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  1. Article: Donepezil in vascular dementia: a viewpoint by David S. Geldmacher.

    Geldmacher, David S

    Drugs & aging

    2003  Volume 20, Issue 15, Page(s) 1137

    MeSH term(s) Cholinesterase Inhibitors/administration & dosage ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/therapeutic use ; Clinical Trials as Topic ; Dementia, Vascular/drug therapy ; Dose-Response Relationship, Drug ; Humans ; Indans/administration & dosage ; Indans/pharmacology ; Indans/therapeutic use ; Piperidines/administration & dosage ; Piperidines/pharmacology ; Piperidines/therapeutic use
    Chemical Substances Cholinesterase Inhibitors ; Indans ; Piperidines ; donepezil (8SSC91326P)
    Language English
    Publishing date 2003-11-20
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 1075770-3
    ISSN 1179-1969 ; 1170-229X
    ISSN (online) 1179-1969
    ISSN 1170-229X
    DOI 10.2165/00002512-200320150-00006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3481: Show issues Location:
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  2. Book: Alzheimer's disease and dementia

    Geldmacher, David S.

    (Clinics in geriatric medicine ; 20,1)

    2004  

    Author's details guest ed. David S. Geldmacher
    Series title Clinics in geriatric medicine ; 20,1
    Collection
    Language English
    Size XII, 157 S.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT013961418
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 987 -20,1- verfügbar in Königswinter Königswinter

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  3. Book ; Conference proceedings: Dementia update

    Geldmacher, David S.

    overview from the First Annual Dementia Congress

    (Journal of the American Geriatrics Society ; 51,5, Suppl.)

    2003  

    Institution Dementia Congress
    Author's details David S. Geldmacher, guest ed
    Series title Journal of the American Geriatrics Society ; 51,5, Suppl.
    Collection
    Language English
    Size S. S282 - S325 : Ill., graph. Darst.
    Publisher Blackwell Publ
    Publishing place S.l.
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT013686878
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ud II Zs 168 -51,5,Suppl.- verfügbar in Königswinter Königswinter

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  4. Article ; Online: Glucocerebrosidase, Parkinson disease, and the "senses and intellect".

    Standaert, David G / Geldmacher, David S

    Annals of neurology

    2016  Volume 80, Issue 5, Page(s) 660–661

    MeSH term(s) Cognition ; Gaucher Disease ; Glucosylceramidase/genetics ; Humans ; Mutation ; Parkinson Disease ; alpha-Synuclein
    Chemical Substances alpha-Synuclein ; Glucosylceramidase (EC 3.2.1.45)
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80362-5
    ISSN 1531-8249 ; 0364-5134
    ISSN (online) 1531-8249
    ISSN 0364-5134
    DOI 10.1002/ana.24808
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    Zs.MO 478: Show issues

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  5. Article ; Online: A rationale and framework for addressing physician cognitive impairment.

    Del Bene, Victor A / Geldmacher, David S / Howard, George / Brown, Catherine / Turnipseed, Elizabeth / Fry, T Charles / Jones, Keith A / Lazar, Ronald M

    Frontiers in public health

    2023  Volume 11, Page(s) 1245770

    Abstract: Medical error is costly, in terms of the health and wellbeing of the patient, their family, and the financial burden placed on the medical system. Reducing medical error is paramount to minimizing harm and improving outcomes. One potential source of ... ...

