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Article ; Online: PBPK perspective on alternative CYP3A4 inducers for rifampin.

Chen, Kuan-Fu / Jones, Hannah M

CPT: pharmacometrics & systems pharmacology

2022 Volume 11, Issue 12, Page(s) 1543–1546

MeSH term(s)	Humans ; Cytochrome P-450 CYP3A Inducers ; Rifampin/pharmacology ; Cytochrome P-450 CYP3A Inhibitors ; Cytochrome P-450 CYP3A ; Drug Interactions
Chemical Substances	Cytochrome P-450 CYP3A Inducers ; Rifampin (VJT6J7R4TR) ; Cytochrome P-450 CYP3A Inhibitors ; Cytochrome P-450 CYP3A (EC 1.14.14.1) ; CYP3A4 protein, human (EC 1.14.14.55)
Language	English
Publishing date	2022-09-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2697010-7
ISSN	2163-8306 ; 2163-8306
ISSN (online)	2163-8306
ISSN	2163-8306
DOI	10.1002/psp4.12864
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Why we don't eat as intended: Moderators of the short-term intention-behaviour relation in food intake.

Aulbach, Matthias Burkard / van Alebeek, Hannah / Jones, Christopher M / Blechert, Jens

British journal of health psychology

2024

Abstract: ... participants (m: Results: Two-part multilevel modelling revealed that craving, availability of goal ...

Abstract	Objectives: A healthy diet is essential for preventing chronic disease and promoting overall health. Translating one's intention to eat healthy into actual behaviour has, however, proven difficult with a range of internal and contextual factors identified as driving eating behaviour. Design: We leverage Temporal Self-Regulation Theory to examine these momentary determinants' direct and moderating effects on the intention-behaviour relation with Ecological Momentary Assessment (EMA). Methods: Eighty-seven healthy participants (m Results: Two-part multilevel modelling revealed that craving, availability of goal-incongruent foods, social eating cues, giving in to other temptations and weaker momentary intentions directly increased the risk and severity of goal-incongruent intake within the next 3 hr. Social cues, stress and craving further influence behaviour through altering intention implementation. Conclusions: Results imply that people regularly fail to implement intentions for 3-hr periods and that a range of factors influences this, both directly and by disrupting intentional processes. While for some barriers, fostering strong intentions throughout the day could be beneficial, others require different strategies for dietary adherence.
Language	English
Publishing date	2024-01-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2026500-1
ISSN	2044-8287 ; 1359-107X
ISSN (online)	2044-8287
ISSN	1359-107X
DOI	10.1111/bjhp.12714
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Article ; Online: Opportunities and Challenges for PBPK Model of mAbs in Paediatrics and Pregnancy.

Gill, Katherine L / Jones, Hannah M

The AAPS journal

2022 Volume 24, Issue 4, Page(s) 72

Abstract: New drugs may in some cases need to be tested in paediatric and pregnant patients. However, it is difficult to recruit such patients and there are many ethical issues around their inclusion in clinical trials. Modelling and simulation can help to plan ... ...

Abstract	New drugs may in some cases need to be tested in paediatric and pregnant patients. However, it is difficult to recruit such patients and there are many ethical issues around their inclusion in clinical trials. Modelling and simulation can help to plan well-designed clinical trials with a reduced number of participants and to bridge gaps where recruitment is difficult. Physiologically based pharmacokinetic (PBPK) models for small molecule drugs have been used to aid study design and dose adjustments in paediatrics and pregnancy, with several publications in the literature. However, published PBPK models for monoclonal antibodies (mAb) in these populations are scarce. Here, the current status of mAb PBPK models in paediatrics and pregnancy is discussed. Seven mAb PBPK models published for paediatrics were found, which report good prediction accuracy across a wide age range. No mAb PBPK models for pregnant women have been published to date. Current challenges to the development of such PBPK models are discussed, including gaps in our knowledge of relevant physiological processes and availability of clinical data to verify models. As the availability of such data increases, it will help to improve our confidence in the PBPK model predictive ability. Advantages for using PBPK models to predict mAb PK in paediatrics and pregnancy are discussed. For example, the ability to incorporate ontogeny and gestational changes in physiology, prediction of maternal, placental and foetal exposure and the ability to make predictions from in vitro and preclinical data prior to clinical data being available.
MeSH term(s)	Antibodies, Monoclonal ; Child ; Computer Simulation ; Female ; Humans ; Models, Biological ; Pediatrics ; Placenta ; Pregnancy
Chemical Substances	Antibodies, Monoclonal
Language	English
Publishing date	2022-06-01
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1550-7416
ISSN (online)	1550-7416
DOI	10.1208/s12248-022-00722-0
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Article ; Online: Evidence of Hematoma Prevention After Facelift.

