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  1. Article ; Online: A

    Claesen, Jan / Spagnolo, Jennifer B / Ramos, Stephany Flores / Kurita, Kenji L / Byrd, Allyson L / Aksenov, Alexander A / Melnik, Alexey V / Wong, Weng R / Wang, Shuo / Hernandez, Ryan D / Donia, Mohamed S / Dorrestein, Pieter C / Kong, Heidi H / Segre, Julia A / Linington, Roger G / Fischbach, Michael A / Lemon, Katherine P

    Science translational medicine

    2020  Volume 12, Issue 570

    Abstract: The composition of the skin microbiota varies widely among individuals when sampled at the same body site. A key question is which molecular factors determine strain-level variability within sub-ecosystems of the skin microbiota. Here, we used a genomics- ...

    Abstract The composition of the skin microbiota varies widely among individuals when sampled at the same body site. A key question is which molecular factors determine strain-level variability within sub-ecosystems of the skin microbiota. Here, we used a genomics-guided approach to identify an antibacterial biosynthetic gene cluster in
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Hair Follicle ; Humans ; Microbiota ; Propionibacterium acnes ; Skin
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2020-11-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2518854-9
    ISSN 1946-6242 ; 1946-6234
    ISSN (online) 1946-6242
    ISSN 1946-6234
    DOI 10.1126/scitranslmed.aay5445
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6941: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: A

    Fernandes, Priyanka / Howland, Shanshan W / Heiss, Kirsten / Hoffmann, Angelika / Hernández-Castañeda, Maria A / Obrová, Klára / Frank, Roland / Wiedemann, Philipp / Bendzus, Martin / Rénia, Laurent / Mueller, Ann-Kristin

    Frontiers in immunology

    2018  Volume 9, Page(s) 1875

    Abstract: Cerebral malaria is a complex neurological syndrome caused by an infection ... ...

    Abstract Cerebral malaria is a complex neurological syndrome caused by an infection with
    MeSH term(s) Animals ; Antigens, Protozoan/immunology ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Cross-Priming/immunology ; Disease Models, Animal ; Disease Susceptibility ; Gene Expression ; Genes, Protozoan ; Genes, Reporter ; Life Cycle Stages ; Magnetic Resonance Imaging ; Malaria, Cerebral/diagnosis ; Malaria, Cerebral/immunology ; Malaria, Cerebral/parasitology ; Malaria, Cerebral/pathology ; Mice ; Plasmodium berghei/genetics ; Plasmodium berghei/growth & development ; Plasmodium berghei/immunology
    Chemical Substances Antigens, Protozoan
    Language English
    Publishing date 2018-08-14
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2018.01875
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A

    Ishii, Atsushi / Kang, Jing-Qiong / Schornak, Cara C / Hernandez, Ciria C / Shen, Wangzhen / Watkins, Joseph C / Macdonald, Robert L / Hirose, Shinichi

    Journal of medical genetics

    2016  Volume 54, Issue 3, Page(s) 202–211

    Abstract: Background: Early myoclonic encephalopathy (EME), a disease with a devastating prognosis, is characterised by neonatal onset of seizures and massive myoclonus accompanied by a continuous suppression-burst EEG pattern. Three genes are associated with ... ...

    Abstract Background: Early myoclonic encephalopathy (EME), a disease with a devastating prognosis, is characterised by neonatal onset of seizures and massive myoclonus accompanied by a continuous suppression-burst EEG pattern. Three genes are associated with EMEs that have metabolic features. Here, we report a pathogenic mutation of an ion channel as a cause of EME for the first time.
    Methods: Sequencing was performed for 214 patients with epileptic seizures using a gene panel with 109 genes that are known or suspected to cause epileptic seizures. Functional assessments were demonstrated by using electrophysiological experiments and immunostaining for mutant γ-aminobutyric acid-A (GABA
    Results: We discovered a
    Conclusion: This mutation has complex functional effects on GABA
    MeSH term(s) Brain/diagnostic imaging ; Brain/physiopathology ; Crystallography, X-Ray ; Electroencephalography ; HEK293 Cells ; Humans ; Infant ; Male ; Models, Molecular ; Mutation, Missense ; Opsoclonus-Myoclonus Syndrome/genetics ; Opsoclonus-Myoclonus Syndrome/physiopathology ; Receptors, GABA-A/chemistry ; Receptors, GABA-A/genetics ; Seizures/genetics ; Seizures/physiopathology ; Spasms, Infantile/genetics ; Spasms, Infantile/physiopathology
    Chemical Substances GABRB2 protein, human ; Receptors, GABA-A
    Language English
    Publishing date 2016-10-27
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 220881-7
    ISSN 1468-6244 ; 0022-2593
    ISSN (online) 1468-6244
    ISSN 0022-2593
    DOI 10.1136/jmedgenet-2016-104083
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 177: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Book ; Thesis: Regulation of Ki-67's biophysical properties

