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Article ; Online: Hierarchy of Influences on Press in a “Partly Free” Society

Wai Han Lo

Contemporary Chinese Political Economy and Strategic Relations: An International Journal, Vol 6, Iss 3, Pp 1065-

Dismantling Journalistic Autonomy

2020 Volume 1092

Abstract: This study used the hierarchy of influences model to explain the control of the state over the newsroom in a partly free society of Hong Kong during the anti-extradition movement. We interviewed 20 reporters, who work as leading journalists or editorial ... ...

Abstract	This study used the hierarchy of influences model to explain the control of the state over the newsroom in a partly free society of Hong Kong during the anti-extradition movement. We interviewed 20 reporters, who work as leading journalists or editorial managers in 9 influential media houses in Hong Kong. Previous studies have used the political economy perspective to analyze the autonomy of Hong Kong media and treated self-censorship as an influential practice. By contrast, this paper has shown how the influence of the state, political actors, media owners, advertisers, and the audience have aligned to undercut journalistic professionalism and autonomy. This paper contributes to the literature by demonstrating the effectiveness of the model in illustrating how political control has been exercised from the macro- to the micro-level.
Keywords	journalistic autonomy ; hierarchy of influences ; press freedom ; political control ; Political science (General) ; JA1-92 ; Economics as a science ; HB71-74
Subject code	950
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	National Sun Yat-sen University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Symmetry-breaking malachite green as a near-infrared light-activated fluorogenic photosensitizer for RNA proximity labeling.

Li, Lan / Han, Jinghua / Lo, Hei-Yong G / Tam, Winnie Wai Ling / Jia, Han / Tse, Edmund Chun Ming / Taliaferro, J Matthew / Li, Ying

Nucleic acids research

2024 Volume 52, Issue 7, Page(s) e36

Abstract: Cellular RNA is asymmetrically distributed in cells and the regulation of RNA localization is crucial for proper cellular functions. However, limited chemical tools are available to capture dynamic RNA localization in complex biological systems with high ...

Abstract	Cellular RNA is asymmetrically distributed in cells and the regulation of RNA localization is crucial for proper cellular functions. However, limited chemical tools are available to capture dynamic RNA localization in complex biological systems with high spatiotemporal resolution. Here, we developed a new method for RNA proximity labeling activated by near-infrared (NIR) light, which holds the potential for deep penetration. Our method, termed FAP-seq, utilizes a genetically encoded fluorogen activating protein (FAP) that selectively binds to a set of substrates known as malachite green (MG). FAP binding restricts the rotation of MG and rapidly activates its fluorescence in a wash-free manner. By introducing a monoiodo modification to MG, we created a photosensitizer (MG-HI) with the highest singlet oxygen generation ability among various MG derivatives, enabling both protein and RNA proximity labeling in live cells. New insights are provided in the transcriptome analysis with FAP-seq, while a deeper understanding of the symmetry-breaking structural arrangement of FAP-MG-HI was obtained through molecular dynamics simulations. Overall, our wash-free and NIR light-inducible RNA proximity labeling method (FAP-seq) offers a powerful and versatile approach for investigating complex mechanisms underlying RNA-related biological processes.
MeSH term(s)	Rosaniline Dyes/chemistry ; Photosensitizing Agents/chemistry ; Infrared Rays ; Humans ; Fluorescent Dyes/chemistry ; RNA/chemistry ; RNA/metabolism ; Singlet Oxygen/metabolism ; Singlet Oxygen/chemistry ; Molecular Dynamics Simulation ; HeLa Cells
Chemical Substances	malachite green (12058M7ORO) ; Rosaniline Dyes ; Photosensitizing Agents ; Fluorescent Dyes ; RNA (63231-63-0) ; Singlet Oxygen (17778-80-2)
Language	English
Publishing date	2024-02-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkae125
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Article: Marketing images of marriage rituals

