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  1. Article ; Online: Decoding risk: Caravaggio's insights into risk factors for anticoagulation in cancer-associated thrombosis.

    López Robles, Javier / Carmona-Bayonas, Alberto / Jiménez-Fonseca, Paula

    European journal of internal medicine

    2023  Volume 112, Page(s) 21–23

    MeSH term(s) Humans ; Blood Coagulation ; Thrombosis/etiology ; Thrombosis/prevention & control ; Risk Factors ; Anticoagulants/adverse effects ; Neoplasms/complications
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2023-03-28
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2023.03.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2608: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Olaratumab-induced Biomarker Modulation in Sarcomas-Letter.

    Valenti, Vicente / Carmona-Bayonas, Alberto / Jimenez-Fonseca, Paula / Salazar, Ramon

    Molecular cancer therapeutics

    2021  Volume 20, Issue 10, Page(s) 2093

    MeSH term(s) Antibodies, Monoclonal ; Biomarkers ; Humans ; Sarcoma
    Chemical Substances Antibodies, Monoclonal ; Biomarkers ; olaratumab (TT6HN20MVF)
    Language English
    Publishing date 2021-10-04
    Publishing country United States
    Document type Letter
    ZDB-ID 2063563-1
    ISSN 1538-8514 ; 1535-7163
    ISSN (online) 1538-8514
    ISSN 1535-7163
    DOI 10.1158/1535-7163.MCT-21-0413
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5750: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: A Trial of Lopinavir-Ritonavir in Covid-19.

    Carmona-Bayonas, Alberto / Jimenez-Fonseca, Paula / Castañón, Eduardo

    The New England journal of medicine

    2020  Volume 382, Issue 21, Page(s) e68

    MeSH term(s) Adult ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/drug therapy ; Humans ; Lopinavir ; Pandemics ; Pneumonia, Viral ; Ritonavir ; SARS-CoV-2 ; COVID-19 Drug Treatment
    Chemical Substances Lopinavir (2494G1JF75) ; Ritonavir (O3J8G9O825)
    Keywords covid19
    Language English
    Publishing date 2020-05-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2008043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Causal Considerations Can Inform the Interpretation of Surprising Associations in Medical Registries.

    Carmona-Bayonas, Alberto / Jiménez-Fonseca, Paula / Gallego, Javier / Msaouel, Pavlos

    Cancer investigation

    2021  Volume 40, Issue 1, Page(s) 1–13

    Abstract: An exploratory analysis of registry data from 2437 patients with advanced gastric cancer revealed a surprising association between astrological birth signs and overall survival (OS) ... ...

    Abstract An exploratory analysis of registry data from 2437 patients with advanced gastric cancer revealed a surprising association between astrological birth signs and overall survival (OS) with
    MeSH term(s) Bayes Theorem ; Humans ; Mediation Analysis ; Registries
    Language English
    Publishing date 2021-11-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 604942-4
    ISSN 1532-4192 ; 0735-7907
    ISSN (online) 1532-4192
    ISSN 0735-7907
    DOI 10.1080/07357907.2021.1999971
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    Zs.A 1862: Show issues Location:
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  5. Article ; Online: Medicine before and after David Cox.

    Msaouel, Pavlos / Jimenez-Fonseca, Paula / Lim, Bora / Carmona-Bayonas, Alberto / Agnelli, Giancarlo

    European journal of internal medicine

    2022  Volume 98, Page(s) 1–3

    Abstract: Herein we recount the legacy of Sir David Roxbee Cox (15 July 1924 - 18 January 2022) from the perspective of practicing clinicians. His-pioneering work in developing the logistic and Cox proportional hazard regression models revolutionized the analysis ... ...

    Abstract Herein we recount the legacy of Sir David Roxbee Cox (15 July 1924 - 18 January 2022) from the perspective of practicing clinicians. His-pioneering work in developing the logistic and Cox proportional hazard regression models revolutionized the analysis and interpretation of categorical and time-to-event survival outcomes in modern medicine. This legacy is an inspiration for all those who follow on Sir David Cox's path.
    MeSH term(s) Humans ; Proportional Hazards Models ; Survival Analysis
    Language English
    Publishing date 2022-02-28
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2022.02.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2608: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Prospective study of predictors for anxiety, depression, and somatization in a sample of 1807 cancer patients.

