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  1. Article ; Online: Use of novel taurine-chitosan mediated liposomes for enhancing the oral absorption of doxorubicin via the TAUT transporter.

    Qin, Shuiling / Wen, Zhiwei / Huang, Huajie / Wu, Wei

    Carbohydrate polymers

    2024  Volume 329, Page(s) 121780

    Abstract: Our research aimed to enhance the oral bioavailability of doxorubicin hydrochloride (DOX·HCl) while minimizing the potential for myocardial toxicity. To achieve this goal, we developed a new method that utilizes a coating material to encapsulate the drug ...

    Abstract Our research aimed to enhance the oral bioavailability of doxorubicin hydrochloride (DOX·HCl) while minimizing the potential for myocardial toxicity. To achieve this goal, we developed a new method that utilizes a coating material to encapsulate the drug in liposomes, which can specifically target intestinal taurine transporter proteins. This coating material, TAU-CS, was created by combining taurine with chitosan. We characterized TAU-CS using various methods, including
    MeSH term(s) Chitosan/chemistry ; Doxorubicin/chemistry ; Doxorubicin/pharmacology ; Drug Carriers/chemistry ; Liposomes/chemistry ; Particle Size ; Spectroscopy, Fourier Transform Infrared ; Taurine/drug effects ; Taurine/metabolism
    Chemical Substances Chitosan (9012-76-4) ; Doxorubicin (80168379AG) ; Drug Carriers ; Liposomes ; Taurine (1EQV5MLY3D) ; taurine transporter (148686-53-7)
    Language English
    Publishing date 2024-01-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1501516-6
    ISSN 1879-1344 ; 0144-8617
    ISSN (online) 1879-1344
    ISSN 0144-8617
    DOI 10.1016/j.carbpol.2024.121780
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Quantitative assessment and monitoring of microplastics and nanoplastics distributions and lipid metabolism in live zebrafish using hyperspectral stimulated Raman scattering microscopy.

    Xin, Le / Huang, Meizhen / Huang, Zhiwei

    Environment international

    2024  Volume 187, Page(s) 108679

    Abstract: Microplastics (MP) and nanoplastics (NP) pollutions pose a rising environmental threat to humans and other living species, given their escalating presence in essential resources that living subjects ingest and/or inhale. Herein, to elucidate the ... ...

    Abstract Microplastics (MP) and nanoplastics (NP) pollutions pose a rising environmental threat to humans and other living species, given their escalating presence in essential resources that living subjects ingest and/or inhale. Herein, to elucidate the potential health implications of MP/NP, we report for the first time by using label-free hyperspectral stimulated Raman scattering (SRS) imaging technique developed to quantitatively monitor the bioaccumulation and metabolic toxicity of MP/NP within live zebrafish larvae during their early developmental stages. Zebrafish embryos are exposed to environmentally related concentrations (3-60 μg/ml) of polystyrene (PS) beads with two typical sizes (2 μm and 50 nm). Zebrafish are administered isotope-tagged fatty acids through microinjection and dietary intake for in vivo tracking of lipid metabolism dynamics. In vivo 3D quantitative vibrational imaging of PS beads and intrinsic biomolecules across key zebrafish organs reveals that gut and liver are the primary target organs of MP/NP, while only 50 nm PS beads readily aggregate and adhere to the brain and blood vessels. The 50 nm PS beads are also found to induce more pronounced hepatic inflammatory response compared to 2 μm counterparts, characterized by increased biogenesis of lipid droplets and upregulation of arachidonic acid detected in zebrafish liver. Furthermore, Raman-tagged SRS imaging of fatty acids uncovers that MP/NP exposure significantly reduces yolk lipid utilization and promotes dietary lipid storage in zebrafish, possibly associated with developmental delays and more pronounced food dilution effects in zebrafish larvae exposed to 2 μm PS beads. The hyperspectral SRS imaging in this work shows that MP/NP exposure perturbs the development and lipid metabolism in zebrafish larvae, furthering the understanding of MP/NP ingestions and consequent toxicity in different organs in living species.
    Language English
    Publishing date 2024-04-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 554791-x
    ISSN 1873-6750 ; 0160-4120
    ISSN (online) 1873-6750
    ISSN 0160-4120
    DOI 10.1016/j.envint.2024.108679
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3131: Show issues Location:
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  3. Article ; Online: Unusual Case of Esophageal Foreign Body: A Whole Mantis Shrimp.

    Tai, Junhu / Gao, Kai / Huang, Zhiwei / Zhan, Bin

    Ear, nose, & throat journal

    2024  , Page(s) 1455613241249043

    Abstract: Esophageal foreign bodies (FBs) are one of the common emergencies in otolaryngology, usually involving objects accidentally swallowed, and generally do not result in severe respiratory distress. This article presents an extremely rare case of an ... ...

