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Article ; Online: Esophagobronchial fistula successfully managed with a self-expandable metallic stent followed by fixation using a silicon Y stent.

Ohtsuka, Takashi / Kato, Daiki / Tsukamoto, Yo / Shibazaki, Takamasa / Nakada, Takeo / Yabe, Mitsuo / Hirano, Jun

2022 Volume 13, Issue 20, Page(s) 2908–2910

Abstract: ... in the left main bronchus. Then, a silicone Y stent (16 × 13 × 13 mm in outer diameter) was inserted ... to support the SEMS from the inside. After placing the SEMS and Y stent, the position of the SEMS was ...

Abstract	Esophagobronchial fistula (EBF) formation is a severe complication of advanced thoracic malignancies, that affects the prognosis and quality of life of patients. This study reports the case of an 80-year-old man with advanced esophageal cancer, complicated by EBF formation in the left main bronchus proximal to the carina following chemoradiation therapy. A fully covered stent was placed in the left main bronchus but was dislocated on the oral side. The attempt to place a partially covered self-expandable metallic stent (SEMS) also failed due to stent dislocation on the oral side. To avoid stent dislocation, a partially covered SEMS with a length of 40 mm and a diameter of 16 mm was placed to cover the EBF in the left main bronchus. Then, a silicone Y stent (16 × 13 × 13 mm in outer diameter) was inserted to support the SEMS from the inside. After placing the SEMS and Y stent, the position of the SEMS was stabilized. The patient remained stable with adequate oral intake.
MeSH term(s)	Aged, 80 and over ; Bronchial Fistula/etiology ; Bronchial Fistula/surgery ; Esophageal Fistula/etiology ; Esophageal Fistula/surgery ; Humans ; Male ; Quality of Life ; Retrospective Studies ; Silicon ; Silicones ; Stents/adverse effects ; Treatment Outcome
Chemical Substances	Silicones ; Silicon (Z4152N8IUI)
Language	English
Publishing date	2022-08-31
Publishing country	Singapore
Document type	Case Reports
ZDB-ID	2625856-0
ISSN	1759-7714 ; 1759-7706
ISSN (online)	1759-7714
ISSN	1759-7706
DOI	10.1111/1759-7714.14625
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Zs.A 6921: Show issues

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Article: Polymorphisms of six Y-chromosome STRs in a Chinese population.

Tie, Jian / Wang, Xiuling / Suzuki, Yuka / Tsukamoto, Shojiro / Oshida, Shigemi

Legal medicine (Tokyo, Japan)

2004 Volume 6, Issue 1, Page(s) 41–46

Abstract: The polymorphic short tandem repeat (STR) loci of six Y-chromosome markers were investigated in 112 ... for the Y-specific STR loci DYS19, DYS385, DYS389II, DYS390, DYS391 and DYS393 were analyzed by the Y-PLEX 6 ... were observed in six Y-specific STR loci, the haplotype diversity was raised to 0.999. The results ...

Abstract	The polymorphic short tandem repeat (STR) loci of six Y-chromosome markers were investigated in 112 unrelated Chinese males using a multiplex polymerase chain reaction (PCR). Allele and haplotype frequencies for the Y-specific STR loci DYS19, DYS385, DYS389II, DYS390, DYS391 and DYS393 were analyzed by the Y-PLEX 6 Kit. The commonest allele for each locus was: DYS19, allele 15; DYS385, allele 12; DYS389II, allele 28; DYS390, allele 23; DYS391, 10; and DYS393, allele 12. Gene diversity value was calculated from the allelic frequency for each locus. The DYS385 locus proved to be highly polymorphic (0.890), DYS391 showed the lowest value (0.489), and the other loci showed values ranging from 0.646 to 0.897. A total of 99 haplotypes were observed in six Y-specific STR loci, the haplotype diversity was raised to 0.999. The results revealed that a set of six Y-specific STR loci were able to discriminate most of the male individuals in the Chinese population.
MeSH term(s)	Alleles ; Asian Continental Ancestry Group/genetics ; China ; Chromosomes, Human, Y/genetics ; Genetics, Population ; Haplotypes ; Humans ; Male ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Tandem Repeat Sequences
Language	English
Publishing date	2004-03
Publishing country	Ireland
Document type	Comparative Study ; Journal Article
ZDB-ID	2019555-2
ISSN	1344-6223
ISSN	1344-6223
DOI	10.1016/j.legalmed.2003.09.003
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Zs.A 5250: Show issues

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Article: Electrical synapses for a pooling layer of the convolutional neural network in retinas.