Lo, Wai Han

Journal of international consumer marketing Vol. 30, No. 2 , p. 128-146

a cross-cultural analysis of wedding magazine advertising

2018 Volume 30, Issue 2, Page(s) 128–146

Author's details	Wai Han Lo
Keywords	Advertising ; globalization ; magazines ; rituals ; wedding
Language	English
Dates of publication	2018-9999
Publisher	Taylor & Francis Group
Publishing place	Philadelphia, Pa.
Document type	Article
ZDB-ID	1080285x ; 2069279-1
ISSN	1528-7068 ; 0896-1530
ISSN (online)	1528-7068
ISSN	0896-1530
Database	ECONomics Information System

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Article ; Online: Citizen Camera-Witnessing

Wai Han Lo

Contemporary Chinese Political Economy and Strategic Relations: An International Journal, Vol 2, Iss 2, Pp 795-

A Case Study of the Umbrella Movement

2016 Volume 815

Abstract: Citizen camera-witness is a new concept by which to describe using mobile camera phone to engage in civic expression. I argue that the meaning of this concept should not be limited to painful testimony; instead, it is a mode of civic camera-mediated mass ...

Abstract	Citizen camera-witness is a new concept by which to describe using mobile camera phone to engage in civic expression. I argue that the meaning of this concept should not be limited to painful testimony; instead, it is a mode of civic camera-mediated mass self-testimony to brutality. The use of mobile phone recordings in Hong Kong’s Umbrella Movement is examined to understand how mobile cameras are employed as personal witnessing devices to provide recordings to indict unjust events and engage others in the civic movement. This study has examined the Facebook posts and You Tube videos of the Umbrella Movement between September 22, 2014 and December 22, 2014. The results suggest that the camera phone not only contributes to witnessing the brutal repression of the state, but also witnesses the beauty of the movement, and provides a testimony that allows for rituals to develop and semi-codes to be transformed.
Keywords	citizen journalism ; media witnessing ; social media ; social movement ; visual culture ; Political science (General) ; JA1-92 ; Economics as a science ; HB71-74
Language	English
Publishing date	2016-08-01T00:00:00Z
Publisher	National Sun Yat-sen University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Citizen Camera-Witnessing

Wai Han Lo

Contemporary Chinese Political Economy and Strategic Relations: An International Journal, Vol 2, Iss 2, Pp 795-

A Case Study of the Umbrella Movement

2016 Volume 815

Abstract	Citizen camera-witness is a new concept by which to describe using mobile camera phone to engage in civic expression. I argue that the meaning of this concept should not be limited to painful testimony; instead, it is a mode of civic camera-mediated mass self-testimony to brutality. The use of mobile phone recordings in Hong Kong’s Umbrella Movement is examined to understand how mobile cameras are employed as personal witnessing devices to provide recordings to indict unjust events and engage others in the civic movement. This study has examined the Facebook posts and You Tube videos of the Umbrella Movement between September 22, 2014 and December 22, 2014. The results suggest that the camera phone not only contributes to witnessing the brutal repression of the state, but also witnesses the beauty of the movement, and provides a testimony that allows for rituals to develop and semi-codes to be transformed.
Keywords	citizen journalism ; media witnessing ; social media ; social movement ; visual culture ; Political science (General) ; JA1-92 ; Economics as a science ; HB71-74
Language	English
Publishing date	2016-08-01T00:00:00Z
Publisher	National Sun Yat-sen University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Citizen Camera-Witnessing

Wai Han Lo

Contemporary Chinese Political Economy and Strategic Relations: An International Journal, Vol 2, Iss 2, Pp 795-

