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Article ; Online: The Value of Sonographer Credentialing: An Important First Step.

Waggoner, Alan D / Stevenson, J Geoffrey

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

2016 Volume 29, Issue 1, Page(s) 49–50

MeSH term(s)	Credentialing ; Humans ; United States
Language	English
Publishing date	2016-01
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	1035622-8
ISSN	1097-6795 ; 0894-7317
ISSN (online)	1097-6795
ISSN	0894-7317
DOI	10.1016/j.echo.2015.11.007
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Article ; Online: Barriers and Potential Solutions to Implementing Evidence-Based PTSD Treatment in Military Treatment Facilities.

McLean, Carmen P / Cook, Jeffrey / Riggs, David S / Peterson, Alan L / Young-McCaughan, Stacey / Borah, Elisa V / Comtois, Katherine Anne / Dondanville, Katherine A / Frick, Erin / Haddock, Christopher K / Mann, Jeffrey / Reynolds, David / Mistretta, Melissa / Neitzer, Andrea / Brzuchalski, Amy / Clayton, Spencer P / Conforte, Allison M / DuMars, Tyler D / Ekundayo, Kendra /

Flores, Araceli / Hein, Jessica / Jinkerson, Jeremy / Keith, Felicia / Kim, Hana J / Link, Jared S / Nofziger, Debra / Pollick, Kirsten / Ringdahl, Erik N / Waggoner, John / Woodworth, Craig / Rosen, Craig S

Military medicine

2022 Volume 189, Issue 3-4, Page(s) 721–731

Abstract: Introduction: Prolonged exposure therapy is an effective treatment for posttraumatic stress disorder that is underutilized in health systems, including the military health system. Organizational barriers to prolonged exposure implementation have been ... ...

Abstract	Introduction: Prolonged exposure therapy is an effective treatment for posttraumatic stress disorder that is underutilized in health systems, including the military health system. Organizational barriers to prolonged exposure implementation have been hypothesized but not systematically examined. This multisite project sought to identify barriers to increasing the use of prolonged exposure across eight military treatment facilities and describe potential solutions to addressing these barriers. Materials and methods: As part of a larger project to increase the use of prolonged exposure therapy in the military health system, we conducted a needs assessment at eight military treatment facilities. The needs assessment included analysis of clinic administrative data and a series of stakeholder interviews with behavioral health clinic providers, leadership, and support staff. Key barriers were matched with potential solutions using a rubric developed for this project. Identified facilitators, barriers, and potential solutions were summarized in a collaboratively developed implementation plan for increasing prolonged exposure therapy tailored to each site. Results: There was a greater than anticipated consistency in the barriers reported by the sites, despite variation in the size and type of facility. The identified barriers were grouped into four categories: time-related barriers, provider-related barriers, barriers related to patient education and matching patients to providers, and scheduling-related barriers. Potential solutions to each barrier are described. Conclusions: The findings highlight the numerous organizational-level barriers to implementing evidence-based psychotherapy in the military health system and offer potential solutions that may be helpful in addressing the barriers.
MeSH term(s)	Humans ; Stress Disorders, Post-Traumatic/therapy ; Psychotherapy ; Ambulatory Care Facilities ; Treatment Outcome
Language	English
Publishing date	2022-08-09
Publishing country	England
Document type	Journal Article
ZDB-ID	391061-1
ISSN	1930-613X ; 0026-4075
ISSN (online)	1930-613X
ISSN	0026-4075
DOI	10.1093/milmed/usac240
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Article ; Online: Genetically targeted fluorogenic macromolecules for subcellular imaging and cellular perturbation.

Magenau, Andrew J D / Saurabh, Saumya / Andreko, Susan K / Telmer, Cheryl A / Schmidt, Brigitte F / Waggoner, Alan S / Bruchez, Marcel P

Biomaterials

2015 Volume 66, Page(s) 1–8

Abstract: The alteration of cellular functions by anchoring macromolecules to specified organelles may reveal a new area of therapeutic potential and clinical treatment. In this work, a unique phenotype was evoked by influencing cellular behavior through the ... ...