Tsukamoto, Yoshihiko

Frontiers in cellular neuroscience

2023 Volume 17, Page(s) 1281786

Abstract: We have an example of a synergetic effect between neuroscience and connectome via artificial intelligence. The invention of Neocognitron, a machine learning algorithm, was inspired by the visual cortical circuitry for complex cells to be made by ... ...

Abstract	We have an example of a synergetic effect between neuroscience and connectome via artificial intelligence. The invention of Neocognitron, a machine learning algorithm, was inspired by the visual cortical circuitry for complex cells to be made by combinations of simple cells, which uses a hierarchical convolutional neural network (CNN). The CNN machine learning algorithm is powerful in classifying neuron borderlines on electron micrograph images for automatized connectomic analysis. CNN is also useful as a functional framework to analyze the neurocircuitry of the visual system. The visual system encodes visual patterns in the retina and decodes them in the corresponding cortical areas. The knowledge of evolutionarily chosen mechanisms in retinas may help the innovation of new algorithms. Since over a half-century ago, a classical style of serial section transmission electron microscopy has vastly contributed to cell biology. It is still useful to comprehensively analyze the small area of retinal neurocircuitry that is rich in natural intelligence of pattern recognition. I discuss the perspective of our study on the primary rod signal pathway in mouse and macaque retinas with special reference to electrical synapses. Photon detection under the scotopic condition needs absolute sensitivity but no intricate pattern recognition. This extreme case is regarded as the most simplified pattern recognition of the input with no autocorrelation. A comparative study of mouse and macaque retinas, where exists the 7-fold difference in linear size, may give us the underlying principle with quantitative verification of their adaptational designs of neurocircuitry.
Language	English
Publishing date	2023-10-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452963-1
ISSN	1662-5102
ISSN	1662-5102
DOI	10.3389/fncel.2023.1281786
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Article ; Online: Highly efficient methyl ketone synthesis with photoactivated acetone and olefins assisted by Mg(II)-exchanged zeolite Y.

Tsukamoto, Daijiro / Shiraishi, Yasuhiro / Hirai, Takayuki

The Journal of organic chemistry

2010 Volume 75, Issue 5, Page(s) 1450–1457

Abstract: ... that an addition of Mg(2+)-exchanged zeolite Y (MgY) to the above photoreaction system accelerates the methyl ...

Abstract	We previously found that photoirradiation of an acetone/water mixture containing olefins affords the corresponding methyl ketones highly efficiently and selectively via a water-assisted C-C coupling between the acetonyl radical and olefins (Org. Lett. 2008, 10, 3117-3120). The reaction proceeds at room temperature without any additives and has a potential to be a powerful method for methyl ketone synthesis. Here we report that an addition of Mg(2+)-exchanged zeolite Y (MgY) to the above photoreaction system accelerates the methyl ketone formation, while maintaining high selectivity. Ab initio molecular orbital calculation reveals that the accelerated methyl ketone formation is due to the electrostatic interaction between Mg(2+) and excited-state acetone. This leads to a charge polarization of the carbonyl moiety of excited-state acetone and accelerates the hydrogen abstraction from ground-state acetone (acetonyl radical formation). This promotes efficient addition of the acetonyl radical to olefins, resulting in methyl ketone formation enhancement. Adsorption experiments reveal that accumulation of olefins inside the zeolite pore also affects efficient radical addition to olefins. The present process successfully produces various methyl ketones with very high yield, and the MgY recovered can be reused for further reaction without loss of activity.
MeSH term(s)	Acetone/chemistry ; Alkenes/chemistry ; Catalysis ; Crystallography, X-Ray ; Ketones/chemical synthesis ; Magnesium/chemistry ; Magnetic Resonance Spectroscopy ; Models, Chemical ; Photochemistry ; Stereoisomerism ; Zeolites/chemistry
Chemical Substances	Alkenes ; Ketones ; Zeolites (1318-02-1) ; Acetone (1364PS73AF) ; Magnesium (I38ZP9992A)
Language	English
Publishing date	2010-03-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/jo902321f
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Zs.A 4473: Show issues