A Case Study of the Umbrella Movement

2016 Volume 815

Abstract	Citizen camera-witness is a new concept by which to describe using mobile camera phone to engage in civic expression. I argue that the meaning of this concept should not be limited to painful testimony; instead, it is a mode of civic camera-mediated mass self-testimony to brutality. The use of mobile phone recordings in Hong Kong’s Umbrella Movement is examined to understand how mobile cameras are employed as personal witnessing devices to provide recordings to indict unjust events and engage others in the civic movement. This study has examined the Facebook posts and You Tube videos of the Umbrella Movement between September 22, 2014 and December 22, 2014. The results suggest that the camera phone not only contributes to witnessing the brutal repression of the state, but also witnesses the beauty of the movement, and provides a testimony that allows for rituals to develop and semi-codes to be transformed.
Keywords	citizen journalism ; media witnessing ; social media ; social movement ; visual culture ; Political science (General) ; JA1-92 ; Economics as a science ; HB71-74
Language	English
Publishing date	2016-09-01T00:00:00Z
Publisher	National Sun Yat-sen University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Low-Dose Versus Standard-Dose Alteplase in Bridging Therapy for Large Vessel Stroke: A Systematic Review and Meta-Analysis.

Yang, Ta-Wei / Lee, Ya-Han / Lo, Wei-Cheng / Chen, I-Ting / Lin, Han-Chun / Chen, Ming-Hua / Lee, Chiao-Hua / Hsu, Yuan-Pin / Tam, Ka-Wai

Cerebrovascular diseases (Basel, Switzerland)

2024

Abstract: INTRODUCTION The efficacy and safety of low- and standard-dose alteplase for acute ischemic stroke (AIS) have not been consistently compared in previous studies. Nevertheless, the distinctions in the effects of low- and standard-dose alteplase, ... ...

Abstract	INTRODUCTION The efficacy and safety of low- and standard-dose alteplase for acute ischemic stroke (AIS) have not been consistently compared in previous studies. Nevertheless, the distinctions in the effects of low- and standard-dose alteplase, particularly within the context of bridging therapy (BT) for large vessel occlusion (LVO), warrant further exploration. This study compared clinical outcomes between BT with low- and standard-dose alteplase in patients with LVO-related AIS. METHODS We performed a search for randomized controlled trials and prospective or retrospective cohort studies investigating the clinical outcomes of BT in AIS in the PubMed, Embase, and Cochrane Library databases from inception to November 2022. The outcomes of interest were 90-day functional independence, successful recanalization, symptomatic intracerebral hemorrhage (sICH) and mortality; these outcomes were compared between patients who received BT with low- (primarily 0.6 mg/kg) and standard-dose alteplase (0.9 mg/kg). We used the standard-dose group as the reference and calculated the odds ratio (OR) and its 95% confidence interval (CI) from the raw numbers. Meta-analysis and ethnicity-based subgroup analysis (Asian and non-Asian) were performed. RESULTS Five observational studies, published after 2017 and including 408 patients, were included. The meta-analysis results demonstrated that compared with BT with standard-dose alteplase, BT with low-dose alteplase did not improve 90-day functional independence (odds ratio, [OR] 1.02; 95% confidence interval [CI], 0.58-1.80). Nevertheless, BT with low-dose alteplase was associated with a comparable successful recanalization rate (OR, 1.35; 95% CI, 0.68-2.67) and similar sICH incidence (OR 0.36; 95% CI, 0.10-1.36), and mortality (OR, 0.64; 95% CI, 0.27-1.54) compared with BT with standard-dose alteplase; however, the above three results were nonsignificant. In the ethnicity-based subgroup analyses, no differences were noted between Asian and non-Asian participants. CONCLUSIONS In patients with LVO-related AIS, BT with low- or standard-dose alteplase may provide similar efficacy, with no significant differences in sICH incidence and mortality. Additional well-designed prospective studies are required to confirm this result.
Language	English
Publishing date	2024-01-05
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	1069462-6
ISSN	1421-9786 ; 1015-9770
ISSN (online)	1421-9786
ISSN	1015-9770
DOI	10.1159/000535569
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Zs.A 3181: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Multi-disciplinary diabetic limb salvage programme in octogenarians with diabetic foot ulcers is not futile: An observational study with historical controls.

