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Article ; Online: Liquid-liquid phase separation: A new perspective to understanding aging and pathogenesis.

Xia, Jufeng

2022 Volume 16, Issue 5, Page(s) 359–362

Abstract: Mounting evidence has suggested that phase separation, and especially liquid-liquid phase separation (LLPS), underlies the formation of membraneless organelles, which are supramolecular assemblies of proteins and RNA molecules in cells. These ... ...

Abstract	Mounting evidence has suggested that phase separation, and especially liquid-liquid phase separation (LLPS), underlies the formation of membraneless organelles, which are supramolecular assemblies of proteins and RNA molecules in cells. These membraneless organelles are also called biomolecular condensates. Evidence is now growing that condensates, such as stress granules, P bodies, Cajal bodies, and nucleoli, play vital roles in biological processes, like RNA storage and processing, signaling regulation, transcription regulation, gene regulation, and transport. Conversely, condensates may cause diseases, such as neurodegenerative diseases and tumors, when they go wrong. Condensates initially have liquid-like properties, but accumulating biological and chemical mutations with age render them into a more solid-like state, like amyloids in Alzheimer's disease, Huntington's disease, and Parkinson's disease. Research into phase separation is still in its infancy, but this field is a promising avenue for treatment of aging-related diseases.
MeSH term(s)	Humans ; Organelles/chemistry ; Organelles/metabolism ; Proteins/metabolism ; RNA/metabolism ; Neurodegenerative Diseases
Chemical Substances	Proteins ; RNA (63231-63-0)
Language	English
Publishing date	2022-10-25
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2543899-2
ISSN	1881-7823 ; 1881-7823
ISSN (online)	1881-7823
ISSN	1881-7823
DOI	10.5582/bst.2022.01453
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Does immune privilege result in recovered patients testing positive for COVID-19 again?

Xia, Jufeng

Bioscience trends

2020 Volume 14, Issue 3, Page(s) 209–211

Abstract: Recently, an increasing number of reports have indicated that a few patients who were believed to have recovered from COVID-19 initially tested negative but later tested positive. Several hospitals in different countries have detected SARS-CoV-2 RNA in ... ...

Abstract	Recently, an increasing number of reports have indicated that a few patients who were believed to have recovered from COVID-19 initially tested negative but later tested positive. Several hospitals in different countries have detected SARS-CoV-2 RNA in the semen and cerebrospinal fluid of patients with severe COVID-19. Given the fact that the testes and central nervous system are both immune privilege sites and the fact that Ebola virus and Zika virus can avoid immune clearance and continue proliferating and spreading by hiding in those sites, the question of whether SARS-CoV-2 is present in immune privilege sites, it attacks those sites, and it spreads again after proliferating in those sites needs to be investigated.
MeSH term(s)	Betacoronavirus/immunology ; COVID-19 ; Coronavirus Infections/cerebrospinal fluid ; Coronavirus Infections/immunology ; Humans ; Immune Privilege ; Pandemics ; Pneumonia, Viral/cerebrospinal fluid ; Pneumonia, Viral/immunology ; RNA, Viral/cerebrospinal fluid ; SARS-CoV-2 ; Semen/virology
Chemical Substances	RNA, Viral
Keywords	covid19
Language	English
Publishing date	2020-05-16
Publishing country	Japan
Document type	Letter
ZDB-ID	2543899-2
ISSN	1881-7823 ; 1881-7815
ISSN (online)	1881-7823
ISSN	1881-7815
DOI	10.5582/bst.2020.03154
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Does immune privilege result in recovered patients testing positive for COVID-19 again?

Xia, Jufeng

Biosci Trends

Abstract	Recently, an increasing number of reports have indicated that a few patients who were believed to have recovered from COVID-19 initially tested negative but later tested positive. Several hospitals in different countries have detected SARS-CoV-2 RNA in the semen and cerebrospinal fluid of patients with severe COVID-19. Given the fact that the testes and central nervous system are both immune privilege sites and the fact that Ebola virus and Zika virus can avoid immune clearance and continue proliferating and spreading by hiding in those sites, the question of whether SARS-CoV-2 is present in immune privilege sites, it attacks those sites, and it spreads again after proliferating in those sites needs to be investigated.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #276162
Database	COVID19

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Article: Targeting pyroptosis in breast cancer: biological functions and therapeutic potentials on It.

