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  1. Book ; Thesis: Charakterisierung einer vermehrten Expression von HCN4-Kanälen im Arbeitsmyokard anhand eines transgenen Mausmodells

    Nauck, Sebastian / Schweizer, Patrick Alexander

    2020  

    Institution Universität Heidelberg
    Author's details vorgelegt von Sebastian Nauck ; Referent: Prof. Dr. med. Patrick Schweizer
    Language German
    Size VII, 72 Blätter, Illustrationen, Diagramme
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2021
    HBZ-ID HT021122796
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2021 E 1288 order for loan Magazin

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  2. Book ; Thesis: Klinische und elektrophysiologische Charakterisierung der mit Vorhofflimmern und struktureller Herzerkrankung assoziierten C-terminalen HCN4-Variante P883R

    Weigl, Isabel / Schweizer, Patrick Alexander

    2021  

    Institution Universität Heidelberg
    Author's details vorgelegt von Isabel Madeleine Constanze Weigl ; Doktorvater: Prof. Dr. med. Patrick A. Schweizer
    Language German
    Size 125 Seiten, Illustrationen, Diagramme
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2021
    HBZ-ID HT021210707
    Database Catalogue ZB MED Medicine, Health

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    2022 E 77 order for loan Magazin

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  3. Book ; Thesis: DNA-Reparatur lymphoblastoider Zellen von Patienten mit dem Smith-Magenis-Syndrom

    Schweizer, Patrick Alexander

    2005  

    Author's details vorgelegt von Patrick Alexander Schweizer
    Language German
    Size 112 Bl. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 2005
    HBZ-ID HT014497570
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2005 E 1283 order for loan Magazin

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  4. Article ; Online: A leadership model supporting maturation of high-performance translational teams.

    Brasier, Allan R / Casey, Shannon L / Hatfield, Peggy / Kelly, Patrick W / Sweeney, Whitney A / Schweizer, Marin / Liu, Bo / Burnside, Elizabeth S

    Journal of clinical and translational science

    2023  Volume 7, Issue 1, Page(s) e171

    Abstract: Despite understanding its impact on organizational effectiveness, practical guidance on how to train translational team (TT) leaders is lacking. Previously, we developed an evolutionary learning model of TT maturation consisting of three goal-directed ... ...

    Abstract Despite understanding its impact on organizational effectiveness, practical guidance on how to train translational team (TT) leaders is lacking. Previously, we developed an evolutionary learning model of TT maturation consisting of three goal-directed phases: (1). team assembly (
    Language English
    Publishing date 2023-07-24
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2059-8661
    ISSN (online) 2059-8661
    DOI 10.1017/cts.2023.598
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: GPD1L-A306del modifies sodium current in a family carrying the dysfunctional SCN5A-G1661R mutation associated with Brugada syndrome.

    Semino, Francesca / Darche, Fabrice F / Bruehl, Claus / Koenen, Michael / Skladny, Heyko / Katus, Hugo A / Frey, Norbert / Draguhn, Andreas / Schweizer, Patrick A

    Pflugers Archiv : European journal of physiology

    2023  Volume 476, Issue 2, Page(s) 229–242

    Abstract: Loss-of-function variants of SCN5A, encoding the sodium channel alpha subunit Nav1.5 are associated with high phenotypic variability and multiple cardiac presentations, while underlying mechanisms are incompletely understood. Here we investigated a ... ...

