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Article ; Online: Conviction Narrative Theory and the Theory of Narrative Thought.

Beach, Lee Roy / Wise, James A

2023 Volume 46, Page(s) e84

Abstract: Conviction Narrative Theory bears a close resemblance to the Theory of Narrative Thought, although the two were designed to address different questions. In this commentary, we detail some of the more pronounced similarities and differences and suggest ... ...

Abstract	Conviction Narrative Theory bears a close resemblance to the Theory of Narrative Thought, although the two were designed to address different questions. In this commentary, we detail some of the more pronounced similarities and differences and suggest that resolving the latter could produce a third theory of narrative cognition that is superior to either of these two.
MeSH term(s)	Humans ; Narration ; Cognition
Language	English
Publishing date	2023-05-08
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	423721-3
ISSN	1469-1825 ; 0140-525X
ISSN (online)	1469-1825
ISSN	0140-525X
DOI	10.1017/S0140525X22002795
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Article ; Online: Dopamine, behavior, and addiction.

Wise, Roy A / Jordan, Chloe J

Journal of biomedical science

2021 Volume 28, Issue 1, Page(s) 83

Abstract: Addictive drugs are habit-forming. Addiction is a learned behavior; repeated exposure to addictive drugs can stamp in learning. Dopamine-depleted or dopamine-deleted animals have only unlearned reflexes; they lack learned seeking and learned avoidance. ... ...

Abstract	Addictive drugs are habit-forming. Addiction is a learned behavior; repeated exposure to addictive drugs can stamp in learning. Dopamine-depleted or dopamine-deleted animals have only unlearned reflexes; they lack learned seeking and learned avoidance. Burst-firing of dopamine neurons enables learning-long-term potentiation (LTP)-of search and avoidance responses. It sets the stage for learning that occurs between glutamatergic sensory inputs and GABAergic motor-related outputs of the striatum; this learning establishes the ability to search and avoid. Independent of burst-firing, the rate of single-spiking-or "pacemaker firing"-of dopaminergic neurons mediates motivational arousal. Motivational arousal increases during need states and its level determines the responsiveness of the animal to established predictive stimuli. Addictive drugs, while usually not serving as an external stimulus, have varying abilities to activate the dopamine system; the comparative abilities of different addictive drugs to facilitate LTP is something that might be studied in the future.
MeSH term(s)	Animals ; Appetitive Behavior/drug effects ; Avoidance Learning/drug effects ; Behavior, Addictive/psychology ; Dopamine/deficiency ; Dopaminergic Neurons/metabolism ; Learning/drug effects ; Long-Term Potentiation ; Mice ; Rats ; Reflex/drug effects
Chemical Substances	Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2021-12-02
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1193378-1
ISSN	1423-0127 ; 1021-7770
ISSN (online)	1423-0127
ISSN	1021-7770
DOI	10.1186/s12929-021-00779-7
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Zs.A 4037: Show issues

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Article ; Online: Dopamine and Addiction.

Wise, Roy A / Robble, Mykel A

Annual review of psychology

2020 Volume 71, Page(s) 79–106

Abstract: Addiction is commonly identified with habitual nonmedical self-administration of drugs. It is usually defined by characteristics of intoxication or by characteristics of withdrawal symptoms. Such addictions can also be defined in terms of the brain ... ...