Abstract	The alteration of cellular functions by anchoring macromolecules to specified organelles may reveal a new area of therapeutic potential and clinical treatment. In this work, a unique phenotype was evoked by influencing cellular behavior through the modification of subcellular structures with genetically targetable macromolecules. These fluorogen-functionalized polymers, prepared via controlled radical polymerization, were capable of exclusively decorating actin, cytoplasmic, or nuclear compartments of living cells expressing localized fluorgen-activating proteins. The macromolecular fluorogens were optimized by establishing critical polymer architecture-biophysical property relationships which impacted binding rates, binding affinities, and the level of internalization. Specific labeling of subcellular structures was realized at nanomolar concentrations of polymer, in the absence of membrane permeabilization or transduction domains, and fluorogen-modified polymers were found to bind to protein intact after delivery to the cytosol. Cellular motility was found to be dependent on binding of macromolecular fluorogens to actin structures causing rapid cellular ruffling without migration.
MeSH term(s)	Fluorescent Dyes/chemistry ; Fluorescent Dyes/pharmacokinetics ; Gene Targeting/methods ; HeLa Cells ; Humans ; Microscopy, Fluorescence/methods ; Molecular Imaging/methods ; Proteins/chemistry ; Proteins/genetics ; Proteins/pharmacokinetics ; Subcellular Fractions/metabolism ; Subcellular Fractions/ultrastructure
Chemical Substances	Fluorescent Dyes ; Proteins
Language	English
Publishing date	2015-10
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	603079-8
ISSN	1878-5905 ; 0142-9612
ISSN (online)	1878-5905
ISSN	0142-9612
DOI	10.1016/j.biomaterials.2015.07.002
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Article ; Online: Cardiac resynchronization therapy and the emerging role of echocardiography (part 2): the comprehensive examination.

Agler, Deborah A / Adams, David B / Waggoner, Alan D

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

2007 Volume 20, Issue 1, Page(s) 76–90

Abstract: Cardiac resynchronization therapy has been established as an adjunctive treatment for patients with severe left ventricular systolic dysfunction and medically refractory heart failure symptoms with a prolonged electrocardiographic QRS interval. ... ...

Abstract	Cardiac resynchronization therapy has been established as an adjunctive treatment for patients with severe left ventricular systolic dysfunction and medically refractory heart failure symptoms with a prolonged electrocardiographic QRS interval. Echocardiography has emerged as a useful method to evaluate patients who are considered for cardiac resynchronization therapy. This review outlines measurements of ventricular performance to be used in this patient population including echocardiographic optimization of cardiac resynchronization therapy device settings.
MeSH term(s)	Cardiac Pacing, Artificial/methods ; Echocardiography, Doppler, Color/methods ; Echocardiography, Doppler, Color/trends ; Echocardiography, Three-Dimensional/methods ; Echocardiography, Three-Dimensional/trends ; Electrocardiography ; Female ; Forecasting ; Heart Failure/diagnosis ; Heart Failure/therapy ; Humans ; Male ; Pacemaker, Artificial ; Randomized Controlled Trials as Topic ; Risk Assessment ; Sensitivity and Specificity ; Severity of Illness Index ; Stroke Volume ; Treatment Outcome ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/therapy ; Ventricular Remodeling/physiology
Language	English
Publishing date	2007-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1035622-8
ISSN	1097-6795 ; 0894-7317
ISSN (online)	1097-6795
ISSN	0894-7317
DOI	10.1016/j.echo.2005.11.009
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Zs.A 2638: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Cardiac resynchronization therapy and the emerging role of echocardiography (part 1): indications and results from current studies.

Waggoner, Alan D / Agler, Deborah A / Adams, David B

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

2007 Volume 20, Issue 1, Page(s) 70–75

Abstract: Cardiac resynchronization therapy (CRT) has been established as an adjunctive treatment for patients with left ventricular systolic dysfunction and medically refractory heart failure with a wide QRS interval. Echocardiography can be used to determine the ...

Abstract	Cardiac resynchronization therapy (CRT) has been established as an adjunctive treatment for patients with left ventricular systolic dysfunction and medically refractory heart failure with a wide QRS interval. Echocardiography can be used to determine the response in left ventricular structure and function after device implantation and emerging evidence as a method for selection of patients who may derive clinical benefit from CRT. This review discusses the applications of CRT, including results of clinical trials and the current experience using echocardiography. Part 2 will address the practical aspects of obtaining echocardiographic data in patients who are potential candidates for CRT and optimization of pacemaker settings after device implantation.
MeSH term(s)	Cardiac Pacing, Artificial/methods ; Cardiac Pacing, Artificial/trends ; Echocardiography, Doppler, Color/methods ; Echocardiography, Doppler, Color/trends ; Electrocardiography ; Female ; Forecasting ; Heart Failure/diagnostic imaging ; Heart Failure/therapy ; Humans ; Male ; Pacemaker, Artificial ; Randomized Controlled Trials as Topic ; Sensitivity and Specificity ; Severity of Illness Index ; Stroke Volume ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/therapy
Language	English
Publishing date	2007-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1035622-8
ISSN	1097-6795 ; 0894-7317
ISSN (online)	1097-6795
ISSN	0894-7317
DOI	10.1016/j.echo.2005.10.021
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Zs.A 2638: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Severe pulmonary hypertension without right ventricular failure: the unique hearts of patients with Eisenmenger syndrome.

