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Article ; Online: Engineering a pH-responsive polymeric micelle co-loaded with paclitaxel and triptolide for breast cancer therapy.

Zhang, Mengmeng / Ying, Na / Chen, Jie / Wu, Liwen / Liu, Huajie / Luo, Shihua / Zeng, Dongdong

2024 , Page(s) e13603

Abstract: Breast cancer has overtaken lung cancer as the number one cancer worldwide. Paclitaxel (PTX) is a widely used first-line anti-cancer drug, but it is not very effective in clinical breast cancer therapy. It has been reported that triptolide (TPL) can ... ...

Abstract	Breast cancer has overtaken lung cancer as the number one cancer worldwide. Paclitaxel (PTX) is a widely used first-line anti-cancer drug, but it is not very effective in clinical breast cancer therapy. It has been reported that triptolide (TPL) can enhance the anticancer effect of paclitaxel, and better synergistic therapeutic effects are seen with concomitant administration of PTX and TPL. In this study, we developed pH-responsive polymeric micelles for co-delivery of PTX and TPL, which disassembling in acidic tumour microenvironments to target drug release and effectively kill breast cancer cells. Firstly, we synthesized amphiphilic copolymer mPEG
Language	English
Publishing date	2024-01-16
Publishing country	England
Document type	Journal Article
ZDB-ID	1064202-x
ISSN	1365-2184 ; 0008-8730 ; 0960-7722
ISSN (online)	1365-2184
ISSN	0008-8730 ; 0960-7722
DOI	10.1111/cpr.13603
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Article ; Online: Prediction of Spot Price of Iron Ore Based on PSR-WA-LSSVM Combined Model

Xiangjun Cai / Shihua Luo

Journal of Computing and Information Technology, Vol 29, Iss 1, Pp 27-

2021 Volume 38

Abstract: Aiming at the problems that the existing single time series models are not accurate and robust enough when it comes to forecasting the iron ore prices and the parameters of the traditional LSSVM model are difficult to determine, we propose a combined ... ...

Abstract	Aiming at the problems that the existing single time series models are not accurate and robust enough when it comes to forecasting the iron ore prices and the parameters of the traditional LSSVM model are difficult to determine, we propose a combined model based on Phase Space Reconstruction (PSR), wavelet transform and LSSVM (PSR-WA-LSSVM) to tackle these issues. ARIMA model, LSTM model, PSR-LSSVM model, and PSR-WA-LSSVM models were used for contrast simulation to forecast the spot price data of 61.5%PB powder from January 30, 2019, to February 1, 2021, in Ningbo Zhoushan port. The experimental results show that the PSR-WA-LSSVM combination model achieves better prediction results. At the same time, the model has a good performance in the multistep prediction of the iron ore price.
Keywords	Iron ore spot price ; Price projection ; Combination model ; Electronic computers. Computer science ; QA75.5-76.95
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	University of Zagreb Faculty of Electrical Engineering and Computing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Noninvasive Framework Nucleic Acid Eye Drops for Retinal Administration.

Zhu, Shitai / Yan, Qinglong / Wang, Lihua / Zhu, Ying / Luo, Shihua

ACS applied bio materials

2023 Volume 6, Issue 11, Page(s) 5078–5085

Abstract: Intravitreal injection is widely employed for the treatment of retinal diseases. However, it suffers from various drawbacks, including ocular trauma, risk of infection, and poor patient compliance due to frequent administrations. Due to the presence of ... ...

Abstract	Intravitreal injection is widely employed for the treatment of retinal diseases. However, it suffers from various drawbacks, including ocular trauma, risk of infection, and poor patient compliance due to frequent administrations. Due to the presence of barriers such as the cornea, it has been a challenge to develop efficient noninvasive ophthalmic eye drops that can reach the retina. Framework nucleic acids (FNAs), known for their excellent biocompatibility and precise, controllable shape and size, have been extensively utilized in drug delivery application. Here, we report the development of size- and shape-resolved fluorescent DNA frameworks for noninvasive retinal administration. Results show that tetrahedral DNA nanostructures (TDNs) with an edge length of 20 bp can reach the retina within 6 h with the highest efficiency. Moreover, this delivery method exhibits excellent biocompatibility. Our findings provide an approach for the development of localized treatment strategies for retinal diseases using FNA-based nanocarriers.
MeSH term(s)	Humans ; Nucleic Acids/therapeutic use ; Ophthalmic Solutions ; Retina ; Retinal Diseases ; DNA/chemistry
Chemical Substances	Nucleic Acids ; Ophthalmic Solutions ; DNA (9007-49-2)
Language	English
Publishing date	2023-10-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2576-6422
ISSN (online)	2576-6422
DOI	10.1021/acsabm.3c00760
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Article ; Online: Real-Time Monitoring of Neurotransmitters in the Brain of Living Animals.

