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Article ; Online: Cash Transfer Programs for Child Health-Elucidating Pathways and Optimizing Program Design.

Flynn, Erin F / Kenyon, Chén C / Vasan, Aditi

2023 Volume 177, Issue 7, Page(s) 661–662

MeSH term(s)	Child ; Humans ; Child Health ; Poverty ; Family Characteristics
Language	English
Publishing date	2023-05-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2701223-2
ISSN	2168-6211 ; 2168-6203
ISSN (online)	2168-6211
ISSN	2168-6203
DOI	10.1001/jamapediatrics.2023.1181
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Article ; Online: Drive-Through COVID-19 Testing During the 2020 Pandemic: A Safe, Efficient, and Scalable Model for Pediatric Patients and Health Care Workers.

Flynn, Erin F / Kuhn, Elizabeth / Shaik, Mohammed / Tarr, Elizabeth / Scattolini, Nicole / Ballantine, Allison

Academic pediatrics

2020 Volume 20, Issue 6, Page(s) 753–755

MeSH term(s)	Adolescent ; Adult ; Ambulatory Care/organization & administration ; Betacoronavirus ; COVID-19 ; COVID-19 Testing ; Child ; Child, Preschool ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Delivery of Health Care/organization & administration ; Efficiency, Organizational ; Female ; Health Personnel ; Humans ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Nasopharynx/virology ; Pandemics ; Personal Protective Equipment ; Personnel Staffing and Scheduling ; Pneumonia, Viral/diagnosis ; Public Health ; SARS-CoV-2 ; Young Adult
Keywords	covid19
Language	English
Publishing date	2020-05-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2483385-X
ISSN	1876-2867 ; 1876-2859
ISSN (online)	1876-2867
ISSN	1876-2859
DOI	10.1016/j.acap.2020.05.018
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Article: Locoregional Control Benefit of a Tumor Bed Boost for Ductal Carcinoma In Situ.

Dreyfuss, Alexandra D / Max, Danielle / Flynn, Jessica / Zhang, Zhigang / Gillespie, Erin F / Xu, Amy / Cuaron, John / Mueller, Boris / Khan, Atif J / Cahlon, Oren / Powell, Simon N / McCormick, Beryl / Braunstein, Lior Z

Advances in radiation oncology

2023 Volume 8, Issue 5, Page(s) 101254

Abstract: Purpose: Radiation therapy (RT) after breast-conserving surgery (BCS) for ductal carcinoma in situ (DCIS) reduces invasive and in situ recurrences. Whereas landmark studies suggest that a tumor bed boost improves local control for invasive breast cancer, ...

Abstract	Purpose: Radiation therapy (RT) after breast-conserving surgery (BCS) for ductal carcinoma in situ (DCIS) reduces invasive and in situ recurrences. Whereas landmark studies suggest that a tumor bed boost improves local control for invasive breast cancer, the benefit in DCIS remains less certain. We evaluated outcomes of patients with DCIS treated with or without a boost. Methods and materials: The study cohort comprised patients with DCIS who underwent BCS at our institution from 2004 to 2018. Clinicopathologic features, treatment parameters, and outcomes were ascertained from medical records. Patient and tumor characteristics were evaluated relative to outcomes using univariable and multivariable Cox models. Recurrence-free survival (RFS) estimates were generated using the Kaplan-Meier method. Results: We identified 1675 patients who underwent BCS for DCIS (median age, 56 years; interquartile range, 49-64 years). Boost RT was used in 1146 cases (68%) and hormone therapy in 536 (32%). At a median follow-up of 4.2 years (interquartile range, 1.4-7.0 years), we observed 61 locoregional recurrence events (56 local, 5 regional) and 21 deaths. Univariable logistic regression demonstrated that boost RT was more common among younger patients ( Conclusions: Among patients with DCIS who underwent BCS, use of a tumor bed boost was not associated with locoregional recurrence or RFS. Despite a preponderance of adverse features among the boost cohort, outcomes were similar to those of patients not receiving a boost, suggesting that a boost may mitigate risk of recurrence among patients with high-risk features. Ongoing studies will elucidate the extent to which a tumor bed boost influences disease control rates.
Language	English
Publishing date	2023-04-24
Publishing country	United States
Document type	Journal Article
ISSN	2452-1094
ISSN	2452-1094
DOI	10.1016/j.adro.2023.101254
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Article ; Online: Dose-dependent sensorimotor impairment in human ocular tracking after acute low-dose alcohol administration.