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Article ; Online: Biliary reconstruction for infantile living donor liver transplantation: Roux-en-Y hepaticojejunostomy or duct-to-duct choledochocholedochostomy?

Shirouzu, Yasumasa / Okajima, Hideaki / Ogata, Satsuki / Ohya, Yuki / Tsukamoto, Yukika / Yamamoto, Hidekazu / Takeichi, Takayuki / Kwang-Jong, Lee / Asonuma, Katsuhiro / Inomata, Yukihiro

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

2008 Volume 14, Issue 12, Page(s) 1761–1765

Abstract: ... The incidence of posttransplant biliary complications for DD was compared with that for Roux-en-Y ...

Abstract	Hepaticojejunostomy is a standard biliary reconstruction method for infantile living donor liver transplantation (LDLT), but choledochocholedochostomy for infants is not generally accepted yet. Ten pediatric recipients weighing no more than 10 kg underwent duct-to-duct choledochocholedochostomy (DD) for biliary reconstruction for LDLT. Patients were followed up for a median period of 26.8 months (range: 4.0-79.0 months). The incidence of posttransplant biliary complications for DD was compared with that for Roux-en-Y hepaticojejunostomy (RY). No DD patients and 1 RY patient (5%) developed biliary leakage (P > 0.05), and biliary stricture occurred in 1 DD patient (10%) and none of the RY patients (P > 0.05); none of the DD patients and 5 RY patients (25%) suffered from uncomplicated cholangitis after LDLT (P > 0.05), and 1 DD patient (10%) and 2 RY patients (10%) died of causes unrelated to biliary complications. In conclusion, both hepaticojejunostomy and choledochocholedochostomy resulted in satisfactory outcome in terms of biliary complications, including leakage and stricture, for recipients weighing no more than 10 kg.
MeSH term(s)	Anastomosis, Roux-en-Y/methods ; Body Weight ; Choledochostomy/methods ; Common Bile Duct/surgery ; Female ; Humans ; Infant ; Jejunostomy/methods ; Jejunum/surgery ; Liver/surgery ; Liver Transplantation/methods ; Living Donors ; Male
Language	English
Publishing date	2008-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2006866-9
ISSN	1527-6473 ; 1527-6465
ISSN (online)	1527-6473
ISSN	1527-6465
DOI	10.1002/lt.21599
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Zs.A 4702: Show issues

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Article: Acetic acid activates hepatic AMPK and reduces hyperglycemia in diabetic KK-A(y) mice.

Sakakibara, Shoji / Yamauchi, Toshimasa / Oshima, Yoshifumi / Tsukamoto, Yoshinori / Kadowaki, Takashi

Biochemical and biophysical research communications

2006 Volume 344, Issue 2, Page(s) 597–604

Abstract: ... in type 2 diabetes, we fed either a standard diet or one containing 0.3% AcOH to KK-A(y) mice for 8 weeks ...

