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Article ; Online: Using Chromosomal Abnormalities and Germination Traits for the Assessment of Tritipyrum Amphiploid Lines under Seed-Aging and Germination Priming Treatments

Mansour Taghvaei / Hamideh Maleki / Solmaz Najafi / Hossein Shahsavand Hassani / Younes Rezaee Danesh / Beatrice Farda / Loretta Pace

Sustainability, Vol 15, Iss 9505, p

2023 Volume 9505

Abstract: Primary Trans Chromosomal Tritipyrum (PTCT) amphiploid is a new cereal grown in saline soil and brackish water for grain and forage production. We evaluated the tolerance to seed deterioration in 13 promising PTCT lines, assessing accelerated aging (AA) ... ...

Abstract	Primary Trans Chromosomal Tritipyrum (PTCT) amphiploid is a new cereal grown in saline soil and brackish water for grain and forage production. We evaluated the tolerance to seed deterioration in 13 promising PTCT lines, assessing accelerated aging (AA) tests by using AA boxes with 100% relative humidity at 40 °C for 72 h. The (Ma/b)(Cr/b)F4 and (St/b)(Cr/b)F4) PTCT lines, more sensitive to seed aging, were primed with NaCl, Salicylic Acid (SA), and Polyethylene Glycol (PEG) to increase the seed vigor of artificially aged seeds. Germination and emergence traits, biochemical parameters, and chromosomal abnormalities induced by artificial aging were measured in deteriorated and not-deteriorated seeds. The highest reduction percentages related to seed vigor were observed in (Ka/b)(Cr/b)F2 (34.52) and La(4B,4D)/b (28.15) lines, while the lowest was found in (Ma/b)(Cr/b)F4 (7.65) and (St/b)(Cr/b)F4 (7.46) lines. Seed aging also increases electrolytes, potassium, and protein leakages. Chromosomal abnormalities are caused by seed aging that interferes with chromosome behaviors during cell division. Seed priming on aged seeds revealed an increase in the germination percentage (GP) with PEG treatment, while the priming by SA showed an increase in seedling traits, such as the seedling length (SL2). In conclusion, we highlighted the potential use of different PTCT lines and the effective use of seed priming on deteriorated seed to enhance seed viability and seedling vigor as a useful tool for sustainable agriculture.
Keywords	PTCT lines ; seed deterioration ; leakage ; pre-sowing ; chromosomal aberration ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	580
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Differential tumor inhibitory effects induced by HER3 extracellular subdomain-specific mouse monoclonal antibodies.

Hassani, Danesh / Jeddi-Tehrani, Mahmood / Yousefi, Parisa / Mansouri-Fard, Samaneh / Mobini, Maryam / Ahmadi-Zare, Hengameh / Golsaz-Shirazi, Forough / Amiri, Mohammad Mehdi / Shokri, Fazel

Cancer chemotherapy and pharmacology

2022 Volume 89, Issue 3, Page(s) 347–361

Abstract: Purpose: The therapeutic potential of targeting the human epidermal growth factor receptor-3 (ErbB3/HER3) has long been ignored due to impaired tyrosine kinase function and low expression level in tumor cells compared with EGFR and HER2. Although recent ...

Abstract	Purpose: The therapeutic potential of targeting the human epidermal growth factor receptor-3 (ErbB3/HER3) has long been ignored due to impaired tyrosine kinase function and low expression level in tumor cells compared with EGFR and HER2. Although recent investigations have explored the potential benefit of HER3 targeting and several anti-HER3 agents have been developed, there is still a critical need to design and produce more efficient therapeutics. This study was designed to develop tumor inhibitory monoclonal antibodies (MAbs) against different extracellular subdomains of HER3. Methods: Distinct extracellular subdomains of HER3 (D Results: Four anti-D Conclusion: Some of the anti-HER3 MAbs produced in this study displayed tumor inhibitory function and may be considered promising candidates for future HER3-targeted cancer therapy.
MeSH term(s)	Animals ; Antibodies, Monoclonal/pharmacology ; Cell Line, Tumor ; Humans ; Mice ; Receptor, ErbB-2/metabolism ; Receptor, ErbB-3 ; Trastuzumab/pharmacology
Chemical Substances	Antibodies, Monoclonal ; Receptor, ErbB-2 (EC 2.7.10.1) ; Receptor, ErbB-3 (EC 2.7.10.1) ; Trastuzumab (P188ANX8CK)
Language	English
Publishing date	2022-01-26
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	6820-2
ISSN	1432-0843 ; 0344-5704 ; 0943-9404
ISSN (online)	1432-0843
ISSN	0344-5704 ; 0943-9404
DOI	10.1007/s00280-021-04390-3
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Article: A statistics-based approach for crude oil supply risk assessment

