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  1. Article ; Online: V-I-B-G-Y-O-R of chemistry

    Kartik R. Patel / Dhrubo Jyoti Sen

    International Journal of Drug Development & Research, Vol 5, Iss 3, Pp 87-

    A journey from micro to macro world

    2013  Volume 94

    Abstract: The word ‘colour’ originates from chemistry. The seven different colours V: Violet, I: Indigo, B ... Blue, G: Green, Y: Yellow, O: Orange and R: Red unite to form a single colour which is totally white ...

    Abstract The word ‘colour’ originates from chemistry. The seven different colours V: Violet, I: Indigo, B: Blue, G: Green, Y: Yellow, O: Orange and R: Red unite to form a single colour which is totally white and fragmentation of this white colour through prism again gives the spectrum of seven colours having different wavelength ($) which is in visible range (400-750nm). The colourful chemistry plays a role within the visible range in small scale to large scale. There is not a single element in the world, which is free from chemistry. This is embedded throughout the world in high extent. Either it is biochemistry or photochemistry or physical chemistry or organic chemistry or bioorganic chemistry or inorganic chemistry or analytical chemistry or combinatorial chemistry or environmental chemistry or computational chemistry or supramolecular chemistry or nanochemistry, each and everything is related with chemical science. Even physics is also based on the properties of matter, which also plays the role of chemistry: light, magnetism, electricity all are enlightened with the electronic behavior of the elements of periodic table. Light is free energy of photons, which is the multiplication of h (h: Max Plank’s constant and : Wave number) this can do the phosphorescence and fluorescence. It can also do the photolysis as well as photosynthesis, the destructive as well as creative matters! Material chemistry is build up by the chemical bonding between the elements of the building block. This bonding could be broken by the chemical reaction to form some another compound by four parameters: reactants, reagents, +ve or _ve heat and time. This can be done in laboratory and in environment also. There are huge number of chemical compounds in the world which are used as fine chemicals, reagents, drugs, pharmaceuticals, biochemicals, dyes, petrochemicals, pesticides, explosives, household appliances, domestic purpose, metallurgy and so many things. This chemistry is used as in nano to micro scale and in macro to mega scale but the chemical entity for a specific unit is same and joined by catenation property in which only three major bonding are there: ionic, covalent and coordinate bonds. Biomolecules under this heading is a big chapter under the receptor chemistry, enzyme chemistry, peptide chemistry, hormone chemistry, carbohydrate chemistry, lipid chemistry, vitamins all are chemical entity have definite functional activity in the living beings. The macro unit of chemical substance is based on the micro unit and the infrastructure is build up by elements of periodic table for inorganic chemistry and organic chemistry. A creation of God is a mega unit of genome (macro unit of chromosome which is a micro unit of polypeptides) can enjoy the chemistry in life to a full extent and especially for human who can play with chemistry from micro level to macro level. So we cannot forget the existence of chemistry in our life because this is an endless journey with full of mystery as this is the history of chemistry.
    Keywords Colourful chemistry ; Visible range ; Physics ; Periodic table ; Material chemistry ; Micro- Macro-Mega ; Bonding ; Genome. ; Pharmacy and materia medica ; RS1-441 ; Medicine ; R
    Subject code 540
    Language English
    Publishing date 2013-09-01T00:00:00Z
    Publisher Chauhan Publishers
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: V-shaped scaffold: a new architectural motif identified in an A x (G x G x G x G) pentad-containing dimeric DNA quadruplex involving stacked G(anti) x G(anti) x G(anti) x G(syn) tetrads.

    Zhang, N / Gorin, A / Majumdar, A / Kettani, A / Chernichenko, N / Skripkin, E / Patel, D J

    Journal of molecular biology

    2001  Volume 311, Issue 5, Page(s) 1063–1079

    Abstract: ... a new alignment, the V-shaped type. Each monomer of the dimeric quadruplex contains two stacked G(anti ... topological feature of quadruplex architecture, the V-shaped scaffold. The missing G-G column results ... We report the results of an NMR study of unlabeled and uniformly (13)C,(15)N-labeled d(G(3)AG(2)T(3 ...