    Abstract Esophageal foreign bodies (FBs) are one of the common emergencies in otolaryngology, usually involving objects accidentally swallowed, and generally do not result in severe respiratory distress. This article presents an extremely rare case of an esophageal FB, where a 44-year-old man accidentally ingested an entire mantis shrimp while sucking its flavored tail, and was sent to the emergency department for severe throat pain and difficulty breathing. We immediately performed a laryngoscopy that revealed the FB that obstructs the entrance of the esophagus, obstructing the glottis due to the long shape of the shrimp. The mantis shrimp had barbs on its shell and trying to remove it intact would cause significant damage to the pharyngeal mucosa. Therefore, we extracted the mantis shrimp in segments under general anesthesia and applied electrocoagulation to stop bleeding from the damaged and bleeding posterior pharyngeal mucosa. As an esophagography was performed the following day, there were no signs of esophageal perforation. Through the detailed description and analysis of this case, our aim is to raise clinical awareness among physicians of such rare occurrences. Most important, appropriate examination and procedures of FBs should be performed based on the type, shape, and location of the FB.
    Language English
    Publishing date 2024-04-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 750153-5
    ISSN 1942-7522 ; 0145-5613
    ISSN (online) 1942-7522
    ISSN 0145-5613
    DOI 10.1177/01455613241249043
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    Zs.B 107: Show issues Location:
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  4. Article ; Online: Solitary fibrous tumor of the thyroid: A case report and literature review.

    Zhou, Feilong / He, Zifan / Lu, Zhiwei / Huang, Guomin

    Asian journal of surgery

    2023  Volume 47, Issue 1, Page(s) 689–690

    MeSH term(s) Humans ; Thyroid Gland/pathology ; Solitary Fibrous Tumors/diagnostic imaging ; Solitary Fibrous Tumors/surgery ; Biomarkers, Tumor
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2023-10-11
    Publishing country Netherlands
    Document type Review ; Case Reports ; Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.09.159
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    Zs.B 2831: Show issues Location:
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  5. Article ; Online: Silver-catalyzed C-3 arylthiodifluoromethylation and aryloxydifluoromethylation of coumarins.

    Sun, Jie / Li, Ziwei / Huang, Xiaoxiao / Ke, Zhiwei / Chen, Zhiwei

    Organic & biomolecular chemistry

    2022  Volume 20, Issue 21, Page(s) 4421–4426

    Abstract: A facile silver-catalyzed oxidative decarboxylation of arylthiodifluoroacetic acids or aryloxydifluoroacetic acids with coumarins/quinoxalin-2( ... ...

    Abstract A facile silver-catalyzed oxidative decarboxylation of arylthiodifluoroacetic acids or aryloxydifluoroacetic acids with coumarins/quinoxalin-2(1
    MeSH term(s) Catalysis ; Coumarins ; Molecular Structure ; Oxidation-Reduction ; Quinoxalines ; Silver
    Chemical Substances Coumarins ; Quinoxalines ; Silver (3M4G523W1G)
    Language English
    Publishing date 2022-06-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d2ob00568a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: PET/CT study of dopamine transporter (DAT) binding with the triple reuptake inhibitor toludesvenlafaxine in rats and humans.

    Huang, Zhiwei / Wu, Junhao / Guan, Yihui / Wei, Yumei / Xie, Fang / Shen, Yifeng

    European journal of nuclear medicine and molecular imaging

    2024  

    Language English
    Publishing date 2024-04-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-024-06700-2
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    Zs.A 1227: Show issues Location:
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  7. Article ; Online: Unveiling the Spatiotemporal and Dose Responses within a Single Live Cancer Cell to Photoswitchable Upconversion Nanoparticle Therapeutics Using Hybrid Hyperspectral Stimulated Raman Scattering and Transient Absorption Microscopy.

    Xin, Le / Luo, Zichao / Liu, Xiaogang / Huang, Zhiwei

    Analytical chemistry

    2024  Volume 96, Issue 16, Page(s) 6148–6157

    Abstract: Photodynamic therapy (PDT) provides an alternative approach to targeted cancer treatment, but the therapeutic mechanism of advanced nanodrugs applied to live cells and tissue is still not well understood. Herein, we employ the hybrid hyperspectral ... ...