    Hernández Armendáriz, Alberto / Erhardt, Sylvia / Ellenberg, Jan

    2023  

    Institution Universität Heidelberg
    Author's details presented by M. Sc. Alberto Hernández Armendáriz ; referees: Prof. Dr. Sylvia Erhardt, Dr. Jan Ellenberg
    Language English
    Size xxiv, 152 Seiten, Seite a-l, Illustrationen, Diagramme
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-University Heidelberg, 2023
    Note Mit einer Zusammenfassung in deutscher und englischer Sprache
    HBZ-ID HT030070494
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 E 1107 order for loan Magazin

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  5. Book ; Online: (Un)Equal Pathways to Higher Education : Social Origins and Destinations of Colombian Graduates

    Cuenca Hernández, Andrea

    2021  

    Keywords Organization & management of education ; Labor Market ; Unequal Opportunities ; Equality ; Educational Inequalities
    Size 1 electronic resource (328 pages)
    Publisher Waxmann Verlag
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021232831
    ISBN 9783830942757 ; 3830942753
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  6. Book ; Online ; E-Book: Feedback control for personalized medicine

    Hernandez-Vargas, Esteban A.

    2022  

    Author's details edited by Esteban A. Hernandez-Vargas
    Keywords Precision medicine
    Subject code 610.28
    Language English
    Size 1 online resource (309 pages)
    Publisher Academic Press
    Publishing place London, England
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-323-90665-6 ; 9780323901710 ; 978-0-323-90665-4 ; 0323901719
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  7. Book ; Online: Extremismos políticos e direitas

    Barbosa, Jefferson Rodrigues / Hernández, Oscar A. Piñera

    Bolsonaro, Trump e a crise das "democracias"

    2022  

    Keywords JPA ; Ciência política ; Radicalismo ; Democracia ; Extremistas de direita ; Brasil, Presidente (2019- : Bolsonaro) ; Estados Unidos. Presidente (217-2021: Trump) ; Relações internacionais
    Language Portuguese
    Size 1 electronic resource (254 pages)
    Publisher Editora Oficina Universitária
    Publishing place Marília, São Paulo, Brazil
    Document type Book ; Online
    Note Portuguese
    HBZ-ID HT030377403
    ISBN 9786559542277 ; 6559542270
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Book ; Online: Psychosocial, Educational, and Economic Impacts of COVID-19

    Hernández-Sánchez, Brizeida / Hernández-Sánchez, Brizeida / Carlos Sánchez-García, José / Carrizo Moreira, António / Monteiro, Alcides A

    2023  

    Keywords Epidemiology & medical statistics ; risk factors ; leadership ; pandemic ; trauma ; elderly ; mental health
    Language English
    Size 1 electronic resource (510 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English
    HBZ-ID HT030381258
    ISBN 9781803550411 ; 1803550414
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  9. Article ; Online: Comment on "Sheathed goring: An unusual bull-horn injury".

    Martínez-Hernández, Andreu

    Cirugia espanola

    2024  Volume 102, Issue 4, Page(s) 239–240

    MeSH term(s) Male ; Humans ; Cattle ; Animals ; Wounds, Penetrating
    Language English
    Publishing date 2024-03-15
    Publishing country Spain
    Document type Letter
    ISSN 2173-5077
    ISSN (online) 2173-5077
    DOI 10.1016/j.cireng.2024.02.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Effect of the Mediterranean diet in cardiovascular prevention.

    Martínez-González, Miguel Á / Hernández Hernández, Aitor

    Revista espanola de cardiologia (English ed.)

    2024  

    Abstract: The Mediterranean diet is the best evidence-based model for cardiovascular prevention. In addition to 2 major randomized secondary prevention trials (Lyon Heart and CORDIOPREV) and 1 primary prevention trial (PREDIMED) that have demonstrated these ... ...

    Abstract The Mediterranean diet is the best evidence-based model for cardiovascular prevention. In addition to 2 major randomized secondary prevention trials (Lyon Heart and CORDIOPREV) and 1 primary prevention trial (PREDIMED) that have demonstrated these benefits, there is an unprecedented body of high-quality prospective epidemiological evidence supporting these beneficial effects. The key elements of this traditional pattern are the abundant use of extra-virgin olive oil and high consumption of foods of natural plant-based origin (fruits, vegetables, nuts, and legumes) and fish, along with a reduction in processed meats, red meats, and ultraprocessed products. Moderate consumption of wine, preferably red wine, with meals is an essential element of this traditional pattern. Although removing wine consumption from the Mediterranean diet has been associated with a reduction in its preventive efficacy, doubts have recently arisen about the possible adverse effect of even low or moderate intake of any alcoholic beverages. A new large Spanish trial, UNATI, which will begin in June 2024, will randomize 10 000 drinkers aged 50 to 75 years to abstention or moderate consumption. UNATI aims to answer these doubts with the best possible evidence.
    Language Spanish
    Publishing date 2024-02-07
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 2592481-3
    ISSN 1885-5857 ; 1885-5857
    ISSN (online) 1885-5857
    ISSN 1885-5857
    DOI 10.1016/j.rec.2024.01.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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