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  1. Article: Targeting Epicardial Fat in Obesity and Diabetes Pharmacotherapy.

    Iacobellis, Gianluca / Basilico, Sara / Malavazos, Alexis Elias

    Handbook of experimental pharmacology

    2022  Volume 274, Page(s) 93–108

    Abstract: Epicardial adipose tissue surrounds and infiltrates the heart. Epicardial fat displays unique anatomic, genetic, and biomolecular properties. People with obesity and in particular, those with abdominal obesity and associated type 2 diabetes mellitus, ... ...

    Abstract Epicardial adipose tissue surrounds and infiltrates the heart. Epicardial fat displays unique anatomic, genetic, and biomolecular properties. People with obesity and in particular, those with abdominal obesity and associated type 2 diabetes mellitus, have an increased amount of epicardial adipose tissue (EAT). Epicardial fat works well as therapeutic target due to its fast-responding metabolism, organ fat specificity, and easy measurability. Epicardial fat responds to thiazolidinediones (TZD), glucagon-like peptide 1-receptor agonists (GLP1A), sodium-glucose cotransporter 2 inhibitors (SGLT2i), dipeptidyl peptidase-4 inhibitors (DPP4i), and statins. Modulating epicardial fat morphology and genetic profile with targeted pharmacological agents suggests novel strategies in the pharmacotherapy of diabetes and obesity.
    MeSH term(s) Adipose Tissue ; Diabetes Mellitus, Type 2/drug therapy ; Dipeptidyl-Peptidase IV Inhibitors/pharmacology ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use ; Humans ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Obesity/drug therapy
    Chemical Substances Dipeptidyl-Peptidase IV Inhibitors ; Hypoglycemic Agents
    Language English
    Publishing date 2022-02-12
    Publishing country Germany
    Document type Journal Article
    ISSN 0171-2004
    ISSN 0171-2004
    DOI 10.1007/164_2021_577
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    Sign. bis Bd. 125 (1997): 1982 A 2146: Show issues
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  2. Article ; Online: Could fat distribution have a greater influence than BMI on the antibody titre after SARS-CoV-2 vaccine?

    Basilico, Sara / Dubini, Carola / Milani, Valentina / Bertolini, Caterina / Malavazos, Alexis Elias

    Obesity (Silver Spring, Md.)

    2022  Volume 30, Issue 7, Page(s) 1321–1322

    MeSH term(s) Antibodies, Viral ; Body Mass Index ; COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; SARS-CoV-2
    Chemical Substances Antibodies, Viral ; COVID-19 Vaccines
    Language English
    Publishing date 2022-06-15
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2230457-5
    ISSN 1930-739X ; 1071-7323 ; 1930-7381
    ISSN (online) 1930-739X
    ISSN 1071-7323 ; 1930-7381
    DOI 10.1002/oby.23474
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  3. Article ; Online: COVID-19 Rise in Younger Adults with Obesity: Visceral Adiposity Can Predict the Risk.

    Iacobellis, Gianluca / Malavazos, Alexis Elias / Ferreira, Tanira

    Obesity (Silver Spring, Md.)

    2020  Volume 28, Issue 10, Page(s) 1795

    MeSH term(s) Adiposity ; Adult ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Obesity ; Obesity, Abdominal ; Pandemics ; Pneumonia, Viral ; Retrospective Studies ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-09-02
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2230457-5
    ISSN 1930-739X ; 1071-7323 ; 1930-7381
    ISSN (online) 1930-739X
    ISSN 1071-7323 ; 1930-7381
    DOI 10.1002/oby.22951
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  4. Article ; Online: Does epicardial fat contribute to COVID-19 myocardial inflammation?

    Malavazos, Alexis Elias / Goldberger, Jeffrey J / Iacobellis, Gianluca

    European heart journal

    2020  Volume 41, Issue 24, Page(s) 2333

    MeSH term(s) Adipose Tissue ; Adult ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Female ; Humans ; Inflammation ; Myocarditis ; Pandemics ; Pericardium ; Pneumonia, Viral ; SARS-CoV-2 ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2020-05-23
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehaa471
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  5. Article ; Online: Targeting the Adipose Tissue in COVID-19.

    Malavazos, Alexis Elias / Corsi Romanelli, Massimiliano Marco / Bandera, Francesco / Iacobellis, Gianluca

    Obesity (Silver Spring, Md.)

    2020  Volume 28, Issue 7, Page(s) 1178–1179

    MeSH term(s) Adipose Tissue ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Obesity ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2230457-5
    ISSN 1930-739X ; 1071-7323 ; 1930-7381
    ISSN (online) 1930-739X
    ISSN 1071-7323 ; 1930-7381
    DOI 10.1002/oby.22844
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  6. Article ; Online: Factors associated with body weight gain and insulin-resistance: a longitudinal study.

