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  1. Book ; Online: Revisiting the Relevance of Conceptualism of Godard's film

    Uskokovic, Vuk

    2018  

    Abstract: Jean-Luc Godard's filmmaking is analyzed as a conceptual art, as in agreement with his most accomplished role as a film critic, not a classical filmmaker. In his 1970 manifesto, Godard argues that 1) we must make political films, and 2) we must make ... ...

    Abstract Jean-Luc Godard's filmmaking is analyzed as a conceptual art, as in agreement with his most accomplished role as a film critic, not a classical filmmaker. In his 1970 manifesto, Godard argues that 1) we must make political films, and 2) we must make films politically. While the first point provokes a constructive critique of the art of cinema, the other one leads to the provision of an absolute cinematic experience. Correspondingly, it is argued that albeit rare and systematically unsupported in the academic setting, a most prolific scientific work is such that it implicitly questions the dominant presentation styles and methodological paradigms in parallel with providing meaningful basic and/or practical findings. The relevance of other elements of Godard's conceptual approach to revolutionizing the art of cinema to scientific studies is elaborated too. The importance of ad hoc improvisation, deliberate imperfectness, the aesthetics of poverty, the embracement of collective uncertainties and the eagerness to constantly get lost to be found is particularly emphasized. "I don't make movies; I make cinema" is Godard's precept whose translation to any professional field, including scientific research and teaching, could produce uncountable benefits. Godard's art is intimately tied to the iteration of the point that the value of an act is measured by the extent to which it reaches out away from the subject and into the world, correlating with the Buberian ontology. Corresponding annihilations of the protagonists symbolize the necessity of the artist's working against the self in the attempt to use her art to destroy the art in question and point at everything as an equally precious art. The discourse follows an impulsive and unstructured course so as to veritably reflect Godard's approach to filmmaking
    Size 1 electronic resource (83-113 pages)
    Publisher Schüren Verlag
    Document type Book ; Online
    Note english ; Open Access
    HBZ-ID HT020676612
    ISBN 9783741000690 ; 3741000698
    DOI 10.25364/05.4:2018.2.1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Grand Challenges in Materials Science: A Special Issue.

    Uskoković, Vuk

    Materials (Basel, Switzerland)

    2023  Volume 16, Issue 18

    Abstract: Materials science has and will continue to be a science at a crossroads [ ... ]. ...

    Abstract Materials science has and will continue to be a science at a crossroads [...].
    Language English
    Publishing date 2023-09-07
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma16186109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Natural sciences and chess: A romantic relationship missing from higher education curricula.

    Uskoković, Vuk

    Heliyon

    2023  Volume 9, Issue 4, Page(s) e15015

    Abstract: Chess is a game that delicately weaves analytical thinking around artistic experience, yet recent conversions of STEM (Science-Technology-Engineering-Mathematics) to STEAM (Science-Technology-Engineering-Art-Mathematics) have omitted adding chess as an ... ...

    Abstract Chess is a game that delicately weaves analytical thinking around artistic experience, yet recent conversions of STEM (Science-Technology-Engineering-Mathematics) to STEAM (Science-Technology-Engineering-Art-Mathematics) have omitted adding chess as an elementary coursework to K-12 and higher education curricula. Chess, as per arguments presented in this essay, can be considered as a language and a tool for furthering the development of artistic skills among scientists and analytical, pattern-recognition skills among artists. It can also serve as a missing link between science and art in STEAM curricula thanks to its finding itself halfway between the two. A handful of analogies are drawn here from chess, illustrated sporadically with positions from real-life chess games and converted to lessons in creativity for students in natural sciences. The discussion centered around these analogies is reinforced by a literature review of studies conducted over the past 80 years to assess the effect of exposing students to lessons in chess on their learning in distant domains. Overall, great benefits can emerge from complementing science education with chess and it is hoped that chess will become an integral part of basic education in primary schools and universities worldwide in the near future.
    Language English
    Publishing date 2023-03-31
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e15015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Supplementation of Polymeric Reservoirs with Redox-Responsive Metallic Nanoparticles as a New Concept for the Smart Delivery of Insulin in Diabetes.

