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  1. Article: Effective Treatment of Rosacea and Other Vascular Lesions Using Intense Pulsed Light System Emitting Vascular Chromophore-Specific Wavelengths: A Clinical and Dermoscopical Analysis.

    Piccolo, Domenico / Fusco, Irene / Zingoni, Tiziano / Conforti, Claudio

    Journal of clinical medicine

    2024  Volume 13, Issue 6

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2024-03-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13061646
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Efficacy and Safety of Q-Switched 1064/532 nm Nd:YAG Lasers on Benign Hypermelanosis in Dark-Skinned Individuals-A Preliminary Study.

    Piccolo, Domenico / Fusco, Irene / Crisman, Giuliana / Zingoni, Tiziano / Conforti, Claudio

    Journal of clinical medicine

    2024  Volume 13, Issue 6

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2024-03-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13061615
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Carbon-assisted Q-switched Nd: YAG laser and Microneedling Delivery of Botulinum Toxin: a prospective pilot study.

    Turco, Piergiorgio / Conforti, Claudio / D'andrea, Francesco / La Padula, Simone

    Plastic and reconstructive surgery

    2024  

    Abstract: Introduction: Carbon-assisted Q-switched Nd:Yag laser treatment consists in applying a topical carbon suspension all over the face followed by irradiation with a Q-switched 1064 Nd:YAG laser. The delivery of multiple microdroplets of dilute Onabotulinum ...

    Abstract Introduction: Carbon-assisted Q-switched Nd:Yag laser treatment consists in applying a topical carbon suspension all over the face followed by irradiation with a Q-switched 1064 Nd:YAG laser. The delivery of multiple microdroplets of dilute Onabotulinum Toxin-A into the dermis, has been investigated as a tool for facial rejuvenation. The aim of this study is to assess the effectiveness of the combined treatment with botulinum toxin and carbon peel laser (performed with a standardized technique) in patients with seborrhea, dilated pores and wrinkles, and to demonstrate its benefits in improving the overall skin aspect.
    Material and methods: Patients enrolled in this prospective pilot study were subjected to 3 sessions of the combined treatment carried out 3 months apart. To evaluate the improvement of skin texture, wrinkles, dilated pores and acne lesions, several scales have been used, namely Fitzpatrick Wrinkle Assessment Scale (FWAS), the Physician Global Aesthetic Improvement Scale (GAIS), a photographic scale for the pore assessment and the Investigator Global Assessment of Acne (IGA). Face Q was also administered to assess patients' satisfaction. The scores obtained were compared using a paired T-test.
    Results: Twenty patients were recruited. Difference of pre and post-treatment scores of the FWAS, GAIS, IGA, Face Q and the photographic scale for the pore assessment were statistically significant (p < 0,05).
    Conclusions: This combined protocol could be considered as an useful tool to treat skin flaws affecting texture, microroughness and seborrhea and to reduce enlarged pore size and its versatility allows customized treatment with minimum discomfort in patients.
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208012-6
    ISSN 1529-4242 ; 0032-1052 ; 0096-8501
    ISSN (online) 1529-4242
    ISSN 0032-1052 ; 0096-8501
    DOI 10.1097/PRS.0000000000011198
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.142: Show issues Location:
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  4. Article ; Online: Acne Supplementation: Probiotics, Vitamins, and Diet.

    Chello, Camilla / Conforti, Claudio / Dianzani, Caterina

    Acta dermatovenerologica Croatica : ADC

    2023  Volume 29, Issue 4, Page(s) 215–223

    Abstract: Acne is an inflammatory disease of the pilo-sebaceous unit, which mainly affects young adolescents. The pathogenesis is multifactorial, as a combination of genetic predisposition, hormonal production, hyper-seborrhea, inflammation and overgrowth of C. ... ...

