ultrastructure and cellular bioenergetics were examined. The retinas of streptozotocin-induced diabetic rats were compared to those of non-diabetic rats using light and transmission ... ...

    Abstract The effects of early (5-day) onset of diabetes mellitus (DM) on retina ultrastructure and cellular bioenergetics were examined. The retinas of streptozotocin-induced diabetic rats were compared to those of non-diabetic rats using light and transmission electron microscopy. Tissue localization of glucagon-like-peptide-1 (GLP-1), exendin-4 (EXE-4), and catalase (CAT) in non-diabetic and diabetic rat retinas was conducted using immunohistochemistry, while the retinal and plasma concentration of GLP-1, EXE-4, and CAT were measured with ELISA. Lipid profiles and kidney and liver function markers were measured from the blood of non-diabetic and diabetic rats with an automated biochemical analyzer. Oxygen consumption was monitored using a phosphorescence analyzer, and the adenosine triphosphate (ATP) level was determined using the Enliten ATP assay kit. Blood glucose and cholesterol levels were significantly higher in diabetic rats compared to control. The number of degenerated photoreceptor cells was significantly higher in the diabetic rat retina. Tissue levels of EXE-4, GLP-1 and CAT were significantly (
    MeSH term(s) Adenosine Triphosphate/metabolism ; Animals ; Biomarkers/blood ; Blood Glucose/analysis ; Catalase/blood ; Catalase/metabolism ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/pathology ; Glucagon-Like Peptide 1/blood ; Glucagon-Like Peptide 1/metabolism ; Incretins/blood ; Incretins/genetics ; Incretins/metabolism ; Male ; Microscopy, Electron, Transmission ; Oxygen Consumption ; Photoreceptor Cells/cytology ; Photoreceptor Cells/metabolism ; Rats ; Rats, Wistar ; Retina/metabolism ; Retina/pathology ; Retina/ultrastructure
    Chemical Substances Biomarkers ; Blood Glucose ; Incretins ; Glucagon-Like Peptide 1 (89750-14-1) ; Adenosine Triphosphate (8L70Q75FXE) ; Catalase (EC 1.11.1.6)
    Language English
    Publishing date 2021-08-04
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10081981
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Retinal neovascularization in Susac's syndrome: A rare imaging finding.

    Adeghate, Jennifer O / Bonhomme, Gabrielle R / Indermill, Chad / Taylor, Steven L / Rocha, Marcelo / Moghadam-Kia, Siamak / Errera, Marie-Hélène

    Oman journal of ophthalmology

    2023  Volume 16, Issue 3, Page(s) 570–572

    Language English
    Publishing date 2023-10-18
    Publishing country India
    Document type Journal Article
    ZDB-ID 2484272-2
    ISSN 0974-7842 ; 0974-620X
    ISSN (online) 0974-7842
    ISSN 0974-620X
    DOI 10.4103/ojo.ojo_330_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: An Update on the Molecular and Cellular Basis of Pharmacotherapy in Type 2 Diabetes Mellitus

    Mohamed Omer Mahgoub / Ifrah Ismail Ali / Jennifer O. Adeghate / Kornélia Tekes / Huba Kalász / Ernest A. Adeghate

    International Journal of Molecular Sciences, Vol 24, Iss 9328, p

    2023  Volume 9328

    Abstract: Diabetes mellitus (DM) is a chronic illness with an increasing global prevalence. More than 537 million cases of diabetes were reported worldwide in 2021, and the number is steadily increasing. The worldwide number of people suffering from DM is ... ...