    Uskoković, Vuk

    Materials (Basel, Switzerland)

    2023  Volume 16, Issue 2

    Abstract: Type 1 diabetes is caused by the inability of the pancreatic beta cells to produce sufficient amounts of insulin, an anabolic hormone promoting the absorption of the blood glucose by various cells in the body, primarily hepatocytes and skeletal muscle ... ...

    Abstract Type 1 diabetes is caused by the inability of the pancreatic beta cells to produce sufficient amounts of insulin, an anabolic hormone promoting the absorption of the blood glucose by various cells in the body, primarily hepatocytes and skeletal muscle cells. This form of impaired metabolism has been traditionally treated with subcutaneous insulin injections. However, because one such method of administration does not directly correspond to the glucose concentrations in the blood and may fail to reduce hyperglycemia or cause hypoglycemia, the delivery of insulin in a glucose-dependent manner has been researched intensely in the present and past. This study tested the novel idea that the supplementation of polymeric reservoirs containing insulin with metallic nanoparticle precursors responsive to the redox effect of glucose could be used to create triggers for the release of insulin in direct response to the concentration of glucose in the tissue. For that purpose, manganese oxide nanoparticles were dispersed inside a poly(ε-caprolactone) matrix loaded with an insulin proxy and the resulting composite was exposed to different concentrations of glucose. The release of the insulin proxy occurred in direct proportion to the concentration of glucose in the medium. Mechanistically, as per the central hypothesis of the study, glucose reduced the manganese cations contained within the metal oxide phase, forming finer and more dissipative zero-valent metallic nanoparticles, thus disrupting the polymeric network, opening up pores in the matrix and facilitating the release of the captured drug. The choice of manganese for this study over other metals was justified by its use as a supplement for protection against diabetes. Numerical analysis of the release mechanism revealed an increasingly nonlinear and anomalous release accompanied by a higher diffusion rate at the expense of chain rigidity as the glucose concentration increased. Future studies should focus on rendering the glucose-controlled release (i) feasible within the physiological pH range and (ii) sensitive to physiologically relevant glucose concentrations. These technical improvements of the fundamental new concept proven here may bring it closer to a real-life application for the mitigation of symptoms of hyperglycemia in patients with diabetes.
    Language English
    Publishing date 2023-01-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma16020786
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Lessons from the history of inorganic nanoparticles for inhalable diagnostics and therapeutics.

    Uskoković, Vuk

    Advances in colloid and interface science

    2023  Volume 315, Page(s) 102903

    Abstract: The respiratory tract is one of the most accessible ones to exogenous nanoparticles, yet drug delivery by their means to it is made extraordinarily challenging because of the plexus of aerodynamic, hemodynamic and biomolecular factors at cellular and ... ...

    Abstract The respiratory tract is one of the most accessible ones to exogenous nanoparticles, yet drug delivery by their means to it is made extraordinarily challenging because of the plexus of aerodynamic, hemodynamic and biomolecular factors at cellular and extracellular levels that synergistically define the safety and efficacy of this process. Here, the use of inorganic nanoparticles (INPs) for inhalable diagnostics and therapies of the lung is viewed through the prism of the history of studies on the interaction of INPs with the lower respiratory tract. The most conceptually and methodologically innovative and illuminative studies are referred to in the chronological order, as they were reported in the literature, and the trends in the progress of understanding this interaction of immense therapeutic and toxicological significance are being deduced from it. The most outstanding actual trends delineated include the diminishment of toxicity via surface functionalization, cell targeting, tagging and tracking via controlled binding and uptake, hybrid INP treatments, magnetic guidance, combined drug and gene delivery, use as adjuvants in inhalable vaccines, and other. Many of the understudied research directions, which have been accomplished by the nanostructured organic polymers in the pulmonary niche, are discussed. The progress in the use of INPs as inhalable diagnostics or therapeutics has been hampered by their well-recognized inflammatory potential and toxicity in the respiratory tract. However, the annual numbers of methodologically innovative studies have been on the rise throughout the past two decades, suggesting that this is a prolific direction of research, its comparatively poor commercial takings notwithstanding. Still, the lack of consensus on the effects of many INP compositions at low but therapeutically effective doses, the plethora of contradictory reports on ostensibly identical chemical compositions and NP properties, and the many cases of antagonism in combinatorial NP treatments imply that the rational design of inhalable medical devices based on INPs must rely on qualitative principles for the most part and embrace a partially stochastic approach as well. At the same time, the fact that the most studied INPs for pulmonary applications have been those with some of the thickest records of pulmonary toxicity, e.g., carbon, silver, gold, silica and iron oxide, is a silent call for the expansion of the search for new inorganic compositions for use in inhalable therapies to new territories.
    MeSH term(s) Drug Delivery Systems ; Nanoparticles/chemistry ; Nanostructures ; Pharmaceutical Preparations ; Polymers ; Inorganic Chemicals/chemistry
    Chemical Substances Pharmaceutical Preparations ; Polymers ; Inorganic Chemicals
    Language English
    Publishing date 2023-04-12
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 210507-x
    ISSN 1873-3727 ; 0001-8686
    ISSN (online) 1873-3727
    ISSN 0001-8686
    DOI 10.1016/j.cis.2023.102903
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Natural sciences and chess