Da, Yifan / Luo, Shihua / Tian, Yang

ACS applied materials & interfaces

2022

Abstract: Neurotransmitters, as important chemical small molecules, perform the function of neural signal transmission from cell to cell. Excess concentrations of neurotransmitters are often closely associated with brain diseases, such as Alzheimer's disease, ... ...

Abstract	Neurotransmitters, as important chemical small molecules, perform the function of neural signal transmission from cell to cell. Excess concentrations of neurotransmitters are often closely associated with brain diseases, such as Alzheimer's disease, depression, schizophrenia, and Parkinson's disease. On the other hand, the release of neurotransmitters under the induced stimulation indicates the occurrence of reward-related behaviors, including food and drug addiction. Therefore, to understand the physiological and pathological functions of neurotransmitters, especially in complex environments of the living brain, it is urgent to develop effective tools to monitor their dynamics with high sensitivity and specificity. Over the past 30 years, significant advances in electrochemical sensors and optical probes have brought new possibilities for studying neurons and neural circuits by monitoring the changes in neurotransmitters. This Review focuses on the progress in the construction of sensors for in vivo analysis of neurotransmitters in the brain and summarizes current attempts to address key issues in the development of sensors with high selectivity, sensitivity, and stability. Combined with the latest advances in technologies and methods, several strategies for sensor construction are provided for recording chemical signal changes in the complex environment of the brain.
Language	English
Publishing date	2022-04-08
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.2c02740
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Article ; Online: Image Analysis of TVCDS in Infertile Patients with Polycystic Ovary Syndrome.

Duan, Hongju / Luo, Shihua / Yu, Yang / Yan, Qiaohua

publication RETRACTED

Contrast media & molecular imaging

2022 Volume 2022, Page(s) 1234983

Abstract: In order to analyze and examine the TVCDS images of infertile patients, this paper conducted an in-depth study based on the symptoms of polycystic ovary syndrome. Through the sample size estimation method, mathematical analysis, and other methods, the ... ...

Abstract	In order to analyze and examine the TVCDS images of infertile patients, this paper conducted an in-depth study based on the symptoms of polycystic ovary syndrome. Through the sample size estimation method, mathematical analysis, and other methods, the image examination of the polycystic ovary in TVCDS was successfully analyzed. 86 cases of infertile patients with PCS were divided into a control group treated with clomiphene alone and an observation group treated with clomiphene combined with TCM periodic therapy, with 43 patients in each group. The therapeutic effects of the two groups were compared and analyzed. Results show that the treatment effective rate and pregnancy success rate of the observation group were 95.35% and 88.37%, respectively, and those of the control group were 83.72% and 76.74%, respectively. The difference between the two groups was statistically significant (
MeSH term(s)	Clomiphene/therapeutic use ; Female ; Humans ; Infertility/chemically induced ; Infertility/drug therapy ; Menstruation Disturbances/chemically induced ; Menstruation Disturbances/drug therapy ; Polycystic Ovary Syndrome/complications ; Polycystic Ovary Syndrome/diagnostic imaging ; Pregnancy ; Progesterone/therapeutic use
Chemical Substances	Clomiphene (1HRS458QU2) ; Progesterone (4G7DS2Q64Y)
Language	English
Publishing date	2022-06-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Retracted Publication
ZDB-ID	2232678-9
ISSN	1555-4317 ; 1555-4309
ISSN (online)	1555-4317
ISSN	1555-4309
DOI	10.1155/2022/1234983
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Article ; Online: Detection and Isolation of Incipiently Developing Fault Using Wasserstein Distance

Cheng Lu / Jiusun Zeng / Shihua Luo / Jinhui Cai

Processes, Vol 10, Iss 1081, p

2022 Volume 1081

Abstract: This paper develops an incipient fault detection and isolation method using the Wasserstein distance, which measures the difference between the probability distributions of normal and faulty data sets from the aspect of optimal transport. For fault ... ...

