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  1. Article ; Online: Advances in diagnostic methods for early-stage diabetic polyneuropathy.

    Naruse, Keiko

    Journal of diabetes investigation

    2024  

    Abstract: Significant advancements have been made in diagnostic methods for early-stage diabetic polyneuropathy. Early and accurate diagnosis of diabetic polyneuropathy is crucial for preventing further complications and enabling timely intervention. Furthermore, ... ...

    Abstract Significant advancements have been made in diagnostic methods for early-stage diabetic polyneuropathy. Early and accurate diagnosis of diabetic polyneuropathy is crucial for preventing further complications and enabling timely intervention. Furthermore, there is a need for an objective numerical value to evaluate the early stage of diabetic polyneuropathy.
    Language English
    Publishing date 2024-04-06
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2625840-7
    ISSN 2040-1124 ; 2040-1116
    ISSN (online) 2040-1124
    ISSN 2040-1116
    DOI 10.1111/jdi.14201
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    Zs.A 6920: Show issues Location:
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  2. Article ; Online: Prospects of stem cell therapy for diabetic microvascular complications.

    Naruse, Keiko

    Journal of diabetes investigation

    2022  

    Abstract: The expectations for the clinical application of stem cell therapy for diabetic microvascular complications are increasing, as stem cell transplantation improves histopathological abnormalities mainly through angiogenesis/protection, nerve elongation/ ... ...

    Abstract The expectations for the clinical application of stem cell therapy for diabetic microvascular complications are increasing, as stem cell transplantation improves histopathological abnormalities mainly through angiogenesis/protection, nerve elongation/protection, and anti-inflammatory effects.
    Language English
    Publishing date 2022-10-12
    Publishing country Japan
    Document type Editorial
    ZDB-ID 2625840-7
    ISSN 2040-1124 ; 2040-1116
    ISSN (online) 2040-1124
    ISSN 2040-1116
    DOI 10.1111/jdi.13916
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  3. Article ; Online: Trained immunity: A key player of "metabolic memory" in diabetes.

    Naruse, Keiko

    Journal of diabetes investigation

    2021  Volume 13, Issue 4, Page(s) 608–610

    Abstract: Evidence suggests the involvement of trained immunity in metabolic memory under the diabetic condition. High glucose-induced trained immunity is a possible key player in "metabolic memory" among patients with diabetes. Increased aerobic glycolysis plays ... ...

    Abstract Evidence suggests the involvement of trained immunity in metabolic memory under the diabetic condition. High glucose-induced trained immunity is a possible key player in "metabolic memory" among patients with diabetes. Increased aerobic glycolysis plays an important role in inducing trained immunity in diabetes.
    MeSH term(s) Diabetes Mellitus ; Humans ; Immunity, Innate
    Language English
    Publishing date 2021-12-29
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2625840-7
    ISSN 2040-1124 ; 2040-1116
    ISSN (online) 2040-1124
    ISSN 2040-1116
    DOI 10.1111/jdi.13734
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  4. Article ; Online: Does glycemic control rescue type 2 diabetes patients from COVID-19-related deaths?

    Naruse, Keiko

    Journal of diabetes investigation

    2020  Volume 11, Issue 4, Page(s) 792–794

    Abstract: COVID-19 patients with diabetes are reported to have higher mortality compared with non-diabetic COVID-19 patients. However, recent investigations showed the importance of better glycemic control among diabetes patients to avoid death from COVID-19. ...

    Abstract COVID-19 patients with diabetes are reported to have higher mortality compared with non-diabetic COVID-19 patients. However, recent investigations showed the importance of better glycemic control among diabetes patients to avoid death from COVID-19.
    MeSH term(s) Adult ; Aged ; Betacoronavirus ; Blood Glucose/analysis ; COVID-19 ; Coronavirus Infections/blood ; Coronavirus Infections/complications ; Coronavirus Infections/mortality ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/mortality ; Diabetes Mellitus, Type 2/virology ; Female ; Glycated Hemoglobin/analysis ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/complications ; Pneumonia, Viral/mortality ; SARS-CoV-2
    Chemical Substances Blood Glucose ; Glycated Hemoglobin A ; hemoglobin A1c protein, human
    Keywords covid19
    Language English
    Publishing date 2020-07-10
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 2625840-7
    ISSN 2040-1124 ; 2040-1116
    ISSN (online) 2040-1124
    ISSN 2040-1116
    DOI 10.1111/jdi.13320
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  5. Article ; Online: Does glycemic control rescue type 2 diabetes patients from COVID‐19‐related deaths?

    Keiko Naruse

    Journal of Diabetes Investigation , Vol 11, Iss 4, Pp 792-

    2020  Volume 794

    Keywords COVID‐19 ; Diabetes ; Glycemic control ; Diseases of the endocrine glands. Clinical endocrinology ; RC648-665 ; covid19
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
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  6. Article: Schwann Cells as Crucial Players in Diabetic Neuropathy.