Abstract	Acetic acid (AcOH), which is a short-chain fatty acid, is reported to have some beneficial effects on metabolism. To test the hypothesis that feeding of AcOH exerts beneficial effects on glucose homeostasis in type 2 diabetes, we fed either a standard diet or one containing 0.3% AcOH to KK-A(y) mice for 8 weeks. Fasting plasma glucose and HbA1c levels were lower in mice fed AcOH for 8 weeks than in control mice. AcOH also reduced the expression of genes involved in gluconeogenesis and lipogenesis, which is in part regulated by 5'-AMP-activated protein kinase (AMPK) in the liver. Finally, sodium acetate, in the form of neutralized AcOH, directly activated AMPK and lowered the expression of genes such as for glucose-6-phosphatase and sterol regulatory element binding protein-1 in rat hepatocytes. These results indicate that the hypoglycemic effect of AcOH might be due to activation of AMPK in the liver.
MeSH term(s)	AMP-Activated Protein Kinases ; Acetic Acid/administration & dosage ; Animals ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/enzymology ; Disease Models, Animal ; Enzyme Activation/drug effects ; Hyperglycemia/drug therapy ; Hyperglycemia/enzymology ; Hyperglycemia/etiology ; Liver/drug effects ; Liver/enzymology ; Male ; Mice ; Multienzyme Complexes/drug effects ; Multienzyme Complexes/metabolism ; Protein-Serine-Threonine Kinases/drug effects ; Protein-Serine-Threonine Kinases/metabolism ; Treatment Outcome
Chemical Substances	Multienzyme Complexes ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; Acetic Acid (Q40Q9N063P)
Language	English
Publishing date	2006-06-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2006.03.176
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Zs.A 116: Show issues

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Article: Functional evaluation of four patients treated with V-Y quadricepsplasty in total knee arthroplasty.

Tsukamoto, Nobuaki / Miura, Hiromasa / Matsuda, Shuichi / Mawatari, Taro / Kato, Hiroshi / Iwamoto, Yukihide

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association

2006 Volume 11, Issue 4, Page(s) 394–400

MeSH term(s)	Aged ; Arthroplasty, Replacement, Knee ; Female ; Gait ; Humans ; Knee Joint/physiopathology ; Middle Aged ; Muscle, Skeletal/surgery ; Range of Motion, Articular ; Recovery of Function ; Reoperation ; Treatment Outcome ; Walking
Language	English
Publishing date	2006-07
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1314243-4
ISSN	1436-2023 ; 0949-2658
ISSN (online)	1436-2023
ISSN	0949-2658
DOI	10.1007/s00776-006-1023-z
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Zs.A 4484: Show issues

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Article ; Online: Improvement of Temperature Measurement Accuracy of Hot Airflow Using Ultrafine Thermo-Sensitive Fluorescent Wires of Lumisis Phosphor.

Funatani, Shumpei / Tsukamoto, Yusaku

Sensors (Basel, Switzerland)

2024 Volume 24, Issue 8

Abstract: In this study, the fluorescence properties of Lumisis, a phosphor that can be easily applied to ultrafine wires, were evaluated. By evaluating the wavelength characteristics of Lumisis phosphor, we investigated the possibility of applying it to a dual- ... ...

Abstract	In this study, the fluorescence properties of Lumisis, a phosphor that can be easily applied to ultrafine wires, were evaluated. By evaluating the wavelength characteristics of Lumisis phosphor, we investigated the possibility of applying it to a dual-wavelength laser-induced fluorescence (LIF) measurement system and evaluated the accuracy of temperature measurements. The difference between the decrease in the percentage intensities of the red and green fluorescence of Lumisis phosphors showed that two-color LIF was possible. The Lumisis phosphor-mixture ratio was optimized as 1:1.25, and the average measurement error of the fluorescent wire was 0.20 K, as evaluated through uncertainty analysis. Finally, the application of this measurement method to hot air jet phenomena showed that this method accurately captures the temperature changes in hot air, thus proving its validity.
Language	English
Publishing date	2024-04-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s24082510
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Article ; Online: A self-inactivating invertebrate opsin optically drives biased signaling toward Gβγ-dependent ion channel modulation.

Tsukamoto, Hisao / Kubo, Yoshihiro

Proceedings of the National Academy of Sciences of the United States of America

2023 Volume 120, Issue 21, Page(s) e2301269120

Abstract: Animal opsins, light-sensitive G protein-coupled receptors, have been used for optogenetic tools to control G protein-dependent signaling pathways. Upon G protein activation, the Gα and Gβγ subunits drive different intracellular signaling pathways, ... ...

