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  1. Article ; Online: Early Childcare Precarity and Subsequent Maternal Health.

    Duh-Leong, Carol / Canfield, Caitlin F / Fuller, Anne E / Gross, Rachel S / Reichman, Nancy E

    Women's health issues : official publication of the Jacobs Institute of Women's Health

    2023  Volume 34, Issue 2, Page(s) 115–124

    Abstract: Purpose: We examined prospective associations between early childcare precarity, or the security and reliability of childcare arrangements, and subsequent maternal health.: Study design: We conducted a secondary analysis of survey responses from ... ...

    Abstract Purpose: We examined prospective associations between early childcare precarity, or the security and reliability of childcare arrangements, and subsequent maternal health.
    Study design: We conducted a secondary analysis of survey responses from mothers of 2,836 children in the Future of Families and Child Wellbeing study. We assessed the following childcare measures: insecure childcare, insecure childcare with missed work, inadequate childcare, and emergency childcare support. We used linear and logistic regression models with robust standard errors to examine associations between these measures when the index child was age 3 and maternal health outcomes (overall health, depression, and parenting stress) later when the child was age 9. We then examined additive experiences of childcare measures across child ages 1 and 3 on maternal health outcomes.
    Results: Early inadequate childcare was associated with higher odds of later poor maternal overall health (adjusted odds ratio [aOR], 1.64; 95% confidence interval [CI], 1.11-2.41). All early childcare precarity measures were associated with higher odds of maternal depression (insecure childcare [aOR, 1.64; 95% CI, 1.23-2.18]; insecure childcare with missed work [aOR, 1.58; 95% CI, 1.13-2.22]; and inadequate childcare [aOR, 1.75; 95% CI, 1.22-2.51]). Emergency childcare support was associated with lower odds of adverse maternal health outcomes (poor overall health [aOR, 0.65; 95% CI, 0.48 to 0.88]; depression [aOR, 0.73; 95% CI, 0.54 to 0.99]; and parenting stress [B -0.45; 95% CI, -0.80 to -0.10]). Prolonged experiences had stronger associations with maternal health than shorter experiences.
    Conclusion: Early childcare precarity has long-term adverse associations with maternal health, and emergency childcare support seems to be favorable for maternal health. These findings highlight childcare precarity as a social determinant of women's health for researchers, clinicians, and decision-makers.
    MeSH term(s) Child ; Humans ; Female ; Child, Preschool ; Child Care ; Maternal Health ; Reproducibility of Results ; Mothers ; Surveys and Questionnaires
    Language English
    Publishing date 2023-11-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1085396-0
    ISSN 1878-4321 ; 1049-3867
    ISSN (online) 1878-4321
    ISSN 1049-3867
    DOI 10.1016/j.whi.2023.10.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cost-effectiveness analysis alongside the inter-B-NHL ritux 2010 trial: rituximab in children and adolescents with B cell non-Hodgkin's lymphoma.

    Lueza, Béranger / Aupérin, Anne / Rigaud, Charlotte / Gross, Thomas G / Pillon, Marta / Delgado, Rafael F / Uyttebroeck, Anne / Amos Burke, G A / Zsíros, József / Csóka, Monika / Simonin, Mathieu / Patte, Catherine / Minard-Colin, Véronique / Bonastre, Julia

    The European journal of health economics : HEPAC : health economics in prevention and care

    2023  Volume 25, Issue 2, Page(s) 307–317

    Abstract: Objectives: The randomized controlled trial Inter-B-NHL ritux 2010 showed overall survival (OS) benefit and event-free survival (EFS) benefit with the addition of rituximab to standard Lymphomes Malins B (LMB) chemotherapy in children and adolescents ... ...