Abstract	Addiction is commonly identified with habitual nonmedical self-administration of drugs. It is usually defined by characteristics of intoxication or by characteristics of withdrawal symptoms. Such addictions can also be defined in terms of the brain mechanisms they activate; most addictive drugs cause elevations in extracellular levels of the neurotransmitter dopamine. Animals unable to synthesize or use dopamine lack the conditioned reflexes discussed by Pavlov or the appetitive behavior discussed by Craig; they have only unconditioned consummatory reflexes. Burst discharges (phasic firing) of dopamine-containing neurons are necessary to establish long-term memories associating predictive stimuli with rewards and punishers. Independent discharges of dopamine neurons (tonic or pacemaker firing) determine the motivation to respond to such cues. As a result of habitual intake of addictive drugs, dopamine receptors expressed in the brain are decreased, thereby reducing interest in activities not already stamped in by habitual rewards.
MeSH term(s)	Animals ; Behavior, Addictive/metabolism ; Dopamine/metabolism ; Dopaminergic Neurons/physiology ; Humans ; Memory, Long-Term/physiology ; Motivation/physiology ; Receptors, Dopamine/metabolism ; Reward
Chemical Substances	Receptors, Dopamine ; Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2020-01-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Review
ZDB-ID	207937-9
ISSN	1545-2085 ; 0066-4308 ; 0547-1567
ISSN (online)	1545-2085
ISSN	0066-4308 ; 0547-1567
DOI	10.1146/annurev-psych-010418-103337
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Article ; Online: Modulation of Structural, Electronic, and Optical Properties of Titanium Nitride Thin Films by Regulated In Situ Oxidation.

Roy, Manosi / Sarkar, Kaushik / Som, Jacob / Pfeifer, Mark A / Craciun, Valentin / Schall, J David / Aravamudhan, Shyam / Wise, Frank W / Kumar, Dhananjay

ACS applied materials & interfaces

2023 Volume 15, Issue 3, Page(s) 4733–4742

Abstract: Epitaxial titanium nitride (TiN) and titanium oxynitride (TiON) thin films have been grown on sapphire substrates using a pulsed laser deposition (PLD) method in high-vacuum conditions (base pressure <3 × ... ...

Abstract	Epitaxial titanium nitride (TiN) and titanium oxynitride (TiON) thin films have been grown on sapphire substrates using a pulsed laser deposition (PLD) method in high-vacuum conditions (base pressure <3 × 10
Language	English
Publishing date	2023-01-10
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.2c18926
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Article ; Online: Graphical methods for understanding changes in states: Understanding medication use pathways.

Wise, Elizabeth A / Adams, Roy J / Lyketsos, Constantine G / Leoutsakos, Jeannie-Marie

International journal of methods in psychiatric research

2022 Volume 31, Issue 4, Page(s) e1932

Abstract: Objectives: As epidemiological studies become longer and larger, the field needs novel graphical methods to visualize complex longitudinal data. The aim of this study was to present the Slinkyplot, a longitudinal crosstabulation, to illustrate patterns ... ...

Abstract	Objectives: As epidemiological studies become longer and larger, the field needs novel graphical methods to visualize complex longitudinal data. The aim of this study was to present the Slinkyplot, a longitudinal crosstabulation, to illustrate patterns of antidepressant use in a large prospective cohort of older adults with mild cognitive impairment. Methods: Data from the National Alzheimer's Coordinating Center are used to track switches between different states and types of antidepressant use. A Slinkyplot is populated with rows representing the state of medication use at each timepoint and columns representing the state at each subsequent visit. Results: The constructed Slinkyplots display the common practice of switching on and off different antidepressants over time, with citalopram, sertraline, and bupropion most commonly used followed by switching to another SSRI or SNRI as second-line treatment. Conclusions: Slinkyplots are an innovative graphical means of visualizing complex patterns of transitions between different states over time for large longitudinal studies.
MeSH term(s)	Humans ; Aged ; Selective Serotonin Reuptake Inhibitors/pharmacology ; Selective Serotonin Reuptake Inhibitors/therapeutic use ; Prospective Studies ; Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use ; Citalopram/therapeutic use ; Sertraline/pharmacology ; Sertraline/therapeutic use
Chemical Substances	Serotonin Uptake Inhibitors ; Antidepressive Agents ; Citalopram (0DHU5B8D6V) ; Sertraline (QUC7NX6WMB)
Language	English
Publishing date	2022-07-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	1078002-6
ISSN	1557-0657 ; 1049-8931
ISSN (online)	1557-0657
ISSN	1049-8931
DOI	10.1002/mpr.1932
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Article ; Online: Notes from the Field: Seizures, Hyperthermia, and Myocardial Injury in Three Young Adults Who Consumed Bromazolam Disguised as Alprazolam - Chicago, Illinois, February 2023.