Chen, Cong / Ye, Qianwei / Wang, Linbo / Zhou, Jichun / Xiang, Aizhai / Lin, Xia / Guo, Jufeng / Hu, Shufang / Rui, Tao / Liu, Jian

Cell death discovery

2023 Volume 9, Issue 1, Page(s) 75

Abstract: Pyroptosis is a lytic and inflammatory type of programmed cell death that is mediated by Gasdermin proteins (GSDMs). Attractively, recent evidence indicates that pyroptosis involves in the development of tumors and can serve as a new strategy for cancer ... ...

Abstract	Pyroptosis is a lytic and inflammatory type of programmed cell death that is mediated by Gasdermin proteins (GSDMs). Attractively, recent evidence indicates that pyroptosis involves in the development of tumors and can serve as a new strategy for cancer treatment. Here, we present a basic knowledge of pyroptosis, and an overview of the expression patterns and roles of GSDMs in breast cancer. In addition, we further summarize the available evidence of pyroptosis in breast cancer progression and give insight into the clinical potential of applying pyroptosis in anticancer strategies for breast cancer. This review will deepen our understanding of the relationship between pyroptosis and breast cancer, and provide a novel potential therapeutic avenue for breast cancer.
Language	English
Publishing date	2023-02-23
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2058-7716
ISSN	2058-7716
DOI	10.1038/s41420-023-01370-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Schisandrin B promotes T

Guo, Jufeng / Shen, Yingying / Lin, Xia / Chen, Honggang / Liu, Jian

International immunopharmacology

2021 Volume 101, Issue Pt A, Page(s) 108213

Abstract: Schisandrin B (Sch B) is the major active ingredient of the traditional Chinese medicine Schisandra chinensis and has antitumor activity, anti-inflammatory activity. ... ...

Abstract	Schisandrin B (Sch B) is the major active ingredient of the traditional Chinese medicine Schisandra chinensis and has antitumor activity, anti-inflammatory activity. CD4
MeSH term(s)	Animals ; B-Lymphocytes/drug effects ; Cell Differentiation/drug effects ; Cyclooctanes/pharmacology ; Dose-Response Relationship, Drug ; Enzyme-Linked Immunosorbent Assay ; Female ; Fluorescent Antibody Technique ; Immunoblotting ; Interferon-gamma/metabolism ; Interleukin-4/metabolism ; Lignans/pharmacology ; Mice ; Mice, Inbred C57BL ; Polycyclic Compounds/pharmacology ; Real-Time Polymerase Chain Reaction ; STAT1 Transcription Factor/drug effects ; STAT1 Transcription Factor/metabolism ; Th1 Cells/drug effects
Chemical Substances	Cyclooctanes ; Il4 protein, mouse ; Lignans ; Polycyclic Compounds ; STAT1 Transcription Factor ; Stat1 protein, mouse ; schizandrin B (02XA4X3KZW) ; Interleukin-4 (207137-56-2) ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2021-10-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2021.108213
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Article ; Online: CAR-expressing NK cells for cancer therapy: a new hope.

Xia, Jufeng / Minamino, Shuichi / Kuwabara, Kazuma

Bioscience trends

2020 Volume 14, Issue 5, Page(s) 354–359

Abstract: Since the approval in 2017 and the amazing achievement of Kymriah and Yescarta, the number of basic researchers and clinical trials investigating the safety and efficacy of chimeric antigen receptor-expressing T cells (CAR-T cells) has been relentlessly ... ...