Stewart, Christopher M / Bassiri-Tehrani, Brian / Jones, Hannah Elizabeth / Nahai, Foad

Aesthetic surgery journal

2023 Volume 44, Issue 2, Page(s) 134–143

MeSH term(s)	Humans ; Male ; Rhytidoplasty/adverse effects ; Rhytidoplasty/methods ; Anesthesia, Local ; Hypertension/prevention & control ; Hypertension/complications ; Fibrin Tissue Adhesive/therapeutic use ; Hematoma/etiology ; Hematoma/prevention & control ; Postoperative Complications/etiology ; Postoperative Complications/prevention & control
Chemical Substances	Fibrin Tissue Adhesive
Language	English
Publishing date	2023-08-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2087022-X
ISSN	1527-330X ; 1090-820X ; 1084-0761
ISSN (online)	1527-330X
ISSN	1090-820X ; 1084-0761
DOI	10.1093/asj/sjad247
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Zs.A 5721: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 570: Show issues

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Article ; Online: Mendelian randomisation for psychiatry: how does it work, and what can it tell us?

Wootton, Robyn E / Jones, Hannah J / Sallis, Hannah M

Molecular psychiatry

2021 Volume 27, Issue 1, Page(s) 53–57

Abstract: The successful prevention of mental illness relies upon the identification of causal, modifiable risk factors. However, observational evidence exploring such risk factors often produces contradictory results and randomised control trials are often ... ...

Abstract	The successful prevention of mental illness relies upon the identification of causal, modifiable risk factors. However, observational evidence exploring such risk factors often produces contradictory results and randomised control trials are often expensive, time-consuming or unethical to conduct. Mendelian randomisation (MR) is a complementary approach that uses naturally occurring genetic variation to identify possible causal effects between a risk factor and an outcome in a time-efficient and low-cost manner. MR utilises genetic variants as instrumental variables for the risk factor of interest. MR studies are becoming more frequent in the field of psychiatry, warranting a reflection upon both the possibilities and the pitfalls. In this Perspective, we consider several limitations of the MR method that are of particular relevance to psychiatry. We also present new MR methods that have exciting applications to questions of mental illness. While we believe that MR can make an important contribution to the field of psychiatry, we also wish to emphasise the importance of clear causal questions, thorough sensitivity analyses, and triangulation with other forms of evidence.
MeSH term(s)	Causality ; Mendelian Randomization Analysis/methods ; Psychiatry ; Risk Factors
Language	English
Publishing date	2021-06-04
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1330655-8
ISSN	1476-5578 ; 1359-4184
ISSN (online)	1476-5578
ISSN	1359-4184
DOI	10.1038/s41380-021-01173-3
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Zs.A 4812: Show issues

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Article ; Online: Physiologically-based pharmacokinetic modeling of the drug-drug interaction between ivacaftor and lefamulin in cystic fibrosis patients.

Amiel, Magali / Ke, Alice / Gelone, Steven P / Jones, Hannah M / Wicha, Wolfgang

CPT: pharmacometrics & systems pharmacology

2024 Volume 13, Issue 4, Page(s) 589–598

Abstract: Lefamulin is being evaluated as a treatment for bacterial exacerbations in cystic fibrosis (CF). Ivacaftor is approved for the treatment of patients with CF. Lefamulin is a moderate CYP3A inhibitor and co-administration with ivacaftor may result in a ... ...

