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  1. Book ; Online ; E-Book: Febrile seizures

    Baram, Tallie Z. / Shinnar, S. / Stafstrom, Carl E.

    new concepts and consequences

    2022  

    Author's details Tallie Z. Baram, Shlomo Shinnar, and Carl E. Stafstrom
    Keywords Fever/Treatment ; Fever/Immunological aspects
    Subject code 616.047
    Language English
    Size 1 online resource (370 pages)
    Edition 2nd ed.
    Publisher Elsevier
    Publishing place Amsterdam, Netherlands
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-323-98418-5 ; 9780323899321 ; 978-0-323-98418-8 ; 0323899323
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Principles of emotional brain circuit maturation.

    Birnie, Matthew T / Baram, Tallie Z

    Science (New York, N.Y.)

    2022  Volume 376, Issue 6597, Page(s) 1055–1056

    Abstract: Early-life environmental signals contribute to how the brain handles reward, stress, and fear. ...

    Abstract Early-life environmental signals contribute to how the brain handles reward, stress, and fear.
    MeSH term(s) Afferent Pathways/growth & development ; Afferent Pathways/physiology ; Brain/growth & development ; Brain/physiology ; Emotions ; Fear ; Humans ; Memory/physiology ; Reward ; Stress, Psychological/psychology ; Synapses/physiology
    Language English
    Publishing date 2022-06-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abn4016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 27: Show issues Location:
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    Zs.MG 77: Show issues

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  3. Book: Febrile seizures

    Baram, Tallie Z.

    2002  

    Author's details ed. by Tallie Z. Baram
    Keywords Fieberkrampf
    Subject Fieberfraisen ; Initialkrampf ; Infektkrampf ; Fieberanfall
    Language English
    Size XXIII, 337 S. : Ill., graph. Darst.
    Publisher Acad. Press
    Publishing place San Diego u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT013196596
    ISBN 0-12-078141-7 ; 978-0-12-078141-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2001 A 5709 order for loan Magazin

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  4. Article ; Online: Genetic Tagging Uncovers a Robust, Selective Activation of the Thalamic Paraventricular Nucleus by Adverse Experiences Early in Life.

    Kooiker, Cassandra L / Chen, Yuncai / Birnie, Matthew T / Baram, Tallie Z

    Biological psychiatry global open science

    2023  Volume 3, Issue 4, Page(s) 746–755

    Abstract: Background: Early-life adversity (ELA) is associated with increased risk for mood disorders, including depression and substance use disorders. These disorders are characterized by impaired reward-related behaviors, suggesting compromised operations of ... ...

    Abstract Background: Early-life adversity (ELA) is associated with increased risk for mood disorders, including depression and substance use disorders. These disorders are characterized by impaired reward-related behaviors, suggesting compromised operations of reward-related brain circuits. However, the brain regions engaged by ELA that mediate these enduring consequences of ELA remain largely unknown. In an animal model of ELA, we identified aberrant reward-seeking behaviors, a discovery that provides a framework for assessing the underlying circuits.
    Methods: Employing TRAP2 (targeted recombination in active populations) male and female mice, in which neurons activated within a defined time frame are permanently tagged, we compared ELA- and control-reared mice, assessing the quantity and distribution of ELA-related neuronal activation. After validating the TRAP2 results using native c-Fos labeling, we defined the molecular identity of this population of activated neurons.
    Results: We uniquely demonstrated that the TRAP2 system is feasible and efficacious in neonatal mice. Surprisingly, the paraventricular nucleus of the thalamus was robustly and almost exclusively activated by ELA and was the only region distinguishing ELA from typical rearing. Remarkably, a large proportion of ELA-activated paraventricular nucleus of the thalamus neurons expressed CRF
    Conclusions: The paraventricular nucleus of the thalamus, an important component of reward circuits that is known to encode remote, emotionally salient experiences to influence future motivated behaviors, encodes adverse experiences as remote as those occurring during the early postnatal period and is thus poised to contribute to the enduring deficits in reward-related behaviors consequent to ELA.
    Language English
    Publishing date 2023-01-24
    Publishing country United States
    Document type Journal Article
    ISSN 2667-1743
    ISSN (online) 2667-1743
    DOI 10.1016/j.bpsgos.2023.01.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Intra-individual changes in methylome profiles: an epigenetic 'scar' of early-life adversity?