Abstract	Since the approval in 2017 and the amazing achievement of Kymriah and Yescarta, the number of basic researchers and clinical trials investigating the safety and efficacy of chimeric antigen receptor-expressing T cells (CAR-T cells) has been relentlessly increasing. Up to now, more than 200 clinical trials are listed on clinical trial database of NIH and the basic research is countless. However, the production of allogeneic CAR-T cells products is still expensive and has toxicity. Thus, more effort is needed to develop reliable off-the-shelf cellular therapeutic methods with safety and efficiency for the treatment of patients with cancer. As a kind of innate effector lymphocyte with potent antitumor activity, natural killer cells (NK cells) have attracted much attention. Until now, basic and clinical research has shown that chimeric antigen receptor-expressing NK cell (CAR-NK) therapy may play a significant anti-tumor role and its safety is higher than CAR-T cell therapy. In this review, we discuss advantages and shortages of employing CAR-NK cells as a novel cellular therapy against cancer.
MeSH term(s)	Clinical Trials as Topic ; Humans ; Immunotherapy, Adoptive/methods ; Killer Cells, Natural/immunology ; Killer Cells, Natural/transplantation ; Neoplasms/immunology ; Neoplasms/therapy ; Receptors, Chimeric Antigen/genetics ; Receptors, Chimeric Antigen/immunology ; Receptors, Chimeric Antigen/therapeutic use ; Transfection/methods
Chemical Substances	Receptors, Chimeric Antigen
Language	English
Publishing date	2020-09-06
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	2543899-2
ISSN	1881-7823 ; 1881-7815
ISSN (online)	1881-7823
ISSN	1881-7815
DOI	10.5582/bst.2020.03308
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Mir-4728 is a Valuable Biomarker for Diagnostic and Prognostic Assessment of HER2-Positive Breast Cancer.

Rui, Tao / Xiang, Aizhai / Guo, Jufeng / Tang, Ning / Lin, Xia / Jin, Xin / Liu, Jian / Zhang, Xiaobing

Frontiers in molecular biosciences

2022 Volume 9, Page(s) 818493

Abstract: Breast cancer remains one of the most common malignancies in female cancer patients. The rapid and accurate diagnosis of human epidermal growth factor receptor 2 (HER2) status is indispensable for breast cancer patients. The pre-miR-4728 (mir-4728) is ... ...

Abstract	Breast cancer remains one of the most common malignancies in female cancer patients. The rapid and accurate diagnosis of human epidermal growth factor receptor 2 (HER2) status is indispensable for breast cancer patients. The pre-miR-4728 (mir-4728) is encoded within an intron of the HER2 gene. We showed here that mir-4728 was the most significantly upregulated pre-miRNA in HER2-positive breast cancer patients (fold-change: 4.37), and it could serve as a strong diagnostic factor for the HER2 status in breast cancer patients (
Language	English
Publishing date	2022-05-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2814330-9
ISSN	2296-889X
ISSN	2296-889X
DOI	10.3389/fmolb.2022.818493
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Stem cell secretome as a new booster for regenerative medicine.

Xia, Jufeng / Minamino, Shuichi / Kuwabara, Kazuma / Arai, Shunichi

Bioscience trends

2019 Volume 13, Issue 4, Page(s) 299–307

Abstract: Stem cells are an undifferentiated cell population that has the ability to develop into many different cell types and also has the ability to repair damaged tissues in some cases. For a long time, the stem cell regenerative paradigm has been based on the ...