    Naruse, Keiko

    Advances in experimental medicine and biology

    2019  Volume 1190, Page(s) 345–356

    Abstract: Schwann cells maintain peripheral nerve structure and function by ensheathment of unmyelinated axons, myelination of myelinated axons, and secretion of neurotrophic factors, and these cells also play a crucial role in the pathogenic mechanisms of ... ...

    Abstract Schwann cells maintain peripheral nerve structure and function by ensheathment of unmyelinated axons, myelination of myelinated axons, and secretion of neurotrophic factors, and these cells also play a crucial role in the pathogenic mechanisms of diabetic neuropathy. A decrease in unmyelinated and small myelinated axons appeared earlier than a decrease in large myelinated fibers in diabetic neuropathy. Electron microscopic studies of human diabetic neuropathy demonstrated edematous cell cytoplasm, aggregates of glycogen particles, and hyperplasia of the surrounding basal lamina in Schwann cells. Diabetic conditions also induces metabolic disorders, such as polyol pathway hyperactivity, activation of protein kinase C, and increased advanced glycosylation end products in Schwann cells, followed by the depletion of neurotrophic factor production.Cell transplantation using progenitor or stem cells is expected to cure diabetic neuropathy. Many studies demonstrated that the paracrine effect of abundant secreted factors from transplanted stem cells was crucial for the success of cell transplantation in diabetic neuropathy. Transplantation of progenitor or stem cells in diabetic animal models ameliorated impaired nerve conduction velocity, nerve blood flow, sensory disorders, and intraepidermal nerve fiber density, with an increase of myelin thickness. The supernatant from cultured dental pulp stem cells increased the proliferation and production of myelin-related protein in Schwann cells, suggesting that Schwann cells is the main target of cell transplantation for diabetic neuropathy.
    MeSH term(s) Animals ; Axons/pathology ; Diabetic Neuropathies/physiopathology ; Diabetic Neuropathies/therapy ; Disease Models, Animal ; Humans ; Myelin Sheath/pathology ; Peripheral Nerves ; Schwann Cells/pathology ; Stem Cell Transplantation
    Language English
    Publishing date 2019-11-23
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-981-32-9636-7_22
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  7. Article ; Online: Does glycemic control rescue type 2 diabetes patients from COVID‐19‐related deaths?

    Naruse, Keiko

    Journal of Diabetes Investigation

    2020  Volume 11, Issue 4, Page(s) 792–794

    Keywords Internal Medicine ; Endocrinology, Diabetes and Metabolism ; General Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2625840-7
    ISSN 2040-1124 ; 2040-1116
    ISSN (online) 2040-1124
    ISSN 2040-1116
    DOI 10.1111/jdi.13320
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  8. Article: Does glycemic control rescue type 2 diabetic patients from COVID-19-related deaths?

    Naruse, Keiko

    J. diabetes investig. (Online)

    Abstract: Coronavirus SARS-CoV-2, which induced the novel coronavirus disease 2019 (COVID-19), mainly invades respiratory tract and lung. Severe cases infected by SARS-CoV-2 progress to acute respiratory distress syndrome (ARDS), septic shock, and multiple organ ... ...

    Abstract Coronavirus SARS-CoV-2, which induced the novel coronavirus disease 2019 (COVID-19), mainly invades respiratory tract and lung. Severe cases infected by SARS-CoV-2 progress to acute respiratory distress syndrome (ARDS), septic shock, and multiple organ dysfunction syndrome (MODS), which leads to death in some cases.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #592285
    Database COVID19

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  9. Article: Does glycemic control rescue type 2 diabetes patients from COVID-19-related deaths?

    Naruse, Keiko

    J Diabetes Investig

    Abstract: COVID-19 patients with diabetes are reported to have higher mortality compared with non-diabetic COVID-19 patients. However, recent investigations showed the importance of better glycemic control among diabetes patients to avoid death from COVID-19. ...

    Abstract COVID-19 patients with diabetes are reported to have higher mortality compared with non-diabetic COVID-19 patients. However, recent investigations showed the importance of better glycemic control among diabetes patients to avoid death from COVID-19.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #656076
    Database COVID19

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  10. Article ; Online: Stretch-induced reactive oxygen species contribute to the Frank-Starling mechanism.

    Kaihara, Keiko / Kai, Hiroaki / Chiba, Yumiko / Naruse, Keiji / Iribe, Gentaro

    The Journal of physiology

    2023  

    Abstract: Myocardial stretch physiologically activates NADPH oxidase 2 (NOX2) to increase reactive oxygen species (ROS) production. Although physiological low-level ROS are known to be important as signalling molecules, the role of stretch-induced ROS in the ... ...

    Abstract Myocardial stretch physiologically activates NADPH oxidase 2 (NOX2) to increase reactive oxygen species (ROS) production. Although physiological low-level ROS are known to be important as signalling molecules, the role of stretch-induced ROS in the intact myocardium remains unclear. To address this, we investigated the effects of stretch-induced ROS on myocardial cellular contractility and calcium transients in C57BL/6J and NOX2
    Language English
    Publishing date 2023-04-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP284283
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