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Article ; Online: Altered localization and functionality of TAR DNA Binding Protein 43 (TDP-43) in niemann- pick disease type C.

Dardis, A / Zampieri, S / Canterini, S / Newell, K L / Stuani, C / Murrell, J R / Ghetti, B / Fiorenza, M T / Bembi, B / Buratti, E

Acta neuropathologica communications

2016 Volume 4, Issue 1, Page(s) 52

Abstract: Niemann-Pick type C (NPC) disease is a lysosomal storage disorder characterized by the occurrence ...

Abstract	Niemann-Pick type C (NPC) disease is a lysosomal storage disorder characterized by the occurrence of visceral and neurological symptoms. At present, the molecular mechanisms causing neurodegeneration in this disease are unknown. Here we report the altered expression and/or mislocalization of the TAR-DNA binding protein 43 (TDP-43) in both NPC mouse and in a human neuronal model of the disease. We also report the neuropathologic study of a NPC patient's brain, showing that while TDP-43 is below immunohistochemical detection in nuclei of cerebellar Purkinje cells, it has a predominant localization in the cytoplasm of these cells. From a functional point of view, the TDP-43 mislocalization, that occurs in a human experimental neuronal model system, is associated with specific alterations in TDP-43 controlled genes. Most interestingly, treatment with N-Acetyl-cysteine (NAC) or beta-cyclodextrin (CD) can partially restore TDP-43 nuclear localization. Taken together, the results of these studies extend the role of TDP-43 beyond the Amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD)/Alzheimer disease (AD) spectrum. These findings may open novel research/therapeutic avenues for a better understanding of both NPC disease and the TDP-43 proteinopathy disease mechanism.
MeSH term(s)	Acetylcysteine/pharmacology ; Animals ; Brain/metabolism ; Brain/pathology ; Cell Nucleus/drug effects ; Cell Nucleus/metabolism ; Cell Nucleus/pathology ; Cells, Cultured ; DNA-Binding Proteins/metabolism ; Disease Models, Animal ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Humans ; Intracellular Signaling Peptides and Proteins ; Male ; Mice, Inbred BALB C ; Mice, Transgenic ; Middle Aged ; Neurons/drug effects ; Neurons/metabolism ; Neurons/pathology ; Neuroprotective Agents/pharmacology ; Niemann-Pick C1 Protein ; Niemann-Pick Disease, Type C/drug therapy ; Niemann-Pick Disease, Type C/genetics ; Niemann-Pick Disease, Type C/metabolism ; Niemann-Pick Disease, Type C/pathology ; Proteins/genetics ; Proteins/metabolism ; Spinal Cord/metabolism ; Spinal Cord/pathology ; beta-Cyclodextrins/pharmacology
Chemical Substances	DNA-Binding Proteins ; Intracellular Signaling Peptides and Proteins ; Neuroprotective Agents ; Niemann-Pick C1 Protein ; Npc1 protein, mouse ; Proteins ; TARDBP protein, human ; TDP-43 protein, mouse ; beta-Cyclodextrins ; betadex (JV039JZZ3A) ; Acetylcysteine (WYQ7N0BPYC)
Language	English
Publishing date	2016-05-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2715589-4
ISSN	2051-5960 ; 2051-5960
ISSN (online)	2051-5960
ISSN	2051-5960
DOI	10.1186/s40478-016-0325-4
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Article: [(11)C]PiB PET in Gerstmann-Sträussler-Scheinker disease.

Deters, Kacie D / Risacher, Shannon L / Yoder, Karmen K / Oblak, Adrian L / Unverzagt, Frederick W / Murrell, Jill R / Epperson, Francine / Tallman, Eileen F / Quaid, Kimberly A / Farlow, Martin R / Saykin, Andrew J / Ghetti, Bernardino

American journal of nuclear medicine and molecular imaging

2016 Volume 6, Issue 1, Page(s) 84–93

Abstract: ... amyloid plaques composed of prion protein (PrP). The purpose of this study was to evaluate if [(11)C]Pittsburgh ... carriers. Six individuals at risk for GSS and eight controls underwent [(11)C]PiB PET scans using ... with PRNP P102L mutation, one with PRNP F198S mutation) underwent a second [(11)C]PiB PET scan. Three P102L ...