Abstract	Stem cells are an undifferentiated cell population that has the ability to develop into many different cell types and also has the ability to repair damaged tissues in some cases. For a long time, the stem cell regenerative paradigm has been based on the assumption that progenitor cells play a critical role in tissue repair by means of their plasticity and differentiation potential. However, recent works suggest that the mechanism underlying the benefits of stem cell transplantation might relate to a paracrine modulatory effect rather than the replacement of affected cells at the site of injury. This paracrine modulatory effect derives from secretome which comprises a diverse host of growth factors, cytokines, chemokines, angiogenic factors, and exosomes which are extracellular vesicles that are produced in the endosomal compartment of most eukaryotic cells and are from about 30 to several hundred nanometers in diameter. The role of these factors is being increasingly recognized as key to the regulation of many physiological processes including leading endogenous and progenitor cells to sites of injury as well as mediating apoptosis, proliferation, migration, and angiogenesis. In reality, the immunomodulatory and paracrine role of these factors may mainly account for the therapeutic effects of stem cells and a number of in vitro and in vivo researches have proved limited stem cell engraftment at the site of injury. As a cell-free way for regenerative medicine therapies, stem cell secretome has shown great potential in a variety of clinical applications including prevention of cardiac disfunction, neurodegenerative disease, type 1 diabetes, hair loss, tumors, and joint osteoarthritis.
MeSH term(s)	Extracellular Vesicles/physiology ; Extracellular Vesicles/transplantation ; Humans ; Immunomodulation/physiology ; Paracrine Communication/physiology ; Regenerative Medicine/methods ; Stem Cell Transplantation/methods ; Stem Cells/metabolism
Language	English
Publishing date	2019-09-13
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	2543899-2
ISSN	1881-7823 ; 1881-7815
ISSN (online)	1881-7823
ISSN	1881-7815
DOI	10.5582/bst.2019.01226
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mir-4728 is a Valuable Biomarker for Diagnostic and Prognostic Assessment of HER2-Positive Breast Cancer

Tao Rui / Aizhai Xiang / Jufeng Guo / Ning Tang / Xia Lin / Xin Jin / Jian Liu / Xiaobing Zhang

Frontiers in Molecular Biosciences, Vol

2022 Volume 9

Abstract	Breast cancer remains one of the most common malignancies in female cancer patients. The rapid and accurate diagnosis of human epidermal growth factor receptor 2 (HER2) status is indispensable for breast cancer patients. The pre-miR-4728 (mir-4728) is encoded within an intron of the HER2 gene. We showed here that mir-4728 was the most significantly upregulated pre-miRNA in HER2-positive breast cancer patients (fold-change: 4.37), and it could serve as a strong diagnostic factor for the HER2 status in breast cancer patients (p < 0.0001). Moreover, mir-4728 was positively correlated with tumor recurrence and appeared to be a critical independent risk factor of tumor recurrence in patients with high tumor burden (HR: 7.558, 95% CI:1.842-31.006, p = 0.005). Remarkably, HER2-positive patients with higher mir-4728 expression levels had better drug responses to targeted therapies. Furthermore, estrogen receptor (ESR), the predictive marker for endocrine therapies, was found to be the direct target of miR-4728-3p. Taken together, our results supported the potential role of mir-4728 in the diagnosis of HER2 status and the prognostic assessment of HER2-positive patients in response to targeted therapies.
Keywords	breast cancer ; HER2 ; mir-4728 ; early diagnosis ; ESR ; Biology (General) ; QH301-705.5
Subject code	610 ; 616
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Improved ginseng production under continuous cropping through soil health reinforcement and rhizosphere microbial manipulation with biochar: a field study of

Liu, Cheng / Xia, Rong / Tang, Man / Chen, Xue / Zhong, Bin / Liu, Xiaoyu / Bian, Rongjun / Yang, Li / Zheng, Jufeng / Cheng, Kun / Zhang, Xuhui / Drosos, Marios / Li, Lianqing / Shan, Shengdao / Joseph, Stephen / Pan, Genxing

Horticulture research

2022 Volume 9, Page(s) uhac108

Abstract: The production of ginseng, an important Chinese medicine crop, has been increasingly challenged by soil degradation and pathogenic disease under continuous cropping in Northeast China. In a field experiment, an Alfisol garden continuously cropped with ... ...

Abstract	The production of ginseng, an important Chinese medicine crop, has been increasingly challenged by soil degradation and pathogenic disease under continuous cropping in Northeast China. In a field experiment, an Alfisol garden continuously cropped with Chinese ginseng (
Language	English
Publishing date	2022-05-17
Publishing country	England
Document type	Journal Article
ISSN	2662-6810
ISSN	2662-6810
DOI	10.1093/hr/uhac108
Database	MEDical Literature Analysis and Retrieval System OnLINE

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