    Mortazavi, Ali / Baram, Tallie Z

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

    2019  Volume 45, Issue 1, Page(s) 218

    MeSH term(s) Adverse Childhood Experiences/psychology ; Epigenesis, Genetic/genetics ; Epigenome/genetics ; Humans ; Individuality
    Language English
    Publishing date 2019-01-18
    Publishing country England
    Document type News ; Research Support, N.I.H., Extramural
    ZDB-ID 639471-1
    ISSN 1740-634X ; 0893-133X
    ISSN (online) 1740-634X
    ISSN 0893-133X
    DOI 10.1038/s41386-019-0496-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2379: Show issues Location:
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  6. Article ; Online: Inhibition of Neuron Restrictive Silencing Factor (REST/NRSF) Chromatin Binding Attenuates Epileptogenesis.

    Hall, Alicia M / Kamei, Noriko / Shao, Manlin / Mun, Hyun-Seung / Chen, Kevin / Chen, Yuncai / Baram, Tallie Z

    eNeuro

    2024  

    Abstract: The mechanisms by which brain insults lead to subsequent epilepsy remain unclear. Insults including trauma, stroke, infections and long seizures (status epilepticus; SE) increase the nuclear expression and chromatin binding of the neuronal restrictive ... ...

    Abstract The mechanisms by which brain insults lead to subsequent epilepsy remain unclear. Insults including trauma, stroke, infections and long seizures (status epilepticus; SE) increase the nuclear expression and chromatin binding of the neuronal restrictive silencing factor / RE-1 silencing transcription factor (NRSF/REST). REST/NRSF orchestrates major disruption of the expression of key neuronal genes, including ion channels and neurotransmitter receptors, potentially contributing to epileptogenesis. Accordingly, transient interference with REST/NRSF chromatin binding after an epilepsy-provoking SE suppressed spontaneous seizures for the 12- day duration of a prior study. However, whether the onset of epileptogenesis was suppressed or only delayed has remained unresolved. The current experiments determined if transient interference with REST/NRSF chromatin binding prevented epileptogenesis enduringly, or, alternatively, slowed epilepsy onset.Epileptogenesis was elicited in adult male rats via systemic kainic acid-induced SE (KA-SE). We then determined if decoy, NRSF-binding-motif oligodeoxynucleotides (NRSE-ODNs), given twice following KA-SE (a) prevented REST/NRSF binding to chromatin, using chromatin immunoprecipitation; (b) prevented the onset of spontaneous seizures, measured with chronic digital video-EEG.Blocking NRSF function transiently after KA-SE significantly lengthened the latent period to a first spontaneous seizure. Whereas this intervention did not influence the duration and severity of spontaneous seizures, total seizure number and seizure burden were lower in the NRSE- ODN compared with scrambled-ODN cohorts.Transient interference with REST/NRSF function after KA-SE delays and moderately attenuates insult-related hippocampal epilepsy, but does not abolish it. Thus, the anticonvulsant and antiepileptogenic actions of NRSF are but one of the multifactorial mechanisms generating epilepsy in the adult brain.
    Language English
    Publishing date 2024-04-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2800598-3
    ISSN 2373-2822 ; 2373-2822
    ISSN (online) 2373-2822
    ISSN 2373-2822
    DOI 10.1523/ENEURO.0006-24.2024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Corrigendum: Functional Connectivity of the Human Paraventricular Thalamic Nucleus: Insights From High Field Functional MRI.

    Kark, Sarah M / Birnie, Matthew T / Baram, Tallie Z / Yassa, Michael A

    Frontiers in integrative neuroscience

    2021  Volume 15, Page(s) 724071

    Abstract: This corrects the article DOI: 10.3389/fnint.2021.662293.]. ...

    Abstract [This corrects the article DOI: 10.3389/fnint.2021.662293.].
    Language English
    Publishing date 2021-07-26
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2452962-X
    ISSN 1662-5145
    ISSN 1662-5145
    DOI 10.3389/fnint.2021.724071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Infant hedonic/anhedonic processing index (HAPI-Infant): Assessing infant anhedonia and its prospective association with adolescent depressive symptoms.

    Irwin, Jessica L / Davis, Elysia Poggi / Sandman, Curt A / Baram, Tallie Z / Stern, Hal S / Glynn, Laura M

    Journal of affective disorders

    2024  Volume 352, Page(s) 281–287

    Abstract: Background: Anhedonia, an impairment in the motivation for or experience of pleasure, is a well-established transdiagnostic harbinger and core symptom of mental illness. Given increasing recognition of early life origins of mental illness, we posit that ...