Abstract	Gerstmann-Sträussler-Scheinker Disease (GSS) is a familial neurodegenerative disorder characterized clinically by ataxia, parkinsonism, and dementia, and neuropathologically by deposition of diffuse and amyloid plaques composed of prion protein (PrP). The purpose of this study was to evaluate if [(11)C]Pittsburgh Compound B (PiB) positron emission tomography (PET) is capable of detecting PrP-amyloid in PRNP gene carriers. Six individuals at risk for GSS and eight controls underwent [(11)C]PiB PET scans using standard methods. Approximately one year after the initial scan, each of the three asymptomatic carriers (two with PRNP P102L mutation, one with PRNP F198S mutation) underwent a second [(11)C]PiB PET scan. Three P102L carriers, one F198S carrier, and one non-carrier of the F198S mutation were cognitively normal, while one F198S carrier was cognitively impaired during the course of this study. No [(11)C]PiB uptake was observed in any subject at baseline or at follow-up. Neuropathologic study of the symptomatic individual revealed PrP-immunopositive plaques and tau-immunopositive neurofibrillary tangles in cerebral cortex, subcortical nuclei, and brainstem. PrP deposits were also numerous in the cerebellar cortex. This is the first study to investigate the ability of [(11)C]PiB PET to bind to PrP-amyloid in GSS F198S subjects. This finding suggests that [(11)C]PiB PET is not suitable for in vivo assessment of PrP-amyloid plaques in patients with GSS.
Language	English
Publishing date	2016-01-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2623515-8
ISSN	2160-8407
ISSN	2160-8407
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Article ; Online: Kinetics of nuclear phosphorylation (γ-H2AX) in human lymphocytes treated in vitro with UVB, bleomycin and mitomycin C.

Scarpato, Roberto / Castagna, Sara / Aliotta, Rosamaria / Azzarà, Alessia / Ghetti, Francesco / Filomeni, Erika / Giovannini, Caterina / Pirillo, Chiara / Testi, Serena / Lombardi, Sara / Tomei, Antonio

Mutagenesis

2013 Volume 28, Issue 4, Page(s) 465–473

Abstract: ... peripheral lymphocytes in vitro treated with UVB, bleomycin and mitomycin C (MMC). Once the mutagen exposure ...

Abstract	After double-strand break induction, formation of γ-H2AX foci due to phosphorylation at Ser-139 of histone H2AX represents an early event of the DNA damage response (DDR). γ-H2AX foci are then rapidly dephosphorylated as signal for the subsequent recruitment of effector proteins. The induction and disappearance of the foci can be, therefore, used to monitor the functioning of the DDR machinery in a cell population exposed to genotoxic stress. Here, we investigated the time-course of γ-H2AX in unstimulated or cultured peripheral lymphocytes in vitro treated with UVB, bleomycin and mitomycin C (MMC). Once the mutagen exposure was performed, cells were harvested at different interval times from 0.5 to 5h. The results show that (i) in 20-h stimulated peripheral lymphocytes, UVB irradiation caused extensive and dose-dependent increases in nuclear phosphorylation, and disappearance of γ-H2AX foci progressed, proportionally to the UV fluence, with increasing the harvesting time; (ii) UVB-exposed G0 cells cultured for 20-h post-irradiation displayed low amounts of DNA phosphorylation, depicting a time-course in which the maximum effect was reached at 0.5h and dephosphorylation started after 1h; (iii) treatment of unstimulated lymphocytes with bleomycin sulphate induced an increase in nuclear phosphorylation of several folds higher than that of untreated cells, depicting kinetics comparable to those observed for UVB-exposed G1 cells; (iv) in stimulated cells, MMC caused a severe and dose-dependent high degree of H2AX phosphorylation together with a very slower kinetic of dephosphorylation with respect to the other experimental treatments. This study confirms the feasibility of the γ-H2AX focus assay as a genotoxic end-point and supports the view that the proposed type of analysis should be introduced in biomonitoring studies of human populations. This could also represent a feasible and useful tool in the screening and diagnosis of precancerous states or very early stages of other diseases.
MeSH term(s)	Adult ; Bleomycin/pharmacology ; Cell Nucleus/drug effects ; Cell Nucleus/metabolism ; Cell Nucleus/radiation effects ; Cells, Cultured ; Histones/metabolism ; Humans ; Kinetics ; Lymphocytes/drug effects ; Lymphocytes/metabolism ; Lymphocytes/radiation effects ; Male ; Mitomycin/pharmacology ; Phosphorylation/drug effects ; Phosphorylation/radiation effects ; Protein Transport/drug effects ; Protein Transport/radiation effects ; Ultraviolet Rays/adverse effects ; Young Adult
Chemical Substances	H2AX protein, human ; Histones ; Bleomycin (11056-06-7) ; Mitomycin (50SG953SK6)
Language	English
Publishing date	2013-05-21
Publishing country	England
Document type	Journal Article
ZDB-ID	632903-2
ISSN	1464-3804 ; 0267-8357
ISSN (online)	1464-3804
ISSN	0267-8357
DOI	10.1093/mutage/get024
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Zs.A 2189: Show issues