Abstract	Animal opsins, light-sensitive G protein-coupled receptors, have been used for optogenetic tools to control G protein-dependent signaling pathways. Upon G protein activation, the Gα and Gβγ subunits drive different intracellular signaling pathways, leading to complex cellular responses. For some purposes, Gα- and Gβγ-dependent signaling needs to be separately modulated, but these responses are simultaneously evoked due to the 1:1 stoichiometry of Gα and Gβγ Nevertheless, we show temporal activation of G protein using a self-inactivating invertebrate opsin,
MeSH term(s)	Animals ; Opsins/genetics ; Opsins/metabolism ; GTP-Binding Protein beta Subunits/genetics ; GTP-Binding Protein beta Subunits/metabolism ; Rod Opsins/metabolism ; GTP-Binding Proteins/genetics ; GTP-Binding Proteins/metabolism ; Ion Channels ; Invertebrates ; GTP-Binding Protein gamma Subunits/genetics ; GTP-Binding Protein gamma Subunits/metabolism
Chemical Substances	Opsins ; GTP-Binding Protein beta Subunits ; Rod Opsins ; GTP-Binding Proteins (EC 3.6.1.-) ; Ion Channels ; GTP-Binding Protein gamma Subunits
Language	English
Publishing date	2023-05-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2301269120
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Zs.A 1148: Show issues

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Article ; Online: Imaging of pituitary tumors: an update with the 5th WHO Classifications-part 2. Neoplasms other than PitNET and tumor-mimicking lesions.

Tsukamoto, Taro / Miki, Yukio

Japanese journal of radiology

2023 Volume 41, Issue 8, Page(s) 808–829

Abstract: Many types of tumors can develop in the pituitary gland. In the recently revised 5th editions of the World Health Organization (WHO) classifications (2021 WHO Classification of Central Nervous System Tumors and the 2022 WHO Classification of Endocrine ... ...

Abstract	Many types of tumors can develop in the pituitary gland. In the recently revised 5th editions of the World Health Organization (WHO) classifications (2021 WHO Classification of Central Nervous System Tumors and the 2022 WHO Classification of Endocrine and Neuroendocrine Tumors), various changes have been made to the tumors other than pituitary neuroendocrine tumor (PitNET)/pituitary adenoma, as well as PitNET. Adamantinomatous craniopharyngioma and papillary craniopharyngioma are now considered separate tumors in the 5th edition of the WHO classification. Tumors positive for thyroid transcription factor 1, a marker of posterior pituitary cells, are now grouped together in the pituicyte tumor family in the 5th edition of the WHO classification of Endocrine and Neuroendocrine Tumors. Poorly differentiated chordoma is newly listed in the 5th edition of the WHO Classification of Endocrine and Neuroendocrine Tumors. In this paper, we present the latest WHO classification of pituitary tumors (adamantinomatous craniopharyngioma, papillary craniopharyngioma, pituitary blastoma, pituicyte tumor family, tumors of pituitary origin other than those of the pituicyte tumor family, germinoma, meningioma, chordoma, metastatic tumors, lymphoma, and pituitary incidentaloma), review diseases requiring differentiation from tumors (pituitary abscess, hypophysitis, pituitary hyperplasia, Rathke's cleft cyst, arachnoid cyst, and aneurysm), and discuss diagnoses based on imaging findings.
MeSH term(s)	Humans ; Pituitary Neoplasms/pathology ; Craniopharyngioma/pathology ; Chordoma/pathology ; Pituitary Gland ; Pituitary Diseases ; Adenoma/pathology ; Neuroendocrine Tumors/pathology ; Meningeal Neoplasms/pathology ; World Health Organization
Language	English
Publishing date	2023-03-13
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	2488907-6
ISSN	1867-108X ; 1867-1071
ISSN (online)	1867-108X
ISSN	1867-1071
DOI	10.1007/s11604-023-01407-0
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Zs.A 2249: Show issues

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