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Article ; Online: Vitrector-assisted anterior capsulorhexis in adult intumescent cataract.

Bharti, Sudhank / Sharma, Sourabh / Singh, Bhupesh / Bharti, Neha

2022 Volume 70, Issue 4, Page(s) 1408–1409

Abstract: Performing capsulorhexis in white intumescent cataracts during phacoemulsification surgery is challenging for cataract surgeons because of high intralenticular pressure and reduced red reflex. Capsulorhexis extension to the periphery of the lens is a ... ...

Abstract	Performing capsulorhexis in white intumescent cataracts during phacoemulsification surgery is challenging for cataract surgeons because of high intralenticular pressure and reduced red reflex. Capsulorhexis extension to the periphery of the lens is a common occurrence due to lens intumescence. We used a vitrectomy cutter to create an initial tear in the anterior capsule and simultaneously remove a part of milky fluid coming out of the intumescent lens. Once the lens was decompressed, capsulorhexis was completed using capsulorhexis forceps. This technique helped in controlling capsulorhexis in eyes with intumescent cataracts by reducing the intralenticular pressure and thereby preventing unexpected radial capsular tear.
MeSH term(s)	Adult ; Capsulorhexis/methods ; Cataract ; Cataract Extraction/methods ; Humans ; Lens Capsule, Crystalline/surgery ; Phacoemulsification/methods
Language	English
Publishing date	2022-03-24
Publishing country	India
Document type	Journal Article
ZDB-ID	187392-1
ISSN	1998-3689 ; 0301-4738
ISSN (online)	1998-3689
ISSN	0301-4738
DOI	10.4103/ijo.IJO_1626_21
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Zs.MO 598: Show issues

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Article ; Online: Thamnostylum piriforme, a novel etiological agent of superficial mycosis.

Sharma, Bharti / Nonzom, Skarma

Microbial pathogenesis

2024 Volume 188, Page(s) 106544

Abstract: Fungi are opportunistic eukaryotic entities often taking advantage of susceptibilities offered by a host due to its immunocompromised status, changed microbiome, or ruptured physical barriers and eventually cause infections. They either invade the skin ... ...

Abstract	Fungi are opportunistic eukaryotic entities often taking advantage of susceptibilities offered by a host due to its immunocompromised status, changed microbiome, or ruptured physical barriers and eventually cause infections. They either invade the skin superficially or are deep-seated. Superficial mycosis affects the skin, hair, and nails inhabiting the outermost layer, stratum corneum. In the present study, we report a case of superficial mycosis (onychomycosis in particular) in a 45-year-old immunocompetent man who was an ex-defense personnel and presently serving as a security guard at the University of Jammu, District Jammu, Jammu and Kashmir, India. The infection evolved 17 years ago and negatively affected the quality of life of the patient. For the identification of the causal agent, direct microscopy, cultural, micro-morphological, molecular characterization (ITS sequencing), and phylogenetic analysis were taken into account. A mucoralean fungal species, Thamnostylum piriforme, was isolated from the fingernails (left hand) of the investigated patient, which represents a new global report as the causal agent of superficial mycosis. In vitro antifungal susceptibility testing showed T. piriforme sensitivity to itraconazole, amphotericin B and ketoconazole while resistance to fluconazole. Careful selection of optimal therapy for fungal infection based primarily on correct identification and antifungal susceptibility testing could provide effective results during treatment against these opportunistic human fungal pathogens.
MeSH term(s)	Male ; Humans ; Middle Aged ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Phylogeny ; Quality of Life ; Microbial Sensitivity Tests ; Itraconazole/pharmacology ; Itraconazole/therapeutic use ; Dermatomycoses/drug therapy ; Mucorales
Chemical Substances	Antifungal Agents ; Itraconazole (304NUG5GF4)
Language	English
Publishing date	2024-01-19
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	632772-2
ISSN	1096-1208 ; 0882-4010
ISSN (online)	1096-1208
ISSN	0882-4010
DOI	10.1016/j.micpath.2024.106544
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Article ; Online: Considerations for Developing an Autologous Induced Pluripotent Stem Cell (iPSC)-Derived Retinal Pigment Epithelium (RPE) Replacement Therapy.