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Article ; Online: The effect of paternal anxiety on mother-infant bonding in neonatal intensive care.

Ettenberger, Mark / Bieleninik, Łucja / Stordal, Andreas Størksen / Ghetti, Claire

BMC pregnancy and childbirth

2024 Volume 24, Issue 1, Page(s) 55

Abstract: Background: The hospitalization of a preterm infant in the NICU can lead to mental health difficulties in parents, but not much is known how paternal anxiety might affect the mother-infant relationship.: Methods: This prospective cohort study is a ... ...

Abstract	Background: The hospitalization of a preterm infant in the NICU can lead to mental health difficulties in parents, but not much is known how paternal anxiety might affect the mother-infant relationship. Methods: This prospective cohort study is a secondary analysis investigating how paternal anxiety levels might affect maternal bonding in the NICU using the dataset of the multinational pragmatic randomized controlled trial LongSTEP. A linear mixed-effects model was used for correlations of paternal anxiety (GAD-7) and maternal bonding (PBQ) at NICU discharge, and at 6 and 12 months infant corrected age. Secondary analyses examined effects on paternal anxiety related to: site (Argentina, Colombia, Israel, Norway, and Poland), maternal depression (EPDS), infant gestational age at birth, paternal age, and type of pregnancy. Results: Paternal anxiety did not predict maternal bonding at NICU discharge (p = 0.096), at 6 months (p = 0.316), or at 12 months infant corrected age (p = 0.473). Secondary outcomes showed a statistically significant site effect, with higher paternal anxiety levels at the two Colombian sites at baseline (p = 0.014 and p = 0.020) and for one site at discharge (p = 0.012), but not for paternal age (p = 0.925 and p = 0.793), infant gestational age at birth (p = 0.974 and p = 0.686 and p = 0.340), or type of pregnancy (p = 0.381). Maternal depression predicted paternal anxiety at baseline (p < 0.001) and at discharge (p = 0.003). Conclusions: In this study, paternal anxiety did not predict maternal bonding. Paternal anxiety varied by site, indicating a need for research on potential cultural differences in manifestation of paternal anxiety. Maternal depression predicted paternal anxiety, confirming a previously reported correlation. Further research on variations in paternal mental health in the neonatal period is warranted, as well as exploration of the social contagion of mental health in preterm parents. Trial registration: ClinicalTrials.gov NCT03564184.
MeSH term(s)	Male ; Infant ; Female ; Pregnancy ; Infant, Newborn ; Humans ; Mothers/psychology ; Intensive Care, Neonatal ; Infant, Premature/psychology ; Prospective Studies ; Anxiety/epidemiology ; Anxiety/etiology ; Anxiety/psychology ; Intensive Care Units, Neonatal
Language	English
Publishing date	2024-01-11
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2059869-5
ISSN	1471-2393 ; 1471-2393
ISSN (online)	1471-2393
ISSN	1471-2393
DOI	10.1186/s12884-023-06179-z
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Article: Neurofibrillary tangles in Niemann-Pick disease type C.