    Abstract Objectives: The randomized controlled trial Inter-B-NHL ritux 2010 showed overall survival (OS) benefit and event-free survival (EFS) benefit with the addition of rituximab to standard Lymphomes Malins B (LMB) chemotherapy in children and adolescents with high-risk, mature B cell non-Hodgkin's lymphoma. Our aim was to assess the cost-effectiveness of rituximab-chemotherapy versus chemotherapy alone in the French setting.
    Methods: We used a decision-analytic semi-Markov model with four health states and 1-month cycles. Resource use was prospectively collected in the Inter-B-NHL ritux 2010 trial (NCT01516580). Transition probabilities were assessed from patient-level data from the trial (n = 328). In the base case analysis, direct medical costs from the French National Insurance Scheme and life-years (LYs) were computed in both arms over a 3-year time horizon. Incremental net monetary benefit and cost-effectiveness acceptability curve were computed through a probabilistic sensitivity analysis. Deterministic sensitivity analysis and several sensitivity analyses on key assumptions were also conducted, including one exploratory analysis with quality-adjusted life years as the health outcome.
    Results: OS and EFS benefits shown in the Inter-B-NHL ritux 2010 trial translated into the model by rituximab-chemotherapy being the most effective and also the least expensive strategy over the chemotherapy strategy. The mean difference in LYs between arms was 0.13 [95% CI 0.02; 0.25], and the mean cost difference € - 3 710 [95% CI € - 17,877; € 10,525] in favor of rituximab-chemotherapy group. For a € 50,000 per LY willingness-to-pay threshold, the probability of the rituximab-chemotherapy strategy being cost-effective was 91.1%. All sensitivity analyses confirmed these findings.
    Conclusion: Adding rituximab to LMB chemotherapy in children and adolescents with high-risk mature B-cell non-Hodgkin's lymphoma is highly cost-effective in France.
    Trial registration: ClinicalTrials.gov identifier: NCT01516580.
    MeSH term(s) Child ; Humans ; Adolescent ; Rituximab/therapeutic use ; Cost-Effectiveness Analysis ; Cost-Benefit Analysis ; Progression-Free Survival ; Lymphoma, Non-Hodgkin/drug therapy ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use
    Chemical Substances Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2023-04-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2045253-6
    ISSN 1618-7601 ; 1618-7598
    ISSN (online) 1618-7601
    ISSN 1618-7598
    DOI 10.1007/s10198-023-01581-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Estrogen Receptor Mutations as Novel Targets for Immunotherapy in Metastatic Estrogen Receptor-positive Breast Cancer.

    Goldberg, Jonathan / Qiao, Na / Guerriero, Jennifer L / Gross, Brett / Meneksedag, Yagiz / Lu, Yoshimi F / Philips, Anne V / Rahman, Tasnim / Meric-Bernstam, Funda / Roszik, Jason / Chen, Ken / Jeselsohn, Rinath / Tolaney, Sara M / Peoples, George E / Alatrash, Gheath / Mittendorf, Elizabeth A

    Cancer research communications

    2024  Volume 4, Issue 2, Page(s) 496–504

    Abstract: Estrogen receptor-positive (ER+) breast cancer is not considered immunogenic and, to date, has been proven resistant to immunotherapy. Endocrine therapy remains the cornerstone of treatment for ER+ breast cancers. However, constitutively activating ... ...

    Abstract Estrogen receptor-positive (ER+) breast cancer is not considered immunogenic and, to date, has been proven resistant to immunotherapy. Endocrine therapy remains the cornerstone of treatment for ER+ breast cancers. However, constitutively activating mutations in the estrogen receptor alpha (ESR1) gene can emerge during treatment, rendering tumors resistant to endocrine therapy. Although these mutations represent a pathway of resistance, they also represent a potential source of neoepitopes that can be targeted by immunotherapy. In this study, we investigated ESR1 mutations as novel targets for breast cancer immunotherapy. Using machine learning algorithms, we identified ESR1-derived peptides predicted to form stable complexes with HLA-A*0201. We then validated the binding affinity and stability of the top predicted peptides through in vitro binding and dissociation assays and showed that these peptides bind HLA-A*0201 with high affinity and stability. Using tetramer assays, we confirmed the presence and expansion potential of antigen-specific CTLs from healthy female donors. Finally, using in vitro cytotoxicity assays, we showed the lysis of peptide-pulsed targets and breast cancer cells expressing common ESR1 mutations by expanded antigen-specific CTLs. Ultimately, we identified five peptides derived from the three most common ESR1 mutations (D538G, Y537S, and E380Q) and their associated wild-type peptides, which were the most immunogenic. Overall, these data confirm the immunogenicity of epitopes derived from ESR1 and highlight the potential of these peptides to be targeted by novel immunotherapy strategies.
    Significance: Estrogen receptor (ESR1) mutations have emerged as a key factor in endocrine therapy resistance. We identified and validated five novel, immunogenic ESR1-derived peptides that could be targeted through vaccine-based immunotherapy.
    MeSH term(s) Female ; Humans ; Breast Neoplasms/genetics ; Receptors, Estrogen/genetics ; Mutation ; Immunotherapy ; Peptides/genetics
    Chemical Substances Receptors, Estrogen ; Peptides
    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2767-9764
    ISSN (online) 2767-9764
    DOI 10.1158/2767-9764.CRC-23-0244
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The cognitive impact of atrial fibrillation.

