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Article: Research on Nursing Intervention of Qing Dai Cream Walking Jar on Pruritic Discomfort in Patients with Common Psoriasis.

Chen, Hui / Zhang, Liping / Tang, Rui / Liu, Fang / Li, Xiaoping

Alternative therapies in health and medicine

2024

Abstract: Introduction: Qing Dai cream is a Chinese medicine that helps relieve the symptoms of psoriasis ... and comfortableness of Qing Dai cream walking jar as a nursing intervention for patients ... while the subjects in the observation group were joint Qing Dai cream walking jar on this basis. The quality of life ...

Abstract	Introduction: Qing Dai cream is a Chinese medicine that helps relieve the symptoms of psoriasis vulgaris. However, its mechanism hasn't been illustrated well. Objective: To evaluate the effectiveness and comfortableness of Qing Dai cream walking jar as a nursing intervention for patients with psoriasis vulgaris. Methods: Seventy-six patients with vulgar psoriasis admitted to our hospital from February 2020 to February 2021 who met the criteria according to the including and exclusion criteria were screened as this study's subjects. According to the randomized number and double-blind principle, all of them were separated into 2 groups, the subjects in the control group were provided with conventional care, while the subjects in the observation group were joint Qing Dai cream walking jar on this basis. The quality of life and the degree of skin lesions of the patients after the intervention were comprehensively evaluated compared and observed. Results: Compared to the control group, the psoriasis lesion area and severity index (PASI) score after the intervention was remarkably lower in the observation group (P < .05) while the symptom scores, itching degree, itching frequency, duration, lesion area, sleep condition, and self-conscious condition degrees were significantly lower in the observation group (P < .05). The observed group showed a significant effect, effective, and the overall effective rate of 57.89% (22/38), 36.84%, and 94.74% were all significantly more than those of the control group after intervention (P < .05). After the intervention, the scores of dermatological disease quality of life index (DLQI), the subjective symptoms, daily life, work and study, and interpersonal relationships in the observation group were all significantly lower than those in the control group, P < .05. In the intervention, the satisfaction, total satisfaction of 65.79% (25/38), and 97.37% were statistically significantly higher than that of the control group, P < .05. Conclusion: The Qing Dai cream walking jar is effective in improving patients' clinical symptoms, relieving their pruritus discomfort, and promoting the repair of skin lesions, to improve their quality of life and satisfaction.
Language	English
Publishing date	2024-01-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	1225073-9
ISSN	1078-6791
ISSN	1078-6791
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Article ; Online: Skin diseases in the Da Qing Diabetes Study: a cross-sectional study.

Shen, Chang-Bing / Qian, Xin / Yu, Rui-Xing / Ji, Xue-Lei / Shi, Yin-Juan / Gao, Jing / Li, Cheng-Xu / Li, Ke-Ke / Fei, Wen-Min / Shen, Xue / Wang, Zi-Yi / Han, Yang / Ning, Xiao-Li / Ko, Randy / Hsu, Yi-Hsiang / Yin, Xian-Yong / Li, Guang-Wei / Cui, Yong

Chinese medical journal

2021 Volume 134, Issue 10, Page(s) 1191–1198

Abstract: ... and T2DM.: Methods: We collected 383 subjects from the Da Qing Diabetes Study during the period ... of skin diseases in the Da Qing Diabetes Study. To address the skin diseases in the Da Qing Diabetes Study ...