Bose, Devika / Ortolan, Davide / Farnoodian, Mitra / Sharma, Ruchi / Bharti, Kapil

Cold Spring Harbor perspectives in medicine

2024 Volume 14, Issue 3

Abstract: Cell-replacement therapies are a new class of treatments, which include induced pluripotent stem cell (iPSC)-derived tissues that aim to replace degenerated cells. iPSCs can potentially be used to generate any cell type of the body, making them a ... ...

Abstract	Cell-replacement therapies are a new class of treatments, which include induced pluripotent stem cell (iPSC)-derived tissues that aim to replace degenerated cells. iPSCs can potentially be used to generate any cell type of the body, making them a powerful tool for treating degenerative diseases. Cell replacement for retinal degenerative diseases is at the forefront of cell therapies, given the accessibility of the eye for surgical procedures and a huge unmet medical need for retinal degenerative diseases with no current treatment options. Clinical trials are ongoing in different parts of the world using stem cell-derived retinal pigment epithelium (RPE). This review focuses on scientific and regulatory considerations when developing an iPSC-derived RPE cell therapy from the development of a robust and efficient differentiation protocol to critical quality control assays for cell validation, the choice of an appropriate animal model for preclinical testing, and the regulatory aspects that dictate the final approval for proceeding to a first-in-human clinical trial.
MeSH term(s)	Animals ; Humans ; Induced Pluripotent Stem Cells ; Retinal Pigment Epithelium/metabolism ; Cell Differentiation ; Models, Animal
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2157-1422
ISSN (online)	2157-1422
DOI	10.1101/cshperspect.a041295
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Article: Primary Ovarian Pregnancy: A Case Report With a Review of the Literature.

Bharti, Sushma / Sharma, Manupriya / Malik, Nisha / Myes, Deychen / Marwaha, Poojan

Cureus

2024 Volume 16, Issue 3, Page(s) e56688

Abstract: Ectopic pregnancy (EP) constitutes 1%-2% of all pregnancies and is one of the leading causes of maternal morbidity and mortality. The most common site of ectopic pregnancy is the ampulla. Ectopic ovarian pregnancy (EOP) is one of the rare events, with an ...

Abstract	Ectopic pregnancy (EP) constitutes 1%-2% of all pregnancies and is one of the leading causes of maternal morbidity and mortality. The most common site of ectopic pregnancy is the ampulla. Ectopic ovarian pregnancy (EOP) is one of the rare events, with an incidence of 0.5%-3% of all pregnancies. The incidence is higher in intrauterine device users or assisted reproductive techniques. The precise aetiology and pathogenesis of EOP remain elusive. Clinically, EOP mirrors the presentation of tubal pregnancy or a ruptured luteal cyst, often leading to life-threatening hypovolemic shock. Transvaginal sonography is the primary diagnostic tool. Still pinpointing the exact location early on poses challenges, and it's usually misinterpreted as a tubo-ovarian mass, hemorrhagic cyst, or luteal cyst. Furthermore, while a suboptimal rise in serum beta-human chorionic gonadotropin (β-hCG) levels may indicate pregnancy, it doesn't definitively confirm EOP. Only histopathological examination offers a conclusive diagnosis. This paper discusses an EOP case in a young woman who experienced five months of amenorrhea and exhibited no traditional risk factors, underscoring the significant challenges inherent in preoperative diagnosis.
Language	English
Publishing date	2024-03-22
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.56688
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Article ; Online: Diversity, Antimicrobial, Antioxidant, and Anticancer Activity of Culturable Fungal Endophyte Communities in

Sharma, Mahima / Bharti, Sahil / Goswami, Anindya / Mallubhotla, Sharada

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 19

Abstract: Endophytic fungi are a significant source of secondary metabolites, which are chemical compounds with biological activities. The present study emphasizes the first-time isolation and identification of such fungi and their pharmacological activities from ... ...