Suzuki, K / Parker, C C / Pentchev, P G / Katz, D / Ghetti, B / D'Agostino, A N / Carstea, E D

Acta neuropathologica

1995 Volume 89, Issue 3, Page(s) 227–238

Abstract: Niemann-Pick disease type C (NPC) is an autosomal recessive disease, belonging to a clinically ...

Abstract	Niemann-Pick disease type C (NPC) is an autosomal recessive disease, belonging to a clinically heterogeneous group of lipid storage diseases, distinguished by a unique error in cellular trafficking of exogenous cholesterol, associated with lysosomal accumulation of unesterified cholesterol. Unlike Niemann-Pick disease types A and B, there is no primary genetic defect in sphingomyelinase in NPC. During the routine neuropathological study of NPC patients, we found neurofibrillary tangles (NFT) in a series of cases with a slowly progressive chronic course. These were not associated with beta-amyloid deposits. The NFT were most frequent in the orbital gyrus, cingulate gyrus and entorhinal region of the cerebral cortex, but were also frequently found in the basal ganglia, thalamus and hypothalamus. In one of the most severely affected case, the NFT were even found in the neurons in the inferior olivary nucleus and in the spinal cord. The NFT were immunostained with Alz 50, and consisted of paired helical filaments. The distribution of the neurons bearing the NFT was generally similar to that of the swollen storage neurons, and storage neurons often contained NFT in their perikarya and/or in the meganeurites. However, neurons with NFT could be noted without swollen perikarya. The coexistence of neuronal storage and NFT in NPC without amyloid deposits suggests that perturbed cholesterol metabolism and/or lysosomal membrane trafficking may play a role in the formation of NFT, and that amyloid deposits are not necessarily the prerequisite for NFT formation. The results of our study also suggest that NFT formation may be a rather nonspecific cellular reaction of neurons to certain slowly progressive metabolic perturbations of an as yet undefined nature.
MeSH term(s)	Adolescent ; Adult ; Brain/pathology ; Female ; Humans ; Male ; Microscopy, Electron ; Middle Aged ; Neurofibrillary Tangles/pathology ; Niemann-Pick Diseases/classification ; Niemann-Pick Diseases/pathology
Language	English
Publishing date	1995
Publishing country	Germany
Document type	Case Reports ; Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	1079-0
ISSN	1432-0533 ; 0001-6322
ISSN (online)	1432-0533
ISSN	0001-6322
DOI	10.1007/bf00309338
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Ui II Zs.188: Show issues

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Article: Presenilin-1 280Glu-->Ala mutation alters C-terminal APP processing yielding longer abeta peptides: implications for Alzheimer's disease.

Van Vickle, Gregory D / Esh, Chera L / Kokjohn, Tyler A / Patton, R Lyle / Kalback, Walter M / Luehrs, Dean C / Beach, Thomas G / Newel, Amanda J / Lopera, Francisco / Ghetti, Bernardino / Vidal, Ruben / Castaño, Eduardo M / Roher, Alex E

Molecular medicine (Cambridge, Mass.)

2008 Volume 14, Issue 3-4, Page(s) 184–194

Abstract: ... within the membrane walls could impact the structure and function of plasma membrane and organelles. These C ...