Abstract	Background: The prevalence of skin diseases and diabetes mellitus (DM) are prominent around the world. The current scope of knowledge regarding the prevalence of skin diseases and comorbidities with type 2 DM (T2DM) is limited, leading to limited recognition of the correlations between skin diseases and T2DM. Methods: We collected 383 subjects from the Da Qing Diabetes Study during the period from July 9th to September 1st, 2016. The subjects were categorized into three groups: Normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and T2DM. The prevalence and clinical characteristics of skin diseases were recorded and investigated. Results: In this cross-sectional study, 383 individuals with ages ranging from 53 to 89-year-old were recruited. The overall prevalence of skin diseases was 93.5%, and 75.7% of individuals had two or more kinds of skin diseases. Additionally, there were 47 kinds of comorbid skin diseases in patients with T2DM, of which eight kinds of skin diseases had a prevalence >10%. The prevalence of skin diseases in NGT, IGT, and T2DM groups were 93.3%, 91.5%, and 96.6%, respectively; stratified analysis by categories showed a statistically significant difference in "disturbances of pigmentation" and "neurological and psychogenic dermatoses". The duration of T2DM also significantly associated with the prevalence of "disturbances of pigmentation" and "neurological and psychogenic dermatoses". Subsequently, the prevalence of "disturbances of pigmentation" was higher in males than females in NGT (P < 0.01) and T2DM (P < 0.01) groups. In addition, the difference in the prevalence of "disturbances of pigmentation" was also significant in NGT and T2DM groups (P < 0.01). Conclusions: There was a high prevalence of skin diseases in the Da Qing Diabetes Study. To address the skin diseases in the Da Qing Diabetes Study, increased awareness and intervention measures should be implemented.
MeSH term(s)	Aged ; Aged, 80 and over ; Blood Glucose ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/epidemiology ; Female ; Glucose Intolerance/epidemiology ; Glucose Tolerance Test ; Humans ; Male ; Middle Aged ; Skin Diseases/epidemiology
Chemical Substances	Blood Glucose
Language	English
Publishing date	2021-04-14
Publishing country	China
Document type	Journal Article
ZDB-ID	127089-8
ISSN	2542-5641 ; 0366-6999 ; 1002-0187
ISSN (online)	2542-5641
ISSN	0366-6999 ; 1002-0187
DOI	10.1097/CM9.0000000000001453
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Article ; Online: Contrasting the microbial community and non-volatile metabolites involved in ester synthesis between Qing-flavor Daqu and Nong-flavor Daqu.

Quan, Shikai / Wang, Yan / Ran, Maofang / Zhang, Rui / Luo, Xue / Wang, Weihao / Wu, Zhengyun / Gomi, Katsuya / Zhang, Wenxue

Journal of bioscience and bioengineering

2023 Volume 136, Issue 3, Page(s) 213–222

Abstract: ... and non-volatile profiles of Qing-flavor Daqu and Nong-flavor Daqu samples through the whole making ... Among them, in Qing-flavor Daqu, the top three primary functional microorganisms that had strong correlations ...

Abstract	Daqu, a fermentation starter, was important source of key flavors of Chinese Baijiu. The quality of Chinese Baijiu could be significantly affected by the ester-synthesis microorganisms. In order to clarify the microbial community that promoted the ester formation in Daqu, the dynamic changes of microbial community and non-volatile profiles of Qing-flavor Daqu and Nong-flavor Daqu samples through the whole making process were investigated by Illumina MiSeq platform and liquid chromatograph-mass spectrometry (LC-MS). The non-volatile compounds related to ester synthesis were identified by comparing with ester synthesis pathway and partial least squares discriminant analysis (PLS-DA). Correlations between microbial community and non-volatile metabolites involved in ester synthesis of two types of Daqu were disclosed by Pearson correlation analysis. Results showed that a total of 50 key compounds involved in ester synthesis were identified and 25 primary functional microorganisms were screened in 39 samples. Among them, in Qing-flavor Daqu, the top three primary functional microorganisms that had strong correlations with ester-formation precursors were Lactobacillus, Pantoea, and Sphingomonas; Lactobacillus and Pantoea had significantly positive interactions with various microorganisms, but Sphingomonas did not interact with others. In Nong-flavor Daqu, the top three primary functional microorganisms that had strong correlations with ester-formation precursors were Candida, Apiotrichum, and Cutaneotrichosporon. Candida showed strong positive correlation with other microorganisms, whereas Apiotrichum and Cutaneotrichosporon had no interaction with other microorganisms. The study could help our understanding of the microbial metabolism process in Daqu and provided a scientific basis for a controllable and feasible fermentation system.
MeSH term(s)	Alcoholic Beverages/analysis ; Microbiota ; Fermentation ; Lactobacillus
Language	English
Publishing date	2023-07-08
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1465387-4
ISSN	1347-4421 ; 1389-1723
ISSN (online)	1347-4421
ISSN	1389-1723
DOI	10.1016/j.jbiosc.2023.06.004
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Article ; Online: Skin diseases in the Da Qing Diabetes Study

Chang-Bing Shen / Xin Qian / Rui-Xing Yu / Xue-Lei Ji / Yin-Juan Shi / Jing Gao / Cheng-Xu Li / Ke-Ke Li / Wen-Min Fei / Xue Shen / Zi-Yi Wang / Yang Han / Xiao-Li Ning / Randy Ko / Yi-Hsiang Hsu / Xian-Yong Yin / Guang-Wei Li / Yong Cui / Li-Shao Guo

Chinese Medical Journal, Vol 134, Iss 10, Pp 1191-

a cross-sectional study

2021 Volume 1198

Abstract: ... and T2DM. Methods:. We collected 383 subjects from the Da Qing Diabetes Study during the period ... diseases in the Da Qing Diabetes Study. To address the skin diseases in the Da Qing Diabetes Study ...