Hopkins, William E / Waggoner, Alan D

The American journal of cardiology

2002 Volume 89, Issue 1, Page(s) 34–38

Abstract: Why adults with the Eisenmenger syndrome fare so much better than other patients with severe pulmonary hypertension is not known, but may be related to unique hemodynamics found only in these patients and in normal fetuses. We used echocardiography to ... ...

Abstract	Why adults with the Eisenmenger syndrome fare so much better than other patients with severe pulmonary hypertension is not known, but may be related to unique hemodynamics found only in these patients and in normal fetuses. We used echocardiography to evaluate ventricular morphology and function in 80 subjects: 45 cyanotic adults and 5 cyanotic adolescents with Eisenmenger syndrome, 10 infants with nonrestrictive ventricular septal defect and left-to-right shunt flow (pre-Eisenmenger phase), and 20 fetuses with structurally normal hearts. Cross-sectional morphology of the hearts was the same in all 4 groups with a flat ventricular septum throughout the cardiac cycle and equal thickness of the right and left ventricular free walls (regression slope 0.98, r = 0.97, p <0.0001). This morphology was the same in patients independent of age, defect type, and ventricular function. Right ventricular fractional area change was slightly inferior to that of the left ventricle but normal in most patients with Eisenmenger syndrome (0.47 +/- 0.14 vs 0.51 +/- 0.13, p <0.01). Overall, there was a highly significant linear relation between right and left ventricular function (r = 0.81, p <0.0001). The hearts of patients with Eisenmenger syndrome are more like normal fetal hearts than normal adult hearts. Because of the unique cardiovascular hemodynamics, regression of right ventricular wall thickness does not occur and is likely the reason that patients with Eisenmenger syndrome fare so much better than other adults with severe pulmonary hypertension.
MeSH term(s)	Adolescent ; Adult ; Aged ; Echocardiography, Doppler ; Eisenmenger Complex/complications ; Eisenmenger Complex/diagnostic imaging ; Eisenmenger Complex/physiopathology ; Female ; Fetal Diseases/physiopathology ; Hemodynamics ; Humans ; Hypertension, Pulmonary/complications ; Hypertension, Pulmonary/physiopathology ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Pregnancy ; Ventricular Dysfunction, Right/physiopathology
Language	English
Publishing date	2002-01-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/s0002-9149(01)02159-2
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Article: Reagents to measure and manipulate cell functions.

Giuliano, Kenneth A / Taylor, D Lansing / Waggoner, Alan S

Methods in molecular biology (Clifton, N.J.)

2006 Volume 356, Page(s) 141–163

Abstract: Reagents that are used as part of a discovery platform for the measurement and manipulation of cell functions are at the heart of single and multiplexed high content screening assays. Measurement reagents include physiological indicators, immunoreagents, ...

Abstract	Reagents that are used as part of a discovery platform for the measurement and manipulation of cell functions are at the heart of single and multiplexed high content screening assays. Measurement reagents include physiological indicators, immunoreagents, fluorescent analogs of macromolecules, positional biosensors, and fluorescent protein biosensors. Recent developments in reagents that manipulate specific cell functions including small inhibitory RNAs, caged peptides, proteins, and RNAs, and gene switches complement measurement reagents, especially when both classes of reagents are used in the same living cells. The use measurement and manipulation reagents in multiplexed high content screening assays promises to enable a systems cell biology approach to drug discovery and biomedical research.
MeSH term(s)	Animals ; Biomedical Research/methods ; Biosensing Techniques ; Cell Survival ; Cells/metabolism ; Drug Evaluation, Preclinical/methods ; Endpoint Determination ; HeLa Cells ; Histocytochemistry ; Humans ; Indicators and Reagents ; Molecular Probes/analysis ; Molecular Probes/metabolism ; Proteins/metabolism
Chemical Substances	Indicators and Reagents ; Molecular Probes ; Proteins
Language	English
Publishing date	2006-09-01
Publishing country	United States
Document type	Journal Article
ISSN	1064-3745
ISSN	1064-3745
DOI	10.1385/1-59745-217-3:141
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Article ; Online: Potential mechanisms underlying the effect of gender on response to cardiac resynchronization therapy: insights from the SMART-AV multicenter trial.

Cheng, Alan / Gold, Michael R / Waggoner, Alan D / Meyer, Timothy E / Seth, Milan / Rapkin, Joshua / Stein, Kenneth M / Ellenbogen, Kenneth A

Heart rhythm

2012 Volume 9, Issue 5, Page(s) 736–741

Abstract: Background: Recent studies demonstrate that women may respond more favorably to cardiac resynchronization therapy (CRT) than do men. The mechanisms remain unclear.: Objectives: To describe the effects of gender on response to CRT and to explore ... ...