    Abstract We report the results of an NMR study of unlabeled and uniformly (13)C,(15)N-labeled d(G(3)AG(2)T(3)G(3)AT) in 100 mM NaCl, conditions under which it forms a dimeric quadruplex containing several new topological features. The DNA oligomer chain in each symmetry-related monomer subunit undergoes three sharp turns to form a compact domain, with all the purine bases involved in pairing alignments. The first turn is of the double chain reversal type, the second is of the edgewise type, and the third represents a new alignment, the V-shaped type. Each monomer of the dimeric quadruplex contains two stacked G(anti) x G(anti) x G(anti) x G(syn) tetrads, one of which forms a newly identified A x (G x G x G x G) pentad, through sheared G.A mismatch formation. There is a break in one of the four G-G columns that link adjacent G x G x G x G tetrads within each monomer. This architectural interruption is compensated by a new topological feature of quadruplex architecture, the V-shaped scaffold. The missing G-G column results in an opening that could facilitate insertion of planar ligands into the quadruplex. The dimeric interface contains stacked A.(G.G.G.G) pentads, with each pentad containing four bases from one monomer and a syn G1 from the partner monomer. Several potential ligand-binding pockets, positioned towards either end of the folded architecture, were identifiable in a surface view of the solution structure of the dimeric d(G(3)AG(2)T(3)G(3)AT) quadruplex.
    MeSH term(s) Base Sequence ; DNA/chemistry ; DNA/genetics ; DNA/metabolism ; Dimerization ; G-Quadruplexes ; Hydrogen Bonding ; Models, Molecular ; Nuclear Magnetic Resonance, Biomolecular ; Nucleic Acid Conformation ; Protons
    Chemical Substances Protons ; DNA (9007-49-2)
    Language English
    Publishing date 2001-08-31
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 80229-3
    ISSN 1089-8638 ; 0022-2836
    ISSN (online) 1089-8638
    ISSN 0022-2836
    DOI 10.1006/jmbi.2001.4916
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Conditional stimulation of type V and VI adenylyl cyclases by G protein betagamma subunits.

    Gao, Xianlong / Sadana, Rachna / Dessauer, Carmen W / Patel, Tarun B

    The Journal of biological chemistry

    2006  Volume 282, Issue 1, Page(s) 294–302

    Abstract: ... V adenylyl cyclase (hACV) as bait, we identified G protein beta2 subunit as an interacting partner ... the N termini, were not enhanced by Gbetagamma subunits. Transfection of the C terminus of G protein ... to increase cAMP accumulation in COS-7 cells overexpressing hACVI even when G(i) was inactivated ...

    Abstract In a yeast two-hybrid screen of mouse brain cDNA library, using the N-terminal region of human type V adenylyl cyclase (hACV) as bait, we identified G protein beta2 subunit as an interacting partner. Additional yeast two-hybrid assays showed that the Gbeta(1) subunit also interacts with the N-terminal segments of hACV and human type VI adenylyl cyclase (hACVI). In vitro adenylyl cyclase (AC) activity assays using membranes of Sf9 cells expressing hACV or hACVI showed that Gbetagamma subunits enhance the activity of these enzymes provided either Galpha(s) or forskolin is present. Deletion of residues 77-151, but not 1-76, in the N-terminal region of hACVI obliterated the ability of Gbetagamma subunits to conditionally stimulate the enzyme. Likewise, activities of the recombinant, engineered, soluble forms of ACV and ACVI, which lack the N termini, were not enhanced by Gbetagamma subunits. Transfection of the C terminus of G protein receptor kinase 2 to sequester endogenous Gbetagamma subunits attenuated the ability of isoproterenol to increase cAMP accumulation in COS-7 cells overexpressing hACVI even when G(i) was inactivated by pertussis toxin. Therefore, we conclude that the N termini of human hACV and hACVI are necessary for interactions with, and regulation by, Gbetagamma subunits both in vitro and in intact cells. Moreover, Gbetagamma subunits derived from a source(s) other than G(i) are necessary for the full activation of hACVI by isoproterenol in intact cells.
    MeSH term(s) Adenylyl Cyclases/metabolism ; Animals ; Brain/metabolism ; COS Cells ; Chlorocebus aethiops ; Dogs ; GTP-Binding Protein beta Subunits/metabolism ; GTP-Binding Protein gamma Subunits/metabolism ; Humans ; Insecta ; Isoenzymes/metabolism ; Mice ; Pertussis Toxin/chemistry ; Rats ; Two-Hybrid System Techniques
    Chemical Substances GTP-Binding Protein beta Subunits ; GTP-Binding Protein gamma Subunits ; Isoenzymes ; Pertussis Toxin (EC 2.4.2.31) ; Adenylyl Cyclases (EC 4.6.1.1) ; adenylyl cyclase 6 (EC 4.6.1.1) ; adenylyl cyclase type V (EC 4.6.1.1)
    Language English
    Publishing date 2006-11-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.M607522200
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Conditional Stimulation of Type V and VI Adenylyl Cyclases by G Protein βγ Subunits

    Gao, Xianlong / Sadana, Rachna / Dessauer, Carmen W / Patel, Tarun B

    Journal of biological chemistry. 2007 Jan. 5, v. 282, no. 1

    2007  

    Abstract: ... V adenylyl cyclase (hACV) as bait, we identified G protein β2 subunit as an interacting partner ... termini, were not enhanced by Gβγ subunits. Transfection of the C terminus of G protein receptor kinase 2 ...