Abstract	Abstract. Background:. The prevalence of skin diseases and diabetes mellitus (DM) are prominent around the world. The current scope of knowledge regarding the prevalence of skin diseases and comorbidities with type 2 DM (T2DM) is limited, leading to limited recognition of the correlations between skin diseases and T2DM. Methods:. We collected 383 subjects from the Da Qing Diabetes Study during the period from July 9th to September 1st, 2016. The subjects were categorized into three groups: Normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and T2DM. The prevalence and clinical characteristics of skin diseases were recorded and investigated. Results:. In this cross-sectional study, 383 individuals with ages ranging from 53 to 89-year-old were recruited. The overall prevalence of skin diseases was 93.5%, and 75.7% of individuals had two or more kinds of skin diseases. Additionally, there were 47 kinds of comorbid skin diseases in patients with T2DM, of which eight kinds of skin diseases had a prevalence >10%. The prevalence of skin diseases in NGT, IGT, and T2DM groups were 93.3%, 91.5%, and 96.6%, respectively; stratified analysis by categories showed a statistically significant difference in “disturbances of pigmentation” and “neurological and psychogenic dermatoses”. The duration of T2DM also significantly associated with the prevalence of “disturbances of pigmentation” and “neurological and psychogenic dermatoses”. Subsequently, the prevalence of “disturbances of pigmentation” was higher in males than females in NGT (P < 0.01) and T2DM (P < 0.01) groups. In addition, the difference in the prevalence of “disturbances of pigmentation” was also significant in NGT and T2DM groups (P < 0.01). Conclusions:. There was a high prevalence of skin diseases in the Da Qing Diabetes Study. To address the skin diseases in the Da Qing Diabetes Study, increased awareness and intervention measures should be implemented.
Keywords	Medicine ; R
Subject code	571
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	Wolters Kluwer
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Plastome structure, phylogenomics and evolution of plastid genes in Swertia (Gentianaceae) in the Qing-Tibetan Plateau.

Cao, Qian / Gao, Qingbo / Ma, Xiaolei / Zhang, Faqi / Xing, Rui / Chi, Xiaofeng / Chen, Shilong

BMC plant biology

2022 Volume 22, Issue 1, Page(s) 195

Abstract: Background: The genus Swertia is of great medicinal importance and one of the most taxonomically challenging taxa within Gentianaceae, largely due to the morphological similarities of species within this genus and with its closely related genera. ... ...

Abstract	Background: The genus Swertia is of great medicinal importance and one of the most taxonomically challenging taxa within Gentianaceae, largely due to the morphological similarities of species within this genus and with its closely related genera. Previous molecular studies confirmed its polyphyly but suffered from low phylogenetic resolutions because only limited sequence loci were used. Thus, we conducted the structural, gene evolutionary, and phylogenetic analyses of 11 newly obtained plastomes of Swertia. Our result greatly improved the phylogenetic resolutions in Swertia, shed new light on the plastome evolution and phylogenetic relationships of this genus. Results: The 11 Swertia plastomes together with the published seven species proved highly similar in overall size, structure, gene order, and content, but revealed some structural variations caused by the expansion and contraction of the IRb region into the LSC region, due to the heterogeneous length of the ψycf1. The gene rps16 was found to be in a state flux with pseudogenes or completely lost. Similar situation was also documented in other genera of Gentianaceae. This might imply loss of the gene in the common ancestor of Gentianaceae. The distribution plot of ENC vs. GC3 showed all these plastomes arranging very close in the Wright line with an expected ENC value (49-52%), suggesting the codon usage of Swertia was mainly constrained by a GC mutation bias. Most of the genes remained under the purifying selection, however, the cemA was identified under positive selection, possibly reflecting an adaptive response to low CO Conclusions: Our study confirmed the polyphyly of Swertia and demonstrated the power of plastome phylogenomics in improvement of phylogenetic resolution, thus contributing to a better understanding of the evolutionary history of Swertia.
MeSH term(s)	Evolution, Molecular ; Genome, Plastid ; Gentianaceae/genetics ; Phylogeny ; Plastids/genetics ; Swertia ; Tibet
Language	English
Publishing date	2022-04-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2059868-3
ISSN	1471-2229 ; 1471-2229
ISSN (online)	1471-2229
ISSN	1471-2229
DOI	10.1186/s12870-022-03577-x
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Article: Prediction of Srebp-1 as a Key Target of Qing Gan San Against MAFLD in Rats via RNA-Sequencing Profile Analysis.