Hassani, Hossein / Danesh, Mohammad Ali / Javan, Afshin / Odulaja, Adedapo / Pospiech, Ryszard

OPEC energy review volume XLI , number 3 (September), Seite 187-200

2017

Author's details	Hossein Hassani, Mohammad Ali Danesh, Afshin Javan, Ryszard Pospiech and Adedapo Odulaja
Language	English
Publisher	Wiley-Blackwell
Publishing place	Oxford
Document type	Article
ZDB-ID	2449632-7 ; 2452673-3
ISSN	1753-0237 ; 1753-0229
ISSN (online)	1753-0237
ISSN	1753-0229
Database	ECONomics Information System

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Article ; Online: A fluorescent aptasensor based on a DNA pyramid nanostructure for ultrasensitive detection of ochratoxin A.

Nameghi, Morteza Alinezhad / Danesh, Noor Mohammad / Ramezani, Mohammad / Hassani, Faezeh Vahdati / Abnous, Khalil / Taghdisi, Seyed Mohammad

Analytical and bioanalytical chemistry

2016 Volume 408, Issue 21, Page(s) 5811–5818

Abstract: Analytical techniques for detection of ochratoxin A (OTA) in food products and blood serum are of great significance. In this study, a fluorescent aptasensor was developed for sensitive and specific detection of OTA, based on a DNA pyramid nanostructure ( ...

Abstract	Analytical techniques for detection of ochratoxin A (OTA) in food products and blood serum are of great significance. In this study, a fluorescent aptasensor was developed for sensitive and specific detection of OTA, based on a DNA pyramid nanostructure (DPN) and PicoGreen (PG) dye. The designed aptasensor inherits characteristics of DPN, such as high stability and capacity for PG loading. PG, as a fluorescent dye, could bind to double-stranded DNA (dsDNA). In the absence of OTA, the pyramid structure of DPN remains intact, leading to a very strong fluorescence emission. Because of higher affinity of aptamer for its target relative to its complementary strand, upon addition of target, the pyramid structure of DPN is disassembled, leading to a weak fluorescence emission. The presented aptasensor showed high specificity toward OTA with a limit of detection (LOD) as low as 0.135 nM. Besides, the designed sensing strategy was successfully utilized to recognize OTA in serum and grape juice with LODs of 0.184 and 0.149 nM, respectively.
MeSH term(s)	Aptamers, Nucleotide/chemistry ; Biosensing Techniques/methods ; Carcinogens/analysis ; Fluorescent Dyes/chemistry ; Food Analysis/methods ; Fruit and Vegetable Juices/analysis ; Humans ; Limit of Detection ; Nanostructures/chemistry ; Ochratoxins/analysis ; Ochratoxins/blood
Chemical Substances	Aptamers, Nucleotide ; Carcinogens ; Fluorescent Dyes ; Ochratoxins ; ochratoxin A (1779SX6LUY)
Language	English
Publishing date	2016-06-16
Publishing country	Germany
Document type	Evaluation Studies ; Journal Article
ZDB-ID	201093-8
ISSN	1618-2650 ; 0016-1152 ; 0372-7920
ISSN (online)	1618-2650
ISSN	0016-1152 ; 0372-7920
DOI	10.1007/s00216-016-9693-7
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Article ; Online: Does prior immunization with measles, mumps, and rubella vaccines contribute to the antibody response to COVID-19 antigens?

Hassani, Danesh / Amiri, Mohammad Mehdi / Maghsood, Faezeh / Salimi, Vahid / Kardar, Gholam Ali / Barati, Omid / Hashemian, Seyed Mohammad Reza / Jeddi-Tehrani, Mahmood / Zarnani, Amir-Hassan / Shokri, Fazel

Iranian journal of immunology : IJI

2021 Volume 18, Issue 1, Page(s) 47–53

Abstract: Background: Incidence and severity of SARS-CoV2 infection are significantly lower in children and teenagers proposing that certain vaccines, routinely administered to neonates and children may provide cross-protection against this emerging infection.: ...