    Abstract In a yeast two-hybrid screen of mouse brain cDNA library, using the N-terminal region of human type V adenylyl cyclase (hACV) as bait, we identified G protein β2 subunit as an interacting partner. Additional yeast two-hybrid assays showed that the Gβ₁ subunit also interacts with the N-terminal segments of hACV and human type VI adenylyl cyclase (hACVI). In vitro adenylyl cyclase (AC) activity assays using membranes of Sf9 cells expressing hACV or hACVI showed that Gβγ subunits enhance the activity of these enzymes provided either Gαs or forskolin is present. Deletion of residues 77-151, but not 1-76, in the N-terminal region of hACVI obliterated the ability of Gβγ subunits to conditionally stimulate the enzyme. Likewise, activities of the recombinant, engineered, soluble forms of ACV and ACVI, which lack the N termini, were not enhanced by Gβγ subunits. Transfection of the C terminus of G protein receptor kinase 2 to sequester endogenous Gβγ subunits attenuated the ability of isoproterenol to increase cAMP accumulation in COS-7 cells overexpressing hACVI even when Gi was inactivated by pertussis toxin. Therefore, we conclude that the N termini of human hACV and hACVI are necessary for interactions with, and regulation by, Gβγ subunits both in vitro and in intact cells. Moreover, Gβγ subunits derived from a source(s) other than Gi are necessary for the full activation of hACVI by isoproterenol in intact cells.
    Language English
    Dates of publication 2007-0105
    Size p. 294-302.
    Publishing place American Society for Biochemistry and Molecular Biology
    Document type Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    Database NAL-Catalogue (AGRICOLA)

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  5. Article: Six Thinking Hats model of learning-Creative teaching method in physiotherapy-A pilot study.

    Vedawala, Nidhi P / Thakrar, Sakshi J / Thakrar, Jayesh V / Patel, Pratik G / Patel, Yash G

    Journal of education and health promotion

    2024  Volume 13, Page(s) 24

    Abstract: Background: The fast growth of science and technology in the 21: Materials and methods: During the 2021-2022 academic year, there were 42 students registered for III and IV BPT students enrolled for physiotherapy course; however, the research sample ... ...

    Abstract Background: The fast growth of science and technology in the 21
    Materials and methods: During the 2021-2022 academic year, there were 42 students registered for III and IV BPT students enrolled for physiotherapy course; however, the research sample comprised 41 students. The course included 6 h of theory and 18 h of clinical sessions. Students were taught by two instructors via a PowerPoint presentation on SCI, obesity, and for further practice, they were given two case studies taught by Six Thinking Hats model. After the class, each group received a set of hats in one of six colors to use the Six Thinking Hats method effectively, and then students were asked to provide opinions on the Six Thinking Hats model of learning. Data analysis and response reporting were conducted, using literature and student comments.
    Results: The Six Thinking Hats model was discovered to be more efficient in comprehending topics and provides all-encompassing care. The ability to understand patients' views, see both the positive and negative aspects in conditions, develop their ability to think critically, and create with unique concepts all improved for the students. About 90.2% of students stated that they learned to think from different aspects, 85.4% of the students stated that it ensured they considered the patient holistically, 87.8% of the students stated that the method allowed for sharing different ideas and thoughts, 75.6% that it helped them to produce creative ideas. Overall, 95% of students agreed that the Six Thinking Hats approach was better than conventional lectures and case studies, with 5% disagreeing.
    Conclusion: This study concluded that the Six Thinking Hats model of learning is a creative teaching method that is useful for the development of physiotherapy students' critical thinking. Skills and having this type of study in the physiotherapy literature add to the improvement and enrichment of physiotherapy education.
    Language English
    Publishing date 2024-02-07
    Publishing country India
    Document type Journal Article
    ZDB-ID 2715449-X
    ISSN 2319-6440 ; 2277-9531
    ISSN (online) 2319-6440
    ISSN 2277-9531
    DOI 10.4103/jehp.jehp_724_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: In Reply: Integration of Veterans Affairs Medical Centers into Neurosurgical Residency Programs.

