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  1. Article: Evaluation of drug interaction between cyclosporine and lercanidipine: a descriptive study.

    Tecen-Yucel, Kamer / Bayraktar-Ekincioglu, Aygin / Yıldırım, Tolga / Demirkan, Kutay / Erdem, Yunus

    European journal of hospital pharmacy : science and practice

    2023  

    Abstract: Objectives: Cyclosporine is an immunosuppressive drug with a high potential for drug interactions that is frequently used in renal transplant patients. The purpose of this study was to assess the change in cyclosporine concentration in patients taking ... ...

    Abstract Objectives: Cyclosporine is an immunosuppressive drug with a high potential for drug interactions that is frequently used in renal transplant patients. The purpose of this study was to assess the change in cyclosporine concentration in patients taking cyclosporine and lercanidipine concurrently.
    Methods: The potential drug interactions in renal transplant patients who received lercanidipine and cyclosporine concurrently in a university hospital between January 2008 and January 2018 were evaluated retrospectively. Patients had renal transplantation from deceased donors or living related donors. The Drug Interaction Probability Scale (DIPS) criteria were used to assess the causality of cyclosporine and lercanidipine drug interaction.
    Results: The study included six renal transplant patients. The median cyclosporine concentration before lercanidipine use was 325 ng/mL (min-max 101-356) and 592.5 ng/mL (min-max 198-799) thereafter (p=0.028). Serum creatinine and proteinuria levels did not change significantly during lercanidipine treatment (p=0.686 and p=0.116, respectively). According to the DIPS evaluation, cyclosporine and lercanidipine interaction was classified as "possible (score 3)".
    Conclusions: Concomitant use of cyclosporine and lercanidipine increases the concentration of cyclosporine, which may result in side effects during effective treatment in renal transplant patients. Therefore, cyclosporine concentrations should definitely be monitored while patients are taking lercanidipine.
    Language English
    Publishing date 2023-05-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2650179-X
    ISSN 2047-9964 ; 2047-9956
    ISSN (online) 2047-9964
    ISSN 2047-9956
    DOI 10.1136/ejhpharm-2023-003757
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  2. Article ; Online: Factors associated with intention of clinical pharmacists and candidates to provide pharmaceutical care: application of theory planned behaviour.

    Tecen-Yucel, Kamer / Ozdemir, Nesligul / Kara, Emre / Demirkan, Kutay / Sancar, Mesut / Okuyan, Betul

    BMC medical education

    2023  Volume 23, Issue 1, Page(s) 682

    Abstract: Background: Postgraduate education programs in clinical pharmacy have become widespread in Türkiye. This study aimed to identify factors associated with the intention of Turkish clinical pharmacists and candidates (who were graduates and students of ... ...

    Abstract Background: Postgraduate education programs in clinical pharmacy have become widespread in Türkiye. This study aimed to identify factors associated with the intention of Turkish clinical pharmacists and candidates (who were graduates and students of postgraduate clinical pharmacy programs) to provide pharmaceutical care.
    Methods: This prospective observational study was conducted between June 2021 and May 2022. After searching relevant studies, an expert panel discussion, translation, cultural adaptation, and a pilot study developed a 52-item Turkish scale based on the Theory of Planned Behavior (TBP). Cronbach alpha for each construct was calculated after an explanatory factor and test-retest reliability analysis. An online survey link was sent to all graduates or candidates of postgraduate clinical pharmacy programs in Türkiye. After univariate regression analysis, the multiple linear regression model was performed.
    Results: One hundred fifty-six participants completed the survey (response rate: 59.1%). The Cronbach's alpha for attitude (9 items), subjective norm (6 items), perceived behavioural control (5 items), self-efficacy (6 items), intention (11 items) and past behaviour (15 items) were 0.945, 0.720, 0.751, 0.864, 0.934 and 0.955 respectively. The multiple linear regression analysis found a higher score of the subjective norm (p = 0.016), a higher score of self-efficacy (p < 0.001), younger age (p < 0.001) and having PhD (p = 0.038) were associated with increased intention score.
    Conclusions: It was shown that higher self efficacy and positive beliefs of their peers and other healthcare professionals were associated with their higher intention score for providing pharmaceutical care. Younger age and having a PhD were other factors associated with their intention to provide pharmaceutical care.
    MeSH term(s) Humans ; Pharmacists ; Intention ; Pilot Projects ; Reproducibility of Results ; Pharmacy Service, Hospital
    Language English
    Publishing date 2023-09-20
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 2044473-4
    ISSN 1472-6920 ; 1472-6920
    ISSN (online) 1472-6920
    ISSN 1472-6920
    DOI 10.1186/s12909-023-04658-7
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  3. Article ; Online: Assessment of Adherence to Immunosuppressive Treatment in Kidney Transplant Patients

    Kamer Tecen-Yucel / Aygin Bayraktar-Ekincioglu / Tolga Yıldırım / Kutay Demirkan / Yunus Erdem

    Turkish Journal of Nephrology, Vol 32, Iss 3, Pp 241-

    A Descriptive Study

    2023  Volume 248

    Keywords Internal medicine ; RC31-1245 ; Pediatrics ; RJ1-570
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher AVES
    Document type Article ; Online
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  4. Article ; Online: Does therapeutic drug monitoring of hydroxychloroquine improve treatment outcome in intensive care unit patients with COVID-19?

