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  1. Article ; Online: FLI sucht Studienteilnehmer/innen für bundesweite Querschnittsstudie

    Allendorf, Valerie

    2021  

    Abstract: Für eine bundesweite Querschnittsstudie (Projekt „COVMon - Monitoringkonzepte für SARS-CoV-2 – Epidemiologie und Koinfektionen“) bittet das Institut für Epidemiologie des Friedrich-Loeffler-Instituts (FLI) niedergelassene Tierärztinnen und Tierärzte um ... ...

    Abstract Für eine bundesweite Querschnittsstudie (Projekt „COVMon - Monitoringkonzepte für SARS-CoV-2 – Epidemiologie und Koinfektionen“) bittet das Institut für Epidemiologie des Friedrich-Loeffler-Instituts (FLI) niedergelassene Tierärztinnen und Tierärzte um Mithilfe bei der Akquise von Hunde- und Katzenhaltern, in deren Haushalt mindestens eine Person in den vergangenen sechs Wochen mit SARS-CoV-2 infiziert war (PCR-Nachweis), um mittels einer Blutprobe die Seroprävalenz bei Hunden und Katzen einzuschätzen, die in von SARS-CoV-2 betroffenen Haushalten in Deutschland gehalten werden.
    Keywords Text ; ddc:610 ; Pressespiegel -- Friedrich-Loeffler-Institut -- Forschung -- Projektspiegel -- COVMon -- Monitoringkonzepte für SARS-CoV-2
    Language German
    Publishing date 2021-06-29
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Thesis ; Online: Zur Epidemiologie des Bunthörnchen-Bornavirus 1 in Hörnchenhaltungen in Deutschland und Europa ; On the Epidemiology of the Variegated Squirrel Bornavirus 1 in captive squirrels in Germany and Europe

    Allendorf, Valerie

    2021  

    Abstract: Mit der vorliegenden Arbeit wurde der Überblick bezüglich der Struktur und des Netzwerks der Hörnchenhaltung und -zucht in Deutschland, einer von vielen Nischen bei Tier-Mensch-Schnittstellen, erweitert. Dazu wurden Register für in Zoos und ... ...

    Abstract Mit der vorliegenden Arbeit wurde der Überblick bezüglich der Struktur und des Netzwerks der Hörnchenhaltung und -zucht in Deutschland, einer von vielen Nischen bei Tier-Mensch-Schnittstellen, erweitert. Dazu wurden Register für in Zoos und Privathaushalten gehaltene Hörnchen erstellt. Die hierbei auftretenden Schwierigkeiten bezüglich der Erreichbarkeit der betreffenden Personengruppen machten deutlich, dass eine zügige Untersuchung und die Eindämmung eines Infektionsgeschehens erheblich erschwert war. Der Mangel an Daten nicht nur zu Hörnchenhaltungen, sondern auch bezüglich des Besitzes der meisten exotischen Haustiere, ist sowohl im deutschen System als auch dem anderer Länder der Welt inhärent. Die Interaktion mit der Community von Halter*innen und Verkäufer*innen exotischer Haustiere offenbarten das Ausmaß von gehandelten und gehaltenen Arten. Der beschriebene Ansatz kann als Vorlage für die epidemiologische Aufarbeitung neu auftretender Krankheiten bei exotischen Tieren dienen. In auf den Registern aufbauenden Querschnittsstudien wurde für die Hörnchenpopulation in Privathaushalten und die Hörnchenpopulation in Zoos die Prävalenz von Subpopulationen geschätzt, in denen mindestens ein Individuum VSBV-1-infiziert war. Hierzu wurden Maultupfer oder Kotproben von 58 private bzw. 53 zoologische Subpopulationen mittels RT-qPCR auf das Vorhandensein von VSBV-1-spezifischer RNA untersucht. Dabei ergab sich eine VSBV-1-Prävalenz von 0 % (95 % CI 0 – 6,2 %) in privaten Subpopulationen und von 1,9 % (95 % CI 0 – 9,9 %) in Zoo-Subpopulationen. Für die Studienteilnahme wurde über eine Vielzahl von Hörnchen-spezifischen Medien geworben, wodurch innerhalb der Risikopopulation der Hörnchenhalter*innen und –pfleger*innen das Bewusstsein für die potentielle Infektionsgefahr durch ungetestete Hörnchen erhöht werden konnte. Durch Intensivierung der Nachverfolgungsermittlungen in von VSBV-1 betroffenen Hörnchenhaltungen, -subpopulationen und Individuen konnte ein Handelsnetzwerk rekonstruiert werden. Gestützt durch ...
    Keywords Text ; ddc:630 ; Hörnchen -- Bornavirus -- Zoos -- Haushalte -- squirrels -- households -- epidemiology -- population -- Project ZooBoCo
    Subject code 801
    Language German
    Publishing date 2021-07-12
    Publisher Freie Universität Berlin, Fachbereich Veterinärmedizin
    Publishing country de
    Document type Thesis ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Book ; Online ; Thesis: Zur Epidemiologie des Bunthörnchen-Bornavirus 1 in Hörnchenhaltungen in Deutschland und Europa