    Yearley, Alexander G / Patel, Ruchit V / Mooney, Michael A

    Neurosurgery

    2023  Volume 92, Issue 6, Page(s) e137

    MeSH term(s) Humans ; Internship and Residency ; Veterans ; Hospitals
    Language English
    Publishing date 2023-03-30
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1227/neu.0000000000002471
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Regional sources of NH

    Sharma, B R / Kuttippurath, J / Patel, V K / Gopikrishnan, G S

    Environmental research

    2024  Volume 248, Page(s) 118317

    Abstract: The Third Pole (TP) is a high mountain region in the world, and is well-known for its pristine environment, but recent development activities in the region have degraded its air quality. Here, we investigate the spatial and temporal changes of the air ... ...

    Abstract The Third Pole (TP) is a high mountain region in the world, and is well-known for its pristine environment, but recent development activities in the region have degraded its air quality. Here, we investigate the spatial and temporal changes of the air pollutants ammonia (NH₃), sulphur dioxide (SO₂) and carbon monoxide (CO) in TP, and reveal their sources using satellite measurements and emission inventory. We observe a clear seasonal cycle of NH
    MeSH term(s) Humans ; Environmental Monitoring ; Air Pollutants/analysis ; Air Pollution/analysis ; Seasons ; Sulfur Dioxide
    Chemical Substances Air Pollutants ; Sulfur Dioxide (0UZA3422Q4)
    Language English
    Publishing date 2024-01-30
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2024.118317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: EMERGING NATIONS' LEARNING SYSTEMS AND THE COVID-19 PANDEMIC: AN ANALYSIS.

    Prabhakar, A / Kapse, V / Patel M, G / Sharma, U / Singh, A / Kumar, A

    Georgian medical news

    2024  , Issue 345, Page(s) 122–127

    Abstract: National learning systems improve training and proficiency. In order to support education during the COVID-19 epidemic, the rate of online and remote learning accelerated. Since there were some available technologies, strong, flexible educational ... ...

    Abstract National learning systems improve training and proficiency. In order to support education during the COVID-19 epidemic, the rate of online and remote learning accelerated. Since there were some available technologies, strong, flexible educational infrastructures were required to accommodate a range of student demands. Digital resources and inclusive education need government investment. This study highlights the vital role that adaptable educational frameworks play in lessening the effects of the crisis and fostering resilience in the face of uncertainty by examining the complex relationship between the COVID-19 pandemic and the creation of national education methodologies. This study offers a detailed analysis of the intricacy, challenges, and opportunities that have emerged in this significant field by investigating the ways in which the COVID-19 pandemic has affected educational institutions in developing countries. Twenty selected, peer-reviewed scientific journal articles from 2019 to 2023 were included in the research after a comprehensive search of relevant literature. Taking into consideration the viewpoints of parents, children, teachers, and administrators, this extensive and professionally handled research study provides a critical and nuanced examination of many consequences of the COVID-19 epidemic on the educational system. By using a comprehensive analysis of 25 academic articles, it achieves this. A broad number of useful tools and tactics are highlighted in this research, which offers an in-depth analysis of the intricate area of information and computational model deployment. Employing analysis of variance (ANOVA) as a robust statistical method, this analysis uncovers and scrutinizes the complex dynamics at play with the educational systems of developing nations amidst the unprecedented challenges brought by the global COVID-19 crisis. The COVID-19 epidemic has spurred rising countries to rethink and improve their education institutions, accelerating technology-driven education. The epidemic has underlined the need for inclusive and resilient learning infrastructures that respond to emergencies despite the digital device and access inequities.
    MeSH term(s) Humans ; Child ; Pandemics ; COVID-19/epidemiology ; Schools ; Students ; Administrative Personnel
    Language English
    Publishing date 2024-02-02
    Publishing country Georgia (Republic)
    Document type Journal Article
    ZDB-ID 2443648-3
    ISSN 1512-0112
    ISSN 1512-0112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: MEDITERRANEAN DIET AND ITS IMPACT ON THE ILLNESS CHARACTERISTIC OF YOUTH WITH IRRITABLE BOWEL CONDITION.

    Patel M, G / Borah, N / Kumar, B / Rai, R / Singh, V / Maji, Ch

    Georgian medical news

    2024  , Issue 345, Page(s) 62–66

    Abstract: Irritable Bowel Disorder (IBD) is a prevalent digestive illness that frequently affects young people and drastically decreases the Quality of Life (QoL). Adults with IBD indications may find relief from their symptoms through nutritional changes like the ...