    Tecen-Yucel, Kamer / Aras-Atik, Elif / Bayraktar-Ekincioglu, Aygin

    International journal of clinical practice

    2021  Volume 75, Issue 4, Page(s) e13894

    MeSH term(s) COVID-19/drug therapy ; Drug Monitoring ; Humans ; Hydroxychloroquine/therapeutic use ; Intensive Care Units ; SARS-CoV-2 ; Treatment Outcome
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH)
    Language English
    Publishing date 2021-04-08
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1386246-7
    ISSN 1742-1241 ; 1368-5031
    ISSN (online) 1742-1241
    ISSN 1368-5031
    DOI 10.1111/ijcp.13894
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  5. Article ; Online: Are we aware of potential interactions between drugs used in lung cancer and drugs used in the treatment of COVID-19?

    Aras-Atik, Elif / Tecen-Yucel, Kamer / Bayraktar-Ekincioglu, Aygin

    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

    2020  Volume 26, Issue 7, Page(s) 1807–1817

    Keywords covid19
    Language English
    Publishing date 2020-07-05
    Publishing country England
    Document type Letter
    ZDB-ID 1330764-2
    ISSN 1477-092X ; 1078-1552
    ISSN (online) 1477-092X
    ISSN 1078-1552
    DOI 10.1177/1078155220935506
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  6. Article ; Online: The use of Hydroxychloroquine in the Treatment of COVID-19

    Kamer TECEN-YÜCEL / Emre KARA / Kutay DEMİRKAN / Serhat ÜNAL

    Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, Vol 25, Iss 3, Pp 283-

    2020  Volume 291

    Abstract: COVID-19 is a newly emerging human infectious disease of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) origin described as a pandemic by the World Health Organisation (WHO) on March 11, 2020. There is currently no definitive cure for COVID- ...

    Abstract COVID-19 is a newly emerging human infectious disease of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) origin described as a pandemic by the World Health Organisation (WHO) on March 11, 2020. There is currently no definitive cure for COVID-19; however, among the many treatment strategies, hydroxychloroquine has been suggested as a potential treatment. The purpose of this article was to review the pharmacological properties and mechanism of COVID-19 treatment with hydroxychloroquine and its potential use on the current COVID-19 pandemic.
    Keywords hydroxychloroquine ; covid-19 ; Infectious and parasitic diseases ; RC109-216 ; Microbiology ; QR1-502 ; covid19
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Bilimsel Tip Yayinevi
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Are we aware of potential interactions between drugs used in lung cancer and drugs used in the treatment of COVID-19?

    Aras-Atik, Elif / Tecen-Yucel, Kamer / Bayraktar-Ekincioglu, Aygin

    J Oncol Pharm Pract

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #632845
    Database COVID19

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  8. Article ; Online: Are we aware of potential interactions between drugs used in lung cancer and drugs used in the treatment of COVID-19?

    Aras-Atik, Elif / Tecen-Yucel, Kamer / Bayraktar-Ekincioglu, Aygin

    Journal of Oncology Pharmacy Practice

    2020  Volume 26, Issue 7, Page(s) 1807–1817

    Keywords Pharmacology (medical) ; Oncology ; covid19
    Language English
    Publisher SAGE Publications
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1330764-2
    ISSN 1477-092X ; 1078-1552
    ISSN (online) 1477-092X
    ISSN 1078-1552
    DOI 10.1177/1078155220935506
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  9. Article ; Online: Assessment of Clinically Relevant Drug Interactions by Online Programs in Renal Transplant Recipients.

    Tecen-Yucel, Kamer / Bayraktar-Ekincioglu, Aygin / Yildirim, Tolga / Yilmaz, Seref Rahmi / Demirkan, Kutay / Erdem, Yunus

    Journal of managed care & specialty pharmacy

    2020  Volume 26, Issue 10, Page(s) 1291–1296

    Abstract: Background: Potential drug-drug interactions (pDDIs) with immunosuppressive drugs are frequently observed in renal transplant recipients. Drug interaction programs are acknowledged as a fundamental tool to alert physicians to pDDIs, but there is a high ... ...