Abstract	Presenilin (PS) mutations enhance the production of the Abeta42 peptide that is derived from the amyloid precursor protein (APP). The pathway(s) by which the Abeta42 species is preferentially produced has not been elucidated, nor is the mechanism by which PS mutations produce early-onset dementia established. Using a combination of histological, immunohistochemical, biochemical, and mass spectrometric methods, we examined the structural and morphological nature of the amyloid species produced in a patient expressing the PS1 280Glu-->Ala familial Alzheimer's disease mutation. Abundant diffuse plaques were observed that exhibited a staining pattern and morphology distinct from previously described PS cases, as well as discreet amyloid plaques within the white matter. In addition to finding increased amounts of CT99 and Abeta42 peptides, our investigation revealed the presence of a complex array of Abeta peptides substantially longer than 42/43 amino acid residue species. The increased hydrophobic nature of longer Abeta species retained within the membrane walls could impact the structure and function of plasma membrane and organelles. These C-terminally longer peptides may, through steric effects, dampen the rate of turnover by critical amyloid degrading enzymes such as neprilysin and insulin degrading enzyme. A complete understanding of the deleterious side effects of membrane bound Abeta as a consequence of gamma-secretase alterations is needed to understand Alzheimer's disease pathophysiology and will aid in the design of therapeutic interventions.
MeSH term(s)	Adult ; Aged ; Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Alzheimer Disease/physiopathology ; Amyloid beta-Peptides/chemistry ; Amyloid beta-Peptides/genetics ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Autopsy ; Chromatography ; Humans ; Male ; Mass Spectrometry ; Middle Aged ; Peptide Fragments/chemistry ; Peptide Fragments/genetics ; Peptide Fragments/metabolism ; Point Mutation ; Presenilin-1/genetics ; Presenilin-1/metabolism
Chemical Substances	Amyloid beta-Peptides ; Amyloid beta-Protein Precursor ; Peptide Fragments ; Presenilin-1 ; amyloid beta-protein (1-42)
Language	English
Publishing date	2008-01-27
Publishing country	England
Document type	Case Reports ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1283676-x
ISSN	1076-1551
ISSN	1076-1551
DOI	10.2119/2007-00094.Van Vickle
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Zs.A 4456: Show issues

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Article ; Online: Israeli Parents' Lived Experiences of Music Therapy With Their Preterm Infants Post-Hospitalization.

Epstein, Shulamit / Elefant, Cochavit / Ghetti, Claire

Journal of music therapy

2022 Volume 59, Issue 3, Page(s) 239–268

Abstract: In the current study, we aimed to explore the lived experience of Israeli parents who engaged in musical dialogues with their preterm infants during music therapy (MT) after being discharged from the neonatal intensive care unit (NICU), as a part of the ... ...

Abstract	In the current study, we aimed to explore the lived experience of Israeli parents who engaged in musical dialogues with their preterm infants during music therapy (MT) after being discharged from the neonatal intensive care unit (NICU), as a part of the multinational LongSTEP RCT. Seven participants of the main trial were invited to engage in semi-structured in-depth interviews intertwining listening to audio recordings from their music therapy sessions in an adapted interpersonal process recall (IPR) procedure. The interviews were transcribed and analyzed using interpretative phenomenological analysis (IPA). We understood the participants' experiences to reflect two main themes: 1) Music therapy as a potential means of transformation in communication skills, resourcefulness and sense of agency; and 2) emotional and musical preconditions for parental engagement in MT. The findings illustrate how a specific group of Israeli parents experienced MT as offering them a means of expanding their relationship with their preterm infants after discharge. Based on our findings, we recommend that music therapists consider parents' musical and emotional resources during post-discharge MT to meet the individual needs of families.
MeSH term(s)	Aftercare ; Humans ; Infant, Newborn ; Infant, Premature/psychology ; Israel ; Music Therapy/methods ; Parents/psychology ; Patient Discharge
Language	English
Publishing date	2022-06-03
Publishing country	England
Document type	Clinical Trial ; Journal Article
ZDB-ID	218364-x
ISSN	2053-7395 ; 0022-2917
ISSN (online)	2053-7395
ISSN	0022-2917
DOI	10.1093/jmt/thac006
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Zs.A 1009: Show issues

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Article: Codeposition of cystatin C with amyloid-beta protein in the brain of Alzheimer disease patients.

Levy, E / Sastre, M / Kumar, A / Gallo, G / Piccardo, P / Ghetti, B / Tagliavini, F

Journal of neuropathology and experimental neurology

2001 Volume 60, Issue 1, Page(s) 94–104

Abstract: ... that the cysteine proteinase inhibitor cystatin C colocalizes with amyloid beta-protein (Abeta) in parenchymal and vascular ... Immunoelectron microscopy demonstrated dual staining of amyloid fibrils with anti-Abeta and anti-cystatin C antibodies ... Cystatin C immunoreactivity was also observed in amyloid deposits in the brain of transgenic mice ...