Ehlers, Paul F / Deitche, Amy / Wise, Leslie M / Patrick, Sarah L / Holloway-Beth, Alfreda / Ellison, Ross / Trecki, Jordan / Gerona, Roy / Wahl, Michael S

MMWR. Morbidity and mortality weekly report

2024 Volume 72, Issue 5253, Page(s) 1392–1393

MeSH term(s)	Humans ; Young Adult ; Alprazolam/adverse effects ; Chicago ; Illinois ; Seizures ; Hyperthermia ; Hyperthermia, Induced
Chemical Substances	Alprazolam (YU55MQ3IZY)
Language	English
Publishing date	2024-01-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	412775-4
ISSN	1545-861X ; 0149-2195
ISSN (online)	1545-861X
ISSN	0149-2195
DOI	10.15585/mmwr.mm725253a5
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Article ; Online: Dopamine, behavior, and addiction

Roy A. Wise / Chloe J. Jordan

Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-

2021 Volume 9

Abstract: Abstract Addictive drugs are habit-forming. Addiction is a learned behavior; repeated exposure to addictive drugs can stamp in learning. Dopamine-depleted or dopamine-deleted animals have only unlearned reflexes; they lack learned seeking and learned ... ...

Abstract	Abstract Addictive drugs are habit-forming. Addiction is a learned behavior; repeated exposure to addictive drugs can stamp in learning. Dopamine-depleted or dopamine-deleted animals have only unlearned reflexes; they lack learned seeking and learned avoidance. Burst-firing of dopamine neurons enables learning—long-term potentiation (LTP)—of search and avoidance responses. It sets the stage for learning that occurs between glutamatergic sensory inputs and GABAergic motor-related outputs of the striatum; this learning establishes the ability to search and avoid. Independent of burst-firing, the rate of single-spiking—or “pacemaker firing”—of dopaminergic neurons mediates motivational arousal. Motivational arousal increases during need states and its level determines the responsiveness of the animal to established predictive stimuli. Addictive drugs, while usually not serving as an external stimulus, have varying abilities to activate the dopamine system; the comparative abilities of different addictive drugs to facilitate LTP is something that might be studied in the future.
Keywords	Dopamine ; Behavior ; Addiction ; Medicine ; R
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Modulation of Structural, Electronic, and Optical Properties of Titanium Nitride Thin Films by Regulated In Situ Oxidation

Roy, Manosi / Sarkar, Kaushik / Som, Jacob / Pfeifer, Mark A. / Crăciun, V. / Schall, J. David / Aravamudhan, Shyam / Wise, Frank W. / Kumar, Dhananjay

ACS Applied Materials & Interfaces. 2023 Jan. 10, v. 15, no. 3 p.4733-4742

2023

Abstract	Epitaxial titanium nitride (TiN) and titanium oxynitride (TiON) thin films have been grown on sapphire substrates using a pulsed laser deposition (PLD) method in high-vacuum conditions (base pressure <3 × 10-⁶ T). This vacuum contains enough residual oxygen to allow a time-independent gas phase oxidation of the ablated species as well as a time-dependent regulated surface oxidation of TiN to TiON films. The time-dependent surface oxidation is controlled by means of film deposition time that, in turn, is controlled by changing the number of laser pulses impinging on the polycrystalline TiN target at a constant repetition rate. By changing the number of laser pulses from 150 to 5000, unoxidized (or negligibly oxidized) and oxidized TiN films have been obtained with the thickness in the range of four unit cells to 70 unit cells of TiN/TiON. X-ray photoelectron spectroscopy (XPS) investigations reveal higher oxygen content in TiON films prepared with a larger number of laser pulses. The oxidation of TiN films is achieved by precisely controlling the time of deposition, which affects the surface diffusion of oxygen to the TiN film lattice. The lattice constants of the TiON films obtained by x-ray diffraction (XRD) increase with the oxygen content in the film, as predicted by molecular dynamics (MD) simulations. The lattice constant increase is explained based on a larger electrostatic repulsive force due to unbalanced local charges in the vicinity of Ti vacancies and substitutional O. The bandgap of TiN and TiON films, measured using UV-visible spectroscopy, has an asymmetric V-shaped variation as a function of the number of pulses. The bandgap variation following the lower number of laser pulses (150-750) of the V-shaped curve is explained using the quantum confinement effect, while the bandgap variation following the higher number of laser pulses (1000-5000) is associated with the modification in the band structure due to hybridization of O₂ₚ and N₂ₚ energy levels.
Keywords	X-ray diffraction ; X-ray photoelectron spectroscopy ; energy ; hybridization ; molecular dynamics ; nitrides ; oxidation ; oxygen ; titanium ; ultraviolet-visible spectroscopy ; thin films ; pulsed laser deposition ; controlled oxidation ; bandgap energy ; oxynitrides ; transition metal nitrides
Language	English
Dates of publication	2023-0110
Size	p. 4733-4742.
Publishing place	American Chemical Society
Document type	Article ; Online
ISSN	1944-8252
DOI	10.1021/acsami.2c18926
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Dual roles of dopamine in food and drug seeking: the drive-reward paradox.

