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  1. Article ; Online: Immunotherapy approaches for adult glioma: knowledge gained from recent clinical trials.

    Andersen, Brian M / Reardon, David A

    Current opinion in neurology

    2022  Volume 35, Issue 6, Page(s) 803–813

    Abstract: Purpose of review: Summarize principles behind various immunotherapy approaches for high and low-grade glioma in the context of recently completed clinical trials and the new insights they provide.: Recent findings: Despite the widespread success of ... ...

    Abstract Purpose of review: Summarize principles behind various immunotherapy approaches for high and low-grade glioma in the context of recently completed clinical trials and the new insights they provide.
    Recent findings: Despite the widespread success of therapies targeting the T-cell checkpoints programmed-death 1 and cytotoxic T lymphocyte antigen 4 in other malignancies, recent phase III trials in glioblastoma confirm the lack of efficacy of anti-programmed-death 1 monotherapy in more than 90% of patients. Vaccination approaches remain under investigation for high-grade glioma and have shown activity in some low-grade glioma patients. Chimeric antigen receptor T cells now feature a new generation of products engineered to potentially withstand glucocorticoid therapy. Oncolytic viral therapies have similarly advanced in sophistication, with drug-sensitive gene expression and tumor-selective modifications. Combinations of therapies hold promise for overcoming the numerous mechanisms of immune suppression in glioma.
    Summary: Although immunotherapies have yet to show rates of efficacy compared with other malignancies, new knowledge of immunology and combination therapies brings hope for improved efficacy in the future.
    MeSH term(s) Humans ; Glioma/drug therapy ; Immunotherapy ; Glioblastoma/therapy ; Combined Modality Therapy ; Immunologic Factors/therapeutic use
    Chemical Substances Immunologic Factors
    Language English
    Publishing date 2022-10-21
    Publishing country England
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1182686-1
    ISSN 1473-6551 ; 1350-7540
    ISSN (online) 1473-6551
    ISSN 1350-7540
    DOI 10.1097/WCO.0000000000001118
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  2. Article ; Online: Thermally Induced Optical Reflection of Sound (THORS) in Ambient Air: Characterization and Temporal Dynamics.

    Kazal, Daniel S / Reardon, Alex J / Cullum, Brian M

    Applied spectroscopy

    2022  Volume 76, Issue 11, Page(s) 1346–1355

    Abstract: Thermally induced optical reflection of sound (THORS) provides a means to manipulate sound waves without the need for traditional acoustically engineered structures. By photothermally exciting a medium, with infrared light, a barrier can be formed due to ...

    Abstract Thermally induced optical reflection of sound (THORS) provides a means to manipulate sound waves without the need for traditional acoustically engineered structures. By photothermally exciting a medium, with infrared light, a barrier can be formed due to abrupt changes in compressibility of the excited medium. Discovery and initial characterization of the THORS phenomenon utilized air saturated with ethanol vapor as the absorbing medium and a CO
    Language English
    Publishing date 2022-07-05
    Publishing country United States
    Document type Journal Article
    ISSN 1943-3530
    ISSN (online) 1943-3530
    DOI 10.1177/00037028221109238
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  3. Article ; Online: Anxiety Disorders in Athletes.

    Reardon, Claudia L / Gorczynski, Paul / Hainline, Brian / Hitchcock, Mary / Rice, Simon

    Clinics in sports medicine

    2023  Volume 43, Issue 1, Page(s) 33–52

    Abstract: Athletes and non-athletes experience many anxiety-related symptoms and disorders at comparable rates. Contributory factors may include pressure to perform, public scrutiny, sporting career dissatisfaction, injury, and harassment and abuse in sport. ... ...

    Abstract Athletes and non-athletes experience many anxiety-related symptoms and disorders at comparable rates. Contributory factors may include pressure to perform, public scrutiny, sporting career dissatisfaction, injury, and harassment and abuse in sport. Anxiety may negatively impact sport performance. Specific types of anxiety may have unique presentations in athletes. It is important to rule out general medical and substance-related causes of anxiety symptoms. Psychotherapy and pharmacology treatment options should be considered, bearing in mind athletes' environmental circumstances and physiologies.
    MeSH term(s) Humans ; Athletes ; Anxiety Disorders ; Sports ; Anxiety/therapy ; Psychotherapy
    Language English
    Publishing date 2023-07-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 779944-5
    ISSN 1556-228X ; 0278-5919
    ISSN (online) 1556-228X
    ISSN 0278-5919
    DOI 10.1016/j.csm.2023.06.002
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  4. Article ; Online: Breaking a taboo: why the International Olympic Committee convened experts to develop a consensus statement on mental health in elite athletes.