Abstract	Endophytic fungi are a significant source of secondary metabolites, which are chemical compounds with biological activities. The present study emphasizes the first-time isolation and identification of such fungi and their pharmacological activities from the medicinal plant
MeSH term(s)	Antioxidants/pharmacology ; Antioxidants/metabolism ; Endophytes/metabolism ; Cordia ; Anti-Infective Agents/pharmacology ; Anti-Infective Agents/metabolism ; Fungi/metabolism ; Ascomycota/chemistry
Chemical Substances	Antioxidants ; Anti-Infective Agents
Language	English
Publishing date	2023-10-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28196926
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Zs.MO 81: Show issues

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Article ; Online: A novel method of tunnel creation using intraoperative optical coherence tomography-guided deep anterior lamellar keratoplasty.

Singh, Bhupesh / Sharma, Sourabh / Bharti, Neha / Bharti, Sudhank

Indian journal of ophthalmology

2021 Volume 69, Issue 12, Page(s) 3743–3744

Abstract: The big bubble technique has become the technique of choice for performing deep anterior lamellar keratoplasty (DALK) since its inception in 2002. The main challenge with this technique is in achieving a big bubble while preventing inadvertent ... ...

Abstract	The big bubble technique has become the technique of choice for performing deep anterior lamellar keratoplasty (DALK) since its inception in 2002. The main challenge with this technique is in achieving a big bubble while preventing inadvertent perforation of the Descemet's membrane. Although femtosecond lasers have increased the safety, accuracy, and predictability of corneal dissection in DALK, the challenge of achieving a big bubble still exists. To overcome this challenge, Zeimer Z8 Femto LDV has launched a new software module for DALK, which has an added advantage of real-time optical coherence tomography-assisted femtosecond tunnel creation for achieving a big bubble.
MeSH term(s)	Cornea/diagnostic imaging ; Cornea/surgery ; Corneal Transplantation ; Dissection ; Humans ; Keratoconus/surgery ; Tomography, Optical Coherence
Language	English
Publishing date	2021-12-15
Publishing country	India
Document type	Journal Article
ZDB-ID	187392-1
ISSN	1998-3689 ; 0301-4738
ISSN (online)	1998-3689
ISSN	0301-4738
DOI	10.4103/ijo.IJO_531_21
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Article ; Online: Does use of propofol aggravate the inflammatory markers and cause propofol infusion syndrome in intubated cases of severe COVID-19 infections?

Sharma, Bharti

Journal of medical virology

2020 Volume 93, Issue 4, Page(s) 1865–1868

MeSH term(s)	Antibodies, Monoclonal, Humanized ; COVID-19/drug therapy ; Humans ; Hypertriglyceridemia ; Propofol/adverse effects ; Propofol Infusion Syndrome ; SARS-CoV-2
Chemical Substances	Antibodies, Monoclonal, Humanized ; tocilizumab (I031V2H011) ; Propofol (YI7VU623SF)
Keywords	covid19
Language	English
Publishing date	2020-11-22
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.26657
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Zs.A 1320: Show issues

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Article ; Online: Precision Pulse Capsulotomy During Combined Penetrating Keratoplasty With Cataract Surgery and Intraocular Lens in Small Nondilating Pupil.

Singh, Bhupesh / Sharma, Sourabh / Bharti, Neha / Bharti, Sudhank

Eye & contact lens

2021 Volume 47, Issue 4, Page(s) 219–222

Abstract: Objective: To demonstrate precision pulse capsulotomy (PPC) in an open-sky procedure and to evaluate its use during triple procedure keratoplasty in small nondilating pupils.: Methods: This single-center retrospective case series study included 10 ... ...

Abstract	Objective: To demonstrate precision pulse capsulotomy (PPC) in an open-sky procedure and to evaluate its use during triple procedure keratoplasty in small nondilating pupils. Methods: This single-center retrospective case series study included 10 eyes (from 10 patients) with corneal opacity and poorly dilated pupils who were scheduled to undergo triple procedure keratoplasty. The main outcome measures were capsulotomy performance of the PPC device and intraoperative complications. Secondary outcome measures included postoperative best-corrected visual acuity, intraocular pressure, and other postoperative complications. Results: Complete free-floating capsulotomy was achieved in all 10 eyes. There were no cases of anterior capsule tears or tags. There were no postoperative complications that occurred in association with the PPC device. Conclusions: The PPC device facilitates creation of a smooth, round, and appropriately sized anterior capsulotomy in open-sky surgeries, particularly in presence of small nondilating pupils.
MeSH term(s)	Cataract ; Humans ; Keratoplasty, Penetrating ; Lenses, Intraocular ; Phacoemulsification ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2021-03-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2103049-2
ISSN	1542-233X ; 1542-2321
ISSN (online)	1542-233X
ISSN	1542-2321
DOI	10.1097/ICL.0000000000000734
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Article ; Online: Primary soft tissue sarcoma breast with multiphenotypic differentiation.