    Abstract Medical error is costly, in terms of the health and wellbeing of the patient, their family, and the financial burden placed on the medical system. Reducing medical error is paramount to minimizing harm and improving outcomes. One potential source of medical error is physician cognitive impairment. Determining how to effectively assess and mange physician cognitive impairment is an important, albeit difficult problem to address. There have been calls and attempts to implement age-based cognitive screening, but this approach is not optimal. Instead, we propose that neuropsychological assessment is the gold standard for fitness-for-duty evaluations and that there is a need for the development of physician-based, normative data to improve these evaluations. Here, we outline the framework of our research protocol in a large, academic medical center, in partnership with hospital leadership and legal counsel, which can be modeled by other medical centers. With high rates of physician burnout and an aging physician population, the United States is facing a looming public health crisis that requires proactive management.
    MeSH term(s) Humans ; Aging ; Burnout, Psychological ; Cognitive Dysfunction/diagnosis ; Exercise ; Physicians
    Language English
    Publishing date 2023-08-25
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1245770
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Patient Portal Use Among Family Caregivers of Individuals With Dementia and Cancer: Regression Analysis From the National Study of Caregiving.

    Bratches, Reed W R / Wall, Jaclyn A / Puga, Frank / Pilonieta, Giovanna / Jablonski, Rita / Bakitas, Marie / Geldmacher, David S / Odom, J Nicholas

    JMIR aging

    2023  Volume 6, Page(s) e44166

    Abstract: Background: Family caregivers are often inexperienced and require information from clinic visits to effectively provide care for patients. Despite reported deficiencies, 68% of health systems facilitate sharing information with family caregivers through ...

    Abstract Background: Family caregivers are often inexperienced and require information from clinic visits to effectively provide care for patients. Despite reported deficiencies, 68% of health systems facilitate sharing information with family caregivers through the patient portal. The patient portal is especially critical in the context of serious illnesses, like advanced cancer and dementia, where caregiving is intense and informational needs change over the trajectory of disease progression.
    Objective: The objective of our study was to analyze a large, nationally representative sample of family caregivers from the National Study of Caregiving (NSOC) to determine individual characteristics and demographic factors associated with patient portal use among family caregivers of persons living with dementia and those living with cancer.
    Methods: We conducted a secondary data analysis using data from the 2020 NSOC sample of family caregivers linked to National Health and Aging Trends Study. Weighted regression analysis by condition (ie, dementia or cancer) was used to examine associations between family caregiver use of the patient portal and demographic variables, including age, race or ethnicity, gender, employment status, caregiver health, education, and religiosity.
    Results: A total of 462 participants (representing 4,589,844 weighted responses) were included in our analysis. In the fully adjusted regression model for caregivers of persons living with dementia, Hispanic ethnicity was associated with higher odds of patient portal use (OR: 2.81, 95% CI 1.05-7.57; P=.04), whereas qualification lower than a college degree was associated with lower odds of patient portal use by family caregiver (OR 0.36, 95% CI 0.18-0.71; P<.001. In the fully adjusted regression model for caregivers of persons living with cancer, no variables were found to be statistically significantly associated with patient portal use at the .05 level.
    Conclusions: In our analysis of NSOC survey data, we found differences between how dementia and cancer caregivers access the patient portal. As the patient portal is a common method of connecting caregivers with information from clinic visits, future research should focus on understanding how the portal is used by the groups we have identified, and why.
    MeSH term(s) Humans ; Caregivers ; Patient Portals ; Dementia/epidemiology ; Regression Analysis ; Neoplasms/therapy
    Language English
    Publishing date 2023-12-20
    Publishing country Canada
    Document type Journal Article
    ISSN 2561-7605
    ISSN (online) 2561-7605
    DOI 10.2196/44166
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  7. Article: Description of Process and Content of Online Dementia Coaching for Family Caregivers of Persons with Dementia.

    Jablonski, Rita A / Winstead, Vicki / Geldmacher, David S

    Healthcare (Basel, Switzerland)

    2019  Volume 7, Issue 1

    Abstract: Family caregivers of persons with dementia encounter resistance to care behaviors (RCBs). The purpose of this methods paper was to describe the process and content of six weekly 60-min caregiver coaching sessions delivered synchronously through an online ...