    Vuk Uskoković

    Heliyon, Vol 9, Iss 4, Pp e15015- (2023)

    A romantic relationship missing from higher education curricula

    2023  

    Abstract: Chess is a game that delicately weaves analytical thinking around artistic experience, yet recent conversions of STEM (Science-Technology-Engineering-Mathematics) to STEAM (Science-Technology-Engineering-Art-Mathematics) have omitted adding chess as an ... ...

    Abstract Chess is a game that delicately weaves analytical thinking around artistic experience, yet recent conversions of STEM (Science-Technology-Engineering-Mathematics) to STEAM (Science-Technology-Engineering-Art-Mathematics) have omitted adding chess as an elementary coursework to K-12 and higher education curricula. Chess, as per arguments presented in this essay, can be considered as a language and a tool for furthering the development of artistic skills among scientists and analytical, pattern-recognition skills among artists. It can also serve as a missing link between science and art in STEAM curricula thanks to its finding itself halfway between the two. A handful of analogies are drawn here from chess, illustrated sporadically with positions from real-life chess games and converted to lessons in creativity for students in natural sciences. The discussion centered around these analogies is reinforced by a literature review of studies conducted over the past 80 years to assess the effect of exposing students to lessons in chess on their learning in distant domains. Overall, great benefits can emerge from complementing science education with chess and it is hoped that chess will become an integral part of basic education in primary schools and universities worldwide in the near future.
    Keywords Chemistry ; Chess ; Creativity ; Culture ; Education ; Instruction ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 370
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Paving Way for a Paradigm Shift in Oncology

    Vuk Uskoković

    Micro, Vol 3, Iss 53, Pp 749-

    Curing Cancer by Loving It?

    2023  Volume 762

    Abstract: Plateaus in the efficacy of traditional methods for the treatment of cancer reached in the last decades call for the exploration of alternative models as their potential clinical complements. Here, the classical view of cancer as a tissue that is to be ... ...

    Abstract Plateaus in the efficacy of traditional methods for the treatment of cancer reached in the last decades call for the exploration of alternative models as their potential clinical complements. Here, the classical view of cancer as a tissue that is to be eradicated by methods describable by a compendium of militaristic metaphors is being challenged with a provocative idea: what if cancer can be cured with love condensed down to the level of molecular and cell biology? Correspondingly, the idea that love mimics the traits of the objects of its affection and helps them grow was translated to the level of cell biology by incorporating anti-apoptotic properties in healthy cells and promoting tumorigenesis in cancerous cells. Both the indirect and direct co-culture of the two cell types demonstrated hindered growth of cancer cells relative to that of their primary counterparts when these cellular modifications inspired by love for cancer were being implemented. The two experimental models reported here are emphasized as crude and simplistic methods derived from the idea that cancer may be best treated by being loved at the cellular and molecular biology levels. More comprehensive and effective methods may emanate from continued exploration and expansion of the intriguing and innovative avenue for cancer management proposed here.
    Keywords autopoiesis ; cancer ; co-culture ; E297 ; love ; p53 ; Physics ; QC1-999 ; Microscopy ; QH201-278.5 ; Microbiology ; QR1-502 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Natural sciences and chess: A romantic relationship missing from higher education curricula