    Abstract Acne is an inflammatory disease of the pilo-sebaceous unit, which mainly affects young adolescents. The pathogenesis is multifactorial, as a combination of genetic predisposition, hormonal production, hyper-seborrhea, inflammation and overgrowth of C. acnes. Moreover, diet-induced hyperinsulinemia can lead to sebocyte stimulation, androgen production, and thus acne lesions. Pharmacological therapeutic approaches are varied and include topical and systemic antibiotics and, in severe cases, systemic retinoids, with several side-effects. However, increasing evidence has shown that adequate vitamin supplementation, use of probiotics, and proper nutrition with low carbohydrates and fats intake, can significantly contribute to the patient's clinical improvement. In this review, we describe the role of probiotics, vitamins, alimentation, antioxidants, UV exposure, and plants in acne disease.
    MeSH term(s) Adolescent ; Humans ; Vitamins/therapeutic use ; Acne Vulgaris/therapy ; Acne Vulgaris/drug therapy ; Vitamin A/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Vitamin K/therapeutic use ; Diet ; Probiotics/therapeutic use ; Dietary Supplements
    Chemical Substances Vitamins ; Vitamin A (11103-57-4) ; Anti-Bacterial Agents ; Vitamin K (12001-79-5)
    Language English
    Publishing date 2023-02-17
    Publishing country Croatia
    Document type Journal Article ; Review
    ZDB-ID 1180727-1
    ISSN 1847-6538 ; 1330-027X
    ISSN (online) 1847-6538
    ISSN 1330-027X
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3934: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Lichen Striatus Post-COVID-19 Infection: Clinical and Dermoscopic Presentations.

    Chersi, Filippo / Conforti, Claudio / Zalaudek, Iris / di Meo, Nicola

    Dermatology practical & conceptual

    2023  Volume 13, Issue 1

    Language English
    Publishing date 2023-01-01
    Publishing country Austria
    Document type Letter
    ZDB-ID 2685397-8
    ISSN 2160-9381
    ISSN 2160-9381
    DOI 10.5826/dpc.1301a6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Long Pulsed 1064 nm Nd:YAG Laser Treatment for Skin Laxity and Wrinkle Reduction: Evaluation of New Handpiece and "in Motion" Setting Technique-A Case Series Study.

    Piccolo, Domenico / Crisman, Giuliana / Gallo, Giustino / Fusco, Irene / Conforti, Claudio

    Photobiomodulation, photomedicine, and laser surgery

    2023  Volume 41, Issue 6, Page(s) 297–299

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Humans ; Treatment Outcome ; Lasers, Solid-State/therapeutic use ; Skin ; Rejuvenation ; Skin Aging
    Language English
    Publishing date 2023-05-26
    Publishing country United States
    Document type Journal Article
    ISSN 2578-5478
    ISSN (online) 2578-5478
    DOI 10.1089/photob.2023.0024
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  7. Article: Epidemiology and Risk Factors of Melanoma: A Review.

    Conforti, Claudio / Zalaudek, Iris

    Dermatology practical & conceptual

    2021  Volume 11, Issue Suppl 1, Page(s) e2021161S

    Abstract: We are currently witnessing a worldwide increase in the incidence of melanoma. Incidence in Europe is about 25 cases per 100,000 population, while in Australia it reaches a rate of 60 new cases per 100,000. While the epidemiological curves of the 1980's ... ...

    Abstract We are currently witnessing a worldwide increase in the incidence of melanoma. Incidence in Europe is about 25 cases per 100,000 population, while in Australia it reaches a rate of 60 new cases per 100,000. While the epidemiological curves of the 1980's and 1990's suggested an increase in the incidence of melanoma across all age groups, the last 10 years' data indicates a 5% reduction in the incidence of thin melanoma in young individuals aged between 15 and 24. This suggests a positive impact of primary prevention campaigns [1-2]. The risk factors associated with melanoma are different and multifactorial: on one hand there is a genetic predisposition, as evidenced by the increased risk in patients with dysplastic nevus syndrome, with familial melanoma or familial melanoma syndromes; on the other hand, the unprotected interaction between UV rays and phototypes I-II increases the risk of developing melanoma, especially in case of sunburns in pediatric age. This review aims to summarize melanoma epidemiology and risk factors.
    Language English
    Publishing date 2021-07-01
    Publishing country Austria
    Document type Journal Article ; Review
    ZDB-ID 2685397-8
    ISSN 2160-9381
    ISSN 2160-9381
    DOI 10.5826/dpc.11S1a161S
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  8. Article: A Dramatic Response to Second-Line Nivolumab and Ipilimumab in BRAF-V600-Mutated Metastatic Melanoma.

    Fedele, Dahlia / Moroso, Stefano / Turoldo, Angelo / Bazzocchi, Gabriele / Conforti, Claudio / Zalaudek, Iris / Guglielmi, Alessandra

    Case reports in oncology

    2024  Volume 17, Issue 1, Page(s) 161–168

    Abstract: Introduction: Current treatment options for BRAF V600-mutated unresectable stage III/IV melanoma include anti-PD-1 monotherapy or combination with anti-CTLA-4 or anti-LAG-3 agents, BRAF/MEK inhibitors, and clinical trials. The strategy of combination ... ...