    Hainline, Brian / Reardon, Claudia L

    British journal of sports medicine

    2019  Volume 53, Issue 11, Page(s) 665–666

    MeSH term(s) Athletes/psychology ; Consensus ; Humans ; Mental Disorders/diagnosis ; Mental Disorders/therapy ; Mental Health ; Social Stigma ; Sports Medicine
    Language English
    Publishing date 2019-05-16
    Publishing country England
    Document type Editorial
    ZDB-ID 600592-5
    ISSN 1473-0480 ; 0306-3674
    ISSN (online) 1473-0480
    ISSN 0306-3674
    DOI 10.1136/bjsports-2019-100681
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  5. Article: The Pitfalls of Using Pop-Off Valves in Adult Emergency Airway.

    Rauschenbach, Anthony / Pothireddy, Sahini / Young, Paul / Reardon, Robert F / Driver, Brian E

    The Journal of emergency medicine

    2023  Volume 66, Issue 3, Page(s) e361–e364

    Abstract: Background: Although common in pediatric airway equipment, positive-pressure relief ("pop-off") valves are also present on some adult resuscitator bags. These valves are designed to decrease barotrauma but, in doing so, limit the airway pressure ... ...

    Abstract Background: Although common in pediatric airway equipment, positive-pressure relief ("pop-off") valves are also present on some adult resuscitator bags. These valves are designed to decrease barotrauma but, in doing so, limit the airway pressure provided during manual bag-assisted ventilation. In critically ill adult patients with high airway pressures, these valves can be detrimental and result in hypoventilation and subsequent hypoxemia.
    Case reports: In the 7 days after an unannounced introduction of new resuscitator bags with pop-off valves in the emergency department, there were 3 adult patients for whom an open pop-off valve resulted in hypoventilation and hypoxemia. These cases involved both medical and traumatic pathologies. In each case, there was a delay in discovering the change to a resuscitator bag equipped with a pop-off valve. Once the emergency physicians noticed the pop-off valve and closed them, there was significant improvement in ventilation and oxygenation. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Hand-operated resuscitator bags are an essential tool for airway management. These cases represent two main lessons: changing airway equipment without notifying staff is dangerous, and an open pop-off valve will result in inadequate ventilation when patients have high airway pressures, without the tactile feedback of difficult bagging. Emergency physicians should be aware of equipment changes and know to disable the pop-off valve on resuscitator bags if they find them in their departments.
    MeSH term(s) Adult ; Humans ; Child ; Hypoventilation ; Respiration, Artificial/methods ; Cardiopulmonary Resuscitation/methods ; Lung ; Hypoxia
    Language English
    Publishing date 2023-11-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605559-x
    ISSN 0736-4679
    ISSN 0736-4679
    DOI 10.1016/j.jemermed.2023.10.016
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  6. Article ; Online: Sedative Dose for Rapid Sequence Intubation and Postintubation Hypotension: Is There an Association?

    Driver, Brian E / Trent, Stacy A / Prekker, Matthew E / Reardon, Robert F / Brown, Calvin A

    Annals of emergency medicine

    2023  Volume 82, Issue 4, Page(s) 417–424

    Abstract: Study objective: For patients with hemodynamic instability undergoing rapid sequence intubation, experts recommend reducing the sedative medication dose to minimize the risk of further hemodynamic deterioration. Scant data support this practice for ... ...