Abstract	Background: Incidence and severity of SARS-CoV2 infection are significantly lower in children and teenagers proposing that certain vaccines, routinely administered to neonates and children may provide cross-protection against this emerging infection. Objective: To assess the cross-protection induced by prior measles, mumps and rubella (MMR) vaccinations against COVID-19. Methods: The antibody responses to MMR and tetanus vaccines were determined in 53 patients affected with SARS-CoV2 infection and 52 age-matched healthy subjects. Serum levels of antibodies specific for NP and RBD of SARS-CoV2 were also determined in both groups of subjects with ELISA. Results: Our results revealed significant differences in anti-NP (P<0.0001) and anti-RBD (P<0.0001) IgG levels between patients and healthy controls. While the levels of rubella- and mumps specific IgG were not different in the two groups of subjects, measles-specific IgG was significantly higher in patients (P<0.01). The serum titer of anti-tetanus antibody, however, was significantly lower in patients compared to healthy individuals (P<0.01). Conclusion: Our findings suggest that measles vaccination triggers those B cells cross-reactive with SARS-CoV2 antigens leading to the production of increased levels of measles-specific antibody.
MeSH term(s)	Age Factors ; Aged ; Antibodies, Viral/blood ; Antigens, Viral/immunology ; B-Lymphocytes/immunology ; B-Lymphocytes/virology ; Biomarkers/blood ; COVID-19/blood ; COVID-19/diagnosis ; COVID-19/immunology ; COVID-19/virology ; Case-Control Studies ; Cross Protection ; Cross Reactions ; Female ; Host-Pathogen Interactions ; Humans ; Immunization ; Immunoglobulin G/blood ; Male ; Measles-Mumps-Rubella Vaccine/immunology ; Measles-Mumps-Rubella Vaccine/therapeutic use ; Middle Aged ; SARS-CoV-2/immunology ; Tetanus Toxoid/immunology ; Tetanus Toxoid/therapeutic use
Chemical Substances	Antibodies, Viral ; Antigens, Viral ; Biomarkers ; Immunoglobulin G ; Measles-Mumps-Rubella Vaccine ; Tetanus Toxoid
Language	English
Publishing date	2021-05-04
Publishing country	Iran
Document type	Journal Article
ISSN	1735-367X
ISSN (online)	1735-367X
DOI	10.22034/iji.2021.87990.1843
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Article ; Online: A novel tumor inhibitory hybridoma monoclonal antibody with dual specificity for HER3 and HER2.

Hassani, Danesh / Amiri, Mohammad Mehdi / Mohammadi, Mehdi / Yousefi, Parisa / Judaki, Mohammad Ali / Mobini, Maryam / Golsaz-Shirazi, Forough / Jeddi-Tehrani, Mahmood / Shokri, Fazel

Current research in translational medicine

2021 Volume 69, Issue 2, Page(s) 103277

Abstract: Background: The human epidermal growth factor receptor (HER/ErbB) family-targeted therapies result in a significant improvement in cancer immunotherapy. Monoclonal antibodies (MAb) against HER2 demonstrated a survival benefit for patients; however, drug ...

Abstract	Background: The human epidermal growth factor receptor (HER/ErbB) family-targeted therapies result in a significant improvement in cancer immunotherapy. Monoclonal antibodies (MAb) against HER2 demonstrated a survival benefit for patients; however, drug resistance unavoidably occurs due to the overexpression of HER3, which leads to treatment failure. Effective inhibition of HER3 besides HER2 is thought to be required to overcome resistance and enhance therapeutic efficacy. Objective: The present study describes the production and characterization of a novel MAb, designated 1G5D2, which acts as a natural bispecific antibody targeting extracellular domains (ECD) of both HER2 and HER3. Methods: In this study, 1G5D2 was produced by hybridoma technology against HER3-ECD, and its structural and functional characteristics were studied by various methodologies, including enzyme linked-immunosorbent assays, flow cytometry, immunoblotting, cell signaling, and cell proliferation assays. Results: 1G5D2 specifically binds to both HER2 (subdomain III + IV) and HER3 (subdomain I + II) expressed on tumor cells, and these receptors compete with each other for binding to this MAb. Competition flow cytometry experiments demonstrated that 1G5D2 does not compete with heregulin and recognizes an epitope out of HER3 ligand-binding site. Evaluation of 1G5D2 inhibitory effects in tumor cell lines co-expressing HER2 and HER3 showed that 1G5D2 synergizes with trastuzumab to inhibit both PI3K/AKT and MAPK/ERK pathways and potently downregulates the proliferation of these tumor cells more efficiently than each MAb alone. Conclusion: 1G5D2 is the first reported hybridoma antibody, which acts as a natural HER2/HER3 bispecific antibody. It might potentially be a suitable therapeutic candidate for HER2/HER3 overexpressing cancer types.
MeSH term(s)	Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Humans ; Hybridomas ; Phosphatidylinositol 3-Kinases ; Receptor, ErbB-2/genetics ; Receptor, ErbB-3/genetics
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Receptor, ErbB-2 (EC 2.7.10.1) ; Receptor, ErbB-3 (EC 2.7.10.1)
Language	English
Publishing date	2021-02-24
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2452-3186
ISSN (online)	2452-3186
DOI	10.1016/j.retram.2021.103277
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Article ; Online: Does prior immunization with measles, mumps, and rubella vaccines contribute to the antibody response to COVID-19 antigens?