Sharma, Rashim / Khera, Sudeep / Devnani, Bharti / Binit, Sureka

BMJ case reports

2024 Volume 17, Issue 2

Abstract: Primary soft tissue sarcomas of the breast are rare aggressive neoplasms. These often are misdiagnosed with other more common neoplasms like fibroepithelial malignancies, namely phyllodes tumour and metaplastic carcinoma. Being uncommon, chances of being ...

Abstract	Primary soft tissue sarcomas of the breast are rare aggressive neoplasms. These often are misdiagnosed with other more common neoplasms like fibroepithelial malignancies, namely phyllodes tumour and metaplastic carcinoma. Being uncommon, chances of being misdiagnosed are higher leading to early mortality. A multidisciplinary team incorporating surgery, pathology, chemotherapy and radiotherapy is required to formulate an approach to primary soft tissue sarcoma. Generally, these tumours may show single or dual phenotype; we present one rare case report showing multiphenotypic differentiation.
MeSH term(s)	Female ; Humans ; Breast/pathology ; Breast Neoplasms/diagnosis ; Breast Neoplasms/pathology ; Breast Neoplasms/therapy ; Sarcoma/diagnosis ; Sarcoma/pathology ; Sarcoma/therapy ; Soft Tissue Neoplasms/diagnosis ; Soft Tissue Neoplasms/pathology ; Soft Tissue Neoplasms/therapy ; Combined Modality Therapy ; Patient Care Team
Language	English
Publishing date	2024-02-22
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2023-255750
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Article: L-Carnitine and Chronic Kidney Disease: A Comprehensive Review on Nutrition and Health Perspectives.

Sharma, Bharti / Yadav, Dinesh Kumar

Journal of personalized medicine

2023 Volume 13, Issue 2

Abstract: Progressive segmental glomerulosclerosis is acknowledged as a characteristic of Chronic Kidney Disease (CKD). It is a major health issue that exponentially reduces health and economy and also causes serious morbidity and mortality across the globe. This ... ...

Abstract	Progressive segmental glomerulosclerosis is acknowledged as a characteristic of Chronic Kidney Disease (CKD). It is a major health issue that exponentially reduces health and economy and also causes serious morbidity and mortality across the globe. This review is aimed at comprehending the health perspectives of L-Carnitine (LC) as an adjuvant regimen for alleviating CKD and its associated complications. The data were gathered from different online databases such as Science Direct, Google Scholar, ACS publication, PubMed, Springer, etc., using keywords such as CKD/Kidney disease, current epidemiology and its prevalence, LC supplementations, sources of LC, anti-oxidant and anti-inflammatory potential of LC and its supplementation for mimicking the CKD and its associated problem, etc. Various items of literature concerning CKD were gathered and screened by experts based on their inclusion and exclusion criteria. The findings suggest that, among the different comorbidities such as oxidative stress and inflammatory stress, erythropoietin-resistant anemia, intradialytic hypotension, muscle weakness, myalgia, etc., are considered as the most significant onset symptoms in CKD or hemodialysis patients. LC or creatine supplementation provides an effective adjuvant or therapeutic regimen that significantly reduces oxidative and inflammatory stress and erythropoietin-resistant anemia and evades comorbidities such as tiredness, impaired cognition, muscle weakness, myalgia, and muscle wasting. However, no significant changes were found in biochemical alteration such as creatinine, uric acid, urea, etc., after creatine supplementation in a patient with renal dysfunction. The expert-recommended dose of LC or creatine to a patient is approached for better outcomes of LC as a nutritional therapy regimen for CKD-associated complications. Hence, it can be suggested that LC provides an effective nutritional therapy to ameliorate impaired biochemicals and kidney function and to treat CKD and its associated complications.
Language	English
Publishing date	2023-02-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13020298
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