    Abstract Introduction: Current treatment options for BRAF V600-mutated unresectable stage III/IV melanoma include anti-PD-1 monotherapy or combination with anti-CTLA-4 or anti-LAG-3 agents, BRAF/MEK inhibitors, and clinical trials. The strategy of combination immunotherapy with nivolumab and ipilimumab has shown promising results, achieving higher response rates, longer duration of response, improved progression-free survival, and enhanced overall survival. The optimal sequence of treatments remains a topic of interest, with preliminary data suggesting a greater effectiveness of immunotherapy as the first-line approach. Preclinical trials have indicated that the efficacy of this sequence may be due to the modification of the immune environment by BRAF kinase inhibitors, leading to immune escape by tumor cells and resistance to immune checkpoint inhibitors.
    Case presentation: We present a case of a 72-year-old woman with high-burden metastatic melanoma who failed to respond to prior targeted therapy with BRAF/MEK inhibitors and exhibited a successful response to the second-line treatment with ipilimumab and nivolumab. We discuss the potential reasons for this positive outcome contributing to the current debate concerning treatment sequences, resistance mechanisms, and biomarkers predictive of response to immune checkpoint inhibitors in metastatic melanoma.
    Conclusion: We believe that in few years the therapeutic algorithms in BRAF V600-mutated unresectable stage III/IV melanoma will be more complex since they will define clearly the correct therapeutic sequences with the inclusion of new immune checkpoint inhibitor drugs and multiple predictive biomarkers of response to better select patients eligible to immunotherapy.
    Language English
    Publishing date 2024-01-29
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2458961-5
    ISSN 1662-6575
    ISSN 1662-6575
    DOI 10.1159/000535902
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  9. Article: From Cellulite to Post-liposuction Skin Irregularities: A Proposal for Definition and Classification.

    Guida, Stefania / Zerbinati, Nicola / Conforti, Claudio / Paganelli, Alessia / Pellacani, Giovanni / Galadari, Hassan

    The Journal of clinical and aesthetic dermatology

    2024  Volume 17, Issue 4, Page(s) 24–27

    Abstract: Background: Post-liposuction skin irregularities (PLSI) represent a complication of liposuction, even though literature does not report specific data on their characteristics.: Objective: Considering the expanding request of treatment of PLSI and ... ...

    Abstract Background: Post-liposuction skin irregularities (PLSI) represent a complication of liposuction, even though literature does not report specific data on their characteristics.
    Objective: Considering the expanding request of treatment of PLSI and their similarities to cellulite, the aim of this study is to provide a definition or classification of their appearance according to a previously described cellulite scale and to highlight eventual novel features, in patients undergoing previous liposuction and a control group.
    Methods: A total of 47 women, of which 47 percent performed a previous liposuction, were included in this study. Pictures of gluteal area and postero-lateral thighs were analyzed according to number and depth of depressions, skin laxity, asymmetry and v-sign by three investigators. The correlation between parameters and previous liposuction was explored with statistical analysis.
    Results: Our results show good to excellent intraobserver agreement and moderate to good agreement between the evaluators. Additionally, we showed that PLSI can appear as marked cellulite signs (depth of evident depression) or as specific previously not reported features including asymmetry and v-sign.
    Conclusion: Our findings provide information about the previously unreported morphology of PLSI. Further studies will apply validated features of PLSI proposed herein to clinical practice.
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2571623-2
    ISSN 1941-2789
    ISSN 1941-2789
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  10. Article ; Online: Facial naevus count in the identification of patients at higher risk of melanoma.

    Giuffrida, Roberta / Zanin Poletto, Gustavo / Guarneri, Fabrizio / Conforti, Claudio / Guarneri, Claudio / Hofmann-Wellenhof, Rainer / Zalaudek, Iris

    The British journal of dermatology

    2023  Volume 189, Issue 5, Page(s) 626–628

    MeSH term(s) Humans ; Melanoma/diagnosis ; Nevus/diagnosis ; Nevus, Pigmented/diagnosis ; Skin Neoplasms/diagnosis
    Language English
    Publishing date 2023-07-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1093/bjd/ljad216
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    Ui VI Zs.23: Show issues Location:
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