Abstract	Lefamulin is being evaluated as a treatment for bacterial exacerbations in cystic fibrosis (CF). Ivacaftor is approved for the treatment of patients with CF. Lefamulin is a moderate CYP3A inhibitor and co-administration with ivacaftor may result in a drug-drug interaction (DDI). A CF population was built based on literature using the Simcyp Simulator. A previously developed and validated physiologically-based pharmacokinetic (PBPK) model for ivacaftor was used. A PBPK model for lefamulin was developed and verified. Predicted concentrations and pharmacokinetic (PK) parameters for both ivacaftor and lefamulin in healthy subjects and patients with CF were in reasonable agreement with observed data (within 1.4-fold, majority within 1.25-fold). The lefamulin model as a CYP3A4 perpetrator was validated using a different Ki value for oral (p.o.) and intravenous (i.v.) routes. The simulated changes in area under the curve of ivacaftor in patients with CF when co-administered with p.o. and i.v. lefamulin were weak-to-moderate. The predicted change in ivacaftor PK when co-administered with oral lefamulin was less than observed between ivacaftor and fluconazole. These results suggest a low liability for a DDI between lefamulin and ivacaftor in patients with CF.
MeSH term(s)	Humans ; Cystic Fibrosis/drug therapy ; Quinolones/therapeutic use ; Cytochrome P-450 CYP3A Inhibitors/pharmacology ; Cytochrome P-450 CYP3A ; Drug Interactions ; Models, Biological ; Aminophenols ; Diterpenes ; Polycyclic Compounds ; Thioglycolates
Chemical Substances	ivacaftor (1Y740ILL1Z) ; lefamulin (21904A5386) ; Quinolones ; Cytochrome P-450 CYP3A Inhibitors ; Cytochrome P-450 CYP3A (EC 1.14.14.1) ; Aminophenols ; Diterpenes ; Polycyclic Compounds ; Thioglycolates
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2697010-7
ISSN	2163-8306 ; 2163-8306
ISSN (online)	2163-8306
ISSN	2163-8306
DOI	10.1002/psp4.13103
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Article: Super-Enhancer Dysregulation in Rhabdoid Tumor Cells Is Regulated by the SWI/SNF ATPase BRG1.

Jones, Cheyenne A / Wang, Jing / Evans, James R / Sisk, Hannah R / Womack, Carl B / Liu, Qi / Tansey, William P / Weissmiller, April M

Cancers

2024 Volume 16, Issue 5

Abstract: Mutations in the SWI/SNF chromatin remodeling complex occur in ~20% of cancers. In rhabdoid tumors defined by loss of the SWI/SNF ... ...

Abstract	Mutations in the SWI/SNF chromatin remodeling complex occur in ~20% of cancers. In rhabdoid tumors defined by loss of the SWI/SNF subunit
Language	English
Publishing date	2024-02-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16050916
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Article ; Online: Goal pursuit increases more after dietary success than after dietary failure: examining conflicting theories of self-regulation using ecological momentary assessment.

van Alebeek, Hannah / Jones, Christopher M / Reichenberger, Julia / Pannicke, Björn / Schüz, Benjamin / Blechert, Jens

The international journal of behavioral nutrition and physical activity

2024 Volume 21, Issue 1, Page(s) 24

Abstract: Background: Maintaining a healthy body weight and reaching long-term dietary goals requires ongoing self-monitoring and behavioral adjustments. How individuals respond to successes and failures is described in models of self-regulation: while cybernetic ...