    Velasco-Durantez, Veronica / Cruz-Castellanos, Patricia / Hernandez, Raquel / Rodriguez-Gonzalez, Adan / Fernandez Montes, Ana / Gallego, Alejandro / Manzano-Fernandez, Aranzazu / Sorribes, Elena / Zafra, Marta / Carmona-Bayonas, Alberto / Calderon, Caterina / Jiménez-Fonseca, Paula

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 3188

    Abstract: In cancer patients, psychological distress, which encompasses anxiety, depression, and somatization, arises from the complex interplay of emotional and behavioral reactions to the diagnosis and treatment, significantly influencing their functionality and ...

    Abstract In cancer patients, psychological distress, which encompasses anxiety, depression, and somatization, arises from the complex interplay of emotional and behavioral reactions to the diagnosis and treatment, significantly influencing their functionality and quality of life. The aim was to investigate factors associated with psychological distress in cancer patients. This prospective and multicenter study, conducted by the Spanish Society of Medical Oncology (SEOM), included two cohorts of patients with cancer (localized resected or advanced unresectable). They completed surveys assessing psychological distress (BSI-18) before and after cancer treatment and coping (MINI-MAC) and spirituality (FACIT-sp) prior to therapy. A multivariable logistic regression analysis and a Structural Equation Modeling (SEM) were conducted. Between 2019 and 2022, 1807 patients were evaluated, mostly women (54%), average age 64 years. The most frequent cancers were colorectal (30%), breast (25%) and lung (18%). Men had lower levels of anxiety and depression (OR 0.66, 95% CI 0.52-0.84; OR 0.72, 95% CI 0.56-0.93). Colorectal cancer patients experienced less anxiety (OR 0.63, 95% CI 0.43-0.92), depression (OR 0.55, 95% CI 0.37-0.81), and somatization (OR 0.59, 95% CI 0.42-0.83). Patients with localized cancer and spiritual beliefs had reduced psychological distress, whereas those with anxious preoccupation had higher level. SEM revealed a relationship between psychological distress and coping strategies, emphasizing how baseline anxious preoccupation exacerbates post-treatment distress. This study suggests that age, sex, extension and location of cancer, coping and spirituality influence psychological distress in cancer patients.
    MeSH term(s) Female ; Humans ; Male ; Middle Aged ; Adaptation, Psychological ; Anxiety/psychology ; Depression/psychology ; Neoplasms/psychology ; Prospective Studies ; Quality of Life/psychology ; Surveys and Questionnaires ; Aged
    Language English
    Publishing date 2024-02-07
    Publishing country England
    Document type Multicenter Study ; Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-53212-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Systemic Inflammation Response Index and weight loss as prognostic factors in metastatic pancreatic cancer: A concept study from the PANTHEIA-SEOM trial.

    Pacheco-Barcia, Vilma / Custodio-Cabello, Sara / Carrasco-Valero, Fatima / Palka-Kotlowska, Magda / Mariño-Mendez, Axel / Carmona-Bayonas, Alberto / Gallego, Javier / Martín, A J Muñoz / Jimenez-Fonseca, Paula / Cabezon-Gutierrez, Luis

    World journal of gastrointestinal oncology

    2024  Volume 16, Issue 2, Page(s) 386–397

    Abstract: Background: The prognostic value of the Systemic Inflammation Response Index (SIRI) in advanced pancreatic cancer is recognized, but its correlation with patients´ nutritional status and outcomes remains unexplored.: Aim: To study the prognostic ... ...