    Abstract Study objective: For patients with hemodynamic instability undergoing rapid sequence intubation, experts recommend reducing the sedative medication dose to minimize the risk of further hemodynamic deterioration. Scant data support this practice for etomidate and ketamine. We sought to determine if the dose of etomidate or ketamine was independently associated with postintubation hypotension.
    Methods: We analyzed data from the National Emergency Airway Registry from January 2016 to December 2018. Patients aged 14 years or older were included if the first intubation attempt was facilitated with etomidate or ketamine. We used multivariable modeling to determine whether drug dose in milligrams per kilogram of patient weight was independently associated with postintubation hypotension (systolic blood pressure < 100 mm Hg).
    Results: We analyzed 12,175 intubation encounters facilitated by etomidate and 1,849 facilitated by ketamine. The median drug doses were 0.28 mg/kg (interquartile range [IQR] 0.22 mg/kg to 0.32 mg/kg) for etomidate and 1.33 mg/kg (IQR 1 mg/kg to 1.8 mg/kg) for ketamine. Postintubation hypotension occurred in 1,976 patients (16.2%) who received etomidate and in 537 patients (29.0%) who received ketamine. In multivariable models, neither the etomidate dose (adjusted odds ratio [aOR] 0.95, 95% confidence interval [CI] 0.90 to 1.01) nor ketamine dose (aOR 0.97, 95% CI 0.81 to 1.17) was associated with postintubation hypotension. Results were similar in sensitivity analyses excluding patients with preintubation hypotension and including only patients intubated for shock.
    Conclusion: In this large registry of patients intubated after receiving either etomidate or ketamine, we observed no association between the weight-based sedative dose and postintubation hypotension.
    MeSH term(s) Humans ; Hypnotics and Sedatives/adverse effects ; Etomidate/adverse effects ; Rapid Sequence Induction and Intubation ; Ketamine/adverse effects ; Intubation, Intratracheal/adverse effects ; Intubation, Intratracheal/methods ; Retrospective Studies ; Hypotension/etiology ; Hypotension/drug therapy
    Chemical Substances Hypnotics and Sedatives ; Etomidate (Z22628B598) ; Ketamine (690G0D6V8H)
    Language English
    Publishing date 2023-06-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603080-4
    ISSN 1097-6760 ; 0196-0644
    ISSN (online) 1097-6760
    ISSN 0196-0644
    DOI 10.1016/j.annemergmed.2023.05.014
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    Zs.A 1344: Show issues Location:
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  7. Article ; Online: Spinal intervertebral disc regeneration versus repair: cost, outcomes and future considerations.

    Jarrah, Ryan / Reardon, Taylor / Warner, Tyler / Stefano, Frank De / Fiani, Brian

    Regenerative medicine

    2022  Volume 17, Issue 6, Page(s) 337–340

    MeSH term(s) Humans ; Intervertebral Disc ; Intervertebral Disc Degeneration/therapy ; Mesenchymal Stem Cell Transplantation ; Regeneration
    Language English
    Publishing date 2022-05-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2274500-2
    ISSN 1746-076X ; 1746-0751
    ISSN (online) 1746-076X
    ISSN 1746-0751
    DOI 10.2217/rme-2022-0049
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  8. Article ; Online: In reply.

    Driver, Brian E / Reardon, Robert F

    Annals of emergency medicine

    2017  Volume 69, Issue 5, Page(s) 668–669

    Language English
    Publishing date 2017-05
    Publishing country United States
    Document type Letter
    ZDB-ID 603080-4
    ISSN 1097-6760 ; 0196-0644
    ISSN (online) 1097-6760
    ISSN 0196-0644
    DOI 10.1016/j.annemergmed.2017.01.011
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  9. Book ; Online: Compositional Zero-Shot Learning for Attribute-Based Object Reference in Human-Robot Interaction

    Gao, Peng / Jaafar, Ahmed / Reily, Brian / Reardon, Christopher / Zhang, Hao

    2023  

    Abstract: Language-enabled robots have been widely studied over the past years to enable natural human-robot interaction and teaming in various real-world applications. Language-enabled robots must be able to comprehend referring expressions to identify a ... ...

    Abstract Language-enabled robots have been widely studied over the past years to enable natural human-robot interaction and teaming in various real-world applications. Language-enabled robots must be able to comprehend referring expressions to identify a particular object from visual perception using a set of referring attributes extracted from natural language. However, visual observations of an object may not be available when it is referred to, and the number of objects and attributes may also be unbounded in open worlds. To address the challenges, we implement an attribute-based compositional zero-shot learning method that uses a list of attributes to perform referring expression comprehension in open worlds. We evaluate the approach on two datasets including the MIT-States and the Clothing 16K. The preliminary experimental results show that our implemented approach allows a robot to correctly identify the objects referred to by human commands.

    Comment: Equal contribution from the first two authors
    Keywords Computer Science - Robotics ; Computer Science - Artificial Intelligence ; Computer Science - Computation and Language ; Computer Science - Computer Vision and Pattern Recognition
    Subject code 629
    Publishing date 2023-12-21
    Publishing country us
    Document type Book ; Online
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  10. Article ; Online: Definitive Airway Management of Patients with a King Laryngeal Tube

    Sandefur, Benjamin J / Driver, Brian E / Brown, Calvin A / Reardon, Robert F

    The western journal of emergency medicine

    2020  Volume 21, Issue 3, Page(s) 542–545

    Keywords covid19
    Language English
    Publishing date 2020-04-24
    Publishing country United States
    Document type Letter
    ZDB-ID 2375700-0
    ISSN 1936-9018 ; 1936-900X
    ISSN (online) 1936-9018
    ISSN 1936-900X
    DOI 10.5811/westjem.2020.4.47462
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