Abstract	Background: Maintaining a healthy body weight and reaching long-term dietary goals requires ongoing self-monitoring and behavioral adjustments. How individuals respond to successes and failures is described in models of self-regulation: while cybernetic models propose that failures lead to increased self-regulatory efforts and successes permit a reduction of such efforts, motivational models (e.g., social-cognitive theory) make opposite predictions. Here, we tested these conflicting models in an ecological momentary assessment (EMA) context and explored whether effort adjustments are related to inter-individual differences in perceived self-regulatory success in dieting (i.e., weight management). Methods: Using linear mixed effects models, we tested in 174 diet-interested individuals whether current day dietary success or failure (e.g., on Monday) was followed by self-regulatory effort adjustment for the next day (e.g., on Tuesday) across 14 days. Success vs. failure was operationalized with two EMA items: first, whether food intake was higher vs. lower than usual and second, whether food intake was perceived as more vs. less goal-congruent than usual. Trait-level perceived self-regulatory success in dieting was measured on a questionnaire. Results: Intended self-regulatory effort increased more strongly after days with dietary success (i.e., eating less than usual / rating intake as goal-congruent) than after days with dietary failure (i.e., eating more than usual / rating intake as goal-incongruent), especially in those individuals with lower scores on perceived self-regulatory success in dieting. Conclusions: Findings support mechanisms proposed by social-cognitive theory, especially in unsuccessful dieters. Thus, future dietary interventions could focus on preventing the decrease in self-regulatory effort after instances of dietary failures and thereby mitigate the potential risk that a single dietary failure initiates a downward spiral into unhealthy eating.
MeSH term(s)	Humans ; Goals ; Ecological Momentary Assessment ; Feeding Behavior/psychology ; Diet ; Self-Control
Language	English
Publishing date	2024-02-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2134691-4
ISSN	1479-5868 ; 1479-5868
ISSN (online)	1479-5868
ISSN	1479-5868
DOI	10.1186/s12966-024-01566-x
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Article ; Online: Self-rated mental and physical health are prospectively associated with psychosocial and academic adjustment to college.

Jones, Emily J / Schreier, Hannah M C

Journal of American college health : J of ACH

2021 Volume 71, Issue 3, Page(s) 715–724

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Humans ; Students/psychology ; Universities ; Mental Health ; Anxiety/psychology ; Health Behavior
Language	English
Publishing date	2021-04-08
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	604907-2
ISSN	1940-3208 ; 0744-8481
ISSN (online)	1940-3208
ISSN	0744-8481
DOI	10.1080/07448481.2021.1904956
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Zs.A 427: Show issues

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Article ; Online: A perinatal coparenting intervention: Effects of a randomized trial on parent cardiometabolic risk and self-reported health.

Jones, Emily J / Feinberg, Mark E / Graham-Engeland, Jennifer E / Jones, Damon E / Schreier, Hannah M C

Biological psychology

2023 Volume 183, Page(s) 108664

Abstract: Background: The transition to parenthood is a common yet stressful experience faced by many young and midlife adults, and the risk of cardiometabolic conditions also begins to rise at this time. Consequently, parenthood represents an opportune time to ... ...

Abstract	Background: The transition to parenthood is a common yet stressful experience faced by many young and midlife adults, and the risk of cardiometabolic conditions also begins to rise at this time. Consequently, parenthood represents an opportune time to intervene with adults to support their psychological and physical health. Purpose: We examined whether the benefits of the Family Foundations program, a perinatal preventative intervention promoting positive coparenting, extend beyond documented mental health and family relationship outcomes to better cardiometabolic risk factors among parents. Methods: We analyzed data from 183 couples (n = 366 participants) who, eight years prior, were randomly assigned to the 9-session perinatal preventative intervention program or a control condition. We collected dried blood spots to measure C-reactive protein (CRP), interleukin-6 (IL-6), and cholesterol; parents also reported on their self-rated health. Results: Randomization to the intervention condition was associated with lower cholesterol (B=-.081, p = .049). Among parents who demonstrated more negative communication styles at pretest (during pregnancy), the intervention was further associated with better self-rated health (B=.181, p = .018). Participation in the intervention program was also marginally associated with lower CRP (B=-.261, p = .077), particularly among mothers (B=-.428, p = .076). Conclusions: These findings indicate that coparenting-focused interventions, such as Family Foundations, can lead to benefits beyond psychosocial and behavioral outcomes, and suggest that Family Foundations may improve parents' longer-term physical health, with potentially more benefits among couples who demonstrated more negative communication styles during pregnancy.
MeSH term(s)	Adult ; Pregnancy ; Female ; Humans ; Parenting/psychology ; Self Report ; Parents/psychology ; Cholesterol ; Cardiovascular Diseases/prevention & control
Chemical Substances	4-iodine-benzo(b)thiophene-2-carboxamidine ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2023-08-23
Publishing country	Netherlands
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	185105-6
ISSN	1873-6246 ; 0301-0511
ISSN (online)	1873-6246
ISSN	0301-0511
DOI	10.1016/j.biopsycho.2023.108664
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