    Buscemi, Carola / Randazzo, Cristiana / Barile, Anna Maria / Bo, Simona / Ponzo, Valentina / Caldarella, Rosalia / Malavazos, Alexis Elias / Caruso, Roberta / Colombrita, Piero / Lombardo, Martina / Buscemi, Silvio

    Nutrition & diabetes

    2024  Volume 14, Issue 1, Page(s) 21

    Abstract: Background: Obesity is the result of energy intake (EI) chronically exceeding energy expenditure. However, the potential metabolic factors, including insulin resistance, remain unclear. This study longitudinally investigated factors associated with ... ...

    Abstract Background: Obesity is the result of energy intake (EI) chronically exceeding energy expenditure. However, the potential metabolic factors, including insulin resistance, remain unclear. This study longitudinally investigated factors associated with changes in body weight.
    Subjects: A cohort of 707 adults without diabetes were investigated at the 4-year follow-up visit. The habitual intake of energy and macronutrients during the past 12 months was assessed using a validated Food Frequency Questionnaire for the local population. Homeostatic model assessment of β-cell function and insulin resistance (HOMA-IR) was used as a surrogate measure of insulin resistance. Additionally, PNPLA3 was genotyped.
    Results: Eighty-seven participants were weight gainers (G; cutoff value = 5 kg), and 620 were non-gainers (NG). Initial anthropometric (G vs. NG: age, 44 ± 13 vs 51 ± 13 years, P < 0.001; body mass index, 27.8 ± 6.5 vs 28.1 ± 5.1 kg/m
    Conclusions: EI is associated with body weight gain, and genetic factors may influence the energy balance. Insulin resistance is a consequence of weight gain, suggesting a possible intracellular protective mechanism against substrate overflow.
    Clinical trial registration: ISRCTN15840340.
    Language English
    Publishing date 2024-04-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2609314-5
    ISSN 2044-4052 ; 2044-4052
    ISSN (online) 2044-4052
    ISSN 2044-4052
    DOI 10.1038/s41387-024-00283-5
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  7. Article ; Online: Amino acids contribute to adaptive thermogenesis. New insights into the mechanisms of action of recent drugs for metabolic disorders are emerging.

    Ruocco, Chiara / Malavazos, Alexis Elias / Ragni, Maurizio / Carruba, Michele O / Valerio, Alessandra / Iacobellis, Gianluca / Nisoli, Enzo

    Pharmacological research

    2023  Volume 195, Page(s) 106892

    Abstract: Adaptive thermogenesis is the heat production by muscle contractions (shivering thermogenesis) or brown adipose tissue (BAT) and beige fat (non-shivering thermogenesis) in response to external stimuli, including cold exposure. BAT and beige fat ... ...

    Abstract Adaptive thermogenesis is the heat production by muscle contractions (shivering thermogenesis) or brown adipose tissue (BAT) and beige fat (non-shivering thermogenesis) in response to external stimuli, including cold exposure. BAT and beige fat communicate with peripheral organs and the brain through a variegate secretory and absorption processes - controlling adipokines, microRNAs, extracellular vesicles, and metabolites - and have received much attention as potential therapeutic targets for managing obesity-related disorders. The sympathetic nervous system and norepinephrine-releasing adipose tissue macrophages (ATM) activate uncoupling protein 1 (UCP1), expressed explicitly in brown and beige adipocytes, dissolving the electrochemical gradient and uncoupling tricarboxylic acid cycle and the electron transport chain from ATP production. Mounting evidence has attracted attention to the multiple effects of dietary and endogenously synthesised amino acids in BAT thermogenesis and metabolic phenotype in animals and humans. However, the mechanisms implicated in these processes have yet to be conclusively characterized. In the present review article, we aim to define the principal investigation areas in this context, including intestinal microbiota constitution, adipose autophagy modulation, and secretome and metabolic fluxes control, which lead to increased brown/beige thermogenesis. Finally, also based on our recent epicardial adipose tissue results, we summarise the evidence supporting the notion that the new dual and triple agonists of glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon (GCG) receptor - with never before seen weight loss and insulin-sensitizing efficacy - promote thermogenic-like amino acid profiles in BAT with robust heat production and likely trigger sympathetic activation and adaptive thermogenesis by controlling amino acid metabolism and ATM expansion in BAT and beige fat.
    MeSH term(s) Animals ; Humans ; Amino Acids ; Thermogenesis ; Metabolic Diseases ; Adipose Tissue, Brown ; Adipokines
    Chemical Substances Amino Acids ; Adipokines
    Language English
    Publishing date 2023-08-22
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2023.106892
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  8. Article: COVID-19 Rise in Younger Adults with Obesity: Visceral Adiposity Can Predict the Risk

    Iacobellis, Gianluca / Malavazos, Alexis Elias / Ferreira, Tanira

    Obesity (Silver Spring)

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #623454
    Database COVID19

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  10. Article ; Online: Does epicardial fat contribute to COVID-19 myocardial inflammation?

    Malavazos, Alexis Elias / Goldberger, Jeffrey J / Iacobellis, Gianluca

    European Heart Journal

    2020  Volume 41, Issue 24, Page(s) 2333–2333

    Keywords Cardiology and Cardiovascular Medicine ; covid19
    Language English
    Publisher Oxford University Press (OUP)
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehaa471
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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