Yang, Bendong / Sun, Jingyue / Liang, Shufei / Wu, Peixuan / Lv, Rui / He, Yanping / Li, Deqi / Sun, Wenlong / Song, Xinhua

Frontiers in pharmacology

2021 Volume 12, Page(s) 680081

Abstract: ... increasing attention. The Qing Gan San (QGS) formula comprises ...

Abstract	Metabolism-associated fatty liver disease (MAFLD) is the most common chronic liver disease worldwide, and the use of traditional Chinese medicines (TCMs) to treat this disease has attracted increasing attention. The Qing Gan San (QGS) formula comprises
Language	English
Publishing date	2021-07-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.680081
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Article ; Online: Nao Tan Qing ameliorates Alzheimer's disease-like pathology by regulating glycolipid metabolism and neuroinflammation: A network pharmacology analysis and biological validation.

Li, Qianqian / Jia, Caixia / Wu, Hongxing / Liao, Yajin / Yang, Ke / Li, Shuoshuo / Zhang, Jing / Wang, Jinlei / Li, Guo / Guan, Fangxia / Leung, Elaine / Yuan, Zengqiang / Hua, Qian / Pan, Rui-Yuan

Pharmacological research

2022 Volume 185, Page(s) 106489

Abstract: ... a novel Chinese formula Nao Tan Qing (NTQ) was developed and shown to improve AD. In vivo experiments ...

Abstract	Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline and currently there are no available treatments. Alongside the conventional Aβ and tau hypotheses, neuroinflammation and metabolism disruption have also been regarded as crucial hallmarks of AD. In this study, a novel Chinese formula Nao Tan Qing (NTQ) was developed and shown to improve AD. In vivo experiments showed that NTQ significantly mitigated cognitive impairment, Aβ burden and neuroinflammation in a transgenic AD mouse model (5×FAD). Network pharmacology results revealed that the active components of NTQ could target inflammatory and metabolic pathways. In addition, hippocampal transcriptomics suggested that NTQ regulated signaling pathways related to inflammation and lipid metabolism. Consistently, serum metabolomics further indicated that NTQ could modulate glycolipid metabolism. In summary, a combination of systems pharmacology analysis and biological validation study demonstrates that NTQ could alleviate behavioral abnormality and pathological alterations of AD by targeting glycolipid metabolism and neuroinflammation, and is accordingly a potential therapeutic agent for AD.
MeSH term(s)	Animals ; Mice ; Alzheimer Disease/metabolism ; Neuroinflammatory Diseases ; Network Pharmacology ; Mice, Transgenic ; Disease Models, Animal ; Lipid Metabolism ; Glycolipids/therapeutic use ; Amyloid beta-Peptides/metabolism
Chemical Substances	Glycolipids ; Amyloid beta-Peptides
Language	English
Publishing date	2022-10-10
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1003347-6
ISSN	1096-1186 ; 0031-6989 ; 1043-6618
ISSN (online)	1096-1186
ISSN	0031-6989 ; 1043-6618
DOI	10.1016/j.phrs.2022.106489
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Article ; Online: Plastome structure, phylogenomics and evolution of plastid genes in Swertia (Gentianaceae) in the Qing-Tibetan Plateau

Cao, Qian / Gao, Qingbo / Ma, Xiaolei / Zhang, Faqi / Xing, Rui / Chi, Xiaofeng / Chen, Shilong

BMC Plant Biol. 2022 Dec., v. 22, no. 1 p.195-195

2022

Abstract: BACKGROUND: The genus Swertia is of great medicinal importance and one of the most taxonomically challenging taxa within Gentianaceae, largely due to the morphological similarities of species within this genus and with its closely related genera. ... ...