Ge, Lixia / Zhao, Jiashen / Tan, Matthew / Tan, Elaine / Liew, Huiling / Yong, Enming / Hoe, Jeremy / Shi, Claris / Chan, Dexter Yak Seng / Ang, Gary Yee / Molina, Joseph Antonio / Sun, Yan / Hoi, Wai Han / Chandraskear, Sadhana / Lo, Zhiwen Joseph

International wound journal

2024 Volume 21, Issue 3, Page(s) e14801

Abstract: This study evaluated the effectiveness of a multi-disciplinary diabetic limb salvage programme in improving clinical outcomes and optimising healthcare utilisation in 406 patients aged ≥80 years with diabetic foot ulcers (DFUs), compared to 2392 younger ... ...

Abstract	This study evaluated the effectiveness of a multi-disciplinary diabetic limb salvage programme in improving clinical outcomes and optimising healthcare utilisation in 406 patients aged ≥80 years with diabetic foot ulcers (DFUs), compared to 2392 younger patients enrolled from June 2020 to June 2021 and against 1716 historical controls using one-to-one propensity score matching. Results showed that elderly programme patients had lower odds of amputation-free survival (odds ratio: 0.64, 95% CI: 0.47, 0.88) and shorter cumulative length of stay (LOS) compared to younger programme patients (incidence rate ratio: 0.45, 95% CI: 0.29, 0.69). Compared to the matched controls, participating in the programme was associated with 5% higher probability of minor lower extremity amputation, reduced inpatient admissions and emergency visits, shorter LOS but increased specialist and primary care visits (all p-values <0.05). The findings suggest that the programme yielded favourable impacts on the clinical outcomes of patients aged≥80 years with DFUs. Further research is needed to develop specific interventions tailoring to the needs of the elderly population and to determine their effectiveness on patient outcomes while accounting for potential confounding factors.
MeSH term(s)	Aged, 80 and over ; Humans ; Amputation, Surgical ; Diabetes Mellitus ; Diabetic Foot/surgery ; Limb Salvage/methods ; Octogenarians ; Retrospective Studies
Language	English
Publishing date	2024-03-01
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	2170920-8
ISSN	1742-481X ; 1742-4801
ISSN (online)	1742-481X
ISSN	1742-4801
DOI	10.1111/iwj.14801
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Zs.A 6006: Show issues

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Article ; Online: Raddeanin A isolated from Anemone raddeana Regel improves pathological and cognitive deficits of the mice model of Alzheimer's disease by targeting β-amyloidosis.

Liu, Meng Han / Tang, Yong / Qu, Li Qun / Song, Lin Lin / Lo, Hang Hong / Zhang, Rui Long / Yun, Xiao Yun / Wang, Hui Miao / Chan, Joyce Tsz Wai / Wu, Jian Hui / Wang, Cai Ren / Wong, Vincent Kam Wai / Wu, An Guo / Law, Betty Yuen-Kwan

Phytomedicine : international journal of phytotherapy and phytopharmacology

2023 Volume 122, Page(s) 155121

Abstract: Background: Raddeanin A is a triterpenoid isolated from Anemone raddeana Regel. It exhibits a broad spectrum of biological activities such as anti-tumor and anti-inflammatory, however, its neuroprotective effect in targeting Alzheimer's disease (AD) ... ...