    Abstract Background: The prognostic value of the Systemic Inflammation Response Index (SIRI) in advanced pancreatic cancer is recognized, but its correlation with patients´ nutritional status and outcomes remains unexplored.
    Aim: To study the prognostic significance of SIRI and weight loss in metastatic pancreatic cancer.
    Methods: The PANTHEIA-Spanish Society of Medical Oncology (SEOM) study is a multicentric (16 Spanish hospitals), observational, longitudinal, non-interventional initiative, promoted by the SEOM Real World-Evidence work group. This pilot study sought to analyze the association between weight loss and inflammatory status as defined by SIRI. The cohort stems from a proof-of-concept pilot study conducted at one of the coordinating centers. Patients with pathologically confirmed metastatic pancreatic adenocarcinoma, treated from January 2020 to January 2023, were included. The index was calculated using the product of neutrophil and monocyte counts, divided by lymphocyte counts, obtained within 15 days before initiation chemotherapy. This study evaluated associations between overall survival (OS), SIRI and weight loss.
    Results: A total of 50 patients were included. 66% of these patients were male and the median age was 66 years. Metastasis sites: 36% liver, 12% peritoneal carcinomatosis, 10% lung, and 42% multiple locations. Regarding the first line palliative chemotherapy treatments: 50% received gemcitabine plus nab-paclitaxel; 28%, modified fluorouracil, leucovorin, irinotecan and oxaliplatin, and 16% were administered gemcitabine. 42% had a weight loss > 5% in the three months (mo) preceding diagnosis. 21 patients with a SIRI ≥ 2.3 × 10
    Conclusion: A higher SIRI was correlated with decreased survival rates in patients with metastatic pancreatic cancer and associated with weight loss. An elevated SIRI is suggested as a predictor of survival, emphasizing the need for prospective validation in the upcoming PANTHEIA-SEOM study.
    Language English
    Publishing date 2024-02-12
    Publishing country China
    Document type Journal Article
    ZDB-ID 2573696-6
    ISSN 1948-5204
    ISSN 1948-5204
    DOI 10.4251/wjgo.v16.i2.386
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Learning in times of stress: Lessons from COVID-19 that will last throughout this century.

    Jiménez-Fonseca, Paula / Salazar, Ramón / Valentí, Vicent / Carmona-Bayonas, Alberto / Agnelli, Giancarlo

    European journal of internal medicine

    2021  Volume 96, Page(s) 1–4

    Abstract: Systems tend toward inertia until an external pressure pushes them toward change; thus, a situation of crisis such as the COVID-19 pandemic represents an opportunity for technological innovation. The prevailing need for treatments and vaccines has ... ...

    Abstract Systems tend toward inertia until an external pressure pushes them toward change; thus, a situation of crisis such as the COVID-19 pandemic represents an opportunity for technological innovation. The prevailing need for treatments and vaccines has impelled innovation in the world of randomized clinical trials (RCT), resorting to ideas that had been floating around for a while. Is this merely a circumstantial phenomenon or are new methods here to stay?
    MeSH term(s) COVID-19 ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2021-11-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2021.11.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2608: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Fooled by Randomness. The Misleading Effect of Treatment Crossover in Randomized Trials of Therapies with Marginal Treatment Benefit.

    Valentí, Vicente / Jiménez-Fonseca, Paula / Msaouel, Pavlos / Salazar, Ramón / Carmona-Bayonas, Alberto

    Cancer investigation

    2021  Volume 40, Issue 2, Page(s) 184–188

    Abstract: Crossover can bias clinical outcomes of randomized clinical trials by increasing the risk of both type I (false positive) and type II (false negative) errors. To show how crossover can increase type I error, we provide computer simulation and review ... ...

    Abstract Crossover can bias clinical outcomes of randomized clinical trials by increasing the risk of both type I (false positive) and type II (false negative) errors. To show how crossover can increase type I error, we provide computer simulation and review herein illustrative examples (iniparib, olaratumab) of recently reported RCTs that demonstrated false-positive treatment efficacy signals due to crossover. The ethical issues associated with crossover are also discussed.
    MeSH term(s) Antibodies, Monoclonal/therapeutic use ; Benzamides/therapeutic use ; Bias ; Computer Simulation ; Cross-Over Studies ; Humans ; Neoplasms/drug therapy ; Randomized Controlled Trials as Topic ; Research Design ; Treatment Outcome
    Chemical Substances Antibodies, Monoclonal ; Benzamides ; iniparib (2ZWI7KHK8F) ; olaratumab (TT6HN20MVF)
    Language English
    Publishing date 2021-12-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 604942-4
    ISSN 1532-4192 ; 0735-7907
    ISSN (online) 1532-4192
    ISSN 0735-7907
    DOI 10.1080/07357907.2021.2020281
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Prognostic Assessment of Febrile Neutropenia in the Emergency Department.

    Carmona-Bayonas, Alberto / Jiménez-Fonseca, Paula

    Annals of emergency medicine

    2017  Volume 70, Issue 5, Page(s) 753–754

    Language English
    Publishing date 2017-11
    Publishing country United States
    Document type Letter
    ZDB-ID 603080-4
    ISSN 1097-6760 ; 0196-0644
    ISSN (online) 1097-6760
    ISSN 0196-0644
    DOI 10.1016/j.annemergmed.2017.07.015
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    Zs.A 1344: Show issues Location:
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