    Allendorf, Valerie [Verfasser]

    2021  

    Author's details Valerie Allendorf
    Keywords Landwirtschaft, Veterinärmedizin ; Agriculture, Veterinary Science
    Subject code sg630
    Language German
    Publisher Freie Universität Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  4. Article ; Online: Zoonotische Bornaviren ; Zoonotic Borna Viruses

    Rubbenstroth, Dennis / Allendorf, Valerie / Ulrich, Rainer G. / Wysocki, Patrick / Homeier-Bachmann, Timo / Beer, Martin

    2023  

    Keywords Text ; ddc:630 ; FLI-Information -- Tiergesundheit -- Jahresbericht -- Bornavirus -- Borna Disease Virus 1 -- BoDV-1 -- Bunthörnchen-Bornavirus ; Variegated squirrel bornavirus 1 -- VSBV-1 -- Project ZooBoCo -- Deutschland
    Language German
    Publishing date 2023-12-21
    Publisher Friedrich-Loeffler-Inst.
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: SARS-CoV-2 Infection and Clinical Signs in Cats and Dogs from Confirmed Positive Households in Germany.

    Michelitsch, Anna / Allendorf, Valerie / Conraths, Franz Josef / Gethmann, Jörn / Schulz, Jana / Wernike, Kerstin / Denzin, Nicolai

    Viruses

    2023  Volume 15, Issue 4

    Abstract: On a global scale, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a serious threat to the health of the human population. Not only humans can be infected, but also their companion animals. The antibody status of 115 cats and 170 ... ...

    Abstract On a global scale, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a serious threat to the health of the human population. Not only humans can be infected, but also their companion animals. The antibody status of 115 cats and 170 dogs, originating from 177 German households known to have been SARS-CoV-2 positive, was determined by enzyme-linked immunosorbent assay (ELISA), and the results were combined with information gathered from a questionnaire that was completed by the owner(s) of the animals. The true seroprevalences of SARS-CoV-2 among cats and dogs were 42.5% (95% CI 33.5-51.9) and 56.8% (95% CI 49.1-64.4), respectively. In a multivariable logistic regression accounting for data clustered in households, for cats, the number of infected humans in the household and an above-average contact intensity turned out to be significant risk factors; contact with humans outside the household was a protective factor. For dogs, on the contrary, contact outside the household was a risk factor, and reduced contact, once the human infection was known, was a significant protective factor. No significant association was found between reported clinical signs in animals and their antibody status, and no spatial clustering of positive test results was identified.
    MeSH term(s) Animals ; Cats ; Dogs ; Humans ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/veterinary ; SARS-CoV-2 ; Antibodies, Viral ; Risk Factors ; Germany/epidemiology ; Cat Diseases/diagnosis ; Cat Diseases/epidemiology
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2023-03-24
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15040837
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online: [Dataset] SARS-CoV-2 Infection and Clinical Signs in Cats and Dogs from Confirmed Positive Households in Germany

    Denzin, Nicolai / Michelitsch, Anna / Allendorf, Valerie / Conraths, Franz Josef / Gethmann, Jörn / Schulz, Jana / Wernike, Kerstin

    2023  

    Abstract: Supplemental material and raw data referring to specified ... ...