Danesh Hassani / Mohammad Mehdi Amiri / Faezeh Maghsood / Vahid Salimi / Gholam Ali Kardar / Omid Barati / Seyed Mohammad Reza Hashemian / Mahmood Jeddi-Tehrani / Amir-Hassan Zarnani / Fazel Shokri

Iranian Journal of Immunology, Vol 18, Iss 1, Pp 47-

2021 Volume 53

Abstract	Background: Incidence and severity of SARS-CoV2 infection are significantly lower in children and teenagers proposing that certain vaccines, routinely administered to neonates and children may provide cross-protection against this emerging infection. Objective: To assess the cross-protection induced by prior measles, mumps and rubella (MMR) vaccinations against COVID-19. Methods: The antibody responses to MMR and tetanus vaccines were determined in 53 patients affected with SARS-CoV2 infection and 52 age-matched healthy subjects. Serum levels of antibodies specific for NP and RBD of SARS-CoV2 were also determined in both groups of subjects with ELISA. Results: Our results revealed significant differences in anti-NP (p <0.0001) and anti-RBD (p <0.0001) IgG levels between patients and healthy controls. While the levels of rubella- and mumps specific IgG were not different in the two groups of subjects, measles-specific IgG was significantly higher in patients (p <0.01). The serum titer of anti-tetanus antibody, however, was significantly lower in patients compared to healthy individuals (p <0.01). Conclusion: Our findings suggest that measles vaccination triggers those B cells cross-reactive with SARS-CoV2 antigens leading to the production of increased levels of measles-specific antibody.
Keywords	antibody response ; cross-protection ; mmr ; sars-cov2 ; tetanus ; Biology (General) ; QH301-705.5
Subject code	616
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	Shiraz University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Differential Antibody Response to SARS-CoV-2 Antigens in Recovered and Deceased Iranian COVID-19 Patients.

Maghsood, Faezeh / Hassani, Danesh / Salimi, Vahid / Kardar, Gholam Ali / Khoshnoodi, Jalal / Ghaderi, Abbas / Raeeskarami, Seyyed Reza / Rostamian, Abdorrahman / Seyyedsalehi, Monireh Sadat / Ahmadi Fesharaki, Raoufeh / Jeddi-Tehrani, Mahmood / Zarnani, Amir-Hassan / Amiri, Mohammad Mehdi / Shokri, Fazel

Viral immunology

2021 Volume 34, Issue 10, Page(s) 708–713

Abstract: The coronavirus infectious disease 2019 (COVID-19), which is initiated by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has imposed critical challenges to global health. Understanding the kinetic of SARS-CoV-2-specific IgM and IgG ... ...