Abstract	BACKGROUND: The genus Swertia is of great medicinal importance and one of the most taxonomically challenging taxa within Gentianaceae, largely due to the morphological similarities of species within this genus and with its closely related genera. Previous molecular studies confirmed its polyphyly but suffered from low phylogenetic resolutions because only limited sequence loci were used. Thus, we conducted the structural, gene evolutionary, and phylogenetic analyses of 11 newly obtained plastomes of Swertia. Our result greatly improved the phylogenetic resolutions in Swertia, shed new light on the plastome evolution and phylogenetic relationships of this genus. RESULTS: The 11 Swertia plastomes together with the published seven species proved highly similar in overall size, structure, gene order, and content, but revealed some structural variations caused by the expansion and contraction of the IRb region into the LSC region, due to the heterogeneous length of the ψycf1. The gene rps16 was found to be in a state flux with pseudogenes or completely lost. Similar situation was also documented in other genera of Gentianaceae. This might imply loss of the gene in the common ancestor of Gentianaceae. The distribution plot of ENC vs. GC3 showed all these plastomes arranging very close in the Wright line with an expected ENC value (49–52%), suggesting the codon usage of Swertia was mainly constrained by a GC mutation bias. Most of the genes remained under the purifying selection, however, the cemA was identified under positive selection, possibly reflecting an adaptive response to low CO₂ atmospheric conditions during the Late Miocene. Our phylogenomic analyses, based on 74 protein-coding genes (CDS), supported the polyphyly of Swertia with its close allies in the subtribe Swertiinae, presumably due to recent rapid radiation. The topology inferred from our phylogenetic analyses partly supported the current taxonomic treatment. Finally, several highly variable loci were identified, which can be used in future phylogenetic studies and accurate identification of medicinal genuineness of Swertia. CONCLUSIONS: Our study confirmed the polyphyly of Swertia and demonstrated the power of plastome phylogenomics in improvement of phylogenetic resolution, thus contributing to a better understanding of the evolutionary history of Swertia.
Keywords	Miocene epoch ; Swertia ; ancestry ; carbon dioxide ; codon usage ; gene order ; mutation ; polyphyly ; pseudogenes ; topology
Language	English
Dates of publication	2022-12
Size	p. 195.
Publishing place	BioMed Central
Document type	Article ; Online
ZDB-ID	2059868-3
ISSN	1471-2229
ISSN	1471-2229
DOI	10.1186/s12870-022-03577-x
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Qing-Luo-Yin Alleviated Monocytes/Macrophages-Mediated Inflammation in Rats with Adjuvant-Induced Arthritis by Disrupting Their Interaction with (Pre)-Adipocytes Through PPAR-γ Signaling.

Wang, Rui / Li, Dan-Feng / Hu, Yi-Fang / Liao, Qiang / Jiang, Tian-Tian / Olatunji, Opeyemi Joshua / Yang, Kui / Zuo, Jian

Drug design, development and therapy

2021 Volume 15, Page(s) 3105–3118

Abstract: Background: The Chinese herbal formula Qing-Luo-Yin (QLY) has been successfully used in rheumatoid ...

Abstract	Background: The Chinese herbal formula Qing-Luo-Yin (QLY) has been successfully used in rheumatoid arthritis treatment for decades. It exhibits notable immune and metabolism regulatory properties. Thereby, we investigated its effects on the interplay between (pre)-adipocytes and monocytes/macrophages under adjuvant-induced arthritis (AIA) circumstances. Methods: Fat reservoir and histological characteristics of white fat tissues (WAT) in AIA rats receiving QLY treatment were examined upon sacrifice. Metabolic parameters, clinical indicators, and oxidative stress levels were determined using corresponding kits, while mRNA/protein expression was investigated by PCR and immunoblotting methods. M1 macrophage distribution in WAT was assessed by flow cytometry. The effects of QLY on (pre)-adipocytes were further validated by experiments in vitro. Results: Compared with normal healthy controls, body weight and circulating triglyceride were declined in AIA rats, but serological levels of free fatty acids and low-density lipoprotein cholesterol were increased. mRNA IL-1β and iNOS expression in white blood cells and rheumatoid factor, C-reactive protein, anti-cyclic citrullinated peptide antibody, MCP-1 and IL-1β production in serum/WAT were up-regulated. Obvious CD86 Conclusion: QLY was potent in promoting PPAR-γ expression and consequently disrupted inflammatory feedback in WAT by altering monocytes/macrophages polarization and adipocytes differentiation.
MeSH term(s)	Adipocytes/metabolism ; Animals ; Arthritis, Experimental/drug therapy ; Arthritis, Experimental/physiopathology ; Cell Differentiation/drug effects ; Drugs, Chinese Herbal/pharmacology ; Inflammation/drug therapy ; Inflammation/pathology ; Leukocytes, Mononuclear ; Macrophages/drug effects ; Macrophages/pathology ; Male ; Monocytes/drug effects ; Monocytes/pathology ; PPAR gamma/metabolism ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/drug effects
Chemical Substances	Drugs, Chinese Herbal ; PPAR gamma
Language	English
Publishing date	2021-07-16
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2451346-5
ISSN	1177-8881 ; 1177-8881
ISSN (online)	1177-8881
ISSN	1177-8881
DOI	10.2147/DDDT.S320599
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Article ; Online: Effects of Qing Chang Suppository Powder and its Ingredients on IL-17 Signal Pathway in HT-29 Cells and DSS-induced Mice.