Abstract	This paper develops an incipient fault detection and isolation method using the Wasserstein distance, which measures the difference between the probability distributions of normal and faulty data sets from the aspect of optimal transport. For fault detection, a moving window based approach is introduced, resulting in two monitoring statistics that are constructed based on the Wasserstein distance. From analysis of the limiting distribution under multivariate Gaussian case, it is proved that the difference measured by the Wasserstein distance is more sensitive than conventional quadratic statistics like Hotelling’s <math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msup><mi>T</mi><mn>2</mn></msup></semantics></math> and Squared Prediction Error (SPE). For non-Gaussian distributed data, a project robust Wasserstein distance (PRW) model is proposed and the Riemannian block coordinate descent (RBCD) algorithm is applied to estimate the Wasserstein distance, which is fast when the number of sampled data is large. In addition, a fault isolation method is further proposed once the incipiently developing fault is detected. Application studies to a simulation example, a continuous stirred tank reactor (CSTR) process and a real-time boiler water wall over-temperature process demonstrate the effectiveness of the proposed method.
Keywords	Wasserstein distance ; incipient fault detection and isolation ; multivariate statistical analysis ; Riemannian block coordinate descent ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Visualization of the hepatic and renal cell uptake and trafficking of tetrahedral DNA origami in tumour.

Zhu, Shitai / Peng, Hongzhen / Kong, Huating / Yan, Qinglong / Xia, Kai / Wang, Lihua / Zhu, Ying / Luo, Shihua

Cell proliferation

2024 , Page(s) e13643

Abstract: DNA nanostructures, known for their programmability, ease of modification, and favourable biocompatibility, have gained widespread application in the biomedical field. Among them, Tetrahedral DNA Origami (TDOs), as a novel DNA nanostructure, possesses ... ...

Abstract	DNA nanostructures, known for their programmability, ease of modification, and favourable biocompatibility, have gained widespread application in the biomedical field. Among them, Tetrahedral DNA Origami (TDOs), as a novel DNA nanostructure, possesses well-defined structures, multiple modification sites, and large cavities, making it a promising drug carrier. However, current understanding of TDOs' interactions with biological systems, particularly with target cells and organs, remains unexplored, limiting its further applications in biomedicine. In this work, we prepared TDOs with an average particle size of 40 nm and labelled them with Cy5 fluorescent molecules. Following intravenous injection in mice, the uptake of TDOs by different types of liver and kidney cells was observed. Results indicated that TDOs accumulate in renal tubules and are metabolized by Kupffer cells, epithelial cells, and hepatocytes in the liver. Additionally, in a tumour-bearing mouse model, TDOs passively targeted tumour tissues and exhibited excellent tumour penetration and retention after rapid metabolism in hepatocytes. Our findings provide crucial insights for the development of TDO-based drug delivery systems.
Language	English
Publishing date	2024-04-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1064202-x
ISSN	1365-2184 ; 0008-8730 ; 0960-7722
ISSN (online)	1365-2184
ISSN	0008-8730 ; 0960-7722
DOI	10.1111/cpr.13643
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: DNA Framework-Templated Fabrication of Ultrathin Electroactive Gold Nanosheets.

Li, Le / Ding, Yawen / Xie, Gang / Luo, Shihua / Liu, Xiaoguo / Wang, Lihua / Shi, Jiye / Wan, Ying / Fan, Chunhai / Ouyang, Xiangyuan

Angewandte Chemie (International ed. in English)

2024 Volume 63, Issue 10, Page(s) e202318646

Abstract: Generally, two-dimensional gold nanomaterials have unique properties and functions that offer exciting application prospects. However, the crystal phases of these materials tend to be limited to the thermodynamically stable crystal structure. Herein, we ... ...