Abstract	Immunohistochemical analysis of brains of patients with Alzheimer disease (AD) revealed that the cysteine proteinase inhibitor cystatin C colocalizes with amyloid beta-protein (Abeta) in parenchymal and vascular amyloid deposits. No evidence of cerebral hemorrhage was observed in any of the brains studied. Immunoelectron microscopy demonstrated dual staining of amyloid fibrils with anti-Abeta and anti-cystatin C antibodies. Cystatin C immunoreactivity was also observed in amyloid deposits in the brain of transgenic mice overexpressing human beta amyloid precursor protein. Massive deposition of the variant cystatin C in the cerebral vessels of patients with the Icelandic form of hereditary cerebral hemorrhage with amyloidosis is thought to be responsible for the pathological processes leading to stroke. Anti-cystatin C antibodies strongly labeled pyramidal neurons within cortical layers most prone to amyloid deposition in the brains of AD patients. Immunohistochemistry with antibodies against the carboxyl-terminus of Abeta(x-42) showed intracellular immunoreactivity in the same neuronal subpopulation. It remains to be established whether the association of cystatin C to Abeta plays a primary role in amyloidogenesis of AD or is a late event in which the protein is bound to the previously formed Abeta amyloid fibrils.
MeSH term(s)	Aged ; Aged, 80 and over ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyloid/metabolism ; Amyloid beta-Peptides/chemistry ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Animals ; Brain/metabolism ; Cerebral Cortex/metabolism ; Cerebral Cortex/ultrastructure ; Cystatin C ; Cystatins/metabolism ; Female ; Humans ; Immunohistochemistry ; Mice ; Mice, Transgenic/genetics ; Microscopy, Immunoelectron ; Middle Aged ; Peptide Fragments/metabolism ; Pyramidal Cells/metabolism ; Tissue Distribution
Chemical Substances	Amyloid ; Amyloid beta-Peptides ; Amyloid beta-Protein Precursor ; CST3 protein, human ; Cst3 protein, mouse ; Cystatin C ; Cystatins ; Peptide Fragments
Language	English
Publishing date	2001-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	3088-0
ISSN	1554-6578 ; 0022-3069
ISSN (online)	1554-6578
ISSN	0022-3069
DOI	10.1093/jnen/60.1.94
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Ui II Zs.134: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Ui II Zs.194: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Lung dual energy CT: Impact of different technological solutions on quantitative analysis.

Ghetti, Caterina / Ortenzia, Ornella / Bertolini, Marco / Sceni, Giada / Sverzellati, Nicola / Silva, Mario / Maddalo, Michele

European journal of radiology

2023 Volume 163, Page(s) 110812

Abstract: Purpose: To evaluated the accuracy of spectral parameters quantification of four different CT scanners in dual energy examinations of the lung using a dedicated phantom.: Method: Measurements were made with different technologies of the same vendor: ... ...

Abstract	Purpose: To evaluated the accuracy of spectral parameters quantification of four different CT scanners in dual energy examinations of the lung using a dedicated phantom. Method: Measurements were made with different technologies of the same vendor: one dual source CT scanner (DSCT), one TwinBeam (i.e. split filter) and two sequential acquisition single source scanners (SSCT). Angular separation of Calcium and Iodine signals were calculated from scatter plots of low-kVp versus high-kVp HUs. Electron density (ρe), effective atomic number (Zeff) and Iodine concentration (Iconc) were measured using Syngo.via software. Accuracy (A) of ρe, Zeff and Iconc was evaluated as the absolute percentage difference (D%) between reference values and measured ones, while precision (P) was evaluated as the variability σ obtained by repeating the measurement with different acquisition/reconstruction settings. Results: Angular separation was significantly larger for DSCT (α = 9.7°) and for sequential SSCT (α = 9.9°) systems. TwinBeam was less performing in material separation (α = 5.0°). The lowest average A was observed for TwinBeam (A Conclusions: Different technologies performed material separation and spectral parameter quantification with different degrees of accuracy and precision. DSCT performed better while TwinBeam demonstrated not excellent performance. Iodine concentration measurements exhibited high variability due to low Iodine absolute content in lung nodules, thus limiting its clinical usefulness in pulmonary applications.
MeSH term(s)	Humans ; Tomography, X-Ray Computed ; Tomography Scanners, X-Ray Computed ; Lung/diagnostic imaging ; Software ; Phantoms, Imaging ; Iodine
Chemical Substances	Iodine (9679TC07X4)
Language	English
Publishing date	2023-04-06
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	138815-0
ISSN	1872-7727 ; 0720-048X
ISSN (online)	1872-7727
ISSN	0720-048X
DOI	10.1016/j.ejrad.2023.110812
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Zs.A 1630: Show issues