Abstract	Background: Raddeanin A is a triterpenoid isolated from Anemone raddeana Regel. It exhibits a broad spectrum of biological activities such as anti-tumor and anti-inflammatory, however, its neuroprotective effect in targeting Alzheimer's disease (AD) remains uninvestigated. Purpose: To provide scientific base for the development of novel AD drug by clarifying the neuroprotective effect and molecular mechanisms of raddeanin A in both in vitro and in vivo AD model. Study design: To confirm the neuroprotective role of raddeanin A in the treatment of AD, its mechanisms and effects on β-amyloidosis and Aβ fibrillation was studied in U87 cells. Besides, the improvement on cognitive deficit, pathological defects, reactive astrocyte clusters, inhibition on neuronal inflammation and apoptosis were further studied in 3 x Tg-AD mice model of AD. Methods: Real-time PCR, western blot, dot blot, biolayer interferometry and bioinformatics analysis were used to confirm the in vitro effect and targets of raddeanin A on β-amyloidosis and its associated protein network. A series of experiments including Morris water maze, H&E staining, nissl staining and immunofluorescence analysis were conducted to confirm the protective behavioral effect of raddeanin A in the in vivo AD mice model. Results: Raddeanin A was identified to reduce β-amyloidosis in U87 cells and 3 x Tg-AD mice model of AD by decreasing level of BACE1, APP, APP-β and Aβ. Raddeanin A improved behavioral, spatial memory and learning ability in the AD mice. In the cortex and hippocampus, raddeanin A improved the morphology and arrangement of neurons, lower the level of reactive astrocyte marker GFAP and apoptotic marker proteins Bax/Bcl2 ratio. Moreover, raddeanin A upregulated the mRNA and protein level of Prkcα in the hippocampus of AD mice whose neuroprotective effect was exerted possibly via the activation of protein kinase C. Conclusion: As a novel natural agent targeting β-amyloidosis, our results provide the first evidence of the multiple in vitro and in vivo neuroprotective effect of raddeanin A, suggesting its potential therapeutic application in preventing or alleviating the symptoms of AD.
MeSH term(s)	Mice ; Animals ; Alzheimer Disease/metabolism ; Anemone/metabolism ; Amyloid Precursor Protein Secretases ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Aspartic Acid Endopeptidases ; Amyloidosis ; Cognition ; Mice, Transgenic ; Amyloid beta-Peptides/metabolism ; Disease Models, Animal ; Amyloid beta-Protein Precursor/genetics
Chemical Substances	raddeanin A ; Amyloid Precursor Protein Secretases (EC 3.4.-) ; Neuroprotective Agents ; Aspartic Acid Endopeptidases (EC 3.4.23.-) ; Amyloid beta-Peptides ; Amyloid beta-Protein Precursor
Language	English
Publishing date	2023-10-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2023.155121
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Zs.A 4115: Show issues

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Article ; Online: Hyperoside alleviates toxicity of β-amyloid via endoplasmic reticulum-mitochondrial calcium signal transduction cascade in APP/PS1 double transgenic Alzheimer's disease mice.

Song, Lin Lin / Qu, Yuan Qing / Tang, Yong Pei / Chen, Xi / Lo, Hang Hong / Qu, Li Qun / Yun, Yun Xiao / Wong, Vincent Kam Wai / Zhang, Rui Long / Wang, Hui Miao / Liu, Meng Han / Zhang, Wei / Zhang, Hui Xia / Chan, Joyce Tsz Wai / Wang, Cai Ren / Wu, Jian Hui / Law, Betty Yuen Kwan

Redox biology

2023 Volume 61, Page(s) 102637

Abstract: Alzheimer's disease is a neurodegenerative disorder characterized by a decline in cognitive function. The β-amyloid (Aβ) hypothesis suggests that Aβ peptides can spontaneously aggregate into β-fragment-containing oligomers and protofibrils, and this ... ...

Abstract	Alzheimer's disease is a neurodegenerative disorder characterized by a decline in cognitive function. The β-amyloid (Aβ) hypothesis suggests that Aβ peptides can spontaneously aggregate into β-fragment-containing oligomers and protofibrils, and this activation of the amyloid pathway alters Ca
MeSH term(s)	Mice ; Animals ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/metabolism ; Mice, Transgenic ; Calcium/metabolism ; Signal Transduction ; Endoplasmic Reticulum/metabolism ; Disease Models, Animal
Chemical Substances	Amyloid beta-Peptides ; Calcium (SY7Q814VUP) ; hyperoside (8O1CR18L82)
Language	English
Publishing date	2023-02-14
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701011-9
ISSN	2213-2317 ; 2213-2317
ISSN (online)	2213-2317
ISSN	2213-2317
DOI	10.1016/j.redox.2023.102637
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