Tyson, Terence L / Feick, Nathan H / Cravalho, Patrick F / Flynn-Evans, Erin E / Stone, Leland S

The Journal of physiology

2020 Volume 599, Issue 4, Page(s) 1225–1242

Abstract: Key points: Oculomotor behaviours are commonly used to evaluate sensorimotor disruption due to ethanol (EtOH). The current study demonstrates the dose-dependent impairment in oculomotor and ocular behaviours across a range of ultra-low BACs (<0.035%). ... ...

Abstract	Key points: Oculomotor behaviours are commonly used to evaluate sensorimotor disruption due to ethanol (EtOH). The current study demonstrates the dose-dependent impairment in oculomotor and ocular behaviours across a range of ultra-low BACs (<0.035%). Processing of target speed and direction, as well as pursuit eye movements, are significantly impaired at 0.015% BAC, suggesting impaired neural activity within brain regions associated with the visual processing of motion. Catch-up saccades during steady visual tracking of the moving target compensate for the reduced vigour of smooth eye movements that occurs with the ingestion of low-dose alcohol. Saccade dynamics start to become 'sluggish' at as low as 0.035% BAC. Pupillary light responses appear unaffected at BAC levels up to 0.065%. Abstract: Changes in oculomotor behaviours are often used as metrics of sensorimotor disruption due to ethanol (EtOH); however, previous studies have focused on deficits at blood-alcohol concentrations (BACs) above about 0.04%. We investigated the dose dependence of the impairment in oculomotor and ocular behaviours caused by EtOH administration across a range of ultra-low BACs (≤0.035%). We took repeated measures of oculomotor and ocular performance from sixteen participants, both pre- and post-EtOH administration. To assess the neurological impacts across a wide range of brain areas and pathways, our protocol measured 21 largely independent performance metrics extracted from a range of behavioural responses ranging from ocular tracking of radial step-ramp stimuli, to eccentric gaze holding, to pupillary responses evoked by light flashes. Our results show significant impairment of pursuit and visual motion processing at 0.015% BAC, reflecting degraded neural processing within extrastriate cortical pathways. However, catch-up saccades largely compensate for the tracking displacement shortfall caused by low pursuit gain, although there still is significant residual retinal slip and thus degraded dynamic acuity. Furthermore, although saccades are more frequent, their dynamics are more sluggish (i.e. show lower peak velocities) starting at BAC levels as low as 0.035%. Small effects in eccentric gaze holding and no effect in pupillary response dynamics were observed at levels below 0.07%, showing the higher sensitivity of the pursuit response to very low levels of blood alcohol, under the conditions of our study.
MeSH term(s)	Ethanol ; Eye Movements ; Humans ; Psychomotor Performance ; Pursuit, Smooth ; Saccades
Chemical Substances	Ethanol (3K9958V90M)
Language	English
Publishing date	2020-12-17
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	3115-x
ISSN	1469-7793 ; 0022-3751
ISSN (online)	1469-7793
ISSN	0022-3751
DOI	10.1113/JP280395
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Article ; Online: "This is real", "this is hard" and "I'm not making it up": Experience of diagnosis and living with non-epileptic attack disorder.

Walsh, Geralynn / Wilson, Charlotte Emma / Hevey, David / Moore, Susan / Flynn, Cora / Breheny, Erin / O'Keeffe, Fiadhnait

Epilepsy & behavior : E&B

2024 Volume 154, Page(s) 109753

Abstract: Purpose: To use a qualitative research approach to explore adults' experience of living with non-epileptic attack disorder.: Objective: The objective was to explore the experience of adults (18 years+) with a confirmed diagnosis of non-epileptic ... ...

Abstract	Purpose: To use a qualitative research approach to explore adults' experience of living with non-epileptic attack disorder. Objective: The objective was to explore the experience of adults (18 years+) with a confirmed diagnosis of non-epileptic attack disorder (NEAD) across the trajectory of the disorder. The topics investigated included the onset of symptoms, the experience of non-epileptic attacks, the diagnostic process and living with NEAD. Method: Twelve people diagnosed with NEAD who attended a tertiary hospital neurology department took part in semi-structured interviews. The data generated were analysed using reflexive thematic analysis. Results: Eleven women and one man with median age of 25 years took part. Three themes were developed: mind-body (dis)connect, a stigmatised diagnosis and a role for containment. Adults spoke about their experience of nonepileptic attacks, the diagnostic and management process and the impact of both nonepileptic attacks and the NEAD diagnosis on their lives. Conclusions: Adults' experience's within the healthcare system across the trajectory of NEAD influenced their own understanding and trust in their NEAD experience, how they shared this with others in their social and work lives and how they managed their NEAD symptoms on a daily basis. The research suggests the need for a consistent, timely implementation of a rule-in diagnostic approach and multi-disciplinary management of NEAD. It is recommended that lessons be taken from theoretical models including the common-sense model and a modified version of the reattribution model to support the de-stigmatisation of this diagnosis to inform psychoeducation and professionally facilitated peer-support groups.
Language	English
Publishing date	2024-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2010587-3
ISSN	1525-5069 ; 1525-5050
ISSN (online)	1525-5069
ISSN	1525-5050
DOI	10.1016/j.yebeh.2024.109753
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Article: Drive-Through COVID-19 Testing During the 2020 Pandemic: A Safe, Efficient, and Scalable Model for Pediatric Patients and Health Care Workers