    Abstract Supplemental material and raw data referring to specified publication
    Keywords Text ; ddc:570 ; coronavirus -- companion animals -- COVID-19 -- risk assessment -- zooanthroponosis -- COVMon
    Language English
    Publishing date 2023-03-24
    Publisher Zenodo
    Publishing country de
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Zoonotische Bornaviren ; Zoonotic Borna Viruses

    Rubbenstroth, Dennis / Allendorf, Valerie / Ulrich, Rainer G. / Wysocki, Patrick / Homeier-Bachmann, Timo / Beer, Martin

    2022  

    Keywords Text ; ddc:630 ; Tiergesundheit -- Jahresbericht -- Bornavirus -- Borna Disease Virus 1 -- BoDV-1 -- Bunthörnchen-Bornavirus ; Variegated squirrel bornavirus 1 -- VSBV-1 -- Project ZooBoCo -- Deutschland
    Language German
    Publishing date 2022-12-22
    Publisher Friedrich-Loeffler-Inst.
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: SARS-CoV and SARS-CoV -2 cross-reactive antibodies in domestic animals and wildlife in Nigeria suggest circulation of sarbecoviruses.

    Agusi, Ebere R / Schön, Jacob / Allendorf, Valerie / Eze, Emmanuel A / Asala, Olayinka / Shittu, Ismaila / Balkema-Buschmann, Anne / Wernike, Kerstin / Tekki, Ishaya / Ofua, Mark / Adefegha, Omowunmi / Olubade, Oluwatoyin / Ogunmolawa, Oluyemi / Dietze, Klaas / Globig, Anja / Hoffmann, Donata / Meseko, Clement A

    One health (Amsterdam, Netherlands)

    2024  Volume 18, Page(s) 100709

    Abstract: Anthropogenic exposure of domestic animals, as well as wildlife, can result in zoonotic transmission events with known and unknown pathogens including sarbecoviruses. During the COVID-19 pandemic, SARS-CoV-2 infections in animals, most likely resulting ... ...

    Abstract Anthropogenic exposure of domestic animals, as well as wildlife, can result in zoonotic transmission events with known and unknown pathogens including sarbecoviruses. During the COVID-19 pandemic, SARS-CoV-2 infections in animals, most likely resulting from spill-over from humans, have been documented worldwide. However, only limited information is available for Africa. The anthropozoonotic transmission from humans to animals, followed by further inter- and intraspecies propagation may contribute to viral evolution, and thereby subsequently alter the epidemiological patterns of transmission. To shed light on the possible role of domestic animals and wildlife in the ecology and epidemiology of sarbecoviruses in Nigeria, and to analyze the possible circulation of other, undiscovered, but potentially zoonotic sarbecoviruses in animals, we tested 504 serum samples from dogs, rabbits, bats, and pangolins collected between December 2020 and April 2022. The samples were analyzed using an indirect multi-species enzyme-linked immunosorbent assay (ELISA) based on the receptor binding domain (RBD) of SARS-CoV and SARS-CoV -2, respectively. ELISA reactive sera were further analyzed by highly specific virus neutralization test and indirect immunofluorescence assay for confirmation of the presence of antibodies. In this study, we found SARS-CoV reactive antibodies in 16 (11.5%) dogs, 7 (2.97%) rabbits, 2 (7.7%) pangolins and SARS-CoV-2 reactive antibodies in 20 (13.4%) dogs, 6 (2.5%) rabbits and 2 (7.7%) pangolins, respectively. Interestingly, 2 (2.3%) bat samples were positive only for SARS-CoV RBD reactive antibodies. These serological findings of SARS-CoV and/or SARS-CoV-2 infections in both domestic animals and wildlife indicates exposure to sarbecoviruses and requires further One Health-oriented research on the potential reservoir role that different species might play in the ecology and epidemiology of coronaviruses at the human-animal interface.
    Language English
    Publishing date 2024-03-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2834831-X
    ISSN 2352-7714
    ISSN 2352-7714
    DOI 10.1016/j.onehlt.2024.100709
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: SARS-CoV-2 at the Human-Animal Interface: Implication for Global Public Health from an African Perspective.