Abstract	Background: Recent studies demonstrate that women may respond more favorably to cardiac resynchronization therapy (CRT) than do men. The mechanisms remain unclear. Objectives: To describe the effects of gender on response to CRT and to explore potential mechanisms behind these differences. Methods: Data for 846 patients from the SMART-AV trial were used to evaluate the mechanisms behind the effects of gender on CRT response. Atrioventricular optimization (AVO) was performed via SmartDelay or echocardiography. Baseline and 6-month left ventricular end systolic volume index (LVESVi) were fitted to a linear regression model with gender predicting change in LVESVi and adjusted for baseline covariates significantly differing by gender. The interaction variable for AVO and gender was also assessed for its effect on change in LVESVi. Results: Baseline variables, including age, body mass index, left ventricular ejection fraction, QRS width, and severity of heart failure symptoms, were comparable between men and women. Women had a higher incidence of left bundle branch block conduction and nonischemic cardiomyopathy and exhibited greater reductions in LVESVi even after adjustment for these differences (13.4 mL/m(2) vs 8.5 mL/m(2); P = .002). In addition, women had greater percentages of biventricular pacing and appeared to derive greater reductions in left ventricular volume with AVO than did men. Conclusions: Women demonstrated greater reductions in LVESVi with CRT than did men. These observations are not explained by differences in baseline characteristics. Greater degrees of biventricular pacing and enhanced response to AVO in women may partly explain the reason for the gender effect on CRT response.
MeSH term(s)	Bundle-Branch Block/therapy ; Cardiac Resynchronization Therapy/methods ; Echocardiography ; Electrocardiography ; Female ; Heart Failure, Systolic/therapy ; Humans ; Male ; Sex Factors ; Stroke Volume ; Surveys and Questionnaires ; Treatment Outcome ; Ventricular Dysfunction, Left/therapy ; Ventricular Remodeling/physiology
Language	English
Publishing date	2012-05
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2229357-7
ISSN	1556-3871 ; 1547-5271
ISSN (online)	1556-3871
ISSN	1547-5271
DOI	10.1016/j.hrthm.2011.12.013
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Article ; Online: Doppler echocardiographic methods for optimization of the atrioventricular delay during cardiac resynchronization therapy.

Waggoner, Alan D / de las Fuentes, Lisa / Davila-Roman, Victor G

Echocardiography (Mount Kisco, N.Y.)

2008 Volume 25, Issue 9, Page(s) 1047–1055

Abstract: Cardiac resynchronization therapy (CRT) is beneficial for a majority of patients with medically refractory heart failure due to severe left ventricular (LV) systolic dysfunction and prolonged interventricular conduction to improve symptoms and LV ... ...

Abstract	Cardiac resynchronization therapy (CRT) is beneficial for a majority of patients with medically refractory heart failure due to severe left ventricular (LV) systolic dysfunction and prolonged interventricular conduction to improve symptoms and LV performance. An optimally programmed atrioventricular delay (AVD) during CRT can be also important to maximize the response in left ventricular function. Several Doppler echocardiographic methods have been reported to be useful for determination of the optimal AVD. This review will discuss the various Doppler-based approaches to program the AVD in patients that receive CRT.
MeSH term(s)	Atrioventricular Node/diagnostic imaging ; Cardiac Pacing, Artificial/trends ; Echocardiography/methods ; Heart Failure/diagnostic imaging ; Heart Failure/prevention & control ; Humans ; Quality Assurance, Health Care/methods ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/prevention & control
Language	English
Publishing date	2008-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	843645-9
ISSN	1540-8175 ; 0742-2822
ISSN (online)	1540-8175
ISSN	0742-2822
DOI	10.1111/j.1540-8175.2008.00787.x
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Article ; Online: American Society of Echocardiography minimum standards for the cardiac sonographer: a position paper.

Bierig, S Michelle / Ehler, Donna / Knoll, Margaret L / Waggoner, Alan D

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

2006 Volume 19, Issue 5, Page(s) 471–474

MeSH term(s)	Credentialing/standards ; Echocardiography/standards ; Practice Guidelines as Topic ; Practice Patterns, Physicians'/standards ; Professional Competence ; Quality Assurance, Health Care/standards ; Societies, Medical/standards ; United States
Language	English
Publishing date	2006-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1035622-8
ISSN	1097-6795 ; 0894-7317
ISSN (online)	1097-6795
ISSN	0894-7317
DOI	10.1016/j.echo.2006.03.032
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