Flynn, Erin F / Kuhn, Elizabeth / Shaik, Mohammed / Tarr, Elizabeth / Scattolini, Nicole / Ballantine, Allison

Acad Pediatr

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #642512
Database	COVID19

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Article ; Online: Outcomes of Breast Cancer Patients with High Volume of Residual Disease Following Neoadjuvant Chemotherapy.

Zhang, Y Helen / Montagna, Giacomo / Flynn, Jessica / Gillespie, Erin F / Mamtani, Anita / Zhang, Zhigang / Braunstein, Lior Z / Powell, Simon N / Morrow, Monica / Barrio, Andrea / Khan, Atif J

International journal of radiation oncology, biology, physics

2022 Volume 115, Issue 3, Page(s) 622–628

Abstract: Purpose: The use of neoadjuvant chemotherapy (NAC) in patients with operable breast cancer allows for assessment of treatment response and subsequent tailoring of adjuvant therapy. Data are limited with respect to outcomes among patients with a heavy ... ...

Abstract	Purpose: The use of neoadjuvant chemotherapy (NAC) in patients with operable breast cancer allows for assessment of treatment response and subsequent tailoring of adjuvant therapy. Data are limited with respect to outcomes among patients with a heavy residual tumor burden after NAC. We report outcomes in patients who had exceptionally poor responses to NAC: those with >9 involved nodes after NAC or with 5 cm or more of residual disease in the breast. Methods and materials: Between June 2014 and April 2020, 1511 patients with breast cancer received NAC followed by surgery at our institution. Poor responders, defined as those with positive nodes or residual tumor in the breast, were identified for analysis. Patients were further classified into 3 groups for comparison purposes: (1) 1 to 3 positive nodes; (2) 4 to 9 positive nodes; or (3) >9 positive nodes and/or >5 cm of residual tumor, which was defined as high-volume residual (HVR). Recurrence and survival outcomes were compared based on residual disease burden after NAC. Results: Among 934 poor responders, 539 patients had 1 to 3 positive nodes (ypN1), 215 had 4 to 9 positive nodes (ypN2), and 180 had HVR disease. Specifically, 118 had >9 positive nodes (HVR), and 62 patients had >5 cm of residual tumor in the breast. With a median follow-up of 31 months (interquartile range, 18-46), the 5-year overall survival rate was 88% among ypN1, 76% among ypN2, and 72% among patients with HVR disease (P < .001). The 5-year distant recurrence-free survival and locoregional recurrence incidences were 82% and 7.6% among ypN1 versus 67% and 8.4% among ypN2 versus 53% and 12% among HVR, respectively. Conclusions: Our work suggests that patients with HVR disease are at high risk for locoregional and distant recurrence as well as death, despite best available standard-of-care treatment. Intensification of locoregional therapies and/or alternative adjuvant systemic treatment may improve outcomes in these poor responders.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Neoadjuvant Therapy/methods ; Neoplasm, Residual ; Chemotherapy, Adjuvant/methods ; Neoplasm Recurrence, Local/pathology ; Retrospective Studies ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use
Language	English
Publishing date	2022-09-22
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	197614-x
ISSN	1879-355X ; 0360-3016
ISSN (online)	1879-355X
ISSN	0360-3016
DOI	10.1016/j.ijrobp.2022.09.065
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Article ; Online: Drive-Through COVID-19 Testing During the 2020 Pandemic

Flynn, Erin F. / Kuhn, Elizabeth / Shaik, Mohammed / Tarr, Elizabeth / Scattolini, Nicole / Ballantine, Allison

Academic Pediatrics

A Safe, Efficient, and Scalable Model for Pediatric Patients and Health Care Workers

2020 Volume 20, Issue 6, Page(s) 753–755

Keywords	Pediatrics, Perinatology, and Child Health ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	2483385-X
ISSN	1876-2859
ISSN	1876-2859
DOI	10.1016/j.acap.2020.05.018
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Distinct pattern of oculomotor impairment associated with acute sleep loss and circadian misalignment.