    Agusi, Ebere Roseann / Allendorf, Valerie / Eze, Emmanuel Aniebonam / Asala, Olayinka / Shittu, Ismaila / Dietze, Klaas / Busch, Frank / Globig, Anja / Meseko, Clement Adebajo

    Viruses

    2022  Volume 14, Issue 11

    Abstract: The coronavirus disease 2019 (COVID-19) pandemic has become the most far-reaching public health crisis of modern times. Several efforts are underway to unravel its root cause as well as to proffer adequate preventive or inhibitive measures. Zoonotic ... ...

    Abstract The coronavirus disease 2019 (COVID-19) pandemic has become the most far-reaching public health crisis of modern times. Several efforts are underway to unravel its root cause as well as to proffer adequate preventive or inhibitive measures. Zoonotic spillover of the causative virus from an animal reservoir to the human population is being studied as the most likely event leading to the pandemic. Consequently, it is important to consider viral evolution and the process of spread within zoonotic anthropogenic transmission cycles as a global public health impact. The diverse routes of interspecies transmission of SARS-CoV-2 offer great potential for a future reservoir of pandemic viruses evolving from the current SARS-CoV-2 pandemic circulation. To mitigate possible future infectious disease outbreaks in Africa and elsewhere, there is an urgent need for adequate global surveillance, prevention, and control measures that must include a focus on known and novel emerging zoonotic pathogens through a one health approach. Human immunization efforts should be approached equally through the transfer of cutting-edge technology for vaccine manufacturing throughout the world to ensure global public health and one health.
    MeSH term(s) Animals ; Humans ; SARS-CoV-2 ; COVID-19/epidemiology ; COVID-19/prevention & control ; Public Health ; Pandemics/prevention & control ; Zoonoses/epidemiology ; Zoonoses/prevention & control
    Language English
    Publishing date 2022-11-09
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14112473
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: SARS-CoV-2 Infection and Clinical Signs in Cats and Dogs from Confirmed Positive Households in Germany

    Michelitsch, Anna / Allendorf, Valerie / Conraths, Franz Josef / Gethmann, Jörn / Schulz, Jana / Wernike, Kerstin / Denzin, Nicolai

    2023  

    Abstract: On a global scale, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a serious threat to the health of the human population. Not only humans can be infected, but also their companion animals. The antibody status of 115 cats and 170 ... ...

    Abstract On a global scale, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a serious threat to the health of the human population. Not only humans can be infected, but also their companion animals. The antibody status of 115 cats and 170 dogs, originating from 177 German households known to have been SARS-CoV-2 positive, was determined by enzyme-linked immunosorbent assay (ELISA), and the results were combined with information gathered from a questionnaire that was completed by the owner(s) of the animals. The true seroprevalences of SARS-CoV-2 among cats and dogs were 42.5% (95% CI 33.5–51.9) and 56.8% (95% CI 49.1–64.4), respectively. In a multivariable logistic regression accounting for data clustered in households, for cats, the number of infected humans in the household and an above-average contact intensity turned out to be significant risk factors; contact with humans outside the household was a protective factor. For dogs, on the contrary, contact outside the household was a risk factor, and reduced contact, once the human infection was known, was a significant protective factor. No significant association was found between reported clinical signs in animals and their antibody status, and no spatial clustering of positive test results was identified.
    Keywords Text ; ddc:570 ; coronavirus -- companion animals -- COVID-19 -- risk assessment -- zooanthroponosis
    Subject code 630
    Language English
    Publishing date 2023-03-24
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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