Abstract	The coronavirus infectious disease 2019 (COVID-19), which is initiated by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has imposed critical challenges to global health. Understanding the kinetic of SARS-CoV-2-specific IgM and IgG responses in different subsets of COVID-19 patients is crucial to get insight into the humoral immune response elicited against the virus. We investigated IgM and IgG responses against SARS-CoV-2 nucleocapsid (N) and receptor-binding domain (RBD) of spike protein in two groups of recovered and deceased COVID-19 patients. The levels of IgM and IgG specific to N and RBD proteins were detected by ELISA. N- and RBD-specific IgM was higher in deceased patients in comparison with recovered patients, while there was no significant difference in N- and RBD-specific IgG between the two groups. A significant correlation was observed between IgG and IgM titers against RBD and N, in both groups of patients. These results argue against impaired antibody response in deceased COVID-19 patients.
MeSH term(s)	Antibodies, Viral/analysis ; Antibodies, Viral/immunology ; Antibody Formation ; Antigens, Viral/immunology ; COVID-19/immunology ; COVID-19/mortality ; Female ; Humans ; Immunoglobulin G/analysis ; Immunoglobulin G/immunology ; Immunoglobulin M/analysis ; Immunoglobulin M/immunology ; Iran/epidemiology ; Male ; Middle Aged ; Nucleocapsid/chemistry ; Nucleocapsid/immunology ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/immunology
Chemical Substances	Antibodies, Viral ; Antigens, Viral ; Immunoglobulin G ; Immunoglobulin M ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
Language	English
Publishing date	2021-09-17
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639075-4
ISSN	1557-8976 ; 0882-8245
ISSN (online)	1557-8976
ISSN	0882-8245
DOI	10.1089/vim.2021.0061
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Article ; Online: The effect of pilates exercise on quality of life of elderly women with type 2 diabetes

Niloofar Hassani / Majideh Heravi-Karimooi / Nahid Rejeh / Mohammad Hossein Danesh Ashtiani / Hamid Sharifnia / Maryam Ghanbari / Mobin MohammadiNejad

Payesh, Vol 17, Iss 5, Pp 531-

2018 Volume 539

Abstract: objective (s): The study aimed to assess the effectiveness of Pilates on patients with type 2 diabetes Methods: A randomized controlled trial was carried out in forty patients with a diagnosis of diabetes type 2. Patients were randomly assigned to one of ...

Abstract	objective (s): The study aimed to assess the effectiveness of Pilates on patients with type 2 diabetes Methods: A randomized controlled trial was carried out in forty patients with a diagnosis of diabetes type 2. Patients were randomly assigned to one of two groups: experimental group (EG) that in addition to the usual care performed eight weeks of pilates exercises and the control group (CG) that continued to receive the usual care and did not undergo any other intervention. Participants evaluated before and one week after the intervention completed. The quality of life questionnaire (CASP-19) and the short-term test (AMTs) were used to collect data. Results: The groups were homogeneous at baseline. According to the statistical analysis, no significant improvement was observed in the EG. Conclusion: The study did not show benefit for pilates group compared to control group. It is suggested that in the future, this study should be carried out with bigger sample size, increasing the intervention time and a specific questionnaire for assessing the quality of life of the elderly.
Keywords	diabetes mellitus type 2 ; pilates ; quality of life ; aged ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	796
Language	Persian
Publishing date	2018-10-01T00:00:00Z
Publisher	Iranian Institute for Health Sciences Research
Document type	Article ; Online
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Article: A fluorescent aptasensor based on a DNA pyramid nanostructure for ultrasensitive detection of ochratoxin A

Nameghi, Morteza Alinezhad / Faezeh Vahdati Hassani / Khalil Abnous / Mohammad Ramezani / Noor Mohammad Danesh / Seyed Mohammad Taghdisi

Analytical and bioanalytical chemistry. 2016 Aug., v. 408, no. 21

2016

Abstract	Analytical techniques for detection of ochratoxin A (OTA) in food products and blood serum are of great significance. In this study, a fluorescent aptasensor was developed for sensitive and specific detection of OTA, based on a DNA pyramid nanostructure (DPN) and PicoGreen (PG) dye. The designed aptasensor inherits characteristics of DPN, such as high stability and capacity for PG loading. PG, as a fluorescent dye, could bind to double-stranded DNA (dsDNA). In the absence of OTA, the pyramid structure of DPN remains intact, leading to a very strong fluorescence emission. Because of higher affinity of aptamer for its target relative to its complementary strand, upon addition of target, the pyramid structure of DPN is disassembled, leading to a weak fluorescence emission. The presented aptasensor showed high specificity toward OTA with a limit of detection (LOD) as low as 0.135 nM. Besides, the designed sensing strategy was successfully utilized to recognize OTA in serum and grape juice with LODs of 0.184 and 0.149 nM, respectively.
Keywords	analytical methods ; blood serum ; detection limit ; DNA ; fluorescence ; fluorescent dyes ; grape juice ; nanomaterials ; ochratoxin A ; oligonucleotides
Language	English
Dates of publication	2016-08
Size	p. 5811-5818.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ISSN	1618-2642
DOI	10.1007/s00216-016-9693-7
Database	NAL-Catalogue (AGRICOLA)

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