    Gross, Anne F / Stern, Theodore A

    The primary care companion for CNS disorders

    2013  Volume 15, Issue 1

    Language English
    Publishing date 2013-01-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2127230-X
    ISSN 1478-7954 ; 2155-7772
    ISSN (online) 1478-7954
    ISSN 2155-7772
    DOI 10.4088/PCC.12f01471
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Intravenous haloperidol: A systematic review of side effects and recommendations for clinical use.

    Beach, Scott R / Gross, Anne F / Hartney, Kimberly E / Taylor, John B / Rundell, James R

    General hospital psychiatry

    2020  Volume 67, Page(s) 42–50

    Abstract: Introduction: Though not approved by the United States Food and Drug Administration, intravenous haloperidol (IVH) is widely used off-label to manage agitation and psychosis in patients with delirium in the hospital setting. Over the years, concerns ... ...

    Abstract Introduction: Though not approved by the United States Food and Drug Administration, intravenous haloperidol (IVH) is widely used off-label to manage agitation and psychosis in patients with delirium in the hospital setting. Over the years, concerns have emerged regarding side effects of IVH, particularly its potential to cause QT prolongation, torsades de pointes (TdP), extrapyramidal symptoms and catatonia.
    Methods: We conducted a systematic review of literature of published literature related to side effects of IVH in PubMed in accordance with PRISMA guidelines.
    Results: 77 of 196 identified manuscripts met inclusion criteria, including 34 clinical trials and 34 case reports or series.
    Discussion: Extrapyramidal symptoms, catatonia and neuroleptic malignant syndrome appears to be relatively rare with IVH. In most prospective studies, IVH did not cause greater QT prolongation than placebo, and rates of TdP with IVH appear to be low. There is not clear evidence to suggest that IVH carries greater risk for QT prolongation or TdP than other antipsychotics.
    Conclusions: Based on the available literature, we provide modified evidence-based monitoring recommendations for clinicians prescribing IVH in hospital settings. Specifically, we recommend electrocardiogram monitoring only when using doses >5 mg of IVH and telemetry only for high-risk patients receiving cumulative doses of at least 100 mg or with accurately corrected QTc >500 ms.
    MeSH term(s) Antipsychotic Agents/adverse effects ; Electrocardiography ; Haloperidol/adverse effects ; Humans ; Long QT Syndrome ; Prospective Studies ; Torsades de Pointes
    Chemical Substances Antipsychotic Agents ; Haloperidol (J6292F8L3D)
    Language English
    Publishing date 2020-08-22
    Publishing country United States
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 392299-6
    ISSN 1873-7714 ; 0163-8343
    ISSN (online) 1873-7714
    ISSN 0163-8343
    DOI 10.1016/j.genhosppsych.2020.08.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: DNA damage signaling in

    Hersperger, Fabian / Meyring, Tim / Weber, Pia / Chhatbar, Chintan / Monaco, Gianni / Dionne, Marc S / Paeschke, Katrin / Prinz, Marco / Groß, Olaf / Classen, Anne-Kathrin / Kierdorf, Katrin

    eLife

    2024  Volume 12

    Abstract: Environmental factors, infection, or injury can cause oxidative stress in diverse tissues and loss of tissue homeostasis. Effective stress response cascades, conserved from invertebrates to mammals, ensure reestablishment of homeostasis and tissue repair. ...

    Abstract Environmental factors, infection, or injury can cause oxidative stress in diverse tissues and loss of tissue homeostasis. Effective stress response cascades, conserved from invertebrates to mammals, ensure reestablishment of homeostasis and tissue repair. Hemocytes, the
    MeSH term(s) Animals ; Drosophila ; Oxidative Stress ; Macrophages ; Arthropods ; Cytokines ; DNA Damage ; Mammals
    Chemical Substances Cytokines
    Language English
    Publishing date 2024-01-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.86700
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  7. Article ; Online: Neuropsychiatric conditions associated with anesthesia exposure.

