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  1. Article ; Online: Pulmonary Arterial Hypertension and Sex in the Right Ventricle: It Is an Interesting Picture!

    Thenappan, Thenappan / Weir, E Kenneth

    American journal of respiratory and critical care medicine

    2020  Volume 202, Issue 7, Page(s) 928–929

    MeSH term(s) Familial Primary Pulmonary Hypertension ; Female ; Heart Ventricles/diagnostic imaging ; Humans ; Male ; Pulmonary Arterial Hypertension ; Pulmonary Artery ; Ventricular Function, Right
    Keywords covid19
    Language English
    Publishing date 2020-07-21
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202006-2147ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A Case Report of Portopulmonary Hypertension Precipitated by Transjugular Intrahepatic Portosystemic Shunt.

    Tatah, Jasmine H / Weir, E Kenneth / Prins, Kurt W / Thenappan, Thenappan

    Chest

    2021  Volume 159, Issue 4, Page(s) e193–e196

    Abstract: We report here a case of portopulmonary hypertension following transjugular intrahepatic portosystemic shunt. ...

    Abstract We report here a case of portopulmonary hypertension following transjugular intrahepatic portosystemic shunt.
    MeSH term(s) Female ; Humans ; Hypertension, Portal/physiopathology ; Hypertension, Portal/surgery ; Hypertension, Pulmonary/physiopathology ; Hypertension, Pulmonary/surgery ; Middle Aged ; Portal Pressure/physiology ; Portasystemic Shunt, Transjugular Intrahepatic/methods ; Pulmonary Wedge Pressure/physiology
    Language English
    Publishing date 2021-04-06
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2020.11.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Differentiating COVID-19 Pneumonia From Acute Respiratory Distress Syndrome and High Altitude Pulmonary Edema: Therapeutic Implications.

    Archer, Stephen L / Sharp, Willard W / Weir, E Kenneth

    Circulation

    2020  Volume 142, Issue 2, Page(s) 101–104

    MeSH term(s) Altitude Sickness/metabolism ; Altitude Sickness/pathology ; Altitude Sickness/therapy ; Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/metabolism ; Coronavirus Infections/pathology ; Coronavirus Infections/therapy ; Dyspnea/etiology ; Hemodynamics ; Humans ; Hypertension, Pulmonary/metabolism ; Hypertension, Pulmonary/pathology ; Hypertension, Pulmonary/therapy ; Hypoxia/etiology ; Lung/blood supply ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/metabolism ; Pneumonia, Viral/pathology ; Pneumonia, Viral/therapy ; Respiratory Distress Syndrome/metabolism ; Respiratory Distress Syndrome/pathology ; Respiratory Distress Syndrome/therapy ; SARS-CoV-2 ; Vasoconstriction
    Keywords covid19
    Language English
    Publishing date 2020-05-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.120.047915
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  4. Article ; Online: The Nitric Oxide Pathway-A Potential Target for Precision Medicine in Pulmonary Arterial Hypertension.

    Thenappan, Thenappan / Weir, E Kenneth

    The American journal of cardiology

    2018  Volume 120, Issue 8S, Page(s) S69–S70

    MeSH term(s) Cyclic GMP/metabolism ; Drug Therapy, Combination ; Endothelins/metabolism ; Enzyme Activators/therapeutic use ; Humans ; Hypertension, Pulmonary/drug therapy ; Hypertension, Pulmonary/metabolism ; Molecular Targeted Therapy ; Nitric Oxide/metabolism ; Phosphodiesterase 5 Inhibitors/therapeutic use ; Precision Medicine ; Pyrazoles/therapeutic use ; Pyrimidines/therapeutic use ; Signal Transduction ; Sildenafil Citrate/therapeutic use ; Tadalafil/therapeutic use
    Chemical Substances Endothelins ; Enzyme Activators ; Phosphodiesterase 5 Inhibitors ; Pyrazoles ; Pyrimidines ; Nitric Oxide (31C4KY9ESH) ; Tadalafil (742SXX0ICT) ; Sildenafil Citrate (BW9B0ZE037) ; Cyclic GMP (H2D2X058MU) ; riociguat (RU3FE2Y4XI)
    Language English
    Publishing date 2018-01-25
    Publishing country United States
    Document type Introductory Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2017.06.011
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  5. Article ; Online: Efficacy and safety of the Aria pulmonary endovascular device in pulmonary hypertension.

    Gerges, Christian / Vollmers, Karl / Skoro-Sajer, Nika / Dannenberg, Varius / Hartig, Valerie / Pritzker, Marc R / Scandurra, John / Weir, E Kenneth / Lang, Irene M

    European journal of heart failure

    2024  

    Abstract: Aims: A common feature of various forms of pulmonary hypertension (PH) is progressive decline of pulmonary arterial compliance (C: Methods and results: Eight patients with PH-LHD and 10 patients with PH-CLD were included in this study. The device was ...