    Abstract Loss-of-function variants of SCN5A, encoding the sodium channel alpha subunit Nav1.5 are associated with high phenotypic variability and multiple cardiac presentations, while underlying mechanisms are incompletely understood. Here we investigated a family with individuals affected by Brugada Syndrome (BrS) of different severity and aimed to unravel the underlying genetic and electrophysiological basis.Next-generation sequencing was used to identify the genetic variants carried by family members. The index patient, who was severely affected by arrhythmogenic BrS, carried previously uncharacterized variants of Nav1.5 (SCN5A-G1661R) and glycerol-3-phosphate dehydrogenase-1-like protein (GPD1L-A306del) in a double heterozygous conformation. Family members exclusively carrying SCN5A-G1661R showed asymptomatic Brugada ECG patterns, while another patient solely carrying GPD1L-A306del lacked any clinical phenotype.To assess functional mechanisms, Nav1.5 channels were transiently expressed in HEK-293 cells in the presence and absence of GPD1L. Whole-cell patch-clamp recordings revealed loss of sodium currents after homozygous expression of SCN5A-G1661R, and reduction of current amplitude to ~ 50% in cells transfected with equal amounts of wildtype and mutant Nav1.5. Co-expression of wildtype Nav1.5 and GPD1L showed a trend towards increased sodium current amplitudes and a hyperpolarizing shift in steady-state activation and -inactivation compared to sole SCN5A expression. Application of the GPD1L-A306del variant shifted steady-state activation to more hyperpolarized and inactivation to more depolarized potentials.In conclusion, SCN5A-G1661R produces dysfunctional channels and associates with BrS. SCN5A mediated currents are modulated by co-expression of GDP1L and this interaction is altered by mutations in both proteins. Thus, additive genetic burden may aggravate disease severity, explaining higher arrhythmogenicity in double mutation carriers.
    MeSH term(s) Humans ; Brugada Syndrome/genetics ; Brugada Syndrome/metabolism ; Sodium/metabolism ; HEK293 Cells ; Mutation ; Phenotype ; NAV1.5 Voltage-Gated Sodium Channel/genetics ; NAV1.5 Voltage-Gated Sodium Channel/metabolism
    Chemical Substances Sodium (9NEZ333N27) ; NAV1.5 Voltage-Gated Sodium Channel ; SCN5A protein, human
    Language English
    Publishing date 2023-12-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 6380-0
    ISSN 1432-2013 ; 0031-6768
    ISSN (online) 1432-2013
    ISSN 0031-6768
    DOI 10.1007/s00424-023-02882-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.35: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: MEndoB, a chimeric lysin featuring a novel domain architecture and superior activity for the treatment of staphylococcal infections.

    Roehrig, Christian / Huemer, Markus / Lorgé, Dominique / Arn, Fabienne / Heinrich, Nadine / Selvakumar, Lavanja / Gasser, Lynn / Hauswirth, Patrick / Chang, Chun-Chi / Schweizer, Tiziano A / Eichenseher, Fritz / Lehmann, Steffi / Zinkernagel, Annelies S / Schmelcher, Mathias

    mBio

    2024  Volume 15, Issue 2, Page(s) e0254023

    Abstract: Bacterial infections are a growing global healthcare concern, as an estimated annual 4.95 million deaths are associated with antimicrobial resistance (AMR). Methicillin- ... ...

    Abstract Bacterial infections are a growing global healthcare concern, as an estimated annual 4.95 million deaths are associated with antimicrobial resistance (AMR). Methicillin-resistant
    MeSH term(s) Humans ; Animals ; Mice ; Staphylococcus aureus ; Methicillin-Resistant Staphylococcus aureus ; Peptidoglycan ; Zebrafish ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/microbiology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Staphylococcus ; N-Acetylmuramoyl-L-alanine Amidase/genetics ; N-Acetylmuramoyl-L-alanine Amidase/therapeutic use ; Sepsis/drug therapy
    Chemical Substances Peptidoglycan ; Anti-Bacterial Agents ; N-Acetylmuramoyl-L-alanine Amidase (EC 3.5.1.28)
    Language English
    Publishing date 2024-01-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.02540-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Study protocol: short against long antibiotic therapy for infected orthopedic sites - the randomized-controlled SALATIO trials.

    Uçkay, Ilker / Wirth, Stephan / Zörner, Björn / Fucentese, Sandro / Wieser, Karl / Schweizer, Andreas / Müller, Daniel / Zingg, Patrick / Farshad, Mazda

    Trials

    2023  Volume 24, Issue 1, Page(s) 117

    Abstract: Background: Few studies address the appropriate duration of post-surgical antibiotic therapy for orthopedic infections; with or without infected residual implants. We perform two similar randomized-clinical trials (RCT) to reduce the antibiotic use and ... ...

    Abstract Background: Few studies address the appropriate duration of post-surgical antibiotic therapy for orthopedic infections; with or without infected residual implants. We perform two similar randomized-clinical trials (RCT) to reduce the antibiotic use and associated adverse events.
    Methods: Two unblinded RCTs in adult patients (non-inferiority with a margin of 10%, a power of 80%) with the primary outcomes "remission" and "microbiologically-identical recurrences" after a combined surgical and antibiotic therapy. The main secondary outcome is antibiotic-related adverse events. The RCTs allocate the participants between 3 vs. 6 weeks of post-surgical systemic antibiotic therapy for implant-free infections and between 6 vs. 12 weeks for residual implant-related infections. We need a total of 280 episodes (randomization schemes 1:1) with a minimal follow-up of 12 months. We perform two interim analyses starting approximately after 1 and 2 years. The study approximatively lasts 3 years.
    Discussion: Both parallel RCTs will enable to prescribe less antibiotics for future orthopedic infections in adult patients.
    Trial registration: ClinicalTrial.gov NCT05499481. Registered on 12 August 2022.
    Protocol version: 2 (19 May 2022).
    MeSH term(s) Adult ; Humans ; Anti-Bacterial Agents/adverse effects ; Randomized Controlled Trials as Topic ; Orthopedic Procedures ; Postoperative Complications ; Surgical Wound Infection/drug therapy
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-02-18
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1745-6215
    ISSN (online) 1745-6215
    ISSN 1468-6694 ; 1745-6215
    DOI 10.1186/s13063-023-07141-2
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  8. Article: Quantitative multi-energy micro-CT: A simulation and phantom study for simultaneous imaging of four different contrast materials using an energy integrating detector.