    Abstract Diabetes mellitus (DM) is a chronic illness with an increasing global prevalence. More than 537 million cases of diabetes were reported worldwide in 2021, and the number is steadily increasing. The worldwide number of people suffering from DM is projected to reach 783 million in 2045. In 2021 alone, more than USD 966 billion was spent on the management of DM. Reduced physical activity due to urbanization is believed to be the major cause of the increase in the incidence of the disease, as it is associated with higher rates of obesity. Diabetes poses a risk for chronic complications such as nephropathy, angiopathy, neuropathy and retinopathy. Hence, the successful management of blood glucose is the cornerstone of DM therapy. The effective management of the hyperglycemia associated with type 2 diabetes includes physical exercise, diet and therapeutic interventions (insulin, biguanides, second generation sulfonylureas, glucagon-like peptide 1 agonists, dipeptidyl-peptidase 4 inhibitors, thiazolidinediones, amylin mimetics, meglitinides, α-glucosidase inhibitors, sodium-glucose cotransporter-2 inhibitors and bile acid sequestrants). The optimal and timely treatment of DM improves the quality of life and reduces the severe burden of the disease for patients. Genetic testing, examining the roles of different genes involved in the pathogenesis of DM, may also help to achieve optimal DM management in the future by reducing the incidence of DM and by enhancing the use of individualized treatment regimens.
    Keywords type 2 diabetes mellitus ; insulin resistance ; diabetes complications ; hyperglycemia ; physical activity ; diet ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 571
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: Tackling type 2 diabetes-associated cardiovascular and renal comorbidities: a key challenge for drug development.

    Adeghate, Ernest A / Kalász, Huba / Al Jaberi, Saeeda / Adeghate, Jennifer / Tekes, Kornelia

    Expert opinion on investigational drugs

    2020  Volume 30, Issue 2, Page(s) 85–93

    MeSH term(s) Animals ; Cardiovascular Diseases/prevention & control ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Diabetic Nephropathies/prevention & control ; Drug Development ; Humans ; Hypoglycemic Agents/therapeutic use
    Chemical Substances Hypoglycemic Agents
    Language English
    Publishing date 2020-12-28
    Publishing country England
    Document type Editorial
    ZDB-ID 1182884-5
    ISSN 1744-7658 ; 0967-8298 ; 1354-3784
    ISSN (online) 1744-7658
    ISSN 0967-8298 ; 1354-3784
    DOI 10.1080/13543784.2021.1865914
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3739: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Gut dysbiosis, insulin resistance and Alzheimer’s disease

    Evelyn Lazar / Ayesha Sherzai / Jennifer Adeghate / Dean Sherzai

    Frontiers in Bioscience-Scholar, Vol 13, Iss 1, Pp 17-

    review of a novel approach to neurodegeneration

    2021  Volume 29

    Abstract: Alzheimer’s disease (AD) and type 2 diabetes mellitus (T2DM) share many common features including inflammation, oxidative stress and neuronal degeneration. Insulin resistance (IR) appears to be a common path in these pathological processes. IR is an ... ...

    Abstract Alzheimer’s disease (AD) and type 2 diabetes mellitus (T2DM) share many common features including inflammation, oxidative stress and neuronal degeneration. Insulin resistance (IR) appears to be a common path in these pathological processes. IR is an early pathogenic event in AD, which leads to augmentation of hyperphosphorylated tau and Amyloid beta (Aβ). The reviewed studies related to AD have revealed a positive association between T2DM and AD. This association was maintained in peripheral hyperinsulinemia cases without the presence of T2DM, which might be due to decreased insulin transport to the brain or the inadequate cerebral insulin production. Gut dysbiosis induces inflammation and consequently provokes both peripheral and cerebral IR and can amplify processes promoting AD. Additionally, the risk of increased progression of AD was revealed due to pre-diabetes, T2DM and gut dysbiosis. The pro-inflammatory changes might affect progression of AD pathology by inhibition of the autophago-lysosomal pathway and cerebral insulin signaling pathway. This review elaborates the role that cerebral IR might play in the underlying pathological events in AD.
    Keywords alzheimer’s disease ; type 2 diabetes mellitus ; gut dysbiosis ; brain insulin resistance ; peripheral insulin resistance ; Biology (General) ; QH301-705.5 ; Biochemistry ; QD415-436
    Subject code 571
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher IMR Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top