    Abstract Aims: A common feature of various forms of pulmonary hypertension (PH) is progressive decline of pulmonary arterial compliance (C
    Methods and results: Eight patients with PH-LHD and 10 patients with PH-CLD were included in this study. The device was placed in the main pulmonary artery via the right femoral vein and was connected by a catheter to a gas-filled reservoir outside the body. During systole, gas shifts from the balloon to the reservoir, leading to deflation of the balloon. In diastole, the gas returns from the reservoir to the balloon, leading to balloon inflation and enhancing diastolic blood flow to the distal pulmonary capillary bed. Haemodynamics were assessed at baseline, and again with device off, device on and device off. The primary safety endpoint was the incidence of serious adverse events through 30 days after the procedure. No complications or investigational device-related serious adverse events occurred. Device activation in PH-LHD and PH-CLD patients decreased pulmonary arterial pulse pressure by 5.6 ± 4.2 mmHg (-12%; p = 0.003) and 4.2 ± 2.2 mmHg (-11%; p < 0.001), increased C
    Conclusions: Temporary implantation of the Aria endovascular device was feasible and safe. Device activation resulted in acute improvement of C
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.3187
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  6. Article: Differentiating COVID-19 Pneumonia From Acute Respiratory Distress Syndrome and High Altitude Pulmonary Edema: Therapeutic Implications

    Archer, Stephen L / Sharp, Willard W / Weir, E Kenneth

    Circulation

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #186570
    Database COVID19

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  7. Article ; Online: Carvedilol for Treatment of Right Ventricular Dysfunction in Pulmonary Arterial Hypertension.

    Thenappan, Thenappan / Weir, E Kenneth / Prins, Kurt W / Pritzker, Marc R / Archer, Stephen L

    Journal of the American Heart Association

    2021  Volume 10, Issue 14, Page(s) e021518

    MeSH term(s) Antihypertensive Agents/therapeutic use ; Carvedilol/therapeutic use ; Feasibility Studies ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Pilot Projects ; Pulmonary Arterial Hypertension/complications ; Pulmonary Arterial Hypertension/drug therapy ; Pulmonary Arterial Hypertension/physiopathology ; Pulmonary Wedge Pressure/drug effects ; Stroke Volume/drug effects ; Stroke Volume/physiology ; Ventricular Dysfunction, Right/drug therapy ; Ventricular Dysfunction, Right/etiology ; Ventricular Dysfunction, Right/physiopathology ; Ventricular Function, Right/physiology
    Chemical Substances Antihypertensive Agents ; Carvedilol (0K47UL67F2)
    Language English
    Publishing date 2021-07-14
    Publishing country England
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.121.021518
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Does vitamin D deficiency increase the severity of COVID-19?

    Weir, E Kenneth / Thenappan, Thenappan / Bhargava, Maneesh / Chen, Yingjie

    Clinical medicine (London, England)

    2020  Volume 20, Issue 4, Page(s) e107–e108

    Abstract: The severity of coronavirus 2019 infection (COVID-19) is determined by the presence of pneumonia, severe acute respiratory distress syndrome (SARS-CoV-2), myocarditis, microvascular thrombosis and/or cytokine storms, all of which involve underlying ... ...

    Abstract The severity of coronavirus 2019 infection (COVID-19) is determined by the presence of pneumonia, severe acute respiratory distress syndrome (SARS-CoV-2), myocarditis, microvascular thrombosis and/or cytokine storms, all of which involve underlying inflammation. A principal defence against uncontrolled inflammation, and against viral infection in general, is provided by T regulatory lymphocytes (Tregs). Treg levels have been reported to be low in many COVID-19 patients and can be increased by vitamin D supplementation. Low vitamin D levels have been associated with an increase in inflammatory cytokines and a significantly increased risk of pneumonia and viral upper respiratory tract infections. Vitamin D deficiency is associated with an increase in thrombotic episodes, which are frequently observed in COVID-19. Vitamin D deficiency has been found to occur more frequently in patients with obesity and diabetes. These conditions are reported to carry a higher mortality in COVID-19. If vitamin D does in fact reduce the severity of COVID-19 in regard to pneumonia/ARDS, inflammation, inflammatory cytokines and thrombosis, it is our opinion that supplements would offer a relatively easy option to decrease the impact of the pandemic.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/immunology ; Coronavirus Infections/therapy ; Dietary Supplements ; Humans ; Pandemics ; Patient Acuity ; Pneumonia, Viral/complications ; Pneumonia, Viral/immunology ; Pneumonia, Viral/therapy ; SARS-CoV-2 ; T-Lymphocytes, Regulatory ; Vitamin D/therapeutic use ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/drug therapy ; Vitamins/therapeutic use
    Chemical Substances Vitamins ; Vitamin D (1406-16-2)
    Keywords covid19
    Language English
    Publishing date 2020-06-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2048646-7
    ISSN 1473-4893 ; 1470-2118
    ISSN (online) 1473-4893
    ISSN 1470-2118
    DOI 10.7861/clinmed.2020-0301
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  9. Article ; Online: Differentiating COVID-19 Pneumonia From Acute Respiratory Distress Syndrome and High Altitude Pulmonary Edema ; Therapeutic Implications

    Archer, Stephen L. / Sharp, Willard W. / Weir, E. Kenneth

    Circulation

    2020  Volume 142, Issue 2, Page(s) 101–104

    Keywords Physiology (medical) ; Cardiology and Cardiovascular Medicine ; covid19
    Language English
    Publisher Ovid Technologies (Wolters Kluwer Health)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/circulationaha.120.047915
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  10. Article ; Online: Redesign of internal-medicine teaching.

    Weir, E Kenneth

    The New England journal of medicine

    2010  Volume 363, Issue 6, Page(s) 593; author reply 594–5

    MeSH term(s) Humans ; Internal Medicine/education ; Internship and Residency/organization & administration ; Job Satisfaction ; Patient Satisfaction ; Workload
    Language English
    Publishing date 2010-08-05
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1005271
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