    Uskoković, Vuk

    Heliyon. 20232023 Apr. 31, Mar. 31, v. 9, no. 4 p.e15015-

    2023  

    Abstract: Chess is a game that delicately weaves analytical thinking around artistic experience, yet recent conversions of STEM (Science-Technology-Engineering-Mathematics) to STEAM (Science-Technology-Engineering-Art-Mathematics) have omitted adding chess as an ... ...

    Abstract Chess is a game that delicately weaves analytical thinking around artistic experience, yet recent conversions of STEM (Science-Technology-Engineering-Mathematics) to STEAM (Science-Technology-Engineering-Art-Mathematics) have omitted adding chess as an elementary coursework to K-12 and higher education curricula. Chess, as per arguments presented in this essay, can be considered as a language and a tool for furthering the development of artistic skills among scientists and analytical, pattern-recognition skills among artists. It can also serve as a missing link between science and art in STEAM curricula thanks to its finding itself halfway between the two. A handful of analogies are drawn here from chess, illustrated sporadically with positions from real-life chess games and converted to lessons in creativity for students in natural sciences. The discussion centered around these analogies is reinforced by a literature review of studies conducted over the past 80 years to assess the effect of exposing students to lessons in chess on their learning in distant domains. Overall, great benefits can emerge from complementing science education with chess and it is hoped that chess will become an integral part of basic education in primary schools and universities worldwide in the near future.
    Keywords arts ; complement ; curriculum ; elementary schools ; games ; higher education ; languages ; learning ; science education ; scientists ; students ; universities ; weaving ; wills ; Chemistry ; Chess ; Creativity ; Culture ; Education ; Instruction ; Science
    Language English
    Dates of publication 2023-0331
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e15015
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Nanomedicine for the poor: a lost cause or an idea whose time has yet to come?

    Uskoković, Vuk

    Nanomedicine (London, England)

    2021  Volume 16, Issue 14, Page(s) 1203–1218

    Abstract: The most effective COVID-19 vaccines, to date, utilize nanotechnology to deliver immunostimulatory mRNA. However, their high cost equates to low affordability. Total nano-vaccine purchases per capita and their proportion within the total vaccine lots ... ...

    Abstract The most effective COVID-19 vaccines, to date, utilize nanotechnology to deliver immunostimulatory mRNA. However, their high cost equates to low affordability. Total nano-vaccine purchases per capita and their proportion within the total vaccine lots have increased directly with the GDP per capita of countries. While three out of four COVID-19 vaccines procured by wealthy countries by the end of 2020 were nano-vaccines, this amounted to only one in ten for middle-income countries and nil for the low-income countries. Meanwhile, economic gains of saving lives with nano-vaccines in USA translate to large costs in middle-/low-income countries. It is discussed how nanomedicine can contribute to shrinking this gap between rich and poor instead of becoming an exquisite technology for the privileged. Two basic routes are outlined: (1) the use of qualitative contextual analyses to endorse R&D that positively affects the sociocultural climate; (2) challenging the commercial, competitive realities wherein scientific innovation of the day operates.
    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Humans ; Nanomedicine ; Poverty
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-05-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2277839-1
    ISSN 1748-6963 ; 1743-5889
    ISSN (online) 1748-6963
    ISSN 1743-5889
    DOI 10.2217/nnm-2021-0024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Celeste's Plight: What can film teach natural science?

    Uskoković, Vuk

    Film international

    2020  Volume 17, Issue 1, Page(s) 69–88

    Language English
    Publishing date 2020-05-07
    Publishing country England
    Document type Journal Article
    ISSN 2040-3801
    ISSN (online) 2040-3801
    Database MEDical Literature Analysis and Retrieval System OnLINE

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