    Gross, Anne F / Stern, Theodore A

    Psychosomatics

    2014  Volume 55, Issue 1, Page(s) 21–28

    Abstract: Background: Although anesthetics have been used for more than a century, their mechanisms of action remain poorly understood. Given that a number of intraoperative and postoperative neuropsychiatric syndromes have been linked to the use of anesthetics, ... ...

    Abstract Background: Although anesthetics have been used for more than a century, their mechanisms of action remain poorly understood. Given that a number of intraoperative and postoperative neuropsychiatric syndromes have been linked to the use of anesthetics, practitioners should familiarize themselves with these conditions.
    Methods: Basic concepts about anesthesia are reviewed and neuropsychiatric syndromes associated with anesthesia exposure described.
    Conclusions: Emergence delirium, postoperative delirium, postoperative cognitive dysfunction, and intraoperative awareness can develop in association with use of inhalation anesthetics and intravenously administered anesthetics.
    MeSH term(s) Anesthesia, General/adverse effects ; Anesthesia, General/psychology ; Cognition Disorders/psychology ; Delirium/psychology ; Humans ; Intraoperative Awareness/psychology ; Postoperative Complications/psychology ; Stress Disorders, Post-Traumatic/psychology
    Language English
    Publishing date 2014-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 209487-3
    ISSN 1545-7206 ; 0033-3182
    ISSN (online) 1545-7206
    ISSN 0033-3182
    DOI 10.1016/j.psym.2013.06.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Weighing risks and benefits of prescribing antidepressants during pregnancy.

    Silverman, Benjamin C / Gross, Anne F

    The virtual mentor : VM

    2013  Volume 15, Issue 9, Page(s) 746–752

    MeSH term(s) Antidepressive Agents/adverse effects ; Antidepressive Agents/therapeutic use ; Decision Making ; Depression/complications ; Depression/drug therapy ; Depressive Disorder/complications ; Depressive Disorder/drug therapy ; Ethics, Medical ; Female ; Humans ; Personal Autonomy ; Pregnancy ; Pregnancy Complications/drug therapy ; Prescriptions ; Risk Assessment
    Chemical Substances Antidepressive Agents
    Language English
    Publishing date 2013-09
    Publishing country United States
    Document type Journal Article
    ISSN 1937-7010
    ISSN (online) 1937-7010
    DOI 10.1001/virtualmentor.2013.15.9.ecas1-1309
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Early detection of malignant and pre-malignant peripheral nerve tumors using cell-free DNA fragmentomics.

    Taylor Sundby, R / Szymanski, Jeffrey J / Pan, Alexander / Jones, Paul A / Mahmood, Sana Z / Reid, Olivia H / Srihari, Divya / Armstrong, Amy E / Chamberlain, Stacey / Burgic, Sanita / Weekley, Kara / Murray, Béga / Patel, Sneh / Qaium, Faridi / Lucas, Andrea N / Fagan, Margaret / Dufek, Anne / Meyer, Christian F / Collins, Natalie B /
    Pratilas, Christine A / Dombi, Eva / Gross, Andrea M / Kim, AeRang / Chrisinger, John S A / Dehner, Carina A / Widemann, Brigitte C / Hirbe, Angela C / Chaudhuri, Aadel A / Shern, Jack F

    medRxiv : the preprint server for health sciences

    2024  

    Abstract: Early detection of neurofibromatosis type 1 (NF1) associated peripheral nerve sheath tumors (PNST) informs clinical decision-making, potentially averting deadly outcomes. Here, we describe a cell-free DNA (cfDNA) fragmentomic approach which distinguishes ...