    Abstract Family caregivers of persons with dementia encounter resistance to care behaviors (RCBs). The purpose of this methods paper was to describe the process and content of six weekly 60-min caregiver coaching sessions delivered synchronously through an online platform to 26 family caregivers of persons with dementia. All session notes were analyzed for process; two coaching sessions from five purposely-selected participants were transcribed and analyzed thematically for content. The six sessions followed an overall pattern. The first session included the most teaching and goal-setting; the coaches also queried the family caregiver about the premorbid personality, work history, and interpersonal attributes of the person with dementia. Sessions two through five were the most active coaching sessions; previously suggested strategies were evaluated and tailored; caregivers also role-played with the coaches and developed scripts designed to curtail RCB. The sixth session served as a review of successful caregiver strategies and concluded the coaching relationship. Four primary content themes emerged in the coaching process: (1) education; (2) caregiver communication; (3) affirmation of the caregiver; and (4) individualized strategies. These four content categories were used throughout the coaching process and were interwoven with each other so that the participant knew why the behavior was occurring, how to verbally address it, how to use a strategy effectively, and affirmation of the result. The coaching process and content demonstrated alignment with person-centered practices and relationship-centered care.
    Language English
    Publishing date 2019-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare7010013
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  8. Article ; Online: Alabama Brief Cognitive Screener: Utility of a New Cognitive Screening Instrument in a Memory Disorders Clinic.

    Love, Marissa C Natelson / Pilonieta, Giovanna / Geldmacher, David S

    The primary care companion for CNS disorders

    2019  Volume 21, Issue 2

    Abstract: Objective: We assessed the clinical utility of the Alabama Brief Cognitive Screener (ABCs), an alternative to the Mini-Mental State Examination (MMSE), for cognitive screening in a new electronic medical record. Other available nonproprietary ... ...

    Abstract Objective: We assessed the clinical utility of the Alabama Brief Cognitive Screener (ABCs), an alternative to the Mini-Mental State Examination (MMSE), for cognitive screening in a new electronic medical record. Other available nonproprietary instruments were determined to be more tuned to milder deficits than the MMSE.
    Methods: The ABCs was administered as part of routine clinical assessment in the University of Alabama at Birmingham memory disorders clinics from April 30, 2012, to April 30, 2015. Outpatients (N = 1,589) with clinician diagnoses (ICD-9-CM) of memory loss, mild cognitive impairment, neurodegenerative cognitive impairment, Alzheimer's dementia, or dementia not otherwise specified were included in the analysis. Memory disorder clinicians used multiple sources of information for assignment of diagnoses, including interviews with patients and caregivers, the ABCs, figure copy, semantic fluencies, phonemic fluencies, ratings of daily function, imaging, laboratory tests, and medical records.
    Results: Scoring distribution by diagnosis was mild cognitive impairment (n = 310): mean (SD) = 25.47 (3.37), median = 26; Alzheimer's dementia (n = 208): mean (SD) = 16.42 (6.33), median = 17; cerebral degeneration (n = 371): mean (SD) = 20.61 (5.90), median = 21; memory loss (n = 583): mean (SD) = 24.90 (5.09), median = 27; and dementia (n = 117): mean (SD) = 15.18 (6.34), median = 15. Mean ABCs scores differed by diagnosis (Wilcoxon signed-ranks Z = 483.5, P < .001). This finding was consistent with a meta-analysis of MMSE performance between groups.
    Conclusions: ABCs scores vary appropriately by diagnosis and resemble MMSE scoring distributions. The ABCs provides a nonproprietary alternative to the MMSE to assess the severity of cognitive deficits.
    MeSH term(s) Aged ; Cognition ; Cognitive Dysfunction/diagnosis ; Dementia/diagnosis ; Electronic Health Records ; Female ; Humans ; Male ; Memory Disorders/diagnosis ; Neurodegenerative Diseases/diagnosis ; Neuropsychological Tests ; Primary Health Care
    Language English
    Publishing date 2019-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2675414-9
    ISSN 2155-7780 ; 2155-7772
    ISSN (online) 2155-7780
    ISSN 2155-7772
    DOI 10.4088/PCC.18m02336
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  9. Article ; Online: Development and Validation of the Family Quality of Life in Dementia Scale.