    Abstract Photodynamic therapy (PDT) provides an alternative approach to targeted cancer treatment, but the therapeutic mechanism of advanced nanodrugs applied to live cells and tissue is still not well understood. Herein, we employ the hybrid hyperspectral stimulated Raman scattering (SRS) and transient absorption (TA) microscopy developed for real-time in vivo visualization of the dynamic interplay between the unique photoswichable lanthanide-doped upconversion nanoparticle-conjugated rose bengal and triphenylphosphonium (LD-UCNP@CS-Rb-TPP) probe synthesized and live cancer cells. The Langmuir pharmacokinetic model associated with SRS/TA imaging is built to quantitatively track the uptakes and pharmacokinetics of LD-UCNP@CS-Rb-TPP within cancer cells. Rapid SRS/TA imaging quantifies the endocytic internalization rates of the LD-UCNP@CS-Rb-TPP probe in individual HeLa cells, and the translocation of LD-UCNP@CS-Rb-TPP from mitochondria to cell nuclei monitored during PDT can be associated with mitochondria fragmentations and the increased nuclear membrane permeability, cascading the dual organelle ablations in cancer cells. The real-time SRS spectral changes of cellular components (e.g., proteins, lipids, and DNA) observed reflect the PDT-induced oxidative damage and the dose-dependent death pattern within a single live cancer cell, thereby facilitating the real-time screening of optimal light dose and illumination duration controls in PDT. This study provides new insights into the further understanding of drug delivery and therapeutic mechanisms of photoswitchable LD-UCNP nanomedicine in live cancer cells, which are critical in the optimization of nanodrug formulations and development of precision cancer treatment in PDT.
    MeSH term(s) Humans ; HeLa Cells ; Nanoparticles/chemistry ; Photochemotherapy ; Photosensitizing Agents/chemistry ; Photosensitizing Agents/pharmacology ; Spectrum Analysis, Raman ; Rose Bengal/chemistry ; Rose Bengal/pharmacology ; Nonlinear Optical Microscopy ; Dose-Response Relationship, Drug
    Chemical Substances Photosensitizing Agents ; Rose Bengal (1ZPG1ELY14)
    Language English
    Publishing date 2024-04-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c04898
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    Zs.A 4033: Show issues Location:
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  8. Article ; Online: Pelvic metastatic melanoma mimicking malignant schwannoma: A case report.

    Zhang, Qiong / Mao, Zhiwei / Huang, Dong / Chen, Bin

    Asian journal of surgery

    2023  Volume 46, Issue 12, Page(s) 5993–5994

    MeSH term(s) Humans ; Melanoma/diagnosis ; Melanoma/pathology ; Neurofibrosarcoma ; Neurilemmoma/diagnosis ; Neurilemmoma/surgery ; Diagnosis, Differential
    Language English
    Publishing date 2023-09-20
    Publishing country Netherlands
    Document type Case Reports ; Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.09.036
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  9. Article ; Online: New insight into air pollution-related cardiovascular disease: an adverse outcome pathway framework of PM2.5-associated vascular calcification.

    Ding, Ruiyang / Huang, Linyuan / Yan, Kanglin / Sun, Zhiwei / Duan, Junchao

    Cardiovascular research

    2024  

    Abstract: Despite the air quality has been generally improved in recent years, ambient fine particulate matter (PM2.5), a major contributor to air pollution, remains one of the major threats to public health. Vascular calcification is a systematic pathology ... ...

    Abstract Despite the air quality has been generally improved in recent years, ambient fine particulate matter (PM2.5), a major contributor to air pollution, remains one of the major threats to public health. Vascular calcification is a systematic pathology associated with an increased risk of cardiovascular disease. Although the epidemiological evidence has uncovered the association between PM2.5 exposure and vascular calcification, little is known about the underlying mechanisms. The adverse outcome pathway (AOP) concept offers a comprehensive interpretation of all of the findings obtained by toxicological and epidemiological studies. In this review, reactive oxygen species (ROS) generation was identified as the molecular initiating event (MIE), which targeted subsequent key events (KE) such as oxidative stress, inflammation, endoplasmic reticulum (ER) stress, and autophagy, from the cellular to the tissue/organ level. These KEs eventually led to the adverse outcome (AO), namely increased incidence of vascular calcification and atherosclerosis morbidity. To the best of our knowledge, this is the first AOP framework devoted to PM2.5-associated vascular calcification, which benefits future investigations by identifying current limitations and latent biomarkers.
    Language English
    Publishing date 2024-04-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvae082
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    Zs.A 565: Show issues Location:
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  10. Article ; Online: A multicomponent triformylphoroglucinol-based covalent organic framework for overall hydrogen peroxide photosynthesis.

    Chai, Erchong / Huang, Lanting / Jiao, Lei / Xiao, Zhiwei / Zhang, Xiang / Wang, Yaobing

    Chemical communications (Cambridge, England)

    2024  Volume 60, Issue 25, Page(s) 3405–3408

    Abstract: A multicomponent covalent organic framework (COF-Tfp-BpyDaaq) integrating bipyridine with diaminoanthraquinone through a triformylphoroglucinol linkage was synthesized for the first time as a photocatalyst for overall ... ...

    Abstract A multicomponent covalent organic framework (COF-Tfp-BpyDaaq) integrating bipyridine with diaminoanthraquinone through a triformylphoroglucinol linkage was synthesized for the first time as a photocatalyst for overall H
    Language English
    Publishing date 2024-03-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d4cc00511b
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