    Abstract Early detection of neurofibromatosis type 1 (NF1) associated peripheral nerve sheath tumors (PNST) informs clinical decision-making, potentially averting deadly outcomes. Here, we describe a cell-free DNA (cfDNA) fragmentomic approach which distinguishes non-malignant, pre-malignant and malignant forms of NF1 PNST. Using plasma samples from a novel cohort of 101 NF1 patients and 21 healthy controls, we validated that our previous cfDNA copy number alteration (CNA)-based approach identifies malignant peripheral nerve sheath tumor (MPNST) but cannot distinguish among benign and premalignant states. We therefore investigated the ability of fragment-based cfDNA features to differentiate NF1-associated tumors including binned genome-wide fragment length ratios, end motif analysis, and non-negative matrix factorization deconvolution of fragment lengths. Fragmentomic methods were able to differentiate pre-malignant states including atypical neurofibromas (AN). Fragmentomics also adjudicated AN cases suspicious for MPNST, correctly diagnosing samples noninvasively, which could have informed clinical management. Overall, this study pioneers the early detection of malignant and premalignant peripheral nerve sheath tumors in NF1 patients using plasma cfDNA fragmentomics. In addition to screening applications, this novel approach distinguishes atypical neurofibromas from benign plexiform neurofibromas and malignant peripheral nerve sheath tumors, enabling more precise clinical diagnosis and management.
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.18.24301053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Crizotinib in Combination With Chemotherapy for Pediatric Patients With ALK+ Anaplastic Large-Cell Lymphoma: The Results of Children's Oncology Group Trial ANHL12P1.

    Lowe, Eric J / Reilly, Anne F / Lim, Megan S / Gross, Thomas G / Saguilig, Lauren / Barkauskas, Donald A / Wu, Rui / Alexander, Sarah / Bollard, Catherine M

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2022  Volume 41, Issue 11, Page(s) 2043–2053

    Abstract: Purpose: Arm crizotinib (CZ) of the Children's Oncology Group trial ANHL12P1 (ClinicalTrials.gov identifier: NCT01979536) examined the efficacy and toxicity of adding CZ to standard chemotherapy for children with newly diagnosed, nonlocalized ALK+ CD30+ ...

    Abstract Purpose: Arm crizotinib (CZ) of the Children's Oncology Group trial ANHL12P1 (ClinicalTrials.gov identifier: NCT01979536) examined the efficacy and toxicity of adding CZ to standard chemotherapy for children with newly diagnosed, nonlocalized ALK+ CD30+ anaplastic large-cell lymphoma (ALCL).
    Patients and methods: Between 2013 and 2019, 66 enrolled children received CZ with chemotherapy. Patients received a 5-day prophase followed by six chemotherapy cycles at 21-day intervals with CZ administered twice daily during each 21-day cycle. The study was temporarily closed for two periods (total 12 months) to evaluate toxicity, during which CZ was discontinued. Measurements of
    Results: The 2-year event-free survival (EFS) is 76.8% (95% CI, 68.5 to 88.1) and the 2-year overall survival is 95.2% (95% CI, 85.7 to 98.4). Fifteen patients relapsed and one patient died; median time to relapse was 7.4 months from diagnosis, with relapses occurring after chemotherapy was complete. The 66 patients completed 384 cycles of chemotherapy. Thirteen of the 66 patients experienced a grade 2+ thromboembolic adverse event (19.7%; 95% CI, 11.1 to 31.3). In the 25 patients who received mandated prophylactic anticoagulation, there were two thromboembolic events (8.0%; 95% CI, 0.01 to 26). Patients with negative MDD had a superior outcome, with an EFS of 85.6% (95% CI, 68.6 to 93.8); positive MDD was associated with a lower EFS of 58.1% (95% CI, 33.4 to 76.4).
    Conclusion: Arm CZ of ANHL12P1 demonstrated that the addition of CZ to standard treatment prevented relapses during therapy for children with ALCL, MDD predicted EFS, and the addition of CZ resulted in unexpected thromboembolic events. Overall survival and EFS rates are consistent with the highest reported outcomes for children with ALCL.
    MeSH term(s) Humans ; Child ; Crizotinib/therapeutic use ; Lymphoma, Large-Cell, Anaplastic/diagnosis ; Receptor Protein-Tyrosine Kinases/therapeutic use ; Neoplasm Recurrence, Local/drug therapy ; Anaplastic Lymphoma Kinase
    Chemical Substances Crizotinib (53AH36668S) ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1) ; Anaplastic Lymphoma Kinase (EC 2.7.10.1)
    Language English
    Publishing date 2022-12-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.22.00272
    Database MEDical Literature Analysis and Retrieval System OnLINE

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