    Kronfeld, Andrea / Rose, Patrick / Baumgart, Jan / Brockmann, Carolin / Othman, Ahmed E / Schweizer, Bernd / Brockmann, Marc Alexander

    Heliyon

    2023  Volume 10, Issue 1, Page(s) e23013

    Abstract: Emerging from the development of single-energy Computed Tomography (CT) and Dual-Energy Computed Tomography, Multi-Energy Computed Tomography (MECT) is a promising tool allowing advanced material and tissue decomposition and thereby enabling the use of ... ...

    Abstract Emerging from the development of single-energy Computed Tomography (CT) and Dual-Energy Computed Tomography, Multi-Energy Computed Tomography (MECT) is a promising tool allowing advanced material and tissue decomposition and thereby enabling the use of multiple contrast materials in preclinical research. The scope of this work was to evaluate whether a usual preclinical micro-CT system is applicable for the decomposition of different materials using MECT together with a matrix-inversion method and how different changes of the measurement-environment affect the results. A matrix-inversion based algorithm to differentiate up to five materials (iodine, iron, barium, gadolinium, residual material) by applying four different acceleration voltages/energy levels was established. We carried out simulations using different ratios and concentrations (given in fractions of volume units, VU) of the four different materials (plus residual material) at different noise-levels for 30 keV, 40 keV, 50 keV, 60 keV, 80 keV and 100 keV (monochromatic). Our simulation results were then confirmed by using region of interest-based measurements in a phantom-study at corresponding acceleration voltages. Therefore, different mixtures of contrast materials were scanned using a micro-CT. Voxel wise evaluation of the phantom imaging data was conducted to confirm its usability for future imaging applications and to estimate the influence of varying noise-levels, scattering, artifacts and concentrations. The analysis of our simulations showed the smallest deviation of 0.01 (0.003-0.15) VU between given and calculated concentrations of the different contrast materials when using an energy-combination of 30 keV, 40 keV, 50 keV and 100 keV for MECT. Subsequent MECT phantom measurements, however, revealed a combination of acceleration voltages of 30 kV, 40 kV, 60 kV and 100 kV as most effective for performing material decomposition with a deviation of 0.28 (0-1.07) mg/ml. The feasibility of our voxelwise analyses using the proposed algorithm was then confirmed by the generation of phantom parameter-maps that matched the known contrast material concentrations. The results were mostly influenced by the noise-level and the concentrations used in the phantoms. MECT using a standard micro-CT combined with a matrix inversion method is feasible at four different imaging energies and allows the differentiation of mixtures of up to four contrast materials plus an additional residual material.
    Language English
    Publishing date 2023-12-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e23013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Comparative Genomic Reveals Clonal Heterogeneity in Persistent

    Klein, Sabrina / Morath, Benedict / Weitz, Daniel / Schweizer, Patrick A / Sähr, Aline / Heeg, Klaus / Boutin, Sébastien / Nurjadi, Dennis

    Frontiers in cellular and infection microbiology

    2022  Volume 12, Page(s) 817841

    Abstract: Persistent infections caused ... ...

    Abstract Persistent infections caused by
    MeSH term(s) Genomics ; Humans ; Immune Evasion/genetics ; Staphylococcal Infections ; Staphylococcus aureus ; Virulence Factors/genetics
    Chemical Substances Virulence Factors
    Language English
    Publishing date 2022-02-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.817841
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The arrhythmogenic face of COVID-19: Brugada ECG pattern during acute infection.

    Lugenbiel, Patrick / Roth, Leon / Seiz, Mirjam / Zeier, Martin / Katus, Hugo A / Merle, Uta / Schweizer, Patrick A

    European heart journal. Case reports

    2020  Volume 4, Issue FI1, Page(s) 1–2

    Keywords covid19
    Language English
    Publishing date 2020-07-30
    Publishing country England
    Document type Journal Article
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytaa230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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