Stone, Leland S / Tyson, Terence L / Cravalho, Patrick F / Feick, Nathan H / Flynn-Evans, Erin E

The Journal of physiology

2019 Volume 597, Issue 17, Page(s) 4643–4660

Abstract: Key points: Inadequate sleep and irregular work schedules have not only adverse consequences for individual health and well-being, but also enormous economic and safety implications for society as a whole. This study demonstrates that visual motion ... ...

Abstract	Key points: Inadequate sleep and irregular work schedules have not only adverse consequences for individual health and well-being, but also enormous economic and safety implications for society as a whole. This study demonstrates that visual motion processing and coordinated eye movements are significantly impaired when performed after sleep loss and during the biological night, and thus may be contributing to human error and accidents. Because affected individuals are often unaware of their sensorimotor and cognitive deficits, there is a critical need for non-invasive, objective indicators of mild, yet potentially unsafe, impairment due to disrupted sleep or biological rhythms. Our findings show that a set of eye-movement measures can be used to provide sensitive and reliable indicators of such mild neural impairments. Abstract: Sleep loss and circadian misalignment have long been known to impair human cognitive and motor performance with significant societal and health consequences. It is well known that human reaction time to a visual cue is impaired following sleep loss and circadian misalignment, but it has remained unclear how more complex visuomotor control behaviour is altered under these conditions. In this study, we measured 14 parameters of the voluntary ocular tracking response of 12 human participants (six females) to systematically examine the effects of sleep loss and circadian misalignment using a constant routine 24-h acute sleep-deprivation paradigm. The combination of state-of-the-art oculometric and sleep-research methodologies allowed us to document, for the first time, large changes in many components of pursuit, saccades and visual motion processing as a function of time awake and circadian phase. Further, we observed a pattern of impairment across our set of oculometric measures that is qualitatively different from that observed previously with other mild neural impairments. We conclude that dynamic vision and visuomotor control exhibit a distinct pattern of impairment linked with time awake and circadian phase. Therefore, a sufficiently broad set of oculometric measures could provide a sensitive and specific behavioural biomarker of acute sleep loss and circadian misalignment. We foresee potential applications of such oculometric biomarkers assisting in the assessment of readiness-to-perform higher risk tasks and in the characterization of sub-clinical neural impairment in the face of a multiplicity of potential risk factors, including disrupted sleep and circadian rhythms.
MeSH term(s)	Adolescent ; Adult ; Circadian Rhythm/physiology ; Cognition/physiology ; Cognitive Dysfunction/physiopathology ; Eye Movements/physiology ; Female ; Humans ; Male ; Psychomotor Performance/physiology ; Reaction Time/physiology ; Sleep/physiology ; Sleep Deprivation/physiopathology ; Wakefulness/physiology ; Young Adult
Language	English
Publishing date	2019-08-06
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	3115-x
ISSN	1469-7793 ; 0022-3751
ISSN (online)	1469-7793
ISSN	0022-3751
DOI	10.1113/JP277779
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Article ; Online: Tolerability of Breast Radiotherapy Among Carriers of

Modlin, Leslie A / Flynn, Jessica / Zhang, Zhigang / Cahlon, Oren / Mueller, Boris / Khan, Atif J / Gillespie, Erin F / McCormick, Beryl / Stadler, Zsofia K / Robson, Mark E / Powell, Simon N / Braunstein, Lior Z

JCO precision oncology

2021 Volume 5

Abstract: ATM: Methods: Of 167 patients with : Results: Of 91 evaluable carriers of : Conclusion: We found no evidence of excess RT-associated toxicity among carriers of ... ...

Abstract	ATM Methods: Of 167 patients with Results: Of 91 evaluable carriers of Conclusion: We found no evidence of excess RT-associated toxicity among carriers of pathogenic
MeSH term(s)	Adult ; Aged ; Ataxia Telangiectasia Mutated Proteins/genetics ; Breast Neoplasms/genetics ; Breast Neoplasms/radiotherapy ; Female ; Genetic Variation ; Germ Cells ; Humans ; Middle Aged ; Retrospective Studies ; Young Adult
Chemical Substances	ATM protein, human (EC 2.7.11.1) ; Ataxia Telangiectasia Mutated Proteins (EC 2.7.11.1)
Language	English
Publishing date	2021-01-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2473-4284
ISSN (online)	2473-4284
DOI	10.1200/PO.20.00334
Database	MEDical Literature Analysis and Retrieval System OnLINE

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