Abstract	Generally, two-dimensional gold nanomaterials have unique properties and functions that offer exciting application prospects. However, the crystal phases of these materials tend to be limited to the thermodynamically stable crystal structure. Herein, we report a DNA framework-templated approach for the ambient aqueous synthesis of freestanding and microscale amorphous gold nanosheets with ultrathin sub-nanometer thickness. We observe that extended single-stranded DNA on DNA nanosheets can induce site-specific metallization and enable precise modification of the metalized nanostructures at predefined positions. More importantly, the as-prepared gold nanosheets can serve as an electrocatalyst for glucose oxidase-catalyzed aerobic oxidation, exhibiting enhanced electrocatalytic activity (~3-fold) relative to discrete gold nanoclusters owing to a larger electrochemical active area and wider band gap. The proposed DNA framework-templated metallization strategy is expected to be applicable in a broad range of fields, from catalysis to new energy materials.
MeSH term(s)	Gold/chemistry ; Nanostructures/chemistry ; Oxidation-Reduction ; DNA ; Water
Chemical Substances	Gold (7440-57-5) ; DNA (9007-49-2) ; Water (059QF0KO0R)
Language	English
Publishing date	2024-02-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202318646
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Article ; Online: Programming Intracellular Clustering of Spiky Nanoparticles via Liposome Encapsulation.

Huang, Lulu / Mao, Xiuhai / Liu, Bingyi / Fan, Zhiying / Li, Jie / Fan, Chunhai / Tian, Yang / Luo, Shihua / Liu, Mengmeng

ACS nano

2024 Volume 18, Issue 11, Page(s) 8051–8061

Abstract: The intracellular clustering of anisotropic nanoparticles is crucial to the improvement of the localized surface plasmon resonance (LSPR) for phototherapy applications. Herein, we programmed the intracellular clustering process of spiky nanoparticles ( ... ...

Abstract	The intracellular clustering of anisotropic nanoparticles is crucial to the improvement of the localized surface plasmon resonance (LSPR) for phototherapy applications. Herein, we programmed the intracellular clustering process of spiky nanoparticles (SNPs) by encapsulating them into an anionic liposome via a frame-guided self-assembly approach. The liposome-encapsulated SNPs (lipo-SNPs) exhibited distinct and enhanced lysosome-triggered aggregation behavior while maintaining excellent monodispersity, even in acidic or protein-rich environments. We explored the enhancement of the photothermal therapy performance for SNPs as a proof of concept. The photothermal conversion efficiency of lipo-SNPs clusters significantly increased 15 times compared to that of single lipo-SNPs. Upon accumulation in lysosomes with a 2.4-fold increase in clustering, lipo-SNPs resulted in an increase in cell-killing efficiency to 45% from 12% at 24 μg/mL. These findings indicated that liposome encapsulation provides a promising approach to programing nanoparticle clustering at the target site, which facilitates advances in the development of smart nanomedicine with programmable enhancement in LSPR.
MeSH term(s)	Liposomes ; Nanoparticles ; Phototherapy/methods ; Surface Plasmon Resonance ; Nanomedicine
Chemical Substances	Liposomes
Language	English
Publishing date	2024-03-06
Publishing country	United States
Document type	Journal Article
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.3c11152
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Article ; Online: Subcellular localization of DNA nanodevices and their applications.

Liu, Xia / Cao, Shuting / Gao, Yue / Luo, Shihua / Zhu, Ying / Wang, Lihua

Chemical communications (Cambridge, England)

2023 Volume 59, Issue 27, Page(s) 3957–3967

Abstract: The application of nanodevices based on DNA self-assembly in the field of cell biology has made significant progress in the past decade. In this study, the development of DNA nanotechnology is briefly reviewed. The subcellular localization of DNA ... ...

Abstract	The application of nanodevices based on DNA self-assembly in the field of cell biology has made significant progress in the past decade. In this study, the development of DNA nanotechnology is briefly reviewed. The subcellular localization of DNA nanodevices, and their new progress and applications in the fields of biological detection, subcellular and organ pathology, biological imaging, and other fields are reviewed. The future of subcellular localization and biological applications of DNA nanodevices is also discussed.
MeSH term(s)	Nanotechnology/methods ; DNA ; Nanostructures
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2023-03-30
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d2cc06017e
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