    Rose, Karen M / Williams, Ishan C / Anderson, Joel G / Geldmacher, David S

    The Gerontologist

    2020  Volume 61, Issue 6, Page(s) e260–e268

    Abstract: Background and objectives: People with Alzheimer's disease and related dementias (ADRD) exhibit losses in daily function, as well as behavioral and psychological symptoms, that place a great deal of burden on family caregivers and exert a major ... ...

    Abstract Background and objectives: People with Alzheimer's disease and related dementias (ADRD) exhibit losses in daily function, as well as behavioral and psychological symptoms, that place a great deal of burden on family caregivers and exert a major influence on the quality of life of these individuals and their families. Despite years of intervention research in the field, there are few studies related to the impact of providing care for a person with ADRD on the family as the unit of analysis. While numerous findings have reported the effects of the chronic stress of caregiving for an individual, analysis of family quality of life is a concept that has been generally overlooked in the ADRD field. The purpose of the present study was to develop and test the Family Quality of Life in Dementia (FQOL-D) scale.
    Research design and methods: Face validity was obtained via a Delphi survey of a multidisciplinary team of dementia providers and researchers; initial psychometric evaluation of the instrument was obtained via family respondents (N = 244).
    Results: Internal consistency and reliability were established for the instrument. The FQOL-D scale exhibited excellent factorability and concurrent validity with existing scales assessing family psychosocial measures.
    Discussion and implications: The initial psychometric testing of the FQOL-D instrument is favorable. Additional use of the FQOL-D instrument in health care settings is warranted to evaluate further the clinical utility of the instrument.
    MeSH term(s) Caregivers ; Dementia ; Family ; Humans ; Psychometrics ; Quality of Life ; Reproducibility of Results ; Surveys and Questionnaires
    Language English
    Publishing date 2020-04-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 216760-8
    ISSN 1758-5341 ; 0016-9013
    ISSN (online) 1758-5341
    ISSN 0016-9013
    DOI 10.1093/geront/gnaa022
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    In stock of ZB MED Cologne/Königswinter

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  10. Article ; Online: Alzheimer disease prevention: focus on cardiovascular risk, not amyloid?

    Geldmacher, David S

    Cleveland Clinic journal of medicine

    2010  Volume 77, Issue 10, Page(s) 689–704

    Abstract: Autosomal dominant (early-onset) Alzheimer disease and the much more common sporadic Alzheimer disease share a common pathology but not necessarily a common pathophysiology. Common cardiovascular comorbidities are associated with increased risk for ... ...

    Abstract Autosomal dominant (early-onset) Alzheimer disease and the much more common sporadic Alzheimer disease share a common pathology but not necessarily a common pathophysiology. Common cardiovascular comorbidities are associated with increased risk for Alzheimer disease and offer opportunities for intervention. Class I evidence for prevention is extremely limited. The overall body of evidence suggests the best time to intervene is in midlife, not in old age.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Alzheimer Disease/epidemiology ; Alzheimer Disease/genetics ; Alzheimer Disease/physiopathology ; Alzheimer Disease/prevention & control ; Amyloid/metabolism ; Cardiovascular Diseases/epidemiology ; Comorbidity ; Diabetes Mellitus/epidemiology ; Estrogens/adverse effects ; Humans ; Middle Aged ; Mitochondria ; Models, Theoretical ; Oxidative Stress ; PPAR gamma/agonists ; Plaque, Amyloid ; Risk ; Thiazolidinediones/pharmacology
    Chemical Substances Amyloid ; Estrogens ; PPAR gamma ; Thiazolidinediones
    Language English
    Publishing date 2010-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639116-3
    ISSN 1939-2869 ; 0891-1150
    ISSN (online) 1939-2869
    ISSN 0891-1150
    DOI 10.3949/ccjm.77gr.2010
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