    Abstract Background: Potential drug-drug interactions (pDDIs) with immunosuppressive drugs are frequently observed in renal transplant recipients. Drug interaction programs are acknowledged as a fundamental tool to alert physicians to pDDIs, but there is a high concern about variation among different programs in terms of quality and reliability of information.
    Objectives: To (a) characterize the difference in severity levels of pDDIs with tacrolimus and cyclosporine provided by 3 drug interaction programs and (b) identify clinically relevant DDIs with these immunosuppressive drugs in renal transplant recipients.
    Methods: This study was conducted in a nephrology outpatient clinic at the University Research & Training Hospital between November 2017 and February 2018. A clinical pharmacist attended clinic visits with physicians and evaluated drug interactions. Micromedex, Medscape, and Lexicomp drug interaction programs were used to identify pDDIs and their severities. Furthermore, Drug Interaction Probability Scale (DIPS) criteria were applied to identify clinically relevant drug interactions seen in clinic patients. Finally, a clinical pharmacist intervened to manage clinically relevant drug interactions identified by DIPS.
    Results: 80 patients (54 under tacrolimus; 26 under cyclosporine treatment) were included in this study. The 3 drug interaction programs generated 648 pDDIs, 63 of which were different drug interaction pairs. Ninety-eight pDDIs were common to all 3 drug interaction programs. Sixty-three different drug interaction pairs were evaluated according to severity level, and 3 drug interaction pairs were at the same level (moderate) among the programs. The Fleiss' kappa overall interrater agreement was poor. The kappa revealed a moderate agreement for interaction pairs with a "severe" rating and a slight agreement for interaction pairs with a "major" rating. According to the DIPS evaluation, 11 pDDIs were classified as "possible," and the percentage of clinically relevant drug-drug interactions was 4.0% (10/248), 4.2% (11/265), and 8.2% (11/135) for Medscape, Lexicomp, and Micromedex, respectively. Although daily doses of immunosuppressive drugs were not changed, the blood concentrations of these drugs increased after administration of an interacting drug. As a result, in order to maintain normal therapeutic range of concentrations, dose reduction or drug change was applied where appropriate.
    Conclusions: Interaction checker programs are commonly used by health institutions, since they provide quick and summarized information on mechanism and management of drug interactions, when no clinical pharmacist is present to interpret. However, the likelihood of detecting clinically relevant DDIs by interaction checker programs is relatively low, and there are inconsistencies among different programs. Individualized patient monitoring should be maintained by a multidisciplinary health care team that includes a clinical pharmacist, and decision making should be based on professional assessment of the renal transplant patient.
    Disclosures: No outside funding supported this study. The authors have no conflicts of interest to disclose.
    MeSH term(s) Adult ; Clinical Pharmacy Information Systems ; Cyclosporine/administration & dosage ; Cyclosporine/adverse effects ; Drug Information Services ; Drug Interactions ; Female ; Humans ; Immunosuppressive Agents/administration & dosage ; Immunosuppressive Agents/adverse effects ; Kidney Transplantation/methods ; Male ; Online Systems ; Outpatients ; Pharmacists/organization & administration ; Reproducibility of Results ; Tacrolimus/administration & dosage ; Tacrolimus/adverse effects
    Chemical Substances Immunosuppressive Agents ; Cyclosporine (83HN0GTJ6D) ; Tacrolimus (WM0HAQ4WNM)
    Language English
    Publishing date 2020-10-26
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ISSN 2376-1032
    ISSN (online) 2376-1032
    DOI 10.18553/jmcp.2020.26.10.1291
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  10. Article ; Online: Evaluation of internal medicine physicians' attitudes toward the treatment of dyslipidemia.

    Kara, Emre / Tecen Yucel, Kamer / Bayraktar-Ekincioglu, Aygin / Demirkan, Kutay / Tokgozoglu, Lale / Unal, Serhat

    Postgraduate medicine

    2020  Volume 132, Issue 6, Page(s) 538–543

    Abstract: ... ...

    Abstract Objectives
    MeSH term(s) Adult ; Attitude of Health Personnel ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/prevention & control ; Disease Management ; Dyslipidemias/drug therapy ; Dyslipidemias/epidemiology ; Dyslipidemias/psychology ; Female ; Guideline Adherence/statistics & numerical data ; Humans ; Internal Medicine ; Male ; Needs Assessment ; Physicians/psychology ; Physicians/standards ; Physicians/statistics & numerical data ; Practice Guidelines as Topic ; Practice Patterns, Physicians'/standards ; Risk Assessment ; Surveys and Questionnaires ; Turkey
    Language English
    Publishing date 2020-04-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 410138-8
    ISSN 1941-9260 ; 0032-5481
    ISSN (online) 1941-9260
    ISSN 0032-5481
    DOI 10.1080/00325481.2020.1758489
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