Wise, Roy A

Biological psychiatry

2012 Volume 73, Issue 9, Page(s) 819–826

Abstract: The question of whether (or to what degree) obesity reflects addiction to high-energy foods often narrows to the question of whether the overeating of these foods causes the same long-term neuroadaptations as are identified with the late stages of ... ...

Abstract	The question of whether (or to what degree) obesity reflects addiction to high-energy foods often narrows to the question of whether the overeating of these foods causes the same long-term neuroadaptations as are identified with the late stages of addiction. Of equal or perhaps greater interest is the question of whether common brain mechanisms mediate the acquisition and development of eating and drug-taking habits. The earliest evidence on this question is rooted in early studies of brain stimulation reward. Lateral hypothalamic electrical stimulation can be reinforcing in some conditions and can motivate feeding in others. That stimulation of the same brain region should be both reinforcing and drive inducing is paradoxical; why should an animal work to induce a drive-like state such as hunger? This is known as the drive-reward paradox. Insights into the substrates of the drive-reward paradox suggest an answer to the controversial question of whether the dopamine system--a system downstream from the stimulated fibers of the lateral hypothalamus--is more critically involved in wanting or in liking of various rewards including food and addictive drugs. That the same brain circuitry is implicated in the motivation for and the reinforcement by both food and addictive drugs extends the argument for a common mechanism underlying compulsive overeating and compulsive drug taking.
MeSH term(s)	Behavior, Addictive/physiopathology ; Brain/physiopathology ; Dopamine/physiology ; Drive ; Drug-Seeking Behavior/physiology ; Feeding Behavior/physiology ; Food ; Humans ; Reward
Chemical Substances	Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2012-10-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Review
ZDB-ID	209434-4
ISSN	1873-2402 ; 0006-3223
ISSN (online)	1873-2402
ISSN	0006-3223
DOI	10.1016/j.biopsych.2012.09.001
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Article ; Online: Roflumilast May Increase Risk of Exacerbations When Used to Treat Poorly Controlled Asthma in People with Obesity.

Dixon, Anne E / Que, Loretta G / Kalhan, Ravi / Dransfield, Mark T / Rogers, Linda / Gerald, Lynn B / Kraft, Monica / Krishnan, Jerry A / Johnson, Olivia / Hazucha, Heather / Roy, Gem / Holbrook, Janet T / Wise, Robert A

Annals of the American Thoracic Society

2022 Volume 20, Issue 2, Page(s) 206–214

Abstract: Rationale: ...

Abstract	Rationale:
MeSH term(s)	Humans ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Asthma/drug therapy ; Asthma/chemically induced ; Aminopyridines/therapeutic use ; Aminopyridines/adverse effects ; Obesity/complications ; Obesity/drug therapy ; Double-Blind Method
Chemical Substances	Roflumilast (0P6C6ZOP5U) ; Aminopyridines
Language	English
Publishing date	2022-09-18
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2717461-X
ISSN	2325-6621 ; 1943-5665 ; 2325-6621
ISSN (online)	2325-6621 ; 1943-5665
ISSN	2325-6621
DOI	10.1513/AnnalsATS.202204-368OC
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