    Abstract Irritable Bowel Disorder (IBD) is a prevalent digestive illness that frequently affects young people and drastically decreases the Quality of Life (QoL). Adults with IBD indications may find relief from their symptoms through nutritional changes like the Mediterranean-style diet. Concerning the seriousness of symptoms, QoL, and additional pertinent results in young people with IBD, this investigation seeks to determine the impact of the Mediterranean-style diet. 200 individuals with IBD who met the Rome-IV criterion and were between the ages of 13 and 19 were enrolled in the present research. A Mediterranean-style diet was provided to the Study Group (SG), which consisted of 100 individuals, while the Control Group (CG), which consisted of 100 patients, followed the usual diet. Various laboratory and clinical characteristics were also assessed at the beginning and end of the study, in addition to IBD values. The Mediterranean-style diet has been demonstrated to be effective and tolerated well in kids and teenagers with IBD. The IBD -SSS (from 148±42.3 to 224±71) IBD -QoL (from 76.7±8.1 to 61.3±9.8), and cumulative IBD rating (from 29.3±11.7 to 32.6±12.1) all showed notable increases in individuals who followed well to this diet. The CG, in comparison, did not show any significant enhancements in these factors. This indicates that a Mediterranean-style diet might provide therapeutic advantages for IBD individuals, especially those who keep adherent to it, concerning symptom severity and QoL. The Mediterranean-style diet proved to be both secure and associated with notable improvements in IBD rates in young and adolescents with IBD.
    MeSH term(s) Humans ; Adult ; Adolescent ; Young Adult ; Diet, Mediterranean ; Quality of Life ; Irritable Bowel Syndrome ; Inflammatory Bowel Diseases/complications ; Inflammatory Bowel Diseases/diagnosis ; Surveys and Questionnaires
    Language English
    Publishing date 2024-02-02
    Publishing country Georgia (Republic)
    Document type Journal Article
    ZDB-ID 2443648-3
    ISSN 1512-0112
    ISSN 1512-0112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Systematic review of economic evaluations in pediatric ophthalmology and strabismus.

    Woldetensaye, Anania G / Patel, Palak V / Koerner, Jagger C

    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus

    2023  Volume 27, Issue 2, Page(s) 65–69

    Abstract: Background: Economic evaluations in health care quantitatively compare interventions using cost and outcomes data. These evaluations can aid in the adoption of new surgical or medical treatments and inform policy decisions regarding healthcare spending. ...

    Abstract Background: Economic evaluations in health care quantitatively compare interventions using cost and outcomes data. These evaluations can aid in the adoption of new surgical or medical treatments and inform policy decisions regarding healthcare spending. Several common types of economic analysis exist (cost-benefit, cost-analysis, cost-effectiveness, and cost-utility). We review all English-language economic evaluations in strabismus surgery and pediatric ophthalmology.
    Methods: An electronic literature search of the PubMed and Health Economic Evaluations databases was conducted. Two reviewers independently reviewed the search string yield and assessed articles against inclusion and exclusion criteria. Outcome measures included journal of publication, year of publication, domain of ophthalmology, region/country of study, and type of economic evaluation.
    Results: We identified 62 articles. Cost-utility studies comprised 30% of evaluations. The most studied domain was retinopathy of prematurity (33%), followed by amblyopia and vision screening (24%) and cataracts (14%). The Journal of the American Association for Pediatric Ophthalmology and Strabismus published the most economic evaluations (15%) followed by Ophthalmology and Pediatrics. The number of published economic evaluations did not increase over time.
    Conclusions: Economic evaluations in pediatric ophthalmology and strabismus have not increased over time. A minority (30%) of studies used cost utility-analysis, limiting comparisons to other domains of medicine. This suggests the need to alert pediatric ophthalmologists to the benefits of economic analysis, and cost-utility methodology specifically, to better inform and influence policy decisions regarding healthcare spending.
    MeSH term(s) Child ; Humans ; Infant, Newborn ; Amblyopia ; Cost-Benefit Analysis ; Delivery of Health Care ; Ophthalmology ; Strabismus/surgery
    Language English
    Publishing date 2023-03-20
    Publishing country United States
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 1412476-2
    ISSN 1528-3933 ; 1091-8531
    ISSN (online) 1528-3933
    ISSN 1091-8531
    DOI 10.1016/j.jaapos.2022.12.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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