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Article: Clinical implications of GBV-C/HGV infection in patients with "HCV-related" chronic hepatitis.

Francesconi, R / Giostra, F / Ballardini, G / Manzin, A / Solforosi, L / Lari, F / Descovich, C / Ghetti, S / Grassi, A / Bianchi, G / Zauli, D / Clementi, M / Bianchi, F B

Journal of hepatology

1997 Volume 26, Issue 6, Page(s) 1165–1172

Abstract: ... patients with chronic liver disease were tested for GBV-C/HGV coinfection by heminested PCR.: Results ... Twenty-two (26.5%) patients were found to be positive for GBV-C/HGV RNA. GBV-C/HGV+ patients differed ... significantly from GBV-C/HGV- ones for younger age, higher frequency of history of drug addiction, which in turn ...

Abstract	Background/aims: To evaluate the clinical, biochemical and histological implications of a concomitant HGV infection in "HCV-related" chronic liver disease. Methods: Eighty-three HCV-RNA positive patients with chronic liver disease were tested for GBV-C/HGV coinfection by heminested PCR. Results: Twenty-two (26.5%) patients were found to be positive for GBV-C/HGV RNA. GBV-C/HGV+ patients differed significantly from GBV-C/HGV- ones for younger age, higher frequency of history of drug addiction, which in turn might favor coinfection with interferon-sensitive HCV genotypes (3a), and increased probability of long-term response to interferon. GBV-C/HGV infection appears to have no responsibility for specific aspects of HCV infection such as biochemical or histological cholestatic features, lymphoid follicles, symptomatic cryoglobulinemia or presence of serum autoantibodies, including LKM1. It does not worsen the HCV-related disease (ALT levels and histological activity) and does not significantly interfere with HCV infection, as explored by the number of hepatocytes positive for HCV antigens. The amount of steatosis (mean score) was shown to be higher in GBV-C/HGV+ patients. A virological follow up was performed in 17 interferon-treated GBV-C/HGV+ patients On the whole, GBV-C/HGV seems to be as sensitive to IFN treatment as HCV, but recurrence after withdrawal is more frequent. In spite of this, ALT levels often remain normal after treatment withdrawal. Conclusions: The present data suggest that GBV-C/HGV infection, apart from more marked liver steatosis, does not modify the overall picture of chronic hepatitis due to HCV infection.
MeSH term(s)	Adolescent ; Adult ; Age Factors ; Aged ; Biopsy ; Female ; Flaviviridae ; Genotype ; Hepacivirus/genetics ; Hepacivirus/isolation & purification ; Hepatitis Antibodies/blood ; Hepatitis C/complications ; Hepatitis C/pathology ; Hepatitis C/therapy ; Hepatitis C Antigens/analysis ; Hepatitis, Viral, Human/complications ; Hepatitis, Viral, Human/pathology ; Hepatitis, Viral, Human/therapy ; Humans ; Interferons/therapeutic use ; Liver/pathology ; Liver/virology ; Male ; Middle Aged ; RNA, Viral/analysis ; Retrospective Studies ; Substance-Related Disorders
Chemical Substances	Hepatitis Antibodies ; Hepatitis C Antigens ; RNA, Viral ; Interferons (9008-11-1)
Language	English
Publishing date	1997-06
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article
ZDB-ID	605953-3
ISSN	1600-0641 ; 0168-8278
ISSN (online)	1600-0641
ISSN	0168-8278
DOI	10.1016/s0168-8278(97)80448-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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