Zhou, Gui / Kong, Wei-Song / Li, Zhi-Cheng / Xie, Rui-Fang / Yu, Tian-Yuan / Zhou, Xin

Phytomedicine : international journal of phytotherapy and phytopharmacology

2021 Volume 87, Page(s) 153573

Abstract: Background: Qingchang Suppository, a formula used for more than 30 years in Longhua Hospital, has shown satisfactory clinical effects on Ulcerative Colitis (UC). However, its therapeutic mechanism has not been fully elucidated.: Purpose: The study ... ...

Abstract	Background: Qingchang Suppository, a formula used for more than 30 years in Longhua Hospital, has shown satisfactory clinical effects on Ulcerative Colitis (UC). However, its therapeutic mechanism has not been fully elucidated. Purpose: The study aims to investigate the effects of Qingchang Suppository powder (QCSP) and its ingredients by regulating the IL-17A signaling pathway which plays an important role in the development of UC. Methods: HPLC was used to analyze the main ingredients (Gallic acid, Indigo, Indirubin) in QCSP. HT-29 cells were induced by rhIL-17A and TNF-α, and IL-17A related protein expressions were determined by western blot. BALB/C mice were induced by 4% Dextran Sodium sulfate (DSS). The effects of QCSP and its ingredients were evaluated by measuring weight loss, disease activity index (DAI), colon length, histological analysis. Western blot was used for analysis of IL-17A and MAPK related proteins p-ERK, p-JNK, p-P38. Quantitative reverse transcription polymerase chain reaction (q-PCR) was used to detect the expression of IL-17A, HSP90 and ACT1 in colon tissue. Cytokines such as IL-17A, IL-1β, IFN-γ and TNF-α were determinated by enzyme-linked immunosorbent assay (ELISA). Results: QCSP had good therapeutic effect on DSS-induced colitis in mice. QCSP significantly relieved weight loss, restored colon length, repaired colon lesions, reduced histological scores and DAI, decreased TNF-α, IL-1β, IL-17 and IFN-γ contents, significantly suppressed the gene expressions of IL-17A, ACT1 and HSP90, and up-regulated the expressions of tight junction proteins like ZO-1 and Occludin. IL-17A pathway related proteins such as IL-17A, IL-17RA, HSP90, MAPKs, P-iκbα and iNOS were significantly increased in vitro and in vivo. Conclusions: This paper reveals that QCSP inhibited the IL-17A signaling pathway in HT-29 cells and DSS induced mice, presenting a new mechanism of QCS on treating UC.
MeSH term(s)	Animals ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/drug therapy ; Cytokines/genetics ; Cytokines/metabolism ; Dextran Sulfate/toxicity ; Disease Models, Animal ; Drugs, Chinese Herbal/toxicity ; HT29 Cells ; Humans ; Interleukin-17/genetics ; Interleukin-17/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Powders/adverse effects ; Signal Transduction/drug effects ; Suppositories/administration & dosage ; Suppositories/adverse effects
Chemical Substances	Cytokines ; Drugs, Chinese Herbal ; Interleukin-17 ; Powders ; Suppositories ; Dextran Sulfate (9042-14-2)
Language	English
Publishing date	2021-04-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2021.153573
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