    Abstract Background: Anhedonia, an impairment in the motivation for or experience of pleasure, is a well-established transdiagnostic harbinger and core symptom of mental illness. Given increasing recognition of early life origins of mental illness, we posit that anhedonia should, and could, be recognized earlier if appropriate tools were available. However, reliable diagnostic instruments prior to childhood do not currently exist.
    Methods: We developed an assessment instrument for anhedonia/reward processing in infancy, the Infant Hedonic/Anhedonic Processing Index (HAPI-Infant). Exploratory factor and psychometric analyses were conducted using data from 6- and 12-month-old infants from two cohorts (N = 188, N = 212). Then, associations were assessed between infant anhedonia and adolescent self-report of depressive symptoms.
    Results: The HAPI-Infant (47-items), exhibited excellent psychometric properties. Higher anhedonia scores at 6 (r = 0.23, p < .01) and 12 months (r = 0.19, p < .05) predicted elevated adolescent depressive symptoms, and these associations were stronger than for established infant risk indicators such as negative affectivity. Subsequent analyses supported the validity of short (27-item) and very short (12-item) versions of this measure.
    Limitations: The primary limitations of this study are that the HAPI-Infant awaits additional tests of generalizability and of its ability to predict clinical diagnosis of depression.
    Conclusions: The HAPI-Infant is a novel, psychometrically strong diagnostic tool suitable for recognizing anhedonia during the first year of life with strong predictive value for later depressive symptoms. In view of the emerging recognition of increasing prevalence of affective disorders in children and adolescents, the importance of the HAPI-Infant in diagnosing anhedonia is encouraging. Early recognition of anhedonia could target high-risk individuals for intervention and perhaps prevention of mental health disorders.
    MeSH term(s) Child ; Humans ; Adolescent ; Infant ; Anhedonia ; Depression/diagnosis ; Depression/epidemiology ; Depressive Disorder, Major/psychology ; Psychometrics ; Self Report
    Language English
    Publishing date 2024-02-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2024.01.225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1485: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article: The Developmental Origins of Opioid Use Disorder and Its Comorbidities.

    Levis, Sophia C / Mahler, Stephen V / Baram, Tallie Z

    Frontiers in human neuroscience

    2021  Volume 15, Page(s) 601905

    Abstract: Opioid use disorder (OUD) rarely presents as a unitary psychiatric condition, and the comorbid symptoms likely depend upon the diverse risk factors and mechanisms by which OUD can arise. These factors are heterogeneous and include genetic predisposition, ...

    Abstract Opioid use disorder (OUD) rarely presents as a unitary psychiatric condition, and the comorbid symptoms likely depend upon the diverse risk factors and mechanisms by which OUD can arise. These factors are heterogeneous and include genetic predisposition, exposure to prescription opioids, and environmental risks. Crucially, one key environmental risk factor for OUD is early life adversity (ELA). OUD and other substance use disorders are widely considered to derive in part from abnormal reward circuit function, which is likely also implicated in comorbid mental illnesses such as depression, bipolar disorder, and schizophrenia. ELA may disrupt reward circuit development and function in a manner predisposing to these disorders. Here, we describe new findings addressing the effects of ELA on reward circuitry that lead to OUD and comorbid disorders, potentially
    Language English
    Publishing date 2021-02-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2425477-0
    ISSN 1662-5161
    ISSN 1662-5161
    DOI 10.3389/fnhum.2021.601905
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The Paraventricular Thalamus: A Potential Sensor and Integrator of Emotionally Salient Early-Life Experiences.

    Kooiker, Cassandra L / Birnie, Matthew T / Baram, Tallie Z

    Frontiers in behavioral neuroscience

    2021  Volume 15, Page(s) 673162

    Abstract: Early-life experiences influence a broad spectrum of behaviors throughout the lifespan that contribute to resilience or vulnerability to mental health disorders. Yet, how emotionally salient experiences early in life are encoded, stored, and processed ... ...

    Abstract Early-life experiences influence a broad spectrum of behaviors throughout the lifespan that contribute to resilience or vulnerability to mental health disorders. Yet, how emotionally salient experiences early in life are encoded, stored, and processed and the mechanisms by which they influence future behaviors remain poorly understood. The paraventricular nucleus of the thalamus (PVT) is a key structure in modulating positive and negative experiences and behaviors in adults. However, little is known of the PVT's role in encoding and integrating emotionally salient experiences that occur during neonatal, infancy, and childhood periods. In this review, we (1) describe the functions and connections of the PVT and its regulation of behavior, (2) introduce novel technical approaches to elucidating the role of the PVT in mediating enduring changes in adult behaviors resulting from early-life experiences, and (3) conclude that PVT neurons of neonatal rodents are engaged by both positive and negative emotionally salient experiences, and their activation may enduringly govern future behavior-modulating PVT activity during emotionally salient contexts.
    Language English
    Publishing date 2021-05-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2452960-6
    ISSN 1662-5153
    ISSN 1662-5